Santa Cruz Vacation Rentals

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Our top choices for Santa Cruz vacation rentals

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (83 reviews)
"Good price, great hotel!"
United States
James
The price is CA $53
CA $53 total
Feb 9 - Feb 10
Premium Suites Deluxe Aparthotel Equipetrol

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
2.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (11 reviews)
"Perfect hotel"
Turkey
Yener
The price is CA $73
CA $73 total
Mar 10 - Mar 11
Equipetrol Suites Apart Hotel

AMERICA APARTMENTS

AMERICA APARTMENTS
3.0 star property
Santa Cruz
The price is CA $75
CA $75 total
Feb 9 - Feb 10
AMERICA APARTMENTS

Apart Hotel Toborochi

Apart Hotel Toborochi
3.0 star property
Santa Cruz
8.8 out of 10, Excellent, (60 reviews)
"Very comfortable and quiet place and very good location. "
United States
Luis
Apart Hotel Toborochi

Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.

Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.
Santa Cruz de la Sierra
The price is CA $18
CA $48 total
Feb 9 - Feb 10
Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.

Casa Vida

Casa Vida
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (2 reviews)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
Chile
FERNANDO
Casa Vida

Luxury apartment

Luxury apartment
Santa Cruz de la Sierra
The price is CA $27
CA $62 total
Feb 12 - Feb 13
Luxury apartment

Cozy 2-bedroom apartment with AC, WiFi in enjoyable Santa Cruz

Cozy 2-bedroom apartment with AC, WiFi in enjoyable Santa Cruz
Santa Cruz de la Sierra
The price is CA $41
CA $68 total
Feb 13 - Feb 14
Cozy 2-bedroom apartment with AC, WiFi in enjoyable Santa Cruz

Terranova Suites

Terranova Suites
3.5 star property
Santa Cruz
8.0 out of 10, Very good, (90 reviews)
"Easy to access"
United States
Dorothy
The price is CA $65
CA $65 total
Feb 17 - Feb 18
Terranova Suites

Casa de 2 Habitaciones en zona norte

Casa de 2 Habitaciones en zona norte
Santa Cruz de la Sierra
"Muy buen departamento, bien ubicado"
United States
Elva
The price is CA $53
CA $81 total
Feb 9 - Feb 10
Casa de 2 Habitaciones en zona norte

Apartamento confortable para 2 personas

Apartamento confortable para 2 personas
Santa Cruz de la Sierra
The price is CA $30
CA $57 total
Feb 13 - Feb 14
Apartamento confortable para 2 personas

Traveler's Hideout

Traveler's Hideout
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"The place was cozy, neat, and th host was very attentive and supportive. I recomend this place"
United States
Mauricio O.
The price is CA $31
CA $67 total
Feb 9 - Feb 10
Traveler's Hideout

A must-see studio apartment in Sirari-Equipetrol

A must-see studio apartment in Sirari-Equipetrol
Santa Cruz de la Sierra
The price is CA $34
CA $82 total
Feb 24 - Feb 25
A must-see studio apartment in Sirari-Equipetrol

Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC

Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC
Santa Cruz de la Sierra
The price is CA $34
CA $68 total
Feb 24 - Feb 25
Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC

Lujo y confort en zona exclusiva

Lujo y confort en zona exclusiva
Santa Cruz de la Sierra
The price is CA $48
CA $75 total
Feb 9 - Feb 10
Lujo y confort en zona exclusiva

Apartment in Patio Design with private garage

Apartment in Patio Design with private garage
Santa Cruz de la Sierra
The price is CA $31
CA $79 total
Feb 9 - Feb 10
Apartment in Patio Design with private garage

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (98 reviews)
"Yes, staff were very friendly "
United States
veronica
Apart Hotel Premium Suites Santa Cruz

Dppto Luminoso y Lujoso en Equipe Zona Empresarial

Dppto Luminoso y Lujoso en Equipe Zona Empresarial
Santa Cruz de la Sierra
The price is CA $48
CA $89 total
Feb 9 - Feb 10
Dppto Luminoso y Lujoso en Equipe Zona Empresarial

Beautiful Loft in a brand new Condo, 10 minutes from business center.

Beautiful Loft in a brand new Condo, 10 minutes from business center.
Santa Cruz de la Sierra
The price is CA $41
CA $82 total
Feb 9 - Feb 10
Beautiful Loft in a brand new Condo, 10 minutes from business center.

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
Santa Cruz de la Sierra
The price is CA $55
CA $92 total
Feb 9 - Feb 10
COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santa Cruz. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we have vacation rentals in Santa Cruz near Santa Cruz Zoo, or you can go with a secluded option if you're looking for a relaxing stay. Discover why Santa Cruz is known for its shops. Make sure you have time to check out the cafes and zoo during your trip.

What are some of the best vacation home rentals in Santa Cruz?

Casa Vida: This highly rated vacation home rental in Santa Cruz is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other top choices in Santa Cruz are Green Tower-Stunning views from the 27 floor!Chic building in superb Santa Cruz and Jose Luis Noya.

How many vacation rentals will I find in Santa Cruz?

With 22 Expedia vacation rentals, you're sure to find just the right place for your Santa Cruz stay.

What can I see and do in Santa Cruz?

Enjoy the outdoors at Guembe Biocenter and Lomas de Arena Regional Park, or simply take in cultural attractions like Cine Center and Ethno-folkloric Museum. Plaza 24 de Septiembre and Ramon Tahuichi Aguilera Stadium are other places to visit while you're in town.

What are vacation rentals like in Santa Cruz?

Vacation rentals are private accommodations you can stay in for several days or more in Santa Cruz. Vacation rentals provide amenities such as laundry facilities and kitchens so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.