
Eastern Panama Vacation Packages
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Your Eastern Panama Vacation
Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.
Top Eastern Panama Vacation Deals



Central Hotel Panama Casco Viejo
Reviewed on Jul. 25, 2025


Hotel Plaza Herrera
Reviewed on May 5, 2025
Eastern Panama Hotel Deals

Ordovician Beach Resort
Reviewed on Jul. 25, 2025

Ciel y Miel
Reviewed on Jul. 14, 2025

Ranchos de Chalia
Reviewed on Apr. 19, 2025
Discover the most popular places to visit in Eastern Panama
Cayos Holandeses
Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.
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