Santa Ana Vacation Packages
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Your Santa Ana Vacation
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.
Top Holiday Package Deals in Santa Ana
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
Tocumen Airport
CA $1,323
per person
Dec 7 - Dec 13
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
8.6/10 Excellent! (1,811 reviews)
En una de las dos camas de la habitación estaba hundido el colchón! Por lo demás esta muy bien el hotel
Reviewed on Sep 20, 2026
Megapolis Hotel Panamá
San Francisco
CA $1,588
per person
Dec 9 - Dec 16
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
8.4/10 Very good! (1,693 reviews)
The pool
Is on maintenance, my room had 2 water bottles one was open already I called so they could change it but it never happened. Also the toilet had a stain it look like not watched properly.
Reviewed on Sep 20, 2026
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Bella Vista
1 out of top 10 points of interest in this area
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Francisco
1 out of top 10 points of interest in this area
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
San Felipe
If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.
Santa Ana Hotel Deals
Hotel Caracas - Casco Viejo
Plaza De Santa Ana Panama City Provincia di Panama
Fully refundableReserve now, pay when you stay
CA $52
CA $57 total
Oct 14 - Oct 15
includes taxes & fees
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
CA $77
CA $127 total
Sep 23 - Sep 24
includes taxes & fees
9/10 Wonderful! (106 reviews)
"We really enjoyed our stay at Casco View. It was an easy walk into Casca Viejo and centrally located. The host uses a guesty app to provide room details, apartment codes, etc, so it was a really easy and smooth process to get checked in. The room itself was very clean and well appointed. We stayed ..."
Reviewed on Sep 8, 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
CA $193
CA $212 total
Sep 28 - Sep 29
includes taxes & fees
9/10 Wonderful! (5,971 reviews)
"A great deal for the price. The rooms are large and the hotel is located in a prime spot if you’re looking to be close to restaurants, malls, and hotels. Area is safe."
Reviewed on Sep 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Ana vacation package cost?
From as little as CA $1,323. Yes, you read that correctly. Our Santa Ana vacation packages are an easy way to stretch your budget further. Combine your favorite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana vacation.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Santa Ana vacation?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana vacation package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana vacation package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.
Stay near popular Santa Ana attractions
El Machetazo Santa Ana
You can search for that perfect souvenir at El Machetazo Santa Ana during your trip to Panama City. Amble around the area's parks or visit its shops.
Things to do
Panama: Monkey and Sloth Jungle Habitat Panama Tour
CA $58
per adult
100% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
CA $66
per adult
96% of travellers recommend
Half day of Panama city and canal tour: shared and private
CA $92
per adult
98% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.