Title: Hotels by Independent in Byron from CA $154 | Expedia.ca [Byron Travel Guide](https://expedia.ca/Byron.dx553248623858895563)[Hotels in Byron](https://expedia.ca/Byron-Hotels.d553248623858895563.Travel-Guide-Hotels)[Vacation Rentals in Byron](https://expedia.ca/Byron-Vacation-Rentals.d553248623858895563.Travel-Guide-VacationRentals)[Flights to Byron](https://expedia.ca/Cheap-Flights-To-Byron.d553248623858895563.Travel-Guide-Flights)[Byron Car Rentals](https://expedia.ca/Car-Rentals-In-Byron.d553248623858895563.Car-Rental-Guide)[Byron Vacation Packages](https://expedia.ca/Byron.d553248623858895563.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 29 - Jan 30](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-01-29&endDate=2026-01-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 30 - Jan 31](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-01-30&endDate=2026-01-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248623858895563&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Byron Independent ![View from property](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/1062bbaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/86c17899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/ecda08e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/38c15978.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Grand Hotel [](https://www.expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) Downtown Rochester 8.4/10 Very good (1,862 reviews) "Always an enjoyable place in a good location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas [](https://www.expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Indoor pool, open 7:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/41a1c74b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Double Beds, Poolside](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/w7013h4671x0y0-4efbd31a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/053999c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/26c9439d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Inn and Suites - Mayo Clinic Area [](https://www.expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) Downtown Rochester 8.0/10 Very good (1,520 reviews) "The room was great! The staff was excellent. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeff [](https://www.expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/abb2c83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/8ce1111a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/50ee7a29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/a518fccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brentwood Inn & Suites [](https://www.expedia.ca/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) Downtown Rochester 8.8/10 Excellent (1,002 reviews) "Clean and comfortable Close to the hospital for convenience " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dianne [](https://www.expedia.ca/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/404886d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/b56a9dd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/7b237c12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/00440028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aspen Suites [](https://www.expedia.ca/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information) Rochester 9.0/10 Wonderful (712 reviews) "Very clean and nice staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kirk [](https://www.expedia.ca/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/31690353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/60b66a11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/92dc90b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/76a0d413.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aspen Select [](https://www.expedia.ca/Rochester-Hotels-Aspen-Select.h12245240.Hotel-Information) Kutzky Park 8.4/10 Very good (1,003 reviews) "Staff was friendly - room was clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $127 CA $154 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Rochester-Hotels-Aspen-Select.h12245240.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/5776b64a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/50c22b07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/05c31332.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Billiards](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/6b44b2f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Berkman [](https://www.expedia.ca/Rochester-Hotels-Berkman-Hotel.h46291477.Hotel-Information) Folwell 9.6/10 Exceptional (381 reviews) "Everything was excellent, second time staying there. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carolyn [](https://www.expedia.ca/Rochester-Hotels-Berkman-Hotel.h46291477.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/05c87b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handrails in stairways](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/be9b9262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/a2215e68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/81bc0968.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### America's Stay Inn Stewartville [](https://www.expedia.ca/Rochester-Hotels-Americas-Stay-Inn-Stewartville.h3395689.Hotel-Information) Stewartville 8.0/10 Very good (422 reviews) "Room was nicer and furnished better than most high end places I’ve stayed at. It’s a small hotel on a busy road, but comfortable bed and clean." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Robert [](https://www.expedia.ca/Rochester-Hotels-Americas-Stay-Inn-Stewartville.h3395689.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/978fdbcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/5b562205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, individually decorated](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/3144e2d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/c5ed6677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Towers At Kahler Grand Hotel [](https://www.expedia.ca/Rochester-Hotels-The-Towers-At-Kahler-Grand-Hotel.h16119557.Hotel-Information) Downtown Rochester 9.4/10 Exceptional (96 reviews) "Excellent accommodations, amazing staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shannon CA $536 CA $617 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Rochester-Hotels-The-Towers-At-Kahler-Grand-Hotel.h16119557.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/90000000/89600000/89594900/89594888/91609d20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/90000000/89600000/89594900/89594888/69f1b3fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89600000/89594900/89594888/8a52d5ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games, table tennis, books](https://images.trvl-media.com/lodging/90000000/89600000/89594900/89594888/c9e953de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom [](https://www.expedia.ca/Rochester-Hotels-Clean.h89594888.Hotel-Information) Rochester 10/10 Exceptional (79 reviews) "Perfect rental to relax and have all the comforts of home! We were able to cook in the very well stocked kitchen. So much better than a hotel stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) April O. [](https://www.expedia.ca/Rochester-Hotels-Clean.h89594888.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/118000000/117640000/117631900/117631840/b052f01d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/118000000/117640000/117631900/117631840/0715b41f_edited_d19f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/118000000/117640000/117631900/117631840/8b957052.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/118000000/117640000/117631900/117631840/5ff85e45_edited_97c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO [](https://www.expedia.ca/Rochester-Hotels-SUNNY-3BD.h117631840.Hotel-Information) East Side Pioneers 9.8/10 Exceptional (7 reviews) [](https://www.expedia.ca/Rochester-Hotels-SUNNY-3BD.h117631840.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-12&endDate=2026-02-13®ionId=553248623858895563&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FByron-Hotels-Independent.0-0-d553248623858895563--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FByron-Hotels-Independent.0-0-d553248623858895563--bIndependent.Travel-Guide-Filter-Hotels) ## Top Byron Hotel Reviews ![Home2 Suites by Hilton Rochester Mayo Clinic Area](https://images.trvl-media.com/lodging/24000000/23520000/23512700/23512633/444e106b_y.jpg) ### Home2 Suites by Hilton Rochester Mayo Clinic Area 10/10 Excellent "Room was very clean, roomy. Loved having a microwave, mini fridge, and dishwasher. Lots of counter space, drawers for your clothes. Staff were great too." [](https://expedia.ca/Rochester-Hotels-Home2-Suites-By-Hilton-Rochester-Mayo-Clinic-Area.h23512633.Hotel-Information) ![The Berkman](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/50c22b07_y.jpg) ### The Berkman 10/10 Excellent "Everything was excellent, second time staying there. " [](https://expedia.ca/Rochester-Hotels-Berkman-Hotel.h46291477.Hotel-Information) ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "So convenient!" [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "Staff was accommodating, room was good, had some issues. They fixed those promptly. Nice spacious room." [](https://expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Marriott Rochester Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/ae2efa7d_y.jpg) ### Marriott Rochester Mayo Clinic 10/10 Excellent "Quiet, comfortable room. Clean and comforting design and decor. Friendly staff and the concierge level service was quite nice. " [](https://expedia.ca/Rochester-Hotels-Marriott-Rochester-Mayo-Clinic.h3948.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "It was a complete turnaround since July. The room was VERY clean, everything worked, and though the furniture was still dated, it was in great shape! We were very pleased with the improvement! The one staff person we encountered was friendly, polite, helpful and efficient. We'll be back!" [](https://expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Aspen Suites](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/6c7e0658_y.jpg) ### Aspen Suites 10/10 Excellent "Did not have breakfast… but had awesome evening meal…quiet…clean very informed front desk…helpful" [](https://expedia.ca/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information) ![Hyatt House Rochester/Mayo Clinic Area](https://images.trvl-media.com/lodging/57000000/56840000/56833100/56833067/369065b1_y.jpg) ### Hyatt House Rochester/Mayo Clinic Area 10/10 Excellent "Front desk was a huge help and extremely kind to us during our visit to Mayo Clinic " [](https://expedia.ca/Rochester-Hotels-Hyatt-House-RochesterMayo-Clinic.h56833067.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "Everything was excellent" [](https://expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ## Explore a world of travel with Expedia - 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