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Photo by Mike McClain

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    Check prices for these dates, December 15–16, 2026

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    Recommended hotels in Puxico

    1. Hampton Inn By Hilton Dexter

    A Hampton Inn hotel with a modern design, featuring a flat roof and a prominent signage.

    2. Drury Inn & Suites Poplar Bluff

    An indoor swimming pool with a clear view of the outside through large windows.

    3. Hampton Inn Poplar Bluff

    A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

    4. Econo Lodge Dexter

    A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

    5. Fairfield Inn & Suites by Marriott Poplar Bluff

    A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

    6. Travelodge by Wyndham Dexter

    A reception area with a marble counter, potted plants, a clock, and a TV on the wall.

    7. Dexter Inn

    A restaurant with a counter, seating area, and a television.

    8. Holiday Inn Poplar Bluff by IHG

    A Holiday Inn hotel with a covered entrance, multiple floors, and a parking lot.

    9. OYO Hickory House Inn

    A hotel room with a bed, a desk, a chair, a television, and a small refrigerator.

    10. Comfort Inn Poplar Bluff North

    A hotel with a covered entrance, multiple windows, and a yellow facade.

    11. Motel 6 Poplar Bluff, MO

    A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.

    12. Super 8 by Wyndham Poplar Bluff Missouri

    A hotel room with a desk, chair, television, and a bed.

    13. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

    A modern kitchen with stainless steel appliances, wooden cabinets, and a white countertop.

    14. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

    A two-story house with a front porch, a covered entryway, and a small garden with white flowers.

    15. Hunting / Fishing Cabin at Lake Wappapello

    A round metal table with two plates and a blue bowl, surrounded by metal chairs on a wooden deck.

    16. Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

    A hot tub with a wooden interior and a view of a forest through large windows.

    17. EC Reed's Mercantile and Hotel

    A brick building with a sign reading "Mercantile & Hotel".

    18. Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

    A house with a front porch decorated with hay bales, a scarecrow, and pumpkins.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Learn more about Puxico

    Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

    See all hotels in Puxico

    A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.

    Photo by Mike McClain

    Top reviews in Puxico

    Drury Inn & Suites Poplar Bluff

    An indoor swimming pool with a clear view of the outside through large windows.

    Hampton Inn Poplar Bluff

    A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

    Fairfield Inn & Suites by Marriott Poplar Bluff

    A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

    Travelodge by Wyndham Dexter

    A reception area with a marble counter, potted plants, a clock, and a TV on the wall.

    Motel 6 Poplar Bluff, MO

    A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.

    Frequently Asked Questions

    What's it like to stay at an apartment in Puxico?

    There might not be many choices centrally in Puxico, but Expedia can help you search for accommodations within the larger area similar to apartments. When you search for a place to stay on Expedia, you can filter by amenities you might find in an apartment like a kitchen. You can also filter by similar properties such as vacation homes, condos, or cabins.

    Are you thinking about an apartment for your stay?

    An apartment features a kitchen for convenient meals, and usually is more spacious than a traditional hotel room. Apartments are a good option for couples looking to stay away from the tourist areas, and also for families wanting the conveniences of home.

    What's the top apartment for my stay in Puxico?

    Listed below are some of the favorite apartments in the area: Cozy Stay Near Downtown & Lake Wappapello: Situated in Poplar Bluff, 18.7 mi/30.1 km from the heart of Puxico. Includes private balconies. Cozy Stay Near Downtown & Lake Wappapello: Located 18.7 mi/30.1 km away in Poplar Bluff. Amenities include private balconies. Access to free parking is available on site. Waterfront Home Near Mark Twain National Forest: It's located in Poplar Bluff, 21 mi/33.9 km away.

    What can I expect from the weather when I travel to Puxico?

    Weather is only one factor, but it can really affect your travel plans, especially when you're planning an extended stay in Puxico. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Puxico is 59 inches.

    What should I see in Puxico?

    Explore the area and family-friendly sights such as Dexter Welcome Center Depot and Museum, or get out into nature at a spot like Mark Twain National Forest. Mingo Wilderness and Lake Wappapello are a couple of places you'll find in the larger area.

    What's the best way to get to and around Puxico?

    Knowing a bit about the transportation options can save you time when you get to your destination. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is located 37.9 mi (61 km) away from the heart of the city. If you'd like to explore around the area, you may want a rental car for your journey.

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