Santa Cruz Vacation Packages
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Your Santa Cruz Vacation
With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.
Santa Cruz Hotel Deals
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is CA $82 per night from May 29 to May 30
CA $82
CA $82 total
May 29 - May 30
9.4/10 Exceptional! (118 reviews)
"Good location and value for money."
Reviewed on May 23, 2026
Sun Hotel
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is CA $149 per night from Jun 5 to Jun 6
CA $149
CA $149 total
Jun 5 - Jun 6
8.2/10 Very Good! (378 reviews)
"Very well located three start hotel. Clean with everything you need for an in/out night. Hotel needs a redoing."
Reviewed on May 27, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
The price is CA $181 per night from Jun 9 to Jun 10
CA $181
CA $181 total
Jun 9 - Jun 10
9/10 Wonderful! (379 reviews)
"Interesting layout to this hotel with exterior areas incorporated into the footprint of the property. Multiple resturants to chose from. Breakfast buffet was good but variety of fruit offered was a bit lacking. Good locations with great restaurants in area. Items in mini bar were horribly overpriced. ..."
Reviewed on May 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Plaza 24 de Septiembre
5/5(5 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
Ventura Mall
4.5/5(3 reviews)
During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.
Guembe Biocenter
5/5(1 review)
Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.
What to do in Santa Cruz
4D/3N Expedition: Che Guevara Route - Disconnect from the World
CA $1,093
per adult
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
CA $429
per adult
3D/2N Getaway on the Che Guevara Route Live the Adventure!
CA $956
per adult
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
