Hotels in Santa Lucia, Syracuse from CA $90
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Santa Lucia
Family friendly
Check prices for these dates
Santa Lucia hotels and places to stay

B&B Le Saline
B&B Le Saline
10.0 out of 10, Exceptional, (61)
The price is CA $188
CA $215 total
includes taxes & fees
Sep 13 - Sep 14

Il Giardino del Barocco
Il Giardino del Barocco
9.2 out of 10, Wonderful, (106)
The price is CA $138
CA $152 total
includes taxes & fees
Sep 1 - Sep 2

B&B Nike
B&B Nike
9.0 out of 10, Wonderful, (69)
The price is CA $116
CA $132 total
includes taxes & fees
Aug 30 - Aug 31

Il Giardino di Sicilia
Il Giardino di Sicilia
9.6 out of 10, Exceptional, (93)
The price is CA $132
CA $150 total
includes taxes & fees
Sep 9 - Sep 10

Lakkios
Lakkios
9.0 out of 10, Wonderful, (53)
The price is CA $136
CA $172 total
includes taxes & fees
Aug 30 - Aug 31

Giuggiulena Villa
Giuggiulena Villa
10.0 out of 10, Exceptional, (125)
The price is CA $383
CA $437 total
includes taxes & fees
Sep 11 - Sep 12
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Where to stay in Santa Lucia
Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.

Ortigia
1 out of top 10 points of interest in this area
Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.
Acradina
You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.
Grottasanta
Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.
Neapolis
While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.
Tiche
Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.
Top Santa Lucia Hotel Reviews

Mangia's Brucoli, Sicily, Autograph Collection
10/10 Excellent
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Syracuse neighborhoods
More Accommodation Types in Santa Lucia
Hotels Close to Nearby Airports
Explore more hotels
- Ortea Palace Hotel, Sicily, Autograph Collection
- Mangia's Brucoli, Sicily, Autograph Collection
- Archinuè Suite & Apartments
- Grand Hotel Ortigia Siracusa
- Hotel Parco delle Fontane
- Grand Hotel Villa Politi
- Hotel Scala Greca
- Grand Hotel Des Ètrangers - The Leading Hotels of the World
- Domus Mariae Albergo
- Life Hotels Kalaonda Resort
- Charme Hotel Henry's House
- UNA HOTELS One Siracusa
More ways to book
Expedia's Latest Trends
Hotels
Flights