Cayo Santa Maria Vacation Rentals

Save 10% or more on select stays with Expedia Rewards

Most properties are fully refundable. Because flexibility matters.

Search over 2.9 million properties and 550 airlines worldwide

Vacation Rentals in Cayo Santa Maria

Hostal Jose Ramon
3 out of 5
Maximo Gomez 208, Berenguer y Yanes, Santa Clara, Villa Clara, 50100
The price is CA $38 per night from Aug 30 to Aug 31
Stay at this 3-star family-friendly aparthotel in Santa Clara. Enjoy free WiFi, breakfast, and 24-hour room service. Our guests praise the bathrooms and the ...
5/5 Exceptional! (5 reviews)
"We were astonished that we were given a whole apartment to ourselves for a very reasonable price. Jose Ramon could not have been more welcoming. He brought us a cup of coffee while we checked in and nothing was too much trouble. The family live downstairs and we had the upstairs, which comprised ..."

Reviewed on Apr. 6, 2020

Hostal Jose Ramon
Martirena's Hostal
3 out of 5
Callejón de La Palma #20, entre Juan Bruno Zayas y Ezquerra, Santa Clara, Villa Clara, 50100
The price is CA $59 per night from Aug 10 to Aug 11
Stay at this 3-star apartment in Santa Clara. Enjoy breakfast, WiFi, and onsite parking. Popular attractions Santa Clara de Asis Church and Taberna El Mejunje ...
5/5 Exceptional! (2 reviews)
"Bien placé, propre, et accueil chaleureux"

Reviewed on Aug. 1, 2022

Martirena's Hostal
Hostal Vista Park 025 - Habitación 1
1, Leoncio Vidal, Santa Clara, Villa Clara, 50100
Stay at this vacation home in Santa Clara. Enjoy free WiFi, free parking, and a terrace. Popular attractions José Martí Provincial Library of Villa Clara and ...
Hostal Vista Park 025 - Habitación 1
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Apartamento Solaire - Best Location In Santa Clara
3 out of 5
Calle 2da, Santa Clara, Villa Clara, 50100
Stay at this 3-star apartment in Santa Clara. Enjoy free WiFi, a terrace, and a TV. Popular attractions Augusto Cesar Sandino Stadium and Loma del Capiro are ...
Apartamento Solaire - Best Location In Santa Clara
Hostal Buenviaje
Buen viaje(R.Pardo) #157 e/ La Cruz y, Rio,Santa Clara,Villa Clara,Cuba, Santa Clara, 10200
Stay at this business-friendly vacation home in Santa Clara. Enjoy free WiFi, free parking, and a TV. Popular attractions Carmen Church and Camilo Cienfuegos ...
Hostal Buenviaje
Apartamento Hyggelig
2.5 out of 5
101A Maceo, Marti & Julio Jover, Santa Clara, Santa Clara
Stay at this vacation home in Santa Clara. Enjoy onsite parking, a 24-hour front desk, and a terrace. Popular attractions La Caridad Theater and José Martí Provincial ...
Apartamento Hyggelig
Villa Coco Beach
2.5 out of 5
Calle Martí 102 oeste, Santa Clara
Stay at this vacation home in Santa Clara. Enjoy free parking, a terrace, and a garden. Popular attractions Santa Clara de Asis Church and Taberna El Mejunje ...
Villa Coco Beach
Casa de Miriam
3 out of 5
Street Frank Pais (Carmen) # 185A, Camilo Cienfuegos & Lino Perez, Trinidad, 62600
The price is CA $40 per night from Aug 13 to Aug 14
Stay at this 3-star vacation home in Trinidad. Enjoy a rooftop terrace, breakfast, and room service. Our guests praise the breakfast and the helpful staff in ...
5/5 Exceptional! (24 reviews)
"Linda is a loving and caring host , she go out of her way to help us with all our needs, thank you very much"

Reviewed on Jun. 8, 2022

Casa de Miriam
Casa Colonial El Patio
3 out of 5
Street Ciro Redondo, San Jose, Museo street # 274, Trinidad
Stay at this 3-star vacation home in Trinidad. Enjoy room service, onsite parking, and a terrace. Popular attractions San Francisco Church and Municipal Historical ...
4.8/5 Exceptional! (8 reviews)
Un lugar perfecto para alojarse e Trinidad
"En esta casa se vive cómodo, se duerme muy bien, se disfruta Trinidad fácilmente por lo bien ubicada que está y se siente uno bien cuidado por Manuel que es un gran anfitrión"

Reviewed on Aug. 29, 2019

Casa Colonial El Patio
Casa Lunaria
3 out of 5
Vicente Suyama Street #2, Between Piro Guinart & Pablo Pich Girón, Trinidad, Sancti Spíritus, 62600
The price is CA $59 per night from Aug 9 to Aug 10
Stay at this 3-star apartment in Trinidad. Enjoy a rooftop terrace, a Smart TV, and digital TV. Popular attractions Municipal Historical Museum and San Francisco ...
Casa Lunaria
Don't see what you're looking for?
See all available properties in Villa Clara
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other types of properties in Cayo Santa Maria you may be interested in

Grand Memories Santa Maria - All Inclusive

Grand Memories Santa Maria - All Inclusive

3.5 out of 5
Municipio Caibarien, Cayo Santa Maria, Villa Clara, 52610
Grand Memories Santa Maria - All Inclusive
Villa Gaviota Cayo Coco

Villa Gaviota Cayo Coco

Ciego de Avila, Cayo Santa Maria
Villa Gaviota Cayo Coco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Everything you need to know about Cayo Santa Maria vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cayo Santa Maria vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cayo Santa Maria vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Cayo Santa Maria vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cayo Santa Maria. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cayo Santa Maria vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Cayo Santa Maria vacation rentals we have selected for you start as low as CA $38 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Cayo Santa Maria rentals

At Expedia, we put the best Cayo Santa Maria vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Cayo Santa Maria rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cayo Santa Maria vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cayo Santa Maria. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions