Santa Cruz Vacation Packages
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Your Santa Cruz Vacation
With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.
Top Santa Cruz Vacation Deals
Price found within the past 48 hours. Click for updated prices.
Swissôtel Santa Cruz De La Sierra
Price was CA $2,055, price is now CA $1,496 per person
CA $1,496
per person
May 27 - Jun 3
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Santa Cruz (VVI)
9.2/10 Wonderful! (87 reviews)
Excellent. Out of the way, not really walking distance to anything and not many taxis that pass by but the micro is easy to navigate and outside the door.very comfortable and excellent facilities and breakfast.
Reviewed on Feb 8, 2025
Hotel Cortez
Price was CA $1,826, price is now CA $1,519 per person
CA $1,519
per person
May 27 - Jun 3
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Santa Cruz (VVI)
9.2/10 Wonderful! (131 reviews)
Very nice and relaxing. The staff are very friendly and helpful. Very easy.
Reviewed on Apr 5, 2025
Santa Cruz Hotel Deals
Camino Real Hotel
Av. San Martín y 4to. Anillo Santa Cruz
The price is CA $179 per night from May 5 to May 6
CA $179
CA $179 total
May 5 - May 6
9/10 Wonderful! (423 reviews)
Good property the great amenities and service
Reviewed on Mar 24, 2026
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is CA $76 per night from Apr 18 to Apr 19
CA $76
CA $76 total
Apr 18 - Apr 19
9.6/10 Exceptional! (103 reviews)
Muy limpio, ambiente agradable muy bueno para viaje de negocios. La comida es excelente. Es un must comprar el servicio de desayuno es un buffet muy variado, sabroso y hacen cambios diariamente en el menú. Lo único que sugiero mejoren es la señal del wifi es muy inestable. Pero por lo demás muy bueno ...
Reviewed on Apr 3, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
The price is CA $182 per night from May 8 to May 9
CA $182
CA $182 total
May 8 - May 9
9/10 Wonderful! (365 reviews)
Yes
Reviewed on Mar 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Plaza 24 de Septiembre
5/5(5 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
Ventura Mall
4.5/5(3 reviews)
During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.
Guembe Biocenter
5/5(1 review)
Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.
What to do in Santa Cruz
4D/3N Expedition: Che Guevara Route - Disconnect from the World
CA $1,094
per adult
3D/2N Getaway on the Che Guevara Route Live the Adventure!
CA $957
per adult
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
