Santa Isabel Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Santa Isabel Vacation Deals
Price found within the past 48 hours. Click for updated prices.
Villa Marina Hotel
CA $1,380
per person
Oct 24 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
9/10 Wonderful! (174 reviews)
We stayed at the Condos, very clean, spacious, well mantained, comfortable. A little too far from the main hotel and restaurant, i recommend to have a car if staying there.
Staff VERY nice and helpful.
Reviewed on Aug 3, 2026
Surfside Beachfront Suites by Playa Caracol Resorts
CA $1,454
per person
Sep 13 - Sep 20
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
8/10 Very good! (44 reviews)
Everything was great except for the towels they provided, they were smelly and no matter how many times I washed them they were bad, other than that it was great and would go again with my own towels
Reviewed on Aug 8, 2026
Ready to book your vacation to Santa Isabel?
Santa Isabel Hotel Deals
Cocoloco - Catamaran Lagoon 52F SAN BLAS
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
CA $2,764
CA $3,049 total
Aug 17 - Aug 18
includes taxes & fees
Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
CA $262
CA $288 total
Aug 18 - Aug 19
includes taxes & fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."
Reviewed on Mar 15, 2026
Caribbean Haven Of Nature 'Preci Beach'
Nombre de Dios Colon
10/10 Exceptional! (31 reviews)
Beautiful
"This place is special. The inside of the house could use a deep cleaning. But the outdoor area and beach area are incredible. We explored tide pools and snorkeled open areas and crevices all week long. Our one negative experience was fishing with some young men from the nearby town; they did not ..."
Reviewed on Mar 17, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Isabel vacation package cost?
You'll find cheap prices from CA $1,211 on Expedia for your Santa Isabel escape. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
May, August and September are great times to search for cheap Santa Isabel vacation packages. Choosing to travel in quieter periods means you can generally find better prices on hotels and flights.
How many days is enough for Santa Isabel?
Usually, a handful of days is enough to explore the top sights during your Santa Isabel vacation. But if you want to have more time to chill out or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Use Expedia's filters to find some of the best Santa Isabel package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your adventure for midweek, or browse for Santa Isabel package deals in the off-peak season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, flight and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the freedom to create a tailored Santa Isabel vacation by choosing your favourite type of stay, airline and car class.
When to book a vacation package to Santa Isabel?
If you're planning a spur-of-the-moment Santa Isabel adventure, check out our last-minute deals that can be booked up to a week before you go. Prefer not to wait until the last minute? You can land terrific deals on your flights and hotels by booking ahead.
How to plan a trip to Santa Isabel?
- Choose when to go: Check your diary and get your bags packed. Your preferred season and the type of activities available will also help you decide when to escape to Santa Isabel.
- Plan your budget wisely: Besides the price of your stay, you'll need to consider other expenses too. These include transportation, food and flights. Also, put aside a little extra for unexpected costs that may arise during your trip to Santa Isabel.
- Decide your trip length: Consider how much time you'd like to spend discovering Santa Isabel. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
- Combine your accommodations and airfare: Once you've settled on your trip dates and duration, book the ideal Santa Isabel vacation package for you.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
