A calm sea with a small boat and a row of palm trees on the shore.

Eastern Panama Vacation Rentals

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Our top choices for Eastern Panama vacation rentals

san blas luxury tour

san blas luxury tour
2.0 star property
Nusatupo
The price is CA $189
CA $212 total
includes taxes & fees
Jul 29 - Jul 30
san blas luxury tour

San Blas Private Beach Cabin

San Blas Private Beach Cabin
2.5 star property
Narganá
The price is CA $327
CA $360 total
includes taxes & fees
Jul 22 - Jul 23
San Blas Private Beach Cabin

San Blas Private Oceanfront Cabin

San Blas Private Oceanfront Cabin
2.5 star property
Narganá
The price is CA $363
CA $540 total
includes taxes & fees
Jul 21 - Jul 22
San Blas Private Oceanfront Cabin

Sanblastourgy

Sanblastourgy
2.0 star property
Nargana
The price is CA $316
CA $348 total
includes taxes & fees
Jul 21 - Jul 22
Sanblastourgy

San Blas Tour Aridub

San Blas Tour Aridub
2.0 star property
Narganá
The price is CA $120
CA $202 total
includes taxes & fees
Jul 19 - Jul 20
San Blas Tour Aridub

Private Over-Water Cabins on San Blas Island

Private Over-Water Cabins on San Blas Island
2.5 star property
Narganá
The price is CA $293
CA $463 total
includes taxes & fees
Jul 29 - Jul 30
Private Over-Water Cabins on San Blas Island

Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking
Puerto Lindo
The price is CA $316
CA $359 total
includes taxes & fees
Jul 21 - Jul 22
Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

Private Over-the-Water Cabin in San Blas including Meals

Private Over-the-Water Cabin in San Blas including Meals
2.5 star property
Mirladub
The price is CA $618
CA $750 total
includes taxes & fees
Jul 26 - Jul 27
Private Over-the-Water Cabin in San Blas including Meals

Deluxe Beachfront 4-bedroom house in Colón Province

Deluxe Beachfront 4-bedroom house in Colón Province
Colón Province
The price is CA $475
CA $541 total
includes taxes & fees
Jul 19 - Jul 20
Deluxe Beachfront 4-bedroom house in Colón Province

San Blas Private Over-the-Water Cabin

San Blas Private Over-the-Water Cabin
2.5 star property
Narganá
8.0 out of 10, Very good, (2 reviews)
"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling and emailing them. I also disliked the value of what you get with this trip. Id expect better cleanliness and standards for this trip. I also disliked when the staff on the island said i needed to pay...
United States
Andrew
The price is CA $352
CA $528 total
includes taxes & fees
Jul 22 - Jul 23
San Blas Private Over-the-Water Cabin

Jacuzy, pool and lake at the same house.

Jacuzy, pool and lake at the same house.
Colon
7.4 out of 10, Good, (3 reviews)
"Great. Please take care of the cat"
United States
KENNETH E.
The price is CA $48
CA $97 total
includes taxes & fees
Jul 23 - Jul 24
Jacuzy, pool and lake at the same house.

Elegance and comfort in old town panama

Elegance and comfort in old town panama
Panamá
2.0 out of 10, (1 review)
"The address that’s depicted is not accurate to the map that’s shown and I tried multiple times to communicate with the host and no response"
United States
PAMELA
The price is CA $70
CA $126 total
includes taxes & fees
Jul 20 - Jul 21
Elegance and comfort in old town panama

Charming cottage with 2 separate beds and a beautiful view of the river

Charming cottage with 2 separate beds and a beautiful view of the river
Santa Rosa
10.0 out of 10, Exceptional, (1 review)
"Wir fanden die Unterkunft aufgrund der guten Wegbeschreibung sofort. Die Empfang war sehr nett. Das Haus war sehr sehr sauber und wir haben uns sehr wohl gefühlt. Alles war perfekt. Es war die sauberste/beste Unterkunft die wir bei unserer Panama Rundtour in Panama hatte. Erik und Alba alles Gute und vielen Dank."
Germany
Birgit U.
The price is CA $177
CA $205 total
includes taxes & fees
Jul 19 - Jul 20
Charming cottage with 2 separate beds and a beautiful view of the river

BEAUTIFUL APARTMENT IN FRONT OF THE SEA

BEAUTIFUL APARTMENT IN FRONT OF THE SEA
Portobelo
7.0 out of 10, Good, (4 reviews)
"All of it! Gabriel is a marvelous host; absolutely above and beyond. The house is lovely, very unique, and the location, right on the water, superb. We'll be back!"
United States
Rosa M.
The price is CA $220
CA $248 total
includes taxes & fees
Jul 20 - Jul 21
BEAUTIFUL APARTMENT IN FRONT OF THE SEA

Cozy and Safe Environment Close to the Airport.

Cozy and Safe Environment Close to the Airport.
Panamá
The price is CA $87
CA $115 total
includes taxes & fees
Aug 3 - Aug 4
Cozy and Safe Environment Close to the Airport.

Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway
Panamá
The price is CA $168
CA $196 total
includes taxes & fees
Jul 19 - Jul 20
Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama

La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama
Panamá
The price is CA $227
CA $370 total
includes taxes & fees
Jul 19 - Jul 20
La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama

Your Menus de la Montaña country house awaits you

Your Menus de la Montaña country house awaits you
Panama
The price is CA $133
CA $321 total
includes taxes & fees
Jul 19 - Jul 20
Your Menus de la Montaña country house awaits you

Hummingbird House/Casa de Colibri

Hummingbird House/Casa de Colibri
Panamá
The price is CA $351
CA $456 total
includes taxes & fees
Jul 19 - Jul 20
Hummingbird House/Casa de Colibri

Hacienda La Perezosa in Cerro Azul

Hacienda La Perezosa in Cerro Azul
Panamá
The price is CA $1,122
CA $1,395 total
includes taxes & fees
Jul 21 - Jul 22
Hacienda La Perezosa in Cerro Azul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Eastern Panama Hotel Reviews

Find out more about Eastern Panama

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Eastern Panama. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.