Eastern Panama Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
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Your Eastern Panama Vacation
Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.
Top Eastern Panama Vacation Deals
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
CA $2,500
per person
Dec 17 - Dec 23
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9/10 Wonderful! (1,007 reviews)
This is a great hotel, and the location was perfect. The rooms were nice, and the staff were very friendly. I would highly recommend it.
Reviewed on Oct 1, 2026
Casa Mallet by Wynwood House
Casco Viejo
CA $2,030
per person
Dec 4 - Dec 11
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
9.8/10 Exceptional! (30 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect.
The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us.
I would stay here again in a heart beat.
It’s a must stay!
Reviewed on Sep 16, 2026
Ready to book your vacation to Eastern Panama?
Eastern Panama Hotel Deals
Ordovician Beach Resort
Isla Grande Isla Grande Colon
CA $586
CA $648 total
Oct 18 - Oct 19
includes taxes & fees
10/10 Exceptional! (14 reviews)
"La comida estaba deliciosa, el staff con excelente atención. La playa privada es un super plus."
Reviewed on Jul 19, 2026
Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
CA $268
CA $294 total
Nov 2 - Nov 3
includes taxes & fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."
Reviewed on Mar 15, 2026
san blas luxury tour
guna yala Nusatupo Guna Yala
CA $126
CA $143 total
Oct 4 - Oct 5
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Eastern Panama attractions
Isla Diablo
Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.
Isla Chichime
Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.
Museum of the Kuna Nation
You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.
Porvenir Museum
You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.
Frequently asked questions
How much does an Eastern Panama vacation package cost?
The most affordable Eastern Panama vacation package is CA $1,321, so your dream getaway can become a reality — without breaking the bank. Bundle flights, hotels and car rentals to tailor make a package that matches your traveling style.
How do I get a cheap travel package to Eastern Panama?
Lock in flights that suit your schedule, add a hotel to your booking and watch the savings pile up with an Eastern Panama vacation package. It's as simple as that! From flights and hotels to rental cars and activities, Expedia is where your cheap getaway begins. And with over 550 air carriers and 1,000,000 hotels around the world to choose from, you won't be short of choice.
What are the top hotels in Eastern Panama?
For hotels in San Blas Islands with friendly service and cozy beds, look up Private Over The Water Cabin On San Blas Island and San Blas Private Over - The - Water Cabin. If you plan to explore Narganá as well, you can look forward to a great night's sleep at Paradise Over The Water Cabins In San Blas or San Blas Private Over - The - Water Cabin.
How far in advance should I book my Eastern Panama vacation?
Smart travelers often reserve their seats as early as possible. You can generally look up international fares on Expedia up to 12 months before your intended flight. If you're booking last minute, don't despair. Low prices sometimes occur just weeks prior to departure.
What does an Expedia Eastern Panama travel package include?
Flights, rental cars and hotels, or any combination of the three — it's your choice. Whether you're visiting Eastern Panama with the kids or traveling by yourself, there's a package to fit every style and budget. Once you've made your booking, why not add on a couple of tours or activities?
What should I know before booking an Eastern Panama travel package?
Booking all the parts of your getaway together is an excellent way to save. Combine your car rentals, flights and hotels into a neat little package. But it's not just hotels. Expedia features all types of properties, including vacation rentals like mountain cabins and city apartments. Your choices are almost endless!
Can I choose my airline with an Eastern Panama Expedia vacation package?
Yes — that's the beauty of an Expedia vacation package. You're in charge! We have access to more than 550 airline partners across the globe, so you have loads of choice when planning your Eastern Panama getaway.
If I'm not able to travel, can I cancel my Eastern Panama vacation package?
You can. We realize life doesn't always go to plan, so we're happy to help if you have to make changes to your Eastern Panama vacation package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
