Eastern Panama Vacation Packages

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    Save up to CA $4,200 when you book a flight and hotel together*

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

Top Eastern Panama Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was CA $1,787, price is now CA $1,234 per person
CA $1,234
per person
Aug 11 - Aug 18
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
8.6/10 Excellent! (1,692 reviews)
If you are looking for larger space to unwind this could be the hotel for you. However hotel needs room renovations. The bed is very low and the linen is in dire need of replacement. Breakfast is always a highlight at this property.

Reviewed on Jul 2, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $3,136, price is now CA $1,689 per person
CA $1,689
per person
Aug 15 - Aug 21
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,008 reviews)
Beautiful hotel with great history! The location in Casco Viejo was perfect for our visit to Panama City and we were easily able to walk or order a car/Uber from there for various trips. We had a family suite, which was a king and full size bed room that worked well for our family of 3. The rooftop pool is small, but lovely and the restaurant near the pool was great with friendly staff. The Central Hotel is a gorgeous place and the staff at the front desk, door and restaurants were all nice and helpful.

Reviewed on Jun 30, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $2,289, price is now CA $1,439 per person
CA $1,439
per person
Aug 11 - Aug 17
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,570 reviews)
Beautiful hotel and excellent service and attention , food , everything , great location

Reviewed on Jul 4, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was CA $1,913, price is now CA $1,300 per person
CA $1,300
per person
Aug 11 - Aug 17
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,813 reviews)
In the bathroom, the shower tiles and glass door had green mold, the headboard had strange white stains, and the curtains were very dusty. The staff was very friendly and provided excellent service. However, I have other complaints regarding the bathroom and room.

Reviewed on Jul 2, 2026

Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Casco Viejo
Price was CA $1,696, price is now CA $1,277 per person
CA $1,277
per person
Aug 7 - Aug 14
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
7.6/10 Good! (707 reviews)
The staff at the check in was very unhelpful. There were regular loud parties at the rooftop bar (which seemed off limits to guests) and a lot of noise which made getting a good night's sleep tough. Room was tiny and bed was very uncomfortable. We had to leave to go to another hotel just to get some real sleep. The positives were the location and the cleaning staff for our room.

Reviewed on Jul 2, 2026

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Eastern Panama Hotel Deals

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
The price is CA $639 per night from Aug 4 to Aug 5
CA $639
CA $704 total
Aug 4 - Aug 5
includes taxes & fees
10/10 Exceptional! (11 reviews)
"The owners, Rick and Loan, could not be nicer. They had advice for us on what to see and do during our time in Panama which proved very helpful. The staff, particularly Juan, David and Ricardo, were excellent - attentive and friendly. We rented a car from the airport in Panama City and drove ourselves ..."

Reviewed on Jul 3, 2026

Ordovician Beach Resort
san blas luxury tour

san blas luxury tour

2 out of 5
guna yala Nusatupo Guna Yala
The price is CA $201 per night from Jul 15 to Jul 16
CA $201
CA $225 total
Jul 15 - Jul 16
includes taxes & fees
san blas luxury tour
Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
The price is CA $174 per night from Jul 17 to Jul 18
CA $174
CA $192 total
Jul 17 - Jul 18
includes taxes & fees
9.8/10 Exceptional! (18 reviews)
"Here's a natural, conversational review in English: We had a wonderful stay here. The hotel is beautiful, with an amazing pool overlooking both the ocean and the rainforest. Everything was very clean, and the beds were extremely comfortable. The staff were incredibly friendly and welcoming. The owner ..."

Reviewed on Jun 2, 2026

Ranchos de Chalia
See all 191 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
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Beach Vacations
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Stay near popular Eastern Panama attractions

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.
See properties

Frequently asked questions

How much does an Eastern Panama vacation package cost?
The most affordable Eastern Panama vacation package is CA $1,234, so your dream getaway can become a reality — without breaking the bank. Bundle flights, hotels and car rentals to tailor make a package that matches your traveling style.
How do I get a cheap travel package to Eastern Panama?
Lock in flights that suit your schedule, add a hotel to your booking and watch the savings pile up with an Eastern Panama vacation package. It's as simple as that! From flights and hotels to rental cars and activities, Expedia is where your cheap getaway begins. And with over 550 air carriers and 1,000,000 hotels around the world to choose from, you won't be short of choice.
What are the top hotels in Eastern Panama?
For hotels in San Blas Islands with friendly service and cozy beds, look up Private Over The Water Cabin On San Blas Island and San Blas Private Over - The - Water Cabin. If you plan to explore Narganá as well, you can look forward to a great night's sleep at Paradise Over The Water Cabins In San Blas or San Blas Private Over - The - Water Cabin.
How far in advance should I book my Eastern Panama vacation?
Smart travelers often reserve their seats as early as possible. You can generally look up international fares on Expedia up to 12 months before your intended flight. If you're booking last minute, don't despair. Low prices sometimes occur just weeks prior to departure.
What does an Expedia Eastern Panama travel package include?
Flights, rental cars and hotels, or any combination of the three — it's your choice. Whether you're visiting Eastern Panama with the kids or traveling by yourself, there's a package to fit every style and budget. Once you've made your booking, why not add on a couple of tours or activities?
What should I know before booking an Eastern Panama travel package?
Booking all the parts of your getaway together is an excellent way to save. Combine your car rentals, flights and hotels into a neat little package. But it's not just hotels. Expedia features all types of properties, including vacation rentals like mountain cabins and city apartments. Your choices are almost endless!
Can I choose my airline with an Eastern Panama Expedia vacation package?
Yes — that's the beauty of an Expedia vacation package. You're in charge! We have access to more than 550 airline partners across the globe, so you have loads of choice when planning your Eastern Panama getaway.
If I'm not able to travel, can I cancel my Eastern Panama vacation package?
You can. We realize life doesn't always go to plan, so we're happy to help if you have to make changes to your Eastern Panama vacation package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.