Upstate South Carolina Vacation Packages
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
Top Upstate South Carolina Vacation Deals
Price found within the past 48 hours. Click for updated prices.
Where to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Upstate South Carolina Hotel Deals
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
The price is CA $107 per night from Nov 1 to Nov 2
CA $107
CA $117 total
Nov 1 - Nov 2
includes taxes & fees
9.2/10 Wonderful! (1,593 reviews)
"Had a fantastic stay. Great location! Clean! Comfortable! Cozy! Great breakfast!"
Reviewed on Oct 28, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
The price is CA $130 per night from Nov 1 to Nov 2
CA $130
CA $148 total
Nov 1 - Nov 2
includes taxes & fees
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
The price is CA $137 per night from Nov 23 to Nov 24
CA $137
CA $155 total
Nov 23 - Nov 24
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Upstate South Carolina attractions
What to do in Upstate South Carolina
Greenville Ghost Tour with Paranormal Investigation
CA $49
per adult
Frequently asked questions
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
