Title: Hotels by Motel 6 in Depew from CA $100 | Expedia.ca [Depew Travel Guide](https://expedia.ca/Depew.dx6338362)[Hotels in Depew](https://expedia.ca/Depew-Hotels.d6338362.Travel-Guide-Hotels)[Vacation Rentals in Depew](https://expedia.ca/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Flights to Depew](https://expedia.ca/Cheap-Flights-To-Depew.d6338362.Travel-Guide-Flights)[Things to do in Depew](https://expedia.ca/Things-To-Do-In-Depew.d6338362.Travel-Guide-Activities)[Depew Car Rentals](https://expedia.ca/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.ca/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Motel 6 in Depew from CA $100 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Depew Motel 6 Hotels ![Interior entrance](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/df50dbea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/828a364a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/f67f6806.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/9e549435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Amherst, NY - Buffalo Buffalo 6.4/10 (1012) "Great hotel and they allow dogs! " CA $88 CA $100 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Buffalo-Hotels-Motel-6-Amherst.h42198.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/b5e1c222.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/dee86da2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/5130229b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually furnished, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/c87c543c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Buffalo, NY - Airport - Williamsville Buffalo 6.2/10 (1252) "Friendly staff, clean room and easy check in and out " CA $89 CA $102 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Buffalo-Hotels-Motel-6-Buffalo.h18259.Hotel-Information) ![Shower, hair dryer, towels](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/bf368b10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/49d54e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/aeb6dd53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/e06245c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Hamburg, NY Hamburg 6.4/10 (1011) "Been here many times in the last few years always a good time" CA $98 CA $112 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Buffalo-Hotels-Motel-6-Hamburg.h5914180.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-26&endDate=2025-10-27®ionId=6338362&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels-Motel-6.0-0-d6338362--bMotel6.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels-Motel-6.0-0-d6338362--bMotel6.Travel-Guide-Filter-Hotels) ## Top Depew Hotel Reviews ![Wyndham Garden Buffalo Downtown](//images.trvl-media.com/lodging/1000000/160000/159000/158959/2e0799e1_y.jpg) ### Wyndham Garden Buffalo Downtown 10/10 Excellent "The staff was so friendly and accommodating and our connecting rooms were much appreciated!" [](https://expedia.ca/Buffalo-Hotels-Wyndham-Garden-Buffalo-Downtown.h158959.Hotel-Information) ![Buffalo Airport Hotel](//images.trvl-media.com/lodging/1000000/30000/26100/26001/90223c0d_y.jpg) ### Buffalo Airport Hotel 10/10 Excellent "It as a beautiful property and great location " [](https://expedia.ca/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information) ![CenterWay Hotel Tonawanda](//images.trvl-media.com/lodging/1000000/80000/76400/76371/66013c67_y.jpg) ### CenterWay Hotel Tonawanda 10/10 Excellent "The staff is great. " [](https://expedia.ca/Buffalo-Hotels-CenterWay-Hotel-Tonawanda.h76371.Hotel-Information) ![Sleep Inn & Suites Buffalo Airport](//images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d_y.jpg) ### Sleep Inn & Suites Buffalo Airport 10/10 Excellent "Friendly desk service - shuttle driver was great - made a return trip to the hotel for an item that was left behind in error … will definitely come back !" [](https://expedia.ca/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Buffalo Amherst](//images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/456d3072_y.jpg) ### La Quinta Inn & Suites by Wyndham Buffalo Amherst 10/10 Excellent "." [](https://expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information) ![Hyatt Regency Buffalo / Hotel and Conference Center](//images.trvl-media.com/lodging/1000000/30000/23200/23101/00561234_y.jpg) ### Hyatt Regency Buffalo / Hotel and Conference Center 10/10 Excellent "Downtown Buffalo is half urban-renewal empty lots and half glorious century-old buildings. The hotel is a well-run corporate-type place with friendly staff and clean facilities. A safe bet." [](https://expedia.ca/Buffalo-Hotels-Hyatt-Regency-Buffalo-Hotel-And-Conference-Center.h23101.Hotel-Information) ![Hampton Inn Buffalo - Amherst, NY](//images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/63fc013f_y.jpg) ### Hampton Inn Buffalo - Amherst, NY 10/10 Excellent "Great stay will come again." [](https://expedia.ca/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) ![Holiday Inn Express Grand Island - Niagara Falls by IHG](//images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg) ### Holiday Inn Express Grand Island - Niagara Falls by IHG 10/10 Excellent "Check-in was a breeze. The desk and cleaning staff were friendly and helpful. The beds, showers, and bathrooms were spacious and very clean. The room and the halls smelled fresh. The area is away from everything but it was quiet and peaceful. I would stay here again. " [](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Comfort Inn University](//images.trvl-media.com/lodging/1000000/70000/66600/66581/2db1a2f1_y.jpg) ### Comfort Inn University 10/10 Excellent "The room was clean and comfortable. Ease of parking was great. Enjoyed the breakfast" [](https://expedia.ca/Buffalo-Hotels-Comfort-Inn-University.h66581.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Cheektowaga](https://www.expedia.ca/5Star-Cheektowaga-Hotels.s50-0-d7197.Travel-Guide-Filter-Hotels) - [Adam's Mark Hotels in Amherst](https://www.expedia.ca/Amherst-Hotels-Adams-Mark.0-0-d9323--bAdamsMark.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Amherst](https://www.expedia.ca/Amherst-Hotels-Best-Western.0-0-d9323--bBestWestern.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Amherst](https://www.expedia.ca/Amherst-Hotels-La-Quinta-Inn-Suites.0-0-d9323--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Amherst](https://www.expedia.ca/Amherst-Hotels-Marriott-Hotels-Resorts.0-0-d9323--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Millennium Hotels in Amherst](https://www.expedia.ca/Amherst-Hotels-Millennium-Hotels.0-0-d9323--bMillenniumHotels.Travel-Guide-Filter-Hotels) - 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