Title: 10 Best Hotels in Santa Lucia, Syracuse for 2025 | Expedia.ca [Vacation Rentals in Syracuse](https://expedia.ca/Syracuse-Vacation-Rentals.d4912.Travel-Guide-VacationRentals)[Flights to Syracuse](https://expedia.ca/Cheap-Flights-To-Syracuse.d4912.Travel-Guide-Flights)[Things to do in Syracuse](https://expedia.ca/Things-To-Do-In-Syracuse.d4912.Travel-Guide-Activities)[Santa Lucia Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Lucia.d553248635213209885.Car-Rental-Guide)[Santa Lucia Vacations](https://expedia.ca/Santa-Lucia.d553248635213209885.Destination-Travel-Guides) ![Canoe Polo World Championships 2016 - Syracuse](https://images.trvl-media.com/place/553248635213209885/7a687ce9-1325-4785-b769-48c3d6a701b7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Gatanass # Hotels in Santa Lucia, Syracuse ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Lucia Spa [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&amenities=SPA_ON_SITE) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&lodging=APART_HOTEL) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&lodging=APARTMENT) Ocean view [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&amenities=OCEAN_VIEW) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&travelerType=family_friendly) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&amenities=HOT_TUB) Pool [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&amenities=POOL) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&amenities=WATER_PARK) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&amenities=PETS) Villa [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&lodging=VILLA) Farm [](https://www.expedia.ca/Hotel-Search?destination=Santa+Lucia%2C+Syracuse%2C+Sicily%2C+Italy®ionId=553248635213209885&latLong=37.071304%2C15.289151&adults=2&startDate=2025-11-05&d1=2025-11-05&endDate=2025-11-07&d2=2025-11-07&lodging=AGRITOURISM) ## Check prices for these dates Tonight [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=553248635213209885&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=553248635213209885&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635213209885&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635213209885&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Santa Lucia hotels and places to stay ![Aerial view](https://images.trvl-media.com/lodging/3000000/2980000/2974800/2974756/2465bcdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/3000000/2980000/2974800/2974756/3969188e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/3000000/2980000/2974800/2974756/8690ebba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/3000000/2980000/2974800/2974756/d745213b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grande Albergo Alfeo Santa Lucia 8.6/10 Excellent (646) "Great location very walkable. Staff was pleasant and breakfast was plentiful and tasty. Stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) susan CA $182 CA $208 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Syracuse-Hotels-Grande-Albergo-Alfeo.h2974756.Hotel-Information) ![Suite](https://images.trvl-media.com/lodging/104000000/103530000/103523100/103523090/fbe2e278.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite](https://images.trvl-media.com/lodging/104000000/103530000/103523100/103523090/4b17f7a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/104000000/103530000/103523100/103523090/c1e0d589.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Triple Room](https://images.trvl-media.com/lodging/104000000/103530000/103523100/103523090/a8563377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Palazzo Cavalieri Santa Lucia 9.0/10 Wonderful (35) "Enjoyed our stay, nice comfortable room and bed. Very nice breakfast buffet. Within a quick 5 min walk to Ortigia Island, also walkable to train and bus station. Would stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $176 CA $201 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Syracuse-Hotels-Hotel-Cavalieri.h103523090.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/f4662c00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Room](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/9785c0f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/3f45e0ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/f2d141d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caportigia Boutique Hotel Santa Lucia 9.4/10 Exceptional (249) "Great base for exploring Syracuse. " ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Mark CA $163 CA $196 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) ![Quadruple Room, 1 King Bed with Sofa bed, Sea View, Tower | Terrace/patio](https://images.trvl-media.com/lodging/118000000/117120000/117118700/117118661/a167a2e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/118000000/117120000/117118700/117118661/f8c72b7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/118000000/117120000/117118700/117118661/7c13b84e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/118000000/117120000/117118700/117118661/91ad9665.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Miranda Boutique Santa Lucia CA $275 CA $314 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Syracuse-Hotels-Casa-Miranda-Boutique.h117118661.Hotel-Information) ![Superior Triple Room, Sea View](https://images.trvl-media.com/lodging/106000000/105440000/105439100/105439006/43120257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Triple Room, Sea View | Terrace/patio](https://images.trvl-media.com/lodging/106000000/105440000/105439100/105439006/e0cdb4a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105440000/105439100/105439006/f50d20c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/106000000/105440000/105439100/105439006/25540a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fortaleza Charme House Santa Lucia 10/10 Exceptional (26) "Great central location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Craig CA $199 CA $227 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Syracuse-Hotels-Fortaleza-Charme-House.h105439006.Hotel-Information) ![Suite, Balcony, Sea View](https://images.trvl-media.com/lodging/3000000/2530000/2522400/2522354/c6129591.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2530000/2522400/2522354/3adf887e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room Sea View | Balcony view](https://images.trvl-media.com/lodging/3000000/2530000/2522400/2522354/b3240fc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2530000/2522400/2522354/971ae922.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakkios Santa Lucia 9.0/10 Wonderful (62) "Nice, central, clean, easy to park, quiet during the night, staff was welcoming, nice breakfast with view - excellent choice!" ![Norway](https://a.travel-assets.com/egds/marks/flags/no.svg) Jon-Kåre CA $142 CA $162 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Syracuse-Hotels-Lakkios.h2522354.Hotel-Information) ![Double or Twin Room, Balcony, Ocean View](https://images.trvl-media.com/lodging/9000000/8380000/8376700/8376633/08fa3443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, Balcony, Ocean View](https://images.trvl-media.com/lodging/9000000/8380000/8376700/8376633/4e3736f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, Balcony, Ocean View](https://images.trvl-media.com/lodging/9000000/8380000/8376700/8376633/da28e6b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Triple Room, Balcony | Balcony](https://images.trvl-media.com/lodging/9000000/8380000/8376700/8376633/a1e41084.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### B&B Nike Santa Lucia 9.0/10 Wonderful (73) "This is an AMAZING AND EXCEPTIONAL property! Tucked away in a residential area with just a three minute walk to the bus stop. The hotel is beautifully furnished and modern. The rooms are spacious and inviting. This boutique hotel feels like a luxury five star hotel. I definitely want to come back to Cagliari, and when I do, rest assured I will be staying at Nemo. Also breakfast on the roof top is amazing! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory CA $112 CA $127 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Syracuse-Hotels-BB-Nike.h8376633.Hotel-Information) ![Interior detail](https://images.trvl-media.com/lodging/4000000/3050000/3041500/3041424/bdda48ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free full breakfast](https://images.trvl-media.com/lodging/4000000/3050000/3041500/3041424/1234289f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/4000000/3050000/3041500/3041424/df73c39f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/4000000/3050000/3041500/3041424/49e547d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### B&B Triskeles Santa Lucia 8.2/10 Very good (58) "Excellent stay, close to everything and easy parking" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Melissa CA $89 CA $101 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Syracuse-Hotels-BB-Triskeles.h3041424.Hotel-Information) ![Coffee/tea maker, electric kettle](https://images.trvl-media.com/lodging/9000000/8770000/8763800/8763735/a728c4b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/9000000/8770000/8763800/8763735/043cb791.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/9000000/8770000/8763800/8763735/44d2e27e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/9000000/8770000/8763800/8763735/c554e010.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Nostos rooms & Apartments Santa Lucia 9.0/10 Wonderful (270) "On a main thoroughfare close to Isola di Ortigia. Friendly management and helpful to me." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $99 CA $113 total includes taxes & fees Oct 24 - Oct 25 [](https://www.expedia.ca/Syracuse-Hotels-BB-Nostos.h8763735.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/115000000/114690000/114682800/114682713/8646c46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114690000/114682800/114682713/c47ae805.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/115000000/114690000/114682800/114682713/d34d13c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/115000000/114690000/114682800/114682713/b64fbcce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Nicola Rooms Siracusa Santa Lucia 9.0/10 Wonderful (2) "Não se espante com o prédio onde está localizado o hotel (fica no terceiro andar). Os quartos são novos e muito confortáveis. E ficar atento porque não há estacionamento grátis, mas sim pago na rua. " ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Luiz Guilherme CA $125 CA $143 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Syracuse-Hotels-San-Nicola-Rooms-Siracusa.h114682713.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/9000000/8350000/8343300/8343269/328c4e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/9000000/8350000/8343300/8343269/027f65cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8350000/8343300/8343269/ee712d79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Single Room | Terrace/patio](https://images.trvl-media.com/lodging/9000000/8350000/8343300/8343269/53fa88c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Le Muse Santa Lucia 7.4/10 Good (70) "The room was great and the staff was exceptionally helpful" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Henry CA $118 CA $135 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Syracuse-Hotels-Hotel-Le-Muse.h8343269.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/4000000/3100000/3091700/3091630/4c69e8c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/4000000/3100000/3091700/3091630/76baf5d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Double or Twin Room, 1 Bedroom, Balcony, Sea View](https://images.trvl-media.com/lodging/4000000/3100000/3091700/3091630/8656c81b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/4000000/3100000/3091700/3091630/67693419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Giuggiulena Villa Santa Lucia 10/10 Exceptional (126) "Fantastic stay. Made to feel very welcome and what a lovely relaxing place to stay. Evening meal was exceptional. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $338 CA $386 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Syracuse-Hotels-Giuggiulena-Villa.h3091630.Hotel-Information) ![Water view](https://images.trvl-media.com/lodging/36000000/35370000/35360800/35360799/b9e46e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, Turkish bath, deep-tissue massages](https://images.trvl-media.com/lodging/36000000/35370000/35360800/35360799/91bc8ac0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/36000000/35370000/35360800/35360799/ce81f99e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/36000000/35370000/35360800/35360799/8da26db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Re Dionisio Luxury Suites Santa Lucia 8.8/10 Excellent (56) "Spacious room, dated but comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth CA $341 CA $391 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Syracuse-Hotels-Re-Dionisio-Boutique-Hotel.h35360799.Hotel-Information) ![Full-size fridge, oven, stovetop, cookware/dishes/utensils](https://images.trvl-media.com/lodging/34000000/33450000/33444500/33444412/625bbc70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Design Room, 1 Double Bed, Non Smoking](https://images.trvl-media.com/lodging/34000000/33450000/33444500/33444412/57a739b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/34000000/33450000/33444500/33444412/47e24f8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/34000000/33450000/33444500/33444412/9d0b7c7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gymnasium Santa Lucia 8.8/10 Excellent (40) "Nice kitchen area, centrally located." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $88 CA $101 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Syracuse-Hotels-BB-Gymnasium.h33444412.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2540000/2539600/2539517/70b64e81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/3000000/2540000/2539600/2539517/00aaef6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/3000000/2540000/2539600/2539517/de127e9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/3000000/2540000/2539600/2539517/07cf493f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel dei Coloniali Santa Lucia 7.4/10 Good (164) "Convenient location for Syracuse town, but in a scruffy area and the whole property is looking tired. Breakfast was adequate. The owner was charming and happy to help." ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Rod CA $72 CA $83 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Syracuse-Hotels-Hotel-Dei-Coloniali.h2539517.Hotel-Information) ![Triple Room, Housekeeping, City View](https://images.trvl-media.com/lodging/117000000/116080000/116074600/116074546/df13dfdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double or Twin Room, Housekeeping, City View | View from room](https://images.trvl-media.com/lodging/117000000/116080000/116074600/116074546/4a43860f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/117000000/116080000/116074600/116074546/12c7eeb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/117000000/116080000/116074600/116074546/c3652060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Agorà Santa Lucia CA $145 CA $174 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Syracuse-Hotels-Agora.h116074546.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2020000/2010100/2010088/f70e005a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/3000000/2020000/2010100/2010088/e4ffb628.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, free cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/3000000/2020000/2010100/2010088/3dd3629c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/3000000/2020000/2010100/2010088/e87add85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Piccolo Hotel Casa Mia Santa Lucia 8.6/10 Excellent (372) "The staff is extremely nice and friendly and you feel welcome. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Florentina CA $78 CA $89 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Syracuse-Hotels-Piccolo-Hotel-Casa-Mia.h2010088.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/6000000/5030000/5020800/5020784/976bca6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/6000000/5030000/5020800/5020784/ac480855.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/6000000/5030000/5020800/5020784/bcc4a8df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Single Room](https://images.trvl-media.com/lodging/6000000/5030000/5020800/5020784/56ed95ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Populus Santa Lucia 7.8/10 Good (74) "Just stay somewhere else, plain and simple." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $113 CA $129 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Syracuse-Hotels-Populus.h5020784.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/2000000/1140000/1133800/1133702/95edfb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Triple Room, Balcony, Ocean View | View from room](https://images.trvl-media.com/lodging/2000000/1140000/1133800/1133702/ec86de2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/2000000/1140000/1133800/1133702/2ca740bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sport court](https://images.trvl-media.com/lodging/2000000/1140000/1133800/1133702/f98124db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Mediterraneo Santa Lucia 7.8/10 Good (122) "Very friendly and helpful staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $107 CA $122 total includes taxes & fees Nov 8 - Nov 9 [](https://www.expedia.ca/Syracuse-Hotels-Hotel-Mediterraneo.h1133702.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/111000000/110650000/110647700/110647630/d25497d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Room, Balcony | Private kitchen](https://images.trvl-media.com/lodging/111000000/110650000/110647700/110647630/a2985623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/111000000/110650000/110647700/110647630/ba6a8506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Triple Room, Balcony, City View](https://images.trvl-media.com/lodging/111000000/110650000/110647700/110647630/83e23650.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmaCasa Siracusa Santa Lucia 10/10 Exceptional (1) "Siamo stati molto bene, la struttura internamente è abbastanza ammodernata e l'accesso è stato" ![Italy](https://a.travel-assets.com/egds/marks/flags/it.svg) Alessandro CA $127 CA $145 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Syracuse-Hotels-AmaCasa-Siracusa.h110647630.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-06&endDate=2025-11-07®ionId=553248635213209885&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Lucia-Syracuse-Hotels.0-n553248635213209885-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Lucia-Syracuse-Hotels.0-n553248635213209885-0.Travel-Guide-Filter-Hotels) ## Where to stay in Santa Lucia Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most. - Ortigia - Grottasanta - Tiche - Acradina - Neapolis ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/87000/87667-Temple-Of-Apollo.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Temple of Apollo showing heritage elements and building ruins](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/87000/87666-Temple-Of-Apollo.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Temple of Apollo featuring street scenes and heritage elements](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/87000/87663-Temple-Of-Apollo.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Temple of Apollo which includes building ruins and heritage elements](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/87000/87670-Temple-Of-Apollo.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Temple of Apollo featuring a ruin, street scenes and heritage elements](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/87000/87673-Temple-Of-Apollo.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635213212045) ![Ortigia map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:uzeaFygi%7CAwHsJ%7DG%60%40EZkEDrAuGG_AO%5Co%40e%40Pk%40%7DC_%40Qi%40TQlBd%40Z%5B%7CFgKcByCuEyDT_AXCpHfHfCCnCuANf%40%7EDPlCeCl%40qCtEyDjDl%40rDqAItCdCB%5E%60Al%40E%5Ef%40%5CjAWhBPn%40%7E%40S%3FvDv%40tBlBBpKeE%7EC%60CxDkCbAwBf%40Nq%40pDsBfEgB%7E%40cBCsDp%40%7BIxEyAtCgB%60%40%5CtEm%40iDo%40LGe%40qRjDVjC%7B%40Z%7B%40wCgEdG&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=pmNCAHUleb6hkejMUM2kmj7vEZ4=) ### Ortigia Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635213212045) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635213213857) ![Grottasanta map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ejmaFmhg%7CAiCIcKoHuCMaD%7C%40yDTyBpB_L%7DDmF%7DD%5EEGi%40f%40_%40KgBd%40FRgBm%40AAeAv%40TtAiC%5EiFk%40yDlAgDUe%40%5E%5DK%7D%40d%40s%40VqDjADBoAv%40CCu%40%5EGOaA%60A%7D%40u%40uIn%40_C%7D%40sBvCwAfAgBBu%40%5CCOyBl%40uBvGwCCz%40n%40AClApAh%40rEy%40dA%7DA%60FqALcCPSNf%40LOb%40cBrAj%40LaB%60Ic%40Ba%40hCm%40dAiAt%40MbBHd%40%5D%7C%40%60%40hIwBnDRpE%7B%40dC%40%5DgDdB%5BxBb%40HvBz%40i%40Xb%40%7CDaArA%3FlEfFfIp%40fJuEBiA%5Cr%40ZG%60EkCtBMs%40x%40bBr%40%7ECgB%7EDLDXnAi%40vALnCk%40BpAc%40%5C%5C%5Ee%40PXPfBe%40KnAq%40r%40dASr%40lA%5CGI%7ECZ%3FNjCh%40Vr%40nCYlBf%40%60%40xByAGaAXNQxBh%40vCaArBf%40%7C%40IdFoBpHaAa%40RiAiDuA%5Bk%40sMhFjClHcGz%40mBz%40y%40hB%7DTjJ_BmGuG%3FaDaCcCwFwGhF_QcKuBnA_AHa%40dAaETu%40q%40qAt%40ESkCfCaAHq%40_D_Bp%40Bn%40eEpAqCnC%7EEFtChOxDkBx%40dGaLzPl%40jIcBlC_BgAmDn%40a%40tC%5E%7EC&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=JWhQvZH-Tc8NoYmsBpvws_O2oWs=) ### Grottasanta Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635213213857) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635213213825) ![Tiche map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:_bmaFiza%7CAm%40_%40U%7DDvAOBsEj%40sC%40kTi%40Pq%40i%40BsHgID%3FcFfEJJkLkGNA_Ag%40%40Ao%40h%40OiAcKiAq%40aVbAkBuKlBjAfAQ%5C%7D%40Us%40T%7DBs%40qA%5EKoBmCUyDaB_CgDoMp%40yCUyD%60EaC%7C%40oGjD%5BrENnC%7DAZ%5CKrBf%40%5CzMvBhKnDlLe%40xHuF%7CCN%7DBgQ%7CAKWcCbLqAHoCdBeBhVc%40nGqBnChOTjFvPkGjGp%5ClF%7ETmA%60D%7BAzIyEfC%7DDxHgJ%7EKuP%60YkWb%5CyJfKqPxJyKlAeCt%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=RYEHG0yi0IG66-wUmqK_UXNjSTQ=) ### Tiche Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635213213825) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635213214634) ![Acradina map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:isnaFklf%7CAAyApAkFM%7BCVc%40r%40%5Ed%40i%40P%60%40jB%40JoCu%40Ac%40b%40k%40E%3F%5Ba%40VHkAgAYoC%60%40%7B%40gBuCaBIuA%7BAgAVoBs%40%7BAaAYNwAi%40K%3Fe%40pF%7CD%7EK%7CDxBqBxDU%60D%7D%40tCLbKnHhCH_%40_D%60%40uClDo%40%7EAfAbBmCm%40kI%60L%7BPy%40eGyDjBuCiO_FGpCoCdEqACo%40%7EAq%40p%40%7EC%60AIjCgCDRpAu%40t%40p%40%60EU%60%40eA%7E%40ItBoA%7EPbKvGiFbCvF%60D%60CtG%3F%7EAlG%7CTkJx%40iBlB%7B%40bG%7B%40kCmHrMiFZj%40hDtAShA%60A%60%40yCbRv%40zFt%40f%40_AfCLdJ%7B%40%5EQz%40%5CxAWvBzArD%3FpH_VlBqEfCkRbHUkFoCiOoGpB%7DU%5EiBzAQ%7CCcLpAVbC%7DAJ%7CBfQ%7DCOyHtFmLd%40iKoD%7BMwBg%40%5DJsB%5B%5DoC%7CAsEOkDZ%7D%40nGaE%60C&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=eCMT0Ns9gsxOpEYlI-9q1Q5b4I8=) ### Acradina You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635213214634) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=952515174506594304) ![Neapolis map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:e%7ChaF_ne%7CAq%40y%40QPsKkM%5DnCMLKUsDcQm%40eBQ_BsFoYzBoArBiAxAYvS%7DACuHGmSWwDbAaCvI%60B%7CGv%40I%60O%7EKt%40h%40RZpKeDdBr%40bC%60E%7ETyCjGiElCkB%60DmA%7EH%7BEhKqLlD&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=etuAtkTmH-Na-zOlR4CLnA9CYgY=) ### Neapolis While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis. [See properties](https://www.expedia.ca/Hotel-Search?regionId=952515174506594304) ## Top Santa Lucia Hotel Reviews ![Hotel Parco delle Fontane](//images.trvl-media.com/lodging/9000000/8480000/8470400/8470355/9f63b65f_y.jpg) ### Hotel Parco delle Fontane 10/10 Excellent "Overall the place was great. The room was spacious, clean and confortable. The only draw back was that the breakfast had a limited selection." [](https://expedia.ca/Syracuse-Hotels-Hotel-Parco-Delle-Fontane.h8470355.Hotel-Information) ![Hotel Como](//images.trvl-media.com/lodging/2000000/1580000/1575800/1575733/43bb6896_y.jpg) ### Hotel Como 10/10 Excellent "Breakfast without eggs,meat for sandwich and not enought bread." [](https://expedia.ca/Syracuse-Hotels-Hotel-Como.h1575733.Hotel-Information) ![Mercure Siracusa Prometeo](//images.trvl-media.com/lodging/2000000/1540000/1538700/1538612/a195bd7c_y.jpg) ### Mercure Siracusa Prometeo 10/10 Excellent "Great staff. Good location " [](https://expedia.ca/Syracuse-Hotels-Mercure-Siracusa-Prometeo.h1538612.Hotel-Information) ![Eureka Palace Hotel Spa Resort](//images.trvl-media.com/lodging/4000000/3820000/3814900/3814820/af67d93f_y.jpg) ### Eureka Palace Hotel Spa Resort 10/10 Excellent "Great welcome at reception at check in!" [](https://expedia.ca/Syracuse-Hotels-Eureka-Palace-Hotel-Spa-Resort.h3814820.Hotel-Information) ![Lakkios](//images.trvl-media.com/lodging/3000000/2530000/2522400/2522354/c6129591_y.jpg) ### Lakkios 10/10 Excellent "Breakfast was delicious, an assortment of breads, cheese, meats, boiled eggs, bruschetta, and pastries, cakes, croissants, fruit juice and fresh fruit. Francesco was super kind and helpful to plan our excursions as it was our first trip to Siricusa. Room was clean, comfortable and had window views of the harbor. I would recommend it!" [](https://expedia.ca/Syracuse-Hotels-Lakkios.h2522354.Hotel-Information) ![Archinuè Suite & Apartments](//images.trvl-media.com/lodging/23000000/22120000/22110600/22110520/9fb412e9_y.jpg) ### Archinuè Suite & Apartments 10/10 Excellent "The apartment was clean, easy to find and quiet.The staff were helpful and very responsive to our questions.We found parking on the street with no problem. Location wise it was great, everything was reachable by a short walk. The laundry was very helpful. There were a lot of restaurants nearby.We tried a few( googled the reviews) and the food was delicious. " [](https://expedia.ca/Syracuse-Hotels-Archinue-Suite-Apartments.h22110520.Hotel-Information) ![Hotel Palazzo Cavalieri](//images.trvl-media.com/lodging/104000000/103530000/103523100/103523090/fbe2e278_y.jpg) ### Hotel Palazzo Cavalieri 10/10 Excellent "Excelente ubicación!!!" [](https://expedia.ca/Syracuse-Hotels-Hotel-Cavalieri.h103523090.Hotel-Information) ![Algila' Ortigia Charme Hotel](//images.trvl-media.com/lodging/2000000/1890000/1883500/1883438/d402c8e9_y.jpg) ### Algila' Ortigia Charme Hotel 10/10 Excellent "We really enjoyed this property. The buildings are ancient, but completely renovated and clean. Bathrooms are new, beds are comfortable with good linens. Breakfasts are excellent with many choices. " [](https://expedia.ca/Syracuse-Hotels-Algila-Ortigia-Charme-Hotel.h1883438.Hotel-Information) ![Grand Hotel Villa Politi](//images.trvl-media.com/lodging/2000000/1230000/1220700/1220650/73408607_y.jpg) ### Grand Hotel Villa Politi 10/10 Excellent "Wonderful hotel, nice area and great buffet breakfast" [](https://expedia.ca/Syracuse-Hotels-Grand-Hotel-Villa-Politi.h1220650.Hotel-Information) ## Frequently asked questions ### What is Santa Lucia like? > Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood. ### Where is the best place to stay in Santa Lucia? > Based on Expedia customer reviews, [Fortaleza Charme House](https://www.expedia.ca/Syracuse-Hotels-Fortaleza-Charme-House.h105439006.Hotel-Information) is the highest ranked property in Santa Lucia. This inn is a short 6-minute walk from Lungomare di Ortigia, and it offers a beach bar and free WiFi. Other top choices in the neighborhood include [Giuggiulena Villa](https://www.expedia.ca/Syracuse-Hotels-Giuggiulena-Villa.h3091630.Hotel-Information) and [Caportigia Boutique Hotel](https://www.expedia.ca/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information). ### How many hotels can I expect to find in Santa Lucia? > Expedia has 280 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area. ### If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund? > Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia. ### What are the top things to see and do in Santa Lucia? > Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [4 Star Hotels in Syracuse](https://www.expedia.ca/4Star-Syracuse-Hotels.s40-0-d4912.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Syracuse](https://www.expedia.ca/5Star-Syracuse-Hotels.s50-0-d4912.Travel-Guide-Filter-Hotels) - [Arenella Hotels](https://www.expedia.ca/Arenella-Hotels.d6182479.Travel-Guide-Hotels) - [Augusta Hotels](https://www.expedia.ca/Augusta-Hotels.d6131453.Travel-Guide-Hotels) - [Hotels near Beach Lungomare Tremoli](https://www.expedia.ca/Beach-Lungomare-Tremoli-Hotels.0-l553248634042002997-0.Travel-Guide-Filter-Hotels) - [Belvedere Hotels](https://www.expedia.ca/Belvedere-Hotels.d6284570.Travel-Guide-Hotels) - [Canicattini Bagni Hotels](https://www.expedia.ca/Canicattini-Bagni-Hotels.d6344096.Travel-Guide-Hotels) - [Caponegro Hotels](https://www.expedia.ca/Caponegro-Hotels.d553248635975855979.Travel-Guide-Hotels) - 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