Fort Myers bills itself as the Gateway to Southwest Florida, and the city promises many enticing attractions. Its historic downtown, scenic setting on the Caloosahatchee River, and top-notch museums are just a few reasons to choose vacation rentals in Fort Myers for your next getaway in the USA. Do so and you'll join a lineage of such renowned figures as Thomas Edison and Henry Ford, who both selected the city as their own private vacation spot. Follow in their lauded footsteps and find your own home away from home in Fort Myers, enjoying more space, more privacy, and no compromises.

The winter home of Thomas Edison and the adjacent property of his friend Henry Ford make up one of the most visited sites in Fort Myers. Listed on the National Register of Historic Places, these mansions also feature gardens with more than a thousand plant varieties, a museum, and beautiful views of the river. Retire to one of our Fort Myers vacation rentals and enjoy the convenience of your own private abode. Other nearby attractions include the Calusa Nature Center, which features nature trails and a planetarium, as well as the Southwest Florida Museum of History that is housed in an old railroad depot. If you're staying in Fort Myers with children, take them to the Imaginarium Science Center to enjoy its hands-on exhibits—you won’t regret it.

Here at Expedia, we have a large selection of vacation rental properties in the most desirable areas, and booking couldn't be easier. Browse our great selection of short-term apartment rentals in Fort Myers, pick the one that speaks to you, and make your reservations for the dates that best suit your schedule. All that's left to do is pack your suitcase and embrace the pleasures of your vacation in the Sunshine State this season.