Book The Best Hotels in Upstate South Carolina, SC for 2026 from CA $109 - Fully Refundable Options

A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

A reception area with a stone counter, a laptop, and a sign indicating a Chairman's Award.

A pool area with lounge chairs and a sign for Best Western Plus.

A hotel room with a large bed, a desk with a chair, a blue armchair, a wooden nightstand with a lamp, and a wardrobe with a mirror.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Ryan

CA $107

CA $118 total

includes taxes & fees

Oct 11 - Oct 12

A multi-level hotel atrium with a central open area, multiple balconies, and a variety of seating arrangements.

An outdoor patio with a stone fire pit, wicker chairs, and a pergola structure.

A multi-level atrium with a modern design, featuring a central open space with tiered seating and tables, surrounded by balconies with greenery.

A modern living room with a dining table, chairs, a sofa, a television, and bookshelves.

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Pedro

CA $149

CA $169 total

includes taxes & fees

Oct 4 - Oct 5

A hotel with a stone facade, multiple windows, and a sign indicating it's a Wyndham hotel.

A compact living space with a kitchenette, a flat-screen TV, a sofa, and a bed with a patterned cover.

A modern hotel room with a bed, a desk, a TV, a window with curtains, and a view of the outside.

A modern kitchen with a granite countertop, a built-in grill, a microwave, and a coffee maker. There are two framed artworks on the wall and a refrigerator with a built-in ice maker.

3. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Charles

CA $99

CA $109 total

includes taxes & fees

Oct 12 - Oct 13

A covered outdoor area with a stone facade, a bench, and a truck parked nearby.

A hotel room with two beds, a desk, and a chair.

A swimming pool with lounge chairs and umbrellas, surrounded by a building with a modern design and a fence.

A Comfort Inn hotel with a parking lot, a covered walkway, and a well-maintained lawn.

4. Comfort Inn Greenville - Haywood Mall

Greenville

Doug

CA $115

CA $130 total

includes taxes & fees

Oct 18 - Oct 19

A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

A reception area with two reception desks, a large cityscape poster, and a plant.

A modern kitchen with a refrigerator, coffee machine, and various food items.

A modern living room with a fireplace, a flat-screen TV, and comfortable seating.

5. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Lissette

CA $155

CA $176 total

includes taxes & fees

Sep 30 - Oct 1

A modern kitchen with hanging light fixtures and bar seating.

A modern bar area with a central island, bar stools, and overhead lighting.

A modern hotel room with a large desk, a comfortable sofa, and a bed.

A modern lobby with a curved reception desk, comfortable seating, and a large wall-mounted TV.

6. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jeffery

CA $179

CA $203 total

includes taxes & fees

Oct 4 - Oct 5

A modern hotel lobby with a bar area, seating, and a patterned floor.

A modern living room with a sofa, armchairs, a coffee table, and a patterned rug.

A hotel lobby with a reception desk, computers, and a seating area.

A hotel entrance with a welcoming sign, a covered walkway, and a landscaped area with benches and flowers.

7. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Tara

CA $137

CA $155 total

includes taxes & fees

Oct 18 - Oct 19

A modern lounge area with a blue sofa, a round coffee table, a patterned ottoman, and a wooden reception desk.

A gym with treadmills, stationary bikes, and exercise balls.

A vending area with various snack and drink options, including chips, sodas, and bottled water.

A hotel room with two beds, a desk, a TV, and a patterned carpet.

8. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Simone

CA $119

CA $131 total

includes taxes & fees

Sep 27 - Sep 28

A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.

A hotel pool area with lounge chairs, a flag, and a sunset view.

A snack and beverage display with various snacks and drinks.

A cafe with a checkered floor, wooden cabinets, and hanging pendant lights.

9. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

David

CA $146

CA $166 total

includes taxes & fees

Oct 25 - Oct 26

A spacious living area with a staircase, a sofa, a coffee table, and a desk with a chair.

A hotel reception area with a wooden reception desk, a black rug, and a blue sofa.

A hotel room with a bed, a nightstand, a mirror, a sink, and framed pictures on the wall.

A modern kitchen with a bar area, wooden cabinets, and a large island with bar stools.

10. Sleep Inn at Greenville Convention Cente

Greenville

Chris

CA $98

CA $111 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel room with a large bed, a separate bathroom with a bathtub, a nightstand, a lamp, and a wall-mounted artwork.

A reception area with two beige armchairs, a glass-top table, and a vibrant geometric wall art.

A Days Inn by Wyndham hotel with a covered entrance, multiple windows, and a parking area with cars.

A spacious dining area with a central table and chairs, a kitchen in the background, and a sign indicating a breakfast area.

11. Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Martel

CA $103

CA $113 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

A fitness center with treadmills, elliptical machines, and a red exercise ball.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a red accent wall.

A modern hotel lobby with a wooden cabinet, a flat-screen TV, a sofa, and a table.

12. Drury Inn & Suites Greenville

Greenville

Gohan

CA $182

CA $200 total

includes taxes & fees

Oct 4 - Oct 5

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and illuminated pillars.

A modern hotel lobby with blue and white pillars, seating areas, and a bar.

A gym with multiple treadmills, exercise balls, and a bench.

A hotel lobby with a reception desk, seating area, and a view of the outdoors.

13. Holiday Inn Express & Suites Greenville - Taylors by IHG

Greenville

rangsri

CA $137

CA $150 total

includes taxes & fees

Oct 18 - Oct 19

A modern building with a glass facade and a brick base, featuring a prominent entrance with a flag.

A modern living room with a fireplace, seating area, and a kitchen in the background.

A swimming pool with lounge chairs and a no diving sign.

A multi-story hotel with a central courtyard, a pool, and a parking area.

14. Comfort Suites Greenville Airport

Greenville

Ryan

CA $131

CA $148 total

includes taxes & fees

Oct 25 - Oct 26

A circular outdoor seating area with a fire pit, surrounded by sofas and chairs, in front of a multi-story building.

A modern bar area with a curved counter, bar stools, and a wine glass.

A modern bar area with seating arrangements, a counter with various beverages, and a sports screen.

A hotel room with two beds, a desk with a computer, a chair, and a large window with curtains.

15. Courtyard by Marriott Greenville Haywood Mall

Greenville

Sherise

CA $141

CA $160 total

includes taxes & fees

Oct 18 - Oct 19

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

A snack bar with a variety of packaged foods and beverages, a refrigerated display case, and a counter with a sign that reads 'This and that and then some.'

A modern lobby with a reception desk, seating areas, and a large window offering a view.

A modern lobby with a blue sofa, teal armchairs, hanging lights, and a seating area with round chairs.

16. Tru by Hilton Greenville Woodruff Road

Greenville

Sandra

CA $151

CA $179 total

includes taxes & fees

Oct 11 - Oct 12

A spacious hotel lobby with a central bar area, seating arrangements, and large windows providing natural light.

A modern kitchen with a bar area, a seating area with a sofa and chairs, and a television mounted on the wall.

A conference room with a large flat-screen TV, multiple tables with chairs, and water bottles on each table.

A Holiday Inn hotel with a modern design, featuring a prominent entrance and a parking lot with several vehicles.

17. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Candace

CA $142

CA $157 total

includes taxes & fees

Oct 4 - Oct 5

A spacious living area with a fireplace, a beige sofa, and a modern chandelier.

A multi-story hotel with a prominent entrance and a landscaped driveway.

A modern breakfast bar with wooden stools, a coffee station, and a variety of breakfast items.

A modern retail store named 'The Shop' with a variety of products including snacks, beverages, and household items.

18. Hilton Garden Inn Greenville

Greenville

Sue

CA $154

CA $175 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with modern furniture, a chandelier, and potted plants.

An outdoor seating area with tables and chairs, potted plants, and a modern building facade.

A bar with a white countertop, multiple bar stools, and shelves stocked with bottles.

19. Hilton Greenville

Greenville

Edward

CA $161

CA $182 total

includes taxes & fees

Oct 18 - Oct 19

A modern reception area with a counter, seating, and a large screen.

A fitness room with treadmills, a stationary bike, and a mirror wall.

A hotel room with a kitchenette, a sofa, a bed, and artwork on the walls.

A compact kitchen with wooden cabinets, a built-in microwave, a dishwasher, and a refrigerator.

20. Extended Stay America Premier Suites Greenville Woodruff Rd

Greenville

gerri

CA $108

CA $118 total

includes taxes & fees

Oct 4 - Oct 5

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Vacation Rentals in Upstate South Carolina

Aparthotel

A modern hotel with a sign reading "apt suites" and a parking lot with cars.

An outdoor patio with a stone barbecue grill and white Adirondack chairs.

A reception desk with a blue wall, a white counter, and dark cabinets. There is a vase with white flowers on the counter.

stayAPT Suites Greenville-Haywood Mall

Greenville

"I was there for work and I was close to everything"

Cabin

A spacious porch with wooden flooring, a dining area with a table and chairs, and a view of the surrounding landscape.

A swimming pool with lounge chairs and a covered area with tables and chairs.

A spacious living room with a dark leather sofa, a wooden coffee table, and a dining area with a table and chairs. Large windows provide natural light and views of the outdoors.

Carolina Camp Cedar

Pickens

"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"

Aparthotel

A modern living room with a flat-screen TV, a dining area with a round table and chairs, a kitchen with dark cabinets and a refrigerator, and a sofa with a patterned pillow.

A pool area with a covered seating area, lounge chairs, and umbrellas.

A spacious living area with a ceiling fan, a flat-screen TV, and comfortable seating.

A modern kitchen with a coffee bar, wooden wall, and three orange bar stools.

Landing Apartments - Lyman

Lyman

"Great room that was nice and clean. Smooth check-in."

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.

A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Excellent location for our trip. Very clean, had everything we needed."

Cottage

A living room with a sofa, coffee table, and a dining area with chairs and a table.

A covered porch with wicker furniture, a round table with a bowl and a cup, and a view of a lush garden.

A bedroom with a bed, bedside tables, a round mirror, and a ceiling fan.

A modern kitchen with white cabinets, stainless steel appliances, and a patterned rug.

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Greer

"Very cute home close to everything. Super clean and spacious. Well furnished."

Cabin

A wooden interior with a table, chair, and a hanging lantern.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Me and my family had a great time"

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

A cozy cabin interior with wooden walls, a loft bedroom, a dining area, and a sofa with cushions.

A rustic cabin with a porch, wooden steps, and a picnic table.

A wooden interior with a loft bed, a green chair, a wooden table, and a map on the wall.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A wooden deck with a bench and a welcome mat, overlooking a well-maintained lawn and trees.

A spacious living room with hardwood floors, a fireplace, a sofa, a coffee table, and a television.

A rustic cabin with a wooden deck, a covered patio, and a large window overlooking a wooded area.

A bedroom with a large bed, a ceiling fan, a TV, and a window with blinds.

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

Cottage

A spacious living room with a large sofa, a kitchen area with a bar, and a view of the outdoors through the windows.

A modern kitchen with a wooden ceiling, a bar stool, a stove, and a sink.

A kitchen with a wooden countertop, white chairs, and a dining table. There is a mirror on the wall and a window with blinds.

A wooden dock extending into a calm body of water, surrounded by lush greenery and a small wooden structure in the background.

Waterfront Cabin w/ Private Dock on Lake Hartwell!

Townville

"We booked last minute for Clemson parents weekend. It worked out fine, it is really in the middle of no where. There are no outlets in the bathroom you have to use the kitchen mirror and outlets to get ready. There was a coffee machine but no coffee. It was very clean. The deck needs some work."

Cottage

A covered porch with wooden railings and a table with chairs.

A cabin with a wooden deck, a gravel driveway, and a forested backdrop.

A kitchen with a dining area, a sliding glass door to a deck, and a ceiling fan.

A cozy living room with a sectional sofa, a wooden chair, a coffee table, and a red and black patterned rug.

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

Cottage

A cabin with a dock extending into a lake, surrounded by trees and a wooden deck.

A modern kitchen with white cabinets, a large island with bar stools, and a view of the outdoors through large windows.

A modern kitchen with white cabinets, a central island, and a dining area with white chairs.

A forest setting with a fire pit and red chairs arranged around it.

Waterfront Lake Hartwell Home w/ Dock & Fire Pit

Hartwell

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Falls Park on the Reedy

9.6/10 (2,661 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Bon Secours Wellness Arena

8.6/10 (1,219 reviews)

Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.

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Memorial Stadium

9.6/10 (410 reviews)

Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.

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Greenville Convention Center

8.4/10 (571 reviews)

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

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BMW Performance Center

9.0/10 (90 reviews)

You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.

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Haywood Mall

8.8/10 (1,681 reviews)

During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Frankie's Fun Park to Conestee Nature Preserve.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Best Western Spartanburg I-26

10/10 Excellent

"Better than average for less than average..."

Lakeside Lodge Clemson

10/10 Excellent

"clean room"

Comfort Inn & Suites Clemson - University Area

10/10 Excellent

"clean room, but elevator was broken so I was at the far end and it was hard to manipulate luggage all they way there. Staff was never available, ever. Breakfast was ok, nothing to write home about."

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"Overall we had a great stay. The staff was very friendly and our room was clean. The breakfast could be warmer. However, there are omelettes made on demand and the ingredients are very fresh. My family and I have been to this property several times. We have been satisfied each time."

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"Great spot"

Embassy Suites by Hilton Greenville Downtown Riverplace

10/10 Excellent

"Perfect location with river & city views from balcony. Delicious complimentary breakfast and happy hour. Nice rooftop bar"

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent

"Beautiful hotel with all the amenities! Large rooms and bathrooms, great coffee maker and steamer for clothes. Beautiful views outside of restaurant. Will definitely return!"

Hyatt Place Greenville/Haywood

8/10 Good

"The staff was lovely and the rooms were great nice comfortable bed. We had a really nice view from the window on the fifth floor. The only thing was they were doing renovations which I wasn’t expecting. Other than that everything was great."

More cheap stays in Upstate South Carolina

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

1024 Woodruff Rd Greenville SC

CA $99

CA $109 total

Oct 12 - Oct 13

includes taxes & fees

Best Western Plus Greenville I-385 Inn & Suites

831 Congaree Rd Greenville SC

CA $107

CA $118 total

Oct 11 - Oct 12

includes taxes & fees

Comfort Inn Greenville - Haywood Mall

246 Congaree Road Greenville SC

CA $115

CA $130 total

Oct 18 - Oct 19

includes taxes & fees

Comfort Inn & Suites Clemson - University Area

1305 Tiger Blvd Clemson SC

CA $148

CA $165 total

Oct 14 - Oct 15

includes taxes & fees

8.4/10 Very good! (1,002 reviews)

Best Western Plus Clemson Hotel & Conference Center

1310 Tiger Blvd Clemson SC

CA $149

CA $165 total

Sep 27 - Sep 28

includes taxes & fees

8/10 Very good! (1,000 reviews)

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC

CA $153

CA $190 total

Sep 29 - Sep 30

includes taxes & fees

9/10 Wonderful! (1,000 reviews)

Hotels in Upstate South Carolina with star rating

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Book Hotels in Upstate South Carolina on Expedia.com

Find hotels in Upstate South Carolina, SC from CA $109

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Upstate South Carolina

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Upstate South Carolina hotels

1. Best Western Plus Greenville I-385 Inn & Suites

2. Embassy Suites Greenville Golf Resort & Conference Center

3. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

4. Comfort Inn Greenville - Haywood Mall

5. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

6. DoubleTree by Hilton Greenville Woodruff Road

7. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

8. Fairfield Inn & Suites by Marriott Greenville Simpsonville

9. Hampton Inn Greenville I-385 - Woodruff Rd.

10. Sleep Inn at Greenville Convention Cente

11. Days Inn by Wyndham Greenville South/Mauldin

12. Drury Inn & Suites Greenville

13. Holiday Inn Express & Suites Greenville - Taylors by IHG

14. Comfort Suites Greenville Airport

15. Courtyard by Marriott Greenville Haywood Mall

16. Tru by Hilton Greenville Woodruff Road

17. Holiday Inn Greenville - Woodruff Road by IHG

18. Hilton Garden Inn Greenville

19. Hilton Greenville

20. Extended Stay America Premier Suites Greenville Woodruff Rd

Vacation Rentals in Upstate South Carolina

stayAPT Suites Greenville-Haywood Mall

Carolina Camp Cedar

Landing Apartments - Lyman

Mint House Greenville Downtown by Kasa

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Carolina Landing RV Resort - Caravan Park

Serene Cabin w/ Pond & Creek on South Saluda River

Waterfront Cabin w/ Private Dock on Lake Hartwell!

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Waterfront Lake Hartwell Home w/ Dock & Fire Pit

Stay near popular Upstate South Carolina attractions

Clemson University

Falls Park on the Reedy

Bon Secours Wellness Arena

Memorial Stadium

Greenville Convention Center

BMW Performance Center

Haywood Mall

Learn more about Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Best Western Spartanburg I-26

Lakeside Lodge Clemson

Comfort Inn & Suites Clemson - University Area

Embassy Suites Greenville Golf Resort & Conference Center

Best Western Plus Clemson Hotel & Conference Center

Embassy Suites by Hilton Greenville Downtown Riverplace

Grand Bohemian Lodge Greenville, Autograph Collection

Hyatt Place Greenville/Haywood

More cheap stays in Upstate South Carolina

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Best Western Plus Greenville I-385 Inn & Suites

Comfort Inn Greenville - Haywood Mall

Comfort Inn & Suites Clemson - University Area

Best Western Plus Clemson Hotel & Conference Center

Lakeside Lodge Clemson

Hotels in Upstate South Carolina with star rating

Explore a world of travel with Expedia

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