Title: Hotels by Motel 6 in Depew from CA $97 | Expedia.ca [Depew Travel Guide](https://expedia.ca/Depew.dx6338362)[Hotels in Depew](https://expedia.ca/Depew-Hotels.d6338362.Travel-Guide-Hotels)[Vacation Rentals in Depew](https://expedia.ca/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Flights to Depew](https://expedia.ca/Cheap-Flights-To-Depew.d6338362.Travel-Guide-Flights)[Things to do in Depew](https://expedia.ca/Things-To-Do-In-Depew.d6338362.Travel-Guide-Activities)[Depew Car Rentals](https://expedia.ca/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.ca/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Motel 6 in Depew from CA $97 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 27 - Oct 28](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-27&endDate=2025-10-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-28&endDate=2025-10-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Depew Motel 6 Hotels ![Interior entrance](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/df50dbea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/828a364a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/f67f6806.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/9e549435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Amherst, NY - Buffalo Buffalo 6.4/10 (1009) "Overall good price, very pet friendly, helpful staff who went out of there way to find me a room earlier than expected. Comfortable and clean rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $88 CA $100 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Buffalo-Hotels-Motel-6-Amherst.h42198.Hotel-Information) ![Shower, hair dryer, towels](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/bf368b10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/15d80d58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/49d54e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5920000/5914200/5914180/e06245c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Hamburg, NY Hamburg 6.4/10 (1016) "Been here many times in the last few years always a good time" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey CA $98 CA $111 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Buffalo-Hotels-Motel-6-Hamburg.h5914180.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/b5e1c222.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/5130229b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually furnished, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/c87c543c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/18300/18259/dee86da2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Buffalo, NY - Airport - Williamsville Buffalo 6.2/10 (1235) "Friendly staff, clean room and easy check in and out " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Becky CA $86 CA $97 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Buffalo-Hotels-Motel-6-Buffalo.h18259.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-10&endDate=2025-11-11®ionId=6338362&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels-Motel-6.0-0-d6338362--bMotel6.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels-Motel-6.0-0-d6338362--bMotel6.Travel-Guide-Filter-Hotels) ## Top Depew Hotel Reviews ![Sleep Inn & Suites Buffalo Airport](//images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d_y.jpg) ### Sleep Inn & Suites Buffalo Airport 10/10 Excellent "Ciarto limpio, check-in rapido, buen estacionamiento y buen desayuno " [](https://expedia.ca/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![Garden Place Hotel](//images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4_y.jpg) ### Garden Place Hotel 10/10 Excellent "Great location for the airport!" [](https://expedia.ca/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information) ![Extended Stay America Suites - Buffalo - Airport](//images.trvl-media.com/lodging/1000000/10000/8600/8561/0cd596c4_y.jpg) ### Extended Stay America Suites - Buffalo - Airport 10/10 Excellent "Great for the price. Rooms are clean" [](https://expedia.ca/Buffalo-Hotels-Extended-Stay-America-Suites-Buffalo-Airport.h8561.Hotel-Information) ![Hampton Inn Buffalo - Amherst, NY](//images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/63fc013f_y.jpg) ### Hampton Inn Buffalo - Amherst, NY 10/10 Excellent "Very clean, very friendly and great breakfast. " [](https://expedia.ca/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) ![Comfort Inn & Suites Niagara Falls Blvd USA](//images.trvl-media.com/lodging/21000000/20010000/20009600/20009524/716b44ca_y.jpg) ### Comfort Inn & Suites Niagara Falls Blvd USA 10/10 Excellent "Everything went smoothly!" [](https://expedia.ca/Niagara-Falls-Hotels-Comfort-Inn-Suites-Niagara-Falls-Blvd-USA.h20009524.Hotel-Information) ![Holiday Inn Express Grand Island - Niagara Falls by IHG](//images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg) ### Holiday Inn Express Grand Island - Niagara Falls by IHG 10/10 Excellent "This was an excellent place to stay while visiting Canada only 6 miles away. Jamal at front desk was very friendly and helpful as were all the staff. Breakfast was delicious." [](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![M Hotel Buffalo](//images.trvl-media.com/lodging/1000000/20000/11300/11231/2c4d5593_y.jpg) ### M Hotel Buffalo 10/10 Excellent "Close to shopping and a variety of other activities." [](https://expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information) ![Motel 6 Amherst, NY - Buffalo](//images.trvl-media.com/lodging/1000000/50000/42200/42198/df50dbea_y.jpg) ### Motel 6 Amherst, NY - Buffalo 10/10 Excellent "Everything was good, staff was friendly " [](https://expedia.ca/Buffalo-Hotels-Motel-6-Amherst.h42198.Hotel-Information) ![Best Western Summit Inn](//images.trvl-media.com/lodging/1000000/10000/5200/5183/c135a4a6_y.jpg) ### Best Western Summit Inn 10/10 Excellent "Fairly healthy" [](https://expedia.ca/Niagara-Falls-Hotels-Best-Western-Summit-Inn.h5183.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Cheektowaga](https://www.expedia.ca/5Star-Cheektowaga-Hotels.s50-0-d7197.Travel-Guide-Filter-Hotels) - [Adam's Mark Hotels in Amherst](https://www.expedia.ca/Amherst-Hotels-Adams-Mark.0-0-d9323--bAdamsMark.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Amherst](https://www.expedia.ca/Amherst-Hotels-Best-Western.0-0-d9323--bBestWestern.Travel-Guide-Filter-Hotels) - 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