Upstate South Carolina Pet-friendly Vacations

Book a Hotel + Flight or Car together to unlock savings

Photo by RVLuckyorWhat
  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Pet-friendly Hotels in Upstate South Carolina

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this spa hotel in Greenville. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.6/10 Exceptional! (522 reviews)
"The BEST place to stay in Greenville! Great restaurants right inside the lodge with top of the line staff and service. Will definitely be back soon!"

Reviewed on Jul 5, 2026

Grand Bohemian Lodge Greenville, Autograph Collection
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this golf resort in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,301 reviews)
"This hotel does not take cash. This makes tipping their staff extremely difficult."

Reviewed on Jul 7, 2026

Embassy Suites Greenville Golf Resort & Conference Center
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this family-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.4/10 Very good! (1,007 reviews)
"The dated rooms were not the quality I expect from Hilton. I have stayed in quite a few this summer and this one by far was the worst one. Elevators did not work properly and having to take freight elevators was not in my plans."

Reviewed on Jul 5, 2026

Hilton Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.