Title: Santa Cruz Vacation Packages & Trips 2025 from CA $1,674 | Expedia.ca [Santa Cruz Hotels](https://expedia.ca/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Vacation Rentals in Santa Cruz](https://expedia.ca/Destinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)[Santa Cruz Car Rentals](https://expedia.ca/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations) ![](https://images.trvl-media.com/place/6053553/c22e3c92-bd89-4998-8279-debb63bcb80e.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santa Cruz Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence ### Better together Save up to CA $1,096 when you book a flight and hotel together\* ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package ### Rest easy Plan, book, and manage your trip all in one place ### Your Santa Cruz Vacation With a Santa Cruz vacation package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include [Samaipata](https://www.expedia.ca/Samaipata.d6200976.Destination-Travel-Guides), [Roboré](https://www.expedia.ca/Robore.d3000408084.Destination-Travel-Guides) and [Camiri](https://www.expedia.ca/Camiri.d770.Destination-Travel-Guides). Expedia is a one-stop shop when it comes to planning your Santa Cruz vacation. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other. ## Top vacation destinations in Santa Cruz ![San Lorenzo Cathedral which includes a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115563-Santa-Cruz.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Santa Cruz [](https://expedia.ca/Santa-Cruz.d6053940.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/06496d3cec9b6cad4a738ddeb6156d1c.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Samaipata [](https://expedia.ca/Samaipata.d6200976.Destination-Travel-Guides) ## Santa Cruz Hotel Deals ![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/640c92ef_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ibis Santa Cruz DE LA Sierra AVENIDA CRISTOBAL DE MENDOZA, Santa Cruz CA $61 CA $61 total Nov 11 - Nov 12 9.4/10 Exceptional! (61 reviews) "The" Reviewed on Jul 28, 2025 [](https://expedia.ca/Hotel-Search?startDate=11%2F11%2F2025&endDate=12%2F11%2F2025&selected=87138613&PinnedHotelID=87138613&HadPinnedHotel=true®ionId=6297178) ![Marriott Santa Cruz de la Sierra Hotel](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/a95726cf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Santa Cruz de la Sierra Hotel 4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz CA $145 CA $145 total Oct 24 - Oct 25 8.8/10 Excellent! (201 reviews) "Very comfortable" Reviewed on Sep 25, 2025 [](https://expedia.ca/Hotel-Search?startDate=24%2F10%2F2025&endDate=25%2F10%2F2025&selected=21490226&PinnedHotelID=21490226&HadPinnedHotel=true®ionId=6297178) ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel Ave. San Martin, #455, Santa Cruz CA $176 CA $176 total Oct 20 - Oct 21 8.8/10 Excellent! (331 reviews) "Hotel was excellent. Staff excellent, check in good and bar resturant really good. room was good and clean" Reviewed on Oct 3, 2025 [](https://expedia.ca/Hotel-Search?startDate=20%2F10%2F2025&endDate=21%2F10%2F2025&selected=18758&PinnedHotelID=18758&HadPinnedHotel=true®ionId=6297178) [See all 300 properties in Santa Cruz](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6297178) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Frequently asked questions ### How much does a Santa Cruz vacation package cost? > We make it simple to travel the world, with Santa Cruz vacation packages starting from as little as . You'll have the flexibility to combine your favorite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary? ### How do I get a cheap travel package to Santa Cruz? > One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure. ### What are the top hotels in Santa Cruz? > For properties in Samaipata with cozy beds and friendly service, look up [Sun Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) and [Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information). If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at [Camino Real Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) or [Marriott Santa Cruz de la Sierra Hotel](https://www.expedia.ca/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information). ### How far in advance should I book my Santa Cruz vacation? > It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates. ### What does an Expedia Santa Cruz travel package include? > Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favorite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape. ### What should I know before booking a Santa Cruz travel package? > Bundling your bookings into a Santa Cruz vacation package is the most convenient way to organize your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity? ### Can I choose my airline with a Santa Cruz Expedia vacation package? > Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organizing your Santa Cruz getaway. ### If I'm not able to travel, can I cancel my Santa Cruz vacation package? > Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz vacation package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our [Customer Service Portal](https://www.expedia.ca/service/?langid=4105) for more information. ### Discover the most popular places to visit in Santa Cruz ![Plaza 24 de Septiembre showing heritage architecture and heritage elements as well as a large group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115719-Plaza-24-De-Septiembre.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Plaza 24 de Septiembre 5/5(5 reviews) The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere. [](https://expedia.ca/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Vacation-Attraction) #### Ventura Mall 4.5/5(3 reviews) During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area. [](https://expedia.ca/Ventura-Mall-Santa-Cruz.d553248634697753452.Vacation-Attraction) #### Guembe Biocenter 5/5(1 review) Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops. [](https://expedia.ca/Guembe-Biocenter-Santa-Cruz.d553248621532465358.Vacation-Attraction) ### What to do in Santa Cruz ![Tickets Admission Ernesto Che Guevara Historical Museum in Vallegrande](https://mediaim.expedia.com/localexpert/4191385/9530c6db-4a68-46b4-b263-bae4498beefe.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided visit to the Che Guevara Memorial in Vallegrande CA $27 per adult [](https://expedia.ca/things-to-do/guided-visit-to-the-che-guevara-memorial-in-vallegrande.a4191385.activity-details) ![Vallegrande City](https://mediaim.expedia.com/localexpert/4231179/1a3f0126-8501-4ae1-ad3f-63dd629727fe.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Vallegrande City Tour CA $40 per adult [](https://expedia.ca/things-to-do/vallegrande-city-tour.a4231179.activity-details) ![Common grave, where the body of Che Guevara was found in 1997.](https://mediaim.expedia.com/localexpert/4190544/8d37523f-4917-493e-ab9d-482c2c1915da.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided tour of the Che Guevara Museum in Vallegrande CA $27 per adult [](https://expedia.ca/things-to-do/guided-tour-of-the-che-guevara-museum-in-vallegrande.a4190544.activity-details) [See all activities in Santa Cruz](https://expedia.ca/things-to-do/search?rid=6297178) ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)