Santa Ana Vacation Packages
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Your Santa Ana Vacation
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.
Price found within the past 48 hours. Click for updated prices.
- Villa Marina Hotel
Aug 1 - Aug 8Villa Marina Hotel + Flight
Las Escobas del Venado6 nights9.0/10 - Wonderful (159 reviews)"Todo muy bien y personal muy amable"Reviewed May 3, 2026Roundtrip • Toronto (YYZ) - Panama City (PTY)YYZ - PTY • 1 stop PTY - YYZ • 1 stopCA $1,632CA $1,137found 1 day agoper traveller - Central Hotel Panama Casco Viejo
Jul 1 - Jul 7Central Hotel Panama Casco Viejo + Flight
Casco Viejo5 nights9.2/10 - Wonderful (1,008 reviews)Roundtrip • Hamilton (YHM) - Panama City (PTY)YHM - PTY • 2 stops PTY - YHM • 2 stopsCA $4,073CA $2,699found 1 day agoper traveller - Yoo by Wynwood House
Jul 9 - Jul 16Yoo by Wynwood House + Flight
Calidonia7 nights9.4/10 - Exceptional (6 reviews)"Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about..."Reviewed July 26, 2025Roundtrip • Toronto (YYZ) - Panama City (PTY)YYZ - PTY • Nonstop PTY - YYZ • NonstopCA $3,164CA $2,308found 1 day agoper traveller - Casa Mallet by Wynwood House
Jul 17 - Jul 24Casa Mallet by Wynwood House + Flight
Casco Viejo7 nights9.8/10 - Exceptional (27 reviews)"In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions. "Reviewed March 12, 2026Roundtrip • Toronto (YYZ) - Panama City (PTY)YYZ - PTY • Nonstop PTY - YYZ • NonstopCA $2,634CA $1,964found 1 day agoper traveller - Mini Design By Wynwood House
Aug 6 - Aug 13Mini Design By Wynwood House + Flight
Bella Vista6 nights10/10 - Exceptional (2 reviews)"The pool is amazing. I love that is it long enough to do laps if one would like a workout."Reviewed April 20, 2026Roundtrip • Toronto (YYZ) - Panama City (PTY)YYZ - PTY • 1 stop PTY - YYZ • 1 stopCA $1,686CA $1,309found 20 hours agoper traveller
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
4/5(32 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Santa Ana Hotel Deals
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
The price is CA $123 per night from Jun 14 to Jun 15
CA $123
CA $176 total
Jun 14 - Jun 15
includes taxes & fees
9/10 Wonderful! (96 reviews)
"One thing to note is that this hotel is part of the "red zone". We didn't run into any issues but be careful at night. It's in a happening spot and because it's a little dangerous, we didn't go out at night and the hotel is not soundproof, so it was a little hard to sleep. Our room also smelled very ..."
Reviewed on May 31, 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $192 per night from Jun 29 to Jun 30
CA $192
CA $211 total
Jun 29 - Jun 30
includes taxes & fees
9/10 Wonderful! (5,514 reviews)
"I really had a good time at RIU the services was really nice and the breakfast"
Reviewed on May 30, 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is CA $181 per night from Jun 9 to Jun 10
CA $181
CA $208 total
Jun 9 - Jun 10
includes taxes & fees
8.6/10 Excellent! (2,567 reviews)
"The room was clean and spacious. I had a comfy bed with awesome pillows Staff were friendly. Close to the airport. The pool was very big, and my room was quiet. My hot water wasn't very hot, the only breakfast option I had was an $18.50 buffet."
Reviewed on May 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Discover the most popular places to visit in Santa Ana
Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Cinta Costera
After visiting Cinta Costera, make a plan to see the other sights and activities in Panama City. While you're in the area, stroll along the seaside.
Avenida Balboa
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Things to do
The OG Crawl – Afro Vibes Nightlife Experience
CA $80
per adult
98% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
CA $57
per adult
96% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.