Santa Ana Vacation Packages

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    Save up to CA $4,200 when you book a flight and hotel together*

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Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

Top Holiday Package Deals in Santa Ana

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Price was CA $2,048, price is now CA $1,293 per person
CA $1,293
per person
Jan 7 - Jan 14
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
8.6/10 Excellent! (1,824 reviews)

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $2,912, price is now CA $1,428 per person
CA $1,428
per person
Jan 7 - Jan 14
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
8.6/10 Excellent! (1,803 reviews)
Shops nearby

Reviewed on Nov 6, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was CA $2,515, price is now CA $1,360 per person
CA $1,360
per person
Dec 7 - Dec 11
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9.2/10 Wonderful! (1,015 reviews)
The breakfast buffet was gold star quality. Amazing food variety and quality.

Reviewed on Nov 6, 2026

La Concordia Boutique Hotel

La Concordia Boutique Hotel

4 out of 5
Casco Viejo
Price was CA $4,364, price is now CA $2,882 per person
CA $2,882
per person
Jan 7 - Jan 14
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9.6/10 Exceptional! (244 reviews)
Had a very nice day and a beautiful room. Would definitely stay there again.

Reviewed on Oct 19, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was CA $2,026, price is now CA $1,352 per person
CA $1,352
per person
Jan 7 - Jan 14
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9/10 Wonderful! (6,099 reviews)
Todo excelente, lo unico que no me gustó fué que me cobraron por el estacionamiento

Reviewed on Nov 6, 2026

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Santa Ana Hotel Deals

Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo

3 out of 5
Plaza De Santa Ana Panama City Provincia di Panama
Fully refundableReserve now, pay when you stay
The price is CA $73 per night from Nov 10 to Nov 11
CA $73
CA $80 total
Nov 10 - Nov 11
includes taxes & fees
7.6/10 Good! (31 reviews)
"El lugar es acorde a lo q se paga, esta donde termina el casco viejo y empieza un barrio feo"

Reviewed on Nov 5, 2026

Hotel Caracas - Casco Viejo
Casco View Life Residences

Casco View Life Residences

4 out of 5
C. 16 Oeste Panama City Provincia de Panamá
The price is CA $117 per night from Nov 11 to Nov 12
CA $117
CA $171 total
Nov 11 - Nov 12
includes taxes & fees
9/10 Wonderful! (114 reviews)
"The staff was very friendly and helpful which made our stay very pleasant and enjoyable."

Reviewed on Oct 31, 2026

Casco View Life Residences
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $184 per night from Dec 1 to Dec 2
CA $184
CA $203 total
Dec 1 - Dec 2
includes taxes & fees
9/10 Wonderful! (6,180 reviews)
"Todo excelente, lo unico que no me gustó fué que me cobraron por el estacionamiento"

Reviewed on Nov 6, 2026

Hotel Riu Plaza Panama
See all 1,791 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Santa Ana vacation package cost?
From as little as CA $1,293. Yes, you read that correctly. Our Santa Ana vacation packages are an easy way to stretch your budget further. Combine your favorite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana vacation.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Santa Ana vacation?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana vacation package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana vacation package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Stay near popular Santa Ana attractions

El Machetazo Santa Ana

You can search for that perfect souvenir at El Machetazo Santa Ana during your trip to Panama City. Amble around the area's parks or visit its shops.
See properties

Things to do

Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

CA $51
per adult
100% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
Picture 3 for Activity Panama City: All-Inclusive Catamaran Cruise to Taboga Island

Panama City: All-Inclusive Catamaran Cruise to Taboga Island

CA $140
per adult
94% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
Half day of Panama city and canal tour: shared and private

Half day of Panama city and canal tour: shared and private

CA $94
per adult
96% of travellers recommend
Half day of Panama city and canal tour: shared and private
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.