A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.

5 Stars Hotels in Panama City, Panamá Province from CA $148

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Check availability on Panama City 5 Star Hotels

Tonight
Sep 26 - Sep 27
Tomorrow
Sep 27 - Sep 28
Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Our top choices for Panama City 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A modern hotel room with a dining area, a TV, and a city view.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Sandrelly
CA $195
CA $214 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
CA $370
CA $407 total
includes taxes & fees
Oct 17 - Oct 18
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
CA $547
CA $602 total
includes taxes & fees
Oct 5 - Oct 6
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
CA $180
CA $198 total
includes taxes & fees
Oct 9 - Oct 10
Renaissance Panama City Hotel
A poolside area with lounge chairs and a view of the ocean.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.
A terrace with seating and a view of the ocean.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.

5. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Nemanja
CA $395
CA $434 total
includes taxes & fees
Oct 24 - Oct 25
JW Marriott Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A modern interior with a central seating area, potted plants, and a staircase.
A modern building with a sign reading 'HYATT REGENCY.'
A spacious hotel lobby with modern furniture, large windows, and a city view.

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
sheldon z
CA $264
CA $291 total
includes taxes & fees
Oct 3 - Oct 4
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Shelly-Ann
CA $380
CA $418 total
includes taxes & fees
Oct 15 - Oct 16
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A high-rise building with a rooftop pool area, surrounded by other buildings.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.

8. W Panama

W Panama
Bella Vista
United States
Nikkia
CA $338
CA $372 total
includes taxes & fees
Oct 10 - Oct 11
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A modern interior with a spiral staircase, a large window, and a seating area.
A modern bar area with seating and a view of the city.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Kevin
CA $347
CA $381 total
includes taxes & fees
Oct 24 - Oct 25
Hilton Panama
A hotel with a pool, beach, and palm trees.
A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.
A beachfront hotel with a large building, a beach, and a clear sky.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Anna
CA $291
CA $321 total
includes taxes & fees
Oct 5 - Oct 6
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.
A person performing a yoga pose in a living room with a large window and a sofa.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
CA $299
CA $329 total
includes taxes & fees
Oct 2 - Oct 3
Bristol Panama, a Registry Collection Hotel

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
CA $134
CA $148 total
includes taxes & fees
Sep 30 - Oct 1
Waymore Hotel Spa and Casino
A modern hotel room with a sofa, armchair, and a television.

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
CA $318
CA $351 total
includes taxes & fees
Oct 18 - Oct 19
Megapolis Hotel Panamá
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
CA $192
CA $221 total
Oct 6 - Oct 7
includes taxes & fees
8.6/10 Excellent! (2,736 reviews)
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
CA $269
CA $296 total
Sep 29 - Sep 30
includes taxes & fees
9/10 Wonderful! (1,003 reviews)
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
CA $204
CA $225 total
Sep 27 - Sep 28
includes taxes & fees
8.6/10 Excellent! (1,756 reviews)
Megapolis Hotel Panamá
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City
A city skyline with high-rise buildings, a calm waterfront, and a sunset sky.

Top Panama City Hotel Reviews

Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"Beautiful room clean location was good amenities were great"
sheldon z 3-night trip
Posted 18 hours ago
Hyatt Regency Panama City
Renaissance Panama City Hotel

Renaissance Panama City Hotel

8/10 Good
"Beautiful property. I enjoyed the courteous nature of the staff."
Shelly-Ann 3-night trip
Posted 2 days ago
Renaissance Panama City Hotel

Find out more about Panama City

Five Star Hotels in Panama City

There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Panama City so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Panama City and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Panama City

Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places.

Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town.

Make Your Escape to Panama City

The results are in, and Panama City 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Panama City! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Panama City today and settle down in the lap of luxury tomorrow.

Frequently asked questions

What are the best 5-star hotels in Panama City?
Based on Expedia guest reviews, Bristol Panama, a Registry Collection Hotel, W Panama and Hotel Riu Plaza Panama are among the most popular 5-star hotels in Panama City. Featuring top-quality amenities and excellent service, you'll enjoy a luxurious and memorable stay.
How much does it cost to stay in a 5-star hotel in Panama City?
How much you pay for a 5-star hotel in Panama City depends on factors like when you plan to travel and the length of your break. A top tip for bagging the best deal? Use our pricing filters to check out all of the available options for your preferred dates.
  • Search for the lowest price per night from CA $221
What makes a hotel 5 stars in Panama City?
From gourmet dining venues and 24-hour gyms to swimming pools and premium bedding, the 5-star experience in Panama City is all about comfort and luxury. But it requires more than just top-notch conveniences to receive a 5-star rating. Stays must also deliver exceptional guest-focused services like in-room massages, on-site dry cleaning and laundry and a nightly turn-down service.

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