Santa Ana Vacation Packages

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Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

Price found within the past 48 hours. Click for updated prices.
  • On the beach, free beach cabanas, sun loungers, beach towels
    Aug 1 - Aug 8

    Villa Marina Hotel + Flight

    Las Escobas del Venado
    6 nights
    3.5 star property
    9.0/10 - Wonderful (159 reviews)
    "Todo muy bien y personal muy amable"
    Reviewed May 3, 2026
    Roundtrip • Toronto (YYZ) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 1 stop
    CA $1,632
    CA $1,137
    per traveller
    found 1 day ago
    Villa Marina Hotel
  • Front of property
    Jul 1 - Jul 7

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    5 nights
    4.0 star property
    9.2/10 - Wonderful (1,007 reviews)
    Roundtrip • Hamilton (YHM) - Panama City (PTY)
    YHM - PTY • 2 stops PTY - YHM • 2 stops
    CA $4,073
    CA $2,699
    per traveller
    found 1 day ago
    Central Hotel Panama Casco Viejo
  • Exterior
    Jul 9 - Jul 16

    Yoo by Wynwood House + Flight

    Calidonia
    7 nights
    4.0 star property
    9.4/10 - Exceptional (6 reviews)
    "Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about..."
    Reviewed July 26, 2025
    Roundtrip • Toronto (YYZ) - Panama City (PTY)
    YYZ - PTY • Nonstop PTY - YYZ • Nonstop
    CA $3,164
    CA $2,308
    per traveller
    found 1 day ago
    Yoo by Wynwood House
  • Apartment, 3 Bedrooms (CM5) | Living room
    Jul 17 - Jul 24

    Casa Mallet by Wynwood House + Flight

    Casco Viejo
    7 nights
    4.0 star property
    9.8/10 - Exceptional (27 reviews)
    "In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions. "
    Reviewed March 12, 2026
    Roundtrip • Toronto (YYZ) - Panama City (PTY)
    YYZ - PTY • Nonstop PTY - YYZ • Nonstop
    CA $2,634
    CA $1,964
    per traveller
    found 1 day ago
    Casa Mallet by Wynwood House
  • Apartment (14D) | Dining room
    Aug 6 - Aug 13

    Mini Design By Wynwood House + Flight

    Bella Vista
    6 nights
    3.0 star property
    10/10 - Exceptional (2 reviews)
    "The pool is amazing. I love that is it long enough to do laps if one would like a workout."
    Reviewed April 20, 2026
    Roundtrip • Toronto (YYZ) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 1 stop
    CA $1,686
    CA $1,309
    per traveller
    found 16 hours ago
    Mini Design By Wynwood House

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
View of the Panama City Old Town

Casco Viejo

4/5(32 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Santa Ana Hotel Deals

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
The price is CA $123 per night from Jun 14 to Jun 15
CA $123
CA $176 total
Jun 14 - Jun 15
includes taxes & fees
9/10 Wonderful! (95 reviews)
"recommended"

Reviewed on May 28, 2026

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $192 per night from Jun 29 to Jun 30
CA $192
CA $211 total
Jun 29 - Jun 30
includes taxes & fees
9/10 Wonderful! (5,514 reviews)
"I really had a good time at RIU the services was really nice and the breakfast"

Reviewed on May 30, 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is CA $181 per night from Jun 9 to Jun 10
CA $181
CA $208 total
Jun 9 - Jun 10
includes taxes & fees
8.6/10 Excellent! (2,567 reviews)
"The room was clean and spacious. I had a comfy bed with awesome pillows Staff were friendly. Close to the airport. The pool was very big, and my room was quiet. My hot water wasn't very hot, the only breakfast option I had was an $18.50 buffet."

Reviewed on May 30, 2026

Crowne Plaza Panama Airport by IHG
See all 1,755 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
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Frequently asked questions

How much does a Santa Ana vacation package cost?
From as little as . Yes, you read that correctly. Our Santa Ana vacation packages are an easy way to stretch your budget further. Combine your favorite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana vacation.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Santa Ana vacation?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana vacation package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana vacation package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Discover the most popular places to visit in Santa Ana

Multiplaza Pacific Mall

Multiplaza Pacific Mall

4/5(72 reviews)

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Panoramic view at the Downtown of Panama City - Panama

Cinta Costera

4.5/5(54 reviews)

After visiting Cinta Costera, make a plan to see the other sights and activities in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Panama City night skyline

Avenida Balboa

4/5(75 reviews)

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Things to do

The OG Crawl by The Panama Barcrawl -

The OG Crawl – Afro Vibes Nightlife Experience

CA $80
per adult
98% of travellers recommend
The OG Crawl – Afro Vibes Nightlife Experience
Panama Canal Half Transit Experience

Panama Canal Partial Transit

CA $205
per adult
86% of travellers recommend
Panama Canal Partial Transit
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

CA $57
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.