Title: Cheap Flights to Santa Isabel from CA $247 - Expedia.ca ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights to Santa Isabel from CA $247 [View CA $247 flight on Mon, Apr 13, 2026](https://expedia.ca/Flights-Search?trip=oneway&leg1=from:YXX,to:PTY,departure:13/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:246.61&airProductToken=AQpnCjEI16YBEgM0NzIY-L0BIJgWKI6eigMw3J6KAzhFQABYAWoFQkFTSUNyCExJMEQwVEJLCjII16YBEgQyMjY2GJgWIO_EASijpooDMOCpigM4RUABWAFqBUJBU0lDcghMSTBEMFRCSxIKCAEQARgBKgJXUxgBIgQIARABKAIoAygEMAE) [Hotels in Santa Isabel](https://expedia.ca/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Santa Isabel Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Isabel.d6203540.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.ca/Santa-Isabel.d6203540.Destination-Travel-Guides) ## Popular airlines to Santa Isabel - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca [](https://www.expedia.ca/Flights-Search?leg1=from:CMH,to:Santa Isabel, Colón, Panama,departure:14/04/2026TANYT&leg2=from:Santa Isabel, Colón, Panama,to:CMH,departure:21/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AV"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.ca/Flights-Search?leg1=from:CMH,to:Santa Isabel, Colón, Panama,departure:14/04/2026TANYT&leg2=from:Santa Isabel, Colón, Panama,to:CMH,departure:21/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United [](https://www.expedia.ca/Flights-Search?leg1=from:CMH,to:Santa Isabel, Colón, Panama,departure:14/04/2026TANYT&leg2=from:Santa Isabel, Colón, Panama,to:CMH,departure:21/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta [](https://www.expedia.ca/Flights-Search?leg1=from:CMH,to:Santa Isabel, Colón, Panama,departure:14/04/2026TANYT&leg2=from:Santa Isabel, Colón, Panama,to:CMH,departure:21/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_CM.svg) Copa [](https://www.expedia.ca/Flights-Search?leg1=from:CMH,to:Santa Isabel, Colón, Panama,departure:14/04/2026TANYT&leg2=from:Santa Isabel, Colón, Panama,to:CMH,departure:21/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"CM"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg) Aeromexico [](https://www.expedia.ca/Flights-Search?leg1=from:CMH,to:Santa Isabel, Colón, Panama,departure:14/04/2026TANYT&leg2=from:Santa Isabel, Colón, Panama,to:CMH,departure:21/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AM"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_KL.svg) KLM [](https://www.expedia.ca/Flights-Search?leg1=from:CMH,to:Santa Isabel, Colón, Panama,departure:14/04/2026TANYT&leg2=from:Santa Isabel, Colón, Panama,to:CMH,departure:21/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"KL"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.ca/login) ## How much is the cheapest flight to Santa Isabel? Prices were available within the past 7 days and start at CA $247 for one-way flights and CA $514 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![WestJet](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/WS.gif) Sat, Apr 18 - Tue, Apr 21 YYC Calgary PTY Panama City CA $514 Roundtrip found 3 hours ago [](https://expedia.ca/Flights-Search?trip=roundtrip&leg1=from:YYC,to:PTY,departure:18/04/2026TANYT&leg2=from:PTY,to:YYC,departure:21/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:513.11&airProductToken=AQo0CjII16YBEgQyMjY2GJgWIO_EASjD3ooDMIDiigM4RUAAWAFqBUJBU0lDcghMSTBEMFRCSwo0CjII16YBEgQyMjY3GO_EASCYFij8-IoDMNb8igM4RUAAWAFqBUJBU0lDcghMSTBEMFRCSxIKCAEQARgBKgJXUxgBIgQIARABKAIoAygEMAE) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, Oct 11 - Sun, Nov 1 YVR Vancouver PTY Panama City CA $553 Roundtrip found 5 days ago [](https://expedia.ca/Flights-Search?trip=roundtrip&leg1=from:YVR,to:PTY,departure:11/10/2026TANYT&leg2=from:PTY,to:YVR,departure:01/11/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:552.34&airProductToken=AQqcAQozCMGCARIENjMwMxi4jQEgi7gBKI6WmgMwzJeaAzhCQABYAWoFQkFTSUNyCE9OTjBBVEJaCjIIwYIBEgQyNzc3GIu4ASCMAii7mpoDMOScmgM4QkABWAFqBUJBU0lDcghPTk4wQVRCWgoxCMGCARIDOTU5GIwCIO_EASiln5oDMNSgmgM4QkABWAFqBUJBU0lDcghPTk4wQVRCWgqcAQoxCMGCARIDMzU0GO_EASCMAij_gZwDMLqDnAM4QkAAWAFqBUJBU0lDcghPTk4wQVRCWgoyCMGCARIEMTY3ORiMAiCjsQEorYWcAzD2hpwDOEJAAVgBagVCQVNJQ3IIT05OMEFUQloKMwjBggESBDE0MTUYo7EBILiNASjAi5wDMNWNnAM4QkABWAFqBUJBU0lDcghPTk4wQVRCWhIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Thu, May 14 - Sun, May 17 POS Trinidad PTY Panama City CA $721 Roundtrip found 6 days ago [](https://expedia.ca/Flights-Search?trip=roundtrip&leg1=from:POS,to:PTY,departure:14/05/2026TANYT&leg2=from:PTY,to:POS,departure:17/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:720.50&airProductToken=AQo0CjIIw5oBEgMzMTUYz5MBIO_EASjV-IwDMI76jAM4VEAAWAFqBUJBU0lDcghUTEE3VFoyUwo0CjIIw5oBEgMzMTQY78QBIM-TASiho40DMNqkjQM4TEAAWAFqBUJBU0lDcghMTEE4VFkyUxIKCAEQARgBKgJDTRgBIgQIARABKAIoAygEMAE) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Sun, May 3 - Thu, May 7 YYZ Toronto PTY Panama City CA $733 Roundtrip found 6 days ago [](https://expedia.ca/Flights-Search?trip=roundtrip&leg1=from:YYZ,to:PTY,departure:03/05/2026TANYT&leg2=from:PTY,to:YYZ,departure:07/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:732.07&airProductToken=AQpmCjEIwawBEgMzMjUYmM4BIJJYKJuDjAMwx4WMAzhVQABYAWoFTElHSFRyCFVaT0IxSVI3CjEIwawBEgMzMTcYklgg78QBKOeGjAMw34eMAzhVQAFYAWoFTElHSFRyCFVaT0IxSVI3CmUKMAjBrAESAjYxGO_EASDBMyjar4wDMLmwjAM4VUAAWAFqBUxJR0hUcghVWk9CMUlSNwoxCMGsARIDMjU0GMEzIJjOASjxs4wDMOi2jAM4VUABWAFqBUxJR0hUcghVWk9CMUlSNxIKCAEQARgBKgJMUhgBIgQIARABKAIoAygEMAE) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Sat, Dec 5 - Sat, Dec 12 YUL Montreal PTY Panama City CA $811 Roundtrip found 6 hours ago [](https://expedia.ca/Flights-Search?trip=roundtrip&leg1=from:YUL,to:PTY,departure:05/12/2026TANYT&leg2=from:PTY,to:YUL,departure:12/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:810.81&airProductToken=AQpyCjcI1YIBEgQzNjIzGJhdIMSNASjQgJ8DMLOBnwM4U0AAWAFqCjFfYmFzaWNlY29yCFNOQTZBMEJLCjcI1YIBEgMzOTIYxI0BIO_EASjnhJ8DMKKHnwM4U0AAWAFqCjFfYmFzaWNlY29yCFNOQTZBMEJLCnIKNwjVggESAzcyNxjvxAEgxI0BKITNnwMwws-fAzhTQABYAWoKMV9iYXNpY2Vjb3IIU05BNkEwQksKNwjVggESBDM2NDUYxI0BIJhdKNzRnwMwwNKfAzhTQABYAWoKMV9iYXNpY2Vjb3IIU05BNkEwQksSCggBEAEYASoCVUEYASIECAEQASgCKAMoBDAL) ## Find the cheapest month to fly from Columbus (CMH) to Panama City (PTY) ### October is typically the cheapest month to fly From CA $506 - CA $1,507 per traveller. ## Frequently asked questions ### What is the name of Santa Isabel's airport? ### What airport is best to fly into Santa Isabel? ### How many airlines fly to Santa Isabel? ### Which airlines fly to Santa Isabel? ### How many nonstop flights are there to Santa Isabel? ### Where are the most popular flights to Santa Isabel departing from? ### How long is the flight to Santa Isabel Airport? ### How to book the cheapest flight to Santa Isabel? ### Do you have any tips for my flight to Santa Isabel? > - A plane trip can be a cruisy experience if you take the right gear. Firstly, you'll want some basic toiletry items, such as a toothbrush and hairbrush, a clean pair of socks and a magazine or two. Next, find room in your hand luggage for your mobile phone, a charger, your medications and maybe a neck pillow too. Lastly, be sure to bring your passport, travel papers and some money. > > > Do not pack the following items in your hand luggage: > > > - Leave all your full-sized bottles of hair gel and hairspray in your checked luggage. Any gels or liquids in your carry-on bag larger than 3.4 ounces (100 millilitres) will be confiscated by security. Sharp objects, like your treasured Swiss Army knife, and dangerous products which are flammable or explosive, such as aerosol cans, spray paint and poisons, are also banned. > > > What to wear on a flight: > > > - The aisles of an aircraft aren't the place for a fashion parade. Layer your clothing and choose shoes that are flat, enclosed and easy to remove. > - Deep vein thrombosis (DVT) is a risk on long-distance flights. It results from blood clots forming due to poor circulation, so do some gentle foot and leg exercises in your seat and consider wearing compression tights or socks. ### How to get through airport security fast when flying to Santa Isabel? > - Be sure to keep your passport and boarding pass someplace easily accessible. They'll be the first things you'll be asked to show at airport security. > - The X-ray machine is up next. Empty your pockets and remove anything metal that is likely to beep. This includes things like headphones or earphones, as well as your coat or jacket. They'll all need to go on the X-ray conveyor belt. > - Electronic devices like phones and laptops will also have to go through the machine to be scanned. Don't worry though, you'll be back online soon enough. > - Want to bring along your favourite perfume or cologne? Not a problem. As long as the volume is no larger than 3.4 ounces (100 millilitres) and it's stored in a clear zip-close bag, you can keep it with you on board. > - The right choice of footwear can save you valuable minutes. Boots and heavy shoes are often required to be removed and separately scanned. Slip-on shoes are usually not. > - Sharp items such as knives and scissors can't be taken on board. They'll be seized at security, so pack them in your checked luggage. ## Book with confidence Expedia.ca gives you the best tools to secure great deals on flights to Santa Isabel. Use our easy and convenient booking engine to browse nonstop flights and convenient departure points every day of the year. Search airfares from the top airlines to book your perfect flight to Santa Isabel. Whatever your travel needs, you can always rely on Expedia.ca to help you find cheap flights to Santa Isabel. Using our booking engine is simple - just type in your points of travel and preferred dates and Expedia.ca does the rest! If your travel times are flexible, you can find even better bargains by adjusting your flight dates. Browse connecting flights to increase your chances of finding even lower fares. Thanks to Expedia's Best Price Guarantee, you can book your Santa Isabel flights with full confidence knowing that you've found the best deal online. Expedia.ca makes the booking process easy and stress-free by offering support along the entire way. Our friendly staff is available 24 hours a day to provide assistance and help you book your ticket. Call us toll-free at 1-888-397-3342 to answer any questions that you may have about your trip to Santa Isabel. Looking to save even more? Get additional savings by bundling your Santa Isabel flight with a hotel and/or car rental to create a bargain travel package. Early birds can discover terrific savings by booking in advance while last minute travelers can enjoy great last minute deals. With Expedia.ca, there's no shortage of options to save even more on your Santa Isabel trip! ## Travel information | Destination airport | Tocumen Intl. | | ----------------------------- | ------------- | | Destination airport IATA code | PTY | | Destination city name | Panama City | | Roundtrip price | CA $513 | ## Trending flights to Santa Isabel Prices were available within the past 7 days and start at CA $247 for one-way flights and CA $514 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![WestJet](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/WS.gif) Sat, Apr 18 - Tue, Apr 21 YYC Calgary PTY Panama City CA $514 Roundtrip found 3 hours ago [](https://expedia.ca/Flights-Search?trip=roundtrip&leg1=from:YYC,to:PTY,departure:18/04/2026TANYT&leg2=from:PTY,to:YYC,departure:21/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:513.11&airProductToken=AQo0CjII16YBEgQyMjY2GJgWIO_EASjD3ooDMIDiigM4RUAAWAFqBUJBU0lDcghMSTBEMFRCSwo0CjII16YBEgQyMjY3GO_EASCYFij8-IoDMNb8igM4RUAAWAFqBUJBU0lDcghMSTBEMFRCSxIKCAEQARgBKgJXUxgBIgQIARABKAIoAygEMAE) \*Available to Expedia members.