Eastern Panama Vacation Packages

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    Save up to CA $1,096 when you book a flight and hotel together*

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

Top Eastern Panama Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites

Mahogany Suites

2 out of 5
Price was CA $2,209, price is now CA $960 per person
CA $960
per person
Apr 20 - Apr 27
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
10/10 Exceptional! (1 review)
Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $2,658, price is now CA $1,682 per person
CA $1,682
per person
May 4 - May 11
found 15 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
My only problem is there was barely bilingual staff. I had to use my app most of the time to communicate.

Reviewed on Feb 17, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was CA $2,208, price is now CA $1,561 per person
CA $1,561
per person
Apr 25 - May 2
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9.8/10 Exceptional! (24 reviews)
Beautiful apartment definitely recommend staying here if you are coming to Panama

Reviewed on Nov 29, 2025

Las Clementinas

Las Clementinas

3.5 out of 5
Casco Viejo
Price was CA $2,293, price is now CA $1,637 per person
CA $1,637
per person
Apr 11 - Apr 18
found 11 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
9.4/10 Exceptional! (168 reviews)
Amazing staff, so helpful and welcoming! Great size room, Perfectly situated in old town

Reviewed on Feb 7, 2026

Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House

4 out of 5
Casco Viejo
Price was CA $2,162, price is now CA $1,558 per person
CA $1,558
per person
Mar 24 - Mar 31
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.6/10 Excellent! (19 reviews)
Great experience, beautiful apartment. Minor maintenance issues that were addressed in a timely fashion. Would definitely recommend and stay there again!

Reviewed on Mar 28, 2025

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Eastern Panama Hotel Deals

HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
4.6/10 (6 reviews)
Although I gave this hotel a medium rating I enjoyed myself. This is a rough almost close to camping hotel. I must have not seen the message about bringing soap wash clothes, hand towel, tissue actually everything. The water does not get cold and there was a party set up just outside the window lasting ...

Reviewed on Sep 19, 2025

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HOTEL ISLA GRANDE
Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
Fully refundableReserve now, pay when you stay
The price is CA $86 per night from Feb 23 to Feb 24
CA $86
CA $155 total
Feb 23 - Feb 24
includes taxes & fees
8.8/10 Excellent! (7 reviews)
Excelente hospedaje lo mejor la amabilidad de José Ángel y los demás muchachos... Con decirles que hasta te llevan a la habitación si te has tomado algunos tragos.. recomendada al 100

Reviewed on Jan 7, 2026

Hotel Cocotal
Konsenda San Blas

Konsenda San Blas

2 out of 5
Llano Cartí Km 11 El Llano Panamá Province
Fully refundableReserve now, pay when you stay
The price is CA $57 per night from Mar 2 to Mar 3
CA $57
CA $64 total
Mar 2 - Mar 3
includes taxes & fees
10/10 Exceptional! (2 reviews)
Great location for bird watching! The hosts were friendly and helpful. It is best to contact them directly using WhatsApp in addition to booking on Expedia.

Reviewed on Feb 13, 2026

Konsenda San Blas
See all 175 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Can I cancel my flight booking to Eastern Panama due to COVID-19?
Our Customer Service Portal is where you can find useful information about canceling or changing your flight due to COVID-19. Before booking your tickets, it's wise to scroll through the terms and conditions of your airfare too.
What's the best way to find cheap flights to Eastern Panama that have flexible change policies?
It's as easy as counting to three with Expedia. Firstly, enter your travel details and press "Search." Second step: Check the "No change fee" box under the "Flexible change policies" heading to the left of your screen. Step 3. Nab a cheap and flexible flight to Eastern Panama.
What are some of the general tips for travelers to Eastern Panama during the COVID-19 outbreak?
COVID-19 has resulted in significant changes to the way we travel. If you plan to jet off to Eastern Panama, these tips will help you navigate the "new normal:"
  • Before you lock in a flight, find out if any travel restrictions apply — in both your destination and origin. Keep informed with the latest updates by checking government and travel websites.
  • When you go through airport screening, keep your face mask on. You will be asked to lower it briefly to verify your identity. Passengers who refuse to wear a face mask may face civil penalties and may also be escorted from the building.
  • Rather than handing a TSA agent your boarding pass, position it directly on the reader yourself. Once that's done, hold it up for inspection.
  • TSA now allows passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on bags. This will need to be removed from your bag and presented for screening.
  • To minimize handling during screening, place items such as your phone, keys and wallet into your carry-on instead of the bins.
  • Transport all food items in a clear plastic bag and also place them in a screening bin. Keeping food separate from your carry-on means it's less likely a TSA employee will need to open and touch your bag for inspection.

Which airlines fly to Eastern Panama?
Copa Airlines is a well-known airline servicing Eastern Panama. Search for airfares to Tocumen Intl. Airport (PTY) and you'll have 3173 Copa Airlines flights every month to choose from.
How can I find cheap tickets to Eastern Panama?
You'll always find a fabulous deal with Expedia, but our "flexible dates" feature makes it that much easier. Enter your preferred travel date, then click on the flexible dates box above to see prices for nearby days. was the cheapest price for a flight to Eastern Panama in the last seven days.
How much is a flight to Eastern Panama?
There were lots of low-cost fares for the taking in the last seven days, with the cost of a round-trip flight to Eastern Panama varying between and . Many lucky travelers locked in one-way flights from () for only .
What are the most popular airports to fly into in Eastern Panama?
The main gateway to Eastern Panama, roughly 3507 flights land at Tocumen Intl. Airport (PTY) each month. Track down a top deal, book your seat and get ready to enjoy the best of this amazing region.
When is the cheapest time to fly to Eastern Panama?
Jetting off on a Tuesday, followed by a Monday, is generally the best way to land the cheapest fare. Steer clear of the weekend if you can, because Saturday is typically the most expensive day. Spend the dollars you saved having a good time in Eastern Panama instead!
How much is a plane ticket to Eastern Panama?
Prices varied from to over the last seven days. When you're ready to book, we'll be ready to help you pick up the best deal to Eastern Panama.
Which airlines with flights to Eastern Panama employ COVID-19 cleanliness policies?
In order to minimize contact between passengers and cabin crew during the COVID-19 outbreak, the majority of airlines have taken social distancing and other measures to the skies. Just a few of these are:
  • Copa Airlines - this airline is known for conducting passenger temperature checks and electrostatic cleaning.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.