Find hotels in Upstate South Carolina, SC from CA $93
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Cabin
Family friendly
Apart hotel
Cottage
Waterpark
Pet friendly
Farm
Resort
Check prices for these dates
Tonight
Aug 9 - Aug 10Tomorrow
Aug 10 - Aug 11Next weekend
Aug 14 - Aug 16In two weeks
Aug 21 - Aug 23Our top choices for Upstate South Carolina hotels
1. Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
Sidney
CA $133
CA $146 total
includes taxes & fees
Aug 13 - Aug 14
2. Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
Angela
CA $136
CA $154 total
includes taxes & fees
Aug 16 - Aug 17
3. Drury Inn & Suites Greenville
Drury Inn & Suites GreenvilleGreenville
Aaron
CA $160
CA $176 total
includes taxes & fees
Aug 16 - Aug 17
4. Clarion Greenville Airport Inn
Clarion Greenville Airport InnGreenville
Mohamed Ayman
CA $105
CA $116 total
includes taxes & fees
Aug 16 - Aug 17
5. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.Greenville
Kelley
CA $113
CA $128 total
includes taxes & fees
Aug 11 - Aug 12
6. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
Microtel Inn & Suites by Wyndham Greenville / Woodruff RdGreenville
Steven
CA $107
CA $117 total
includes taxes & fees
Aug 24 - Aug 25
7. Courtyard by Marriott Greenville Mauldin
Courtyard by Marriott Greenville MauldinGreenville
sarah
CA $166
CA $182 total
includes taxes & fees
Aug 13 - Aug 14
8. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
Holiday Inn Express & Suites Greenville SE - Simpsonville by IHGSimpsonville
Alicia
CA $173
CA $190 total
includes taxes & fees
Aug 14 - Aug 15
9. Comfort Suites Piedmont - Greenville South
Comfort Suites Piedmont - Greenville SouthPiedmont
Michelle
CA $144
CA $160 total
includes taxes & fees
Aug 30 - Aug 31
10. DoubleTree by Hilton Greenville Woodruff Road
DoubleTree by Hilton Greenville Woodruff RoadGreenville
Jennifer
CA $155
CA $175 total
includes taxes & fees
Aug 16 - Aug 17
11. Hilton Garden Inn Greenville
Hilton Garden Inn GreenvilleGreenville
Robert
CA $136
CA $154 total
includes taxes & fees
Aug 16 - Aug 17
12. Courtyard by Marriott Greenville Haywood Mall
Courtyard by Marriott Greenville Haywood MallGreenville
Sherise
CA $146
CA $166 total
includes taxes & fees
Aug 14 - Aug 15
13. Days Inn by Wyndham Greenville South/Mauldin
Days Inn by Wyndham Greenville South/MauldinMauldin
Kendra
CA $100
CA $109 total
includes taxes & fees
Sep 6 - Sep 7
14. Hampton Inn Greenville I-385 - Woodruff Rd.
Hampton Inn Greenville I-385 - Woodruff Rd.Greenville
Anne
CA $142
CA $161 total
includes taxes & fees
Aug 16 - Aug 17
15. Fairfield Inn & Suites by Marriott Greenville Simpsonville
Fairfield Inn & Suites by Marriott Greenville SimpsonvilleSimpsonville
Carole
CA $117
CA $129 total
includes taxes & fees
Aug 23 - Aug 24
16. Hilton Greenville
Hilton GreenvilleGreenville
Thomas
CA $143
CA $162 total
includes taxes & fees
Sep 3 - Sep 4
17. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHGGreenville
Jessica
CA $132
CA $150 total
includes taxes & fees
Sep 7 - Sep 8
18. Wingate by Wyndham - Greenville-Airport
Wingate by Wyndham - Greenville-AirportGreenville
Meridy
CA $112
CA $123 total
includes taxes & fees
Aug 16 - Aug 17
19. SpringHill Suites by Marriott Greenville Downtown
SpringHill Suites by Marriott Greenville DowntownGreenville Downtown
Don
CA $172
CA $195 total
includes taxes & fees
Aug 16 - Aug 17
20. Comfort Inn Greenville - Haywood Mall
Comfort Inn Greenville - Haywood MallGreenville
Brittney
CA $122
CA $138 total
includes taxes & fees
Sep 6 - Sep 7
Vacation Rentals in Upstate South Carolina
Apartment
Mint House Greenville Downtown by Kasa
Mint House Greenville Downtown by KasaGreenville Downtown
"We had a great time, very close to eating and shopping. The amenities were very helpful and we felt the area was very safe. We had an issue with getting a ticket even though we paid for parking but it was taken care of within an hour!"
Aparthotel
stayAPT Suites Greenville-Haywood Mall
stayAPT Suites Greenville-Haywood MallGreenville
"All the staff from front desk to housekeeping were excellent, friendly and helpful. If looking for rooms with a feel like home StayApt is what you are looking for. I recommend reserving here great place if you want to cook your own meals"
Apartment
Landing Apartments Greer - Sugar Creek
Landing Apartments Greer - Sugar CreekGreer
"The apartment was clean. Excellent value for stay. Amenities were great. Will book again!"
Cottage
2 Mi to Downtown: Luxe Greenville Retreat!
2 Mi to Downtown: Luxe Greenville Retreat!Greenville
"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "
Aparthotel
The Station by Compo Hotels
The Station by Compo HotelsTravelers Rest
"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."
Cabin
Carolina Camp Cedar
Carolina Camp CedarPickens
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
"It was a good getaway trip"
Mobile Home
Carolina Landing RV Resort - Caravan Park
Carolina Landing RV Resort - Caravan ParkFair Play
"Very nice stay with friendly staff"
Cottage
Claires Cottage ~ 4 Mi to Downtown Greenville!
Claires Cottage ~ 4 Mi to Downtown Greenville!Greenville
"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."
Cottage
Cozy Greenville Bungalow ~ 2 Mi to Downtown!
Cozy Greenville Bungalow ~ 2 Mi to Downtown!Greenville
"Amazing place. Great host. "
Cottage
Stay at Jos Taylor Retreat: 9 Mi to Greenville!
Stay at Jos Taylor Retreat: 9 Mi to Greenville!Taylors
"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."
Cottage
Families Welcome, Fenced Yard: Inviting Greer Home
Families Welcome, Fenced Yard: Inviting Greer HomeGreer
"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."
Apartment
Serene Travelers Rest Apartment: 7 Mi to Downtown!
Serene Travelers Rest Apartment: 7 Mi to Downtown!Travelers Rest
"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "
Cottage
1 Mi to Downtown Greer: Family Home w/ Gazebo!
1 Mi to Downtown Greer: Family Home w/ Gazebo!Greer
"Very cute home close to everything. Super clean and spacious. Well furnished."
Cottage
Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!
Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!Seneca
"Beautiful and quaint cabin! Highly recommend, great view of the lake."
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Upstate South Carolina attractions
Clemson University
9.6/10 (1,439 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Photo by Karyn Thompson
Fred W. Symmes Chapel
9.8/10 (29 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
Bon Secours Wellness Arena
8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the acclaimed theater scene in this family-friendly area.
Greenville Convention Center
8.4/10 (571 reviews)
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
Haywood Mall
8.8/10 (1,681 reviews)
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.
See all hotels in Upstate South Carolina
Photo by Visit Greenville, South Carolina
Top Upstate South Carolina Hotel Reviews
Embassy Suites by Hilton Greenville Downtown Riverplace
10/10 Excellent
"Clean Room"
Hilton Greenville
10/10 Excellent
"00"
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
10/10 Excellent
"The staff was awesome in accommodating me and my wheelchair bound child throughout our stay. The location was awesome and accessible to multiple options of food and shopping. The property is tucked just far enough back from Woodruff Rd to not hear any traffic noise."
Comfort Inn Greenville - Haywood Mall
10/10 Excellent
"Thanks as service as well done"
Embassy Suites Greenville Golf Resort & Conference Center
10/10 Excellent
"My stay was absolutely fantastic!"
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
10/10 Excellent
"I have no complaints about the facility. It was clean and well placed. The staff was gracious and helpful."
The Shepherd Hotel Downtown Clemson
10/10 Excellent
"The service was phenomenal as was their valet staff- wonderful experience!"
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"Very relaxing, clean environment. Felt safe and welcoming."
Aloft by Marriott Greenville Downtown
10/10 Excellent
"Awesome"
More cheap stays in Upstate South Carolina
Days Inn by Wyndham Greenville
60 Roper Mountain Rd Greenville SC
CA $84
CA $93 total
Sep 7 - Sep 8
includes taxes & fees
Comfort Inn Greenville - Haywood Mall
246 Congaree Road Greenville SC
CA $122
CA $138 total
Sep 6 - Sep 7
includes taxes & fees
8/10 Very good! (1,016 reviews)
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
161 Sha Ln Spartanburg SC
CA $132
CA $146 total
Aug 30 - Aug 31
includes taxes & fees
8.6/10 Excellent! (985 reviews)
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
CA $133
CA $146 total
Aug 13 - Aug 14
includes taxes & fees
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
CA $147
CA $163 total
Aug 16 - Aug 17
includes taxes & fees
8.2/10 Very good! (1,005 reviews)
Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
CA $152
CA $189 total
Aug 16 - Aug 17
includes taxes & fees
Hotels in Upstate South Carolina with star rating
4 Star Hotels
32 properties
3 Star Hotels
191 properties
2 Star Hotels
144 properties
Explore a world of travel with Expedia
- Judson Mill Lofts with all the amenities
- Una Hotels
- Landrum Hotels
- Piedmont Hotels
- Taylors Hotels
- Greenville Downtown Hotels
- Tru by Hilton Greenville Woodruff Road
- Woodruff Hotels
- Cabin Rentals in Greenville
- Hotels near Greenville-Spartanburg Intl.
- 3 Star Hotels in Greenville
- Ac Hotel By Marriott Greenville
- Hotels near Fred W. Symmes Chapel
- Six Mile Hotels
- Cozy Hub~Comfortable Simpsonville Home ~Long-Term Stays Welcome ~Community Pool
- Hotels near Christ Episcopal Church
- Laurens Hotels
- Hotels with Free Airport Shuttle in Greenville
- All Inclusive Resorts and in Greenville
- Simpsonville Hotels
- Greenville Hotels
- 4 Star Hotels in West End
- Anderson Hotels
- Spartanburg Hotels
- Hotels near Anderson County Regional
- 2 Bed near Greenville
- Lyman Hotels
- Five Forks Hotels
- 2br Cedar Lane Road Retreat at Swamp Rabbit Trail!
- Marietta Hotels
- Apartments in Greenville
- Pumpkintown Hotels
- Farmstay in Greenville
- Hotels with Free Breakfast in Greenville
- Clemson Hotels
- Hotels near Bon Secours Wellness Arena
- Roebuck Hotels
- 24 Riverview Dr
- Central Hotels
- Fountain Inn Hotels
- B&B in Greenville
- Campobello Hotels
- Beach Hotel Hotels in Greenville
- Mint House Greenville Downtown by Kasa
- Greer Hotels
- 5 Star Hotels in Greenville
- Spa Hotels in Upstate South Carolina
- Hotels near Clemson University
- Motels in Greenville
- Pelzer Hotels
- Hotels near Centre Stage
- Flights from Annapolis (ANP) to Greenville (GMU)
- Flights from Detroit (DTW) to Greenville (GDC)
- Flights from Birmingham (BHM) to Greenville (GMU)
- Flights from Vancouver (YVR) to Greenville (GMU)
- Flights from San Diego (SAN) to Greenville (GMU)
- Flights to Simpsonville
- Flights from Manteo (MEO) to Greenville (GMU)
- Flights from Washington (DCA) to Greenville (GDC)
- Flights from Raleigh (RDU) to Greenville (GDC)
- Flights from Detroit (DTW) to Greenville (GSP)
- Flights from New York (JFK) to Greenville (GMU)
- Flights from Greenville
- Flights from Vancouver (YVR) to Greenville (GSP)
- Flights from West Palm Beach (PBI) to Greenville (GMU)
- Flights to Greenville - Spartanburg
- Flights to Greenville
- Flights from Anderson (AND) to Greenville (GDC)
- Flights from Orlando (MCO) to Greenville (GDC)
- Flights from Buffalo (BUF) to Greenville (GSP)
- Flights from Montreal (YUL) to Greenville (GSP)
- Flights from Miami (MIA) to Greenville (GDC)
- Flights from Ottawa (YOW) to Greenville (GSP)
- Flights from Schenectady (SCH) to Greenville (GMU)
- Flights from Rome (FCO) to Greenville (GDC)
- Flights from Donaldson Center
- Flights from Des Moines (DSM) to Greenville (GDC)
- Flights from Philadelphia (PHL) to Greenville (GMU)
- Flights from Montreal (YUL) to Greenville (GMU)
- Flights from Toronto (YYZ) to Greenville (GMU)
- Flights from Toronto (YYZ) to Greenville (GSP)
- Flights from Greenville-Spartanburg Intl.
- Car rental Greenville
- Avis Rental Cars in Greenville
- Car rentals near Prisma Health Greenville Memorial Hospital
- Car rental Simpsonville
- Enterprise Rental Cars in Greenville Downtown
- Europcar Rental Cars in Greenville
- Drive on Holidays Rental Cars in Greenville - Spartanburg
- Ace Rental Cars in Greenville Downtown
- Enterprise Rental Cars in Greenville
