Santa Isabel Vacation Packages

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    Save up to CA $1,096 when you book a flight and hotel together*
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Top Santa Isabel Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B
Hotel Plaza Herrera
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá
Hotel Riu Plaza Panama

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Santa Isabel Hotel Deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door.

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
The price is CA $2,715 per night from Apr 7 to Apr 8
CA $2,715
CA $2,999 total
Apr 7 - Apr 8
includes taxes & fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Trips Guna Yala

Trips Guna Yala

2 out of 5
Urgandi, Mamardub Narganá Guna Yala
Trips Guna Yala
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.