Title: Book The Best Hotels in Upstate South Carolina, SC for 2026 from CA $97 - Fully Refundable Options - Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx6057939)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d6057939.Destination-Travel-Guides) ![I was surprised to see this waterfall in the middle of the city! #parks #nature #southcarolina #waterfall](https://images.trvl-media.com/place/1388/fb367afc-81f4-43d0-8f61-0b0f8e73a9aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by HTN ![](https://images.trvl-media.com/place/1388/fb367afc-81f4-43d0-8f61-0b0f8e73a9aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Upstate South Carolina Cabin [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&lodging=CABIN) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&amenities=HOT_TUB) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&travelerType=family_friendly) Pool [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&amenities=POOL) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&lodging=COTTAGE) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&amenities=PETS) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&amenities=WATER_PARK) Condo [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&lodging=CONDO) Chalet [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&lodging=CHALET) Spa [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&amenities=SPA_ON_SITE) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&lodging=APARTMENT) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=6057939&latLong=34.772137%2C-82.278365&adults=2&startDate=2026-01-28&d1=2026-01-28&endDate=2026-01-30&d2=2026-01-30&lodging=APART_HOTEL) ## Check prices for these dates Tonight [Jan 14 - Jan 15](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2026-01-14&endDate=2026-01-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 15 - Jan 16](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2026-01-15&endDate=2026-01-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Upstate South Carolina hotels ![Free daily full breakfast](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/a5e4dea1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/a9c6228a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/b9808144.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Gaffney by IHG [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) Gaffney 8.8/10 Excellent (435 reviews) "Great people n place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice CA $108 CA $118 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/91e6d418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/589bd84f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/ad742419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) Seneca 9.0/10 Wonderful (1,001 reviews) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gene CA $151 CA $188 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/76f56d99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/ffe59c14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/2a4dd9e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/6bd999f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Greenville Airport [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) Greenville 9.2/10 Wonderful (1,006 reviews) "We stayed here based on proximity to GSP airport. It was clean, parking lot was well lit, room was spacious and comfortable. Would stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lawrence CA $137 CA $155 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/130000/120500/120431/a7e2d124.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, desk](https://images.trvl-media.com/lodging/1000000/130000/120500/120431/39e12856.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar](https://images.trvl-media.com/lodging/1000000/130000/120500/120431/1c93baf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/120500/120431/91f2c765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Simpsonville [](https://www.expedia.ca/Simpsonville-Hotels-Hampton-Inn-Simpsonville.h120431.Hotel-Information) Simpsonville 8.8/10 Excellent (597 reviews) "The hotel staff is excellent here. The rooms were very clean and very well furnished the bedding, and the bed itself was as comfortable as I remember in a while." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew CA $138 CA $164 total includes taxes & fees Jan 23 - Jan 24 [](https://www.expedia.ca/Simpsonville-Hotels-Hampton-Inn-Simpsonville.h120431.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/a55a98c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/4f97c0ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/67359be4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/4179b181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate by Wyndham - Greenville-Airport [](https://www.expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville-Airport.h43464.Hotel-Information) Greenville 8.4/10 Very good (1,002 reviews) "Nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Komal CA $111 CA $122 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville-Airport.h43464.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/877cf1bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/cde26095.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/b4bc2621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/96c48b79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Haywood [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) Greenville 7.4/10 Good (1,131 reviews) "Kind staff, clean room, tasty continental breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen CA $90 CA $99 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/e91d409a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/b54ae3f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/fea97b11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Greenville I-385 Inn & Suites [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) Greenville 9.0/10 Wonderful (1,429 reviews) "Excellent hotel nice and clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Irasema CA $107 CA $118 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Hallway](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/d217b18b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/959a330b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/cb83efe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Patrick Square [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) Clemson 9.8/10 Exceptional (791 reviews) "Clean room, great location, wonderful staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joyce CA $207 CA $230 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/81c4f249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/f6f7c8c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/eab53b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) Seneca 8.0/10 Very good (668 reviews) "Good available parking. Room clean. Breakfast was minimal, but good. The tub was slippery and needed a mat. I almost fell a couple of times. I would stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denise CA $105 CA $124 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b840578e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Double Beds, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/f2d60448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/8238721d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Greenville Golf Resort & Conference Center [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) Greenville 9.0/10 Wonderful (1,024 reviews) "Great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) kurt CA $131 CA $144 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/9bab6d34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/3f88a754.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/0160650e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/227b33b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Hotel-Suites-Anderson-I-85.h848780.Hotel-Information) Anderson 9.0/10 Wonderful (586 reviews) "It was great. Room was clean and staff was friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Veronica CA $143 CA $159 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Hotel-Suites-Anderson-I-85.h848780.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/b3b1b4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/0e19a728.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/e7b52d93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/1ac2fb4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Spartanburg [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) Spartanburg 9.2/10 Wonderful (836 reviews) "The place was perfect for our, trip" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $145 CA $160 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/246311c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/2183f59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/b8bc9f82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/5a73d893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Greer - Greenville [](https://www.expedia.ca/Greer-Hotels-Comfort-Inn-Suites-Greer-Greenville.h67445.Hotel-Information) Greer 8.6/10 Excellent (746 reviews) "this is the best hotel friendly clean rooms, quiet and the staff is great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) pamela CA $124 CA $135 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Greer-Hotels-Comfort-Inn-Suites-Greer-Greenville.h67445.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/2fa8ed98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/bd6af703.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/752d9078.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/33c2ff7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Spartanburg-North I-85 [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) Spartanburg 8.6/10 Excellent (1,000 reviews) "Great staff, clean room, good location. Would definitely stay here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Randall CA $112 CA $125 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/59f41330.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/2f0ad17a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/7796ec2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/2b4321e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Anderson/Clemson [](https://www.expedia.ca/Anderson-Hotels-Microtel-Inn-Suites-By-Wyndham-AndersonClemson.h2739237.Hotel-Information) Anderson 8.2/10 Very good (1,001 reviews) "Room was clean, front desk people were very nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Caressa CA $99 CA $110 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Anderson-Hotels-Microtel-Inn-Suites-By-Wyndham-AndersonClemson.h2739237.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/92684d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/9966f479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1fc30205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) Greenville 8.6/10 Excellent (96 reviews) "Great room, very clean and staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $104 CA $118 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Free breakfast](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/282fab11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/aa533fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2557x3y4-ce9cc597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Clemson Hotel & Conference Center [](https://www.expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) Clemson 8.2/10 Very good (1,001 reviews) "Clean room and staff were great’" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Audrey CA $131 CA $145 total includes taxes & fees Jan 28 - Jan 29 [](https://www.expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/800/708/w2678h1966x0y0-e3e18b8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/800/708/2fe691fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/10000/800/708/f720c9db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/10000/800/708/338fc74f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Greenville Airport Inn [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Greenville-Airport-Inn.h708.Hotel-Information) Greenville 7.8/10 Good (1,005 reviews) "Good hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) magadan CA $100 CA $110 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Greenville-Airport-Inn.h708.Hotel-Information) ![In-room safe, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/5400/5385/ef6b91b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5400/5385/9f16611a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/5400/5385/75efff15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5400/5385/dec5857a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Anderson by IHG [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Anderson.h5385.Hotel-Information) Anderson 8.8/10 Excellent (700 reviews) "Clean, great breakfast, convenient location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reggie CA $151 CA $168 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Anderson.h5385.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily full breakfast for a fee](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/5b31fd3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/0a5500d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/db1c155b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Shepherd Hotel Downtown Clemson [](https://www.expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) Clemson 9.8/10 Exceptional (747 reviews) "Beautiful hotel. Great service. Delicious food. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shannon CA $248 CA $276 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-28&endDate=2026-01-29®ionId=6057939&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Great weekend hotel deals in Upstate South Carolina, SC ### Showing deals for:**Jan 23 - Jan 25** ### Image gallery for Lake Retreat House ![Property grounds](https://images.trvl-media.com/lodging/71000000/70560000/70558900/70558812/2df4c10d.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Lake Retreat House Anderson **10/10**Exceptional (20 reviews) 10% off CA $437 CA $1,873 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=70558812&adults=2) ### Image gallery for The Clemson Cottage - 3.6 mi. to Memorial Stadium ![Private kitchen](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/40d3b059.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### The Clemson Cottage - 3.6 mi. to Memorial Stadium Seneca **10/10**Exceptional (12 reviews) 10% off CA $375 CA $1,178 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=96153668&adults=2) ### Image gallery for Modern amenities in a rustic landscape ![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83610000/83604700/83604625/de53ead0.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Modern amenities in a rustic landscape Cedar Mountain **9.6/10**Exceptional (16 reviews) 10% off CA $202 CA $711 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=83604625&adults=2) ### Image gallery for The Rustic Rectangle ![Outdoor dining](https://images.trvl-media.com/lodging/64000000/63370000/63362400/63362340/90e5f707.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### The Rustic Rectangle Pendleton **10/10**Exceptional (10 reviews) 10% off CA $219 CA $714 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=63362340&adults=2) ### Image gallery for Whiffletree Farmhouse just 2 mins off I-26 & 8 mins from downtown Spartanburg! ![Interior](https://images.trvl-media.com/lodging/92000000/91880000/91872700/91872630/4e374095.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Whiffletree Farmhouse just 2 mins off I-26 & 8 mins from downtown Spartanburg! Roebuck **10/10**Exceptional (32 reviews) 10% off CA $275 CA $803 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=91872630&adults=2) ### Image gallery for Broyles Landing Cottage at Lake Hartwell SC ![Exterior](https://images.trvl-media.com/lodging/111000000/110820000/110812100/110812036/f95c7c86.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Broyles Landing Cottage at Lake Hartwell SC Townville **10/10**Exceptional (16 reviews) 10% off CA $150 CA $467 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=110812036&adults=2) ### Image gallery for Hotel Hartness ![Restaurant](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/91df3d0d.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Hotel Hartness Greenville **9.8/10**Exceptional (638 reviews) 10% off CA $285 CA $721 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=89689223&adults=2) ### Image gallery for Extended Stay America Premier Suites - Greenville - Spartanburg - I-85 ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/97000000/96870000/96862800/96862776/a2db2871.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Extended Stay America Premier Suites - Greenville - Spartanburg - I-85 Duncan **8.6/10**Excellent (205 reviews) 10% off CA $104 CA $230 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=96862776&adults=2) ### Image gallery for NEW!Lakefront retreat with huge dock, private cove. Perfect for Clemson Football ![Exterior](https://images.trvl-media.com/lodging/85000000/84120000/84112700/84112636/078e7353.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### NEW!Lakefront retreat with huge dock, private cove. Perfect for Clemson Football Central **10/10**Exceptional (31 reviews) 10% off CA $625 CA $1,936 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=84112636&adults=2) ### Image gallery for Unique lakefront 3 BR cabin directly on Lake Hartwell! 20 min drive to Clemson! ![Smart TV, fireplace, DVD player, video library](https://images.trvl-media.com/lodging/104000000/103120000/103117200/103117135/ae0f3c35.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Unique lakefront 3 BR cabin directly on Lake Hartwell! 20 min drive to Clemson! Townville **10/10**Exceptional (14 reviews) 10% off CA $394 CA $1,253 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=103117135&adults=2) ### Image gallery for Clemson Lover's Dream Cottage ![Exterior](https://images.trvl-media.com/lodging/36000000/35600000/35592200/35592109/039950d1.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Clemson Lover's Dream Cottage Clemson **10/10**Exceptional (63 reviews) 10% off CA $312 CA $846 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=35592109&adults=2) ### Image gallery for Beautiful 5 Acre Lakefront Private Retreat w/ Boat Dock, Hot Tub, 5 Bdrm/ 5 bath ![Smart TV, fireplace, video games, books](https://images.trvl-media.com/lodging/76000000/75840000/75831400/75831331/d1630233.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Beautiful 5 Acre Lakefront Private Retreat w/ Boat Dock, Hot Tub, 5 Bdrm/ 5 bath Anderson **10/10**Exceptional (78 reviews) 10% off CA $499 CA $1,819 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=75831331&adults=2) ### Image gallery for Lakefront Home on Lake Hartwell, private covered dock, \~16 miles from Clemson ![Smart TV, fireplace](https://images.trvl-media.com/lodging/73000000/72130000/72129200/72129121/47ab46d8.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Lakefront Home on Lake Hartwell, private covered dock, \~16 miles from Clemson Anderson **10/10**Exceptional (62 reviews) 10% off CA $375 CA $1,420 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=72129121&adults=2) ### Image gallery for YELLOW DOOR 2 BEDROOM COTTAGE ![Smart TV](https://images.trvl-media.com/lodging/91000000/90790000/90789500/90789470/b5eca5ec_edited_743b.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### YELLOW DOOR 2 BEDROOM COTTAGE Simpsonville **9.6/10**Exceptional (63 reviews) 10% off CA $169 CA $574 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=90789470&adults=2) ### Image gallery for Walk to Patrick Square for dining and shopping;Spacious house,Perfect for groups ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/97000000/96220000/96219200/96219148/d3676aa4.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Walk to Patrick Square for dining and shopping;Spacious house,Perfect for groups Clemson **10/10**Exceptional (24 reviews) 10% off CA $562 CA $1,927 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=96219148&adults=2) ### Image gallery for Amazing House near mountains -Greenville /Travelers Rest - Hiking Biking Golfing ![Interior](https://images.trvl-media.com/lodging/85000000/84820000/84816200/84816127/6c9a5165.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Amazing House near mountains -Greenville /Travelers Rest - Hiking Biking Golfing Taylors **10/10**Exceptional (38 reviews) 10% off CA $594 CA $2,013 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=84816127&adults=2) ### Image gallery for Walk to Campus! ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/55000000/54800000/54792400/54792379/b6cd9cfa.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Walk to Campus! Clemson **10/10**Exceptional (34 reviews) 10% off CA $875 CA $2,482 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=54792379&adults=2) ### Image gallery for Resort Access - Lake - Pools -Pickleball - Gym. Spacious townhome for groups ![Outdoor dining](https://images.trvl-media.com/lodging/89000000/88690000/88688900/88688880/52d0cb0e.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Resort Access - Lake - Pools -Pickleball - Gym. Spacious townhome for groups Salem **10/10**Exceptional (29 reviews) 10% off CA $362 CA $1,216 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=88688880&adults=2) ### Image gallery for STRATHAM STATION: 4Bd/2.5Ba in Downtown Greenville, SC ![Interior](https://images.trvl-media.com/lodging/77000000/76070000/76065900/76065822/804e8321.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### STRATHAM STATION: 4Bd/2.5Ba in Downtown Greenville, SC Greenville **9.6/10**Exceptional (51 reviews) 10% off CA $325 CA $1,069 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=76065822&adults=2) ### Image gallery for Adorable & recently renovated condo within walking distance to downtown Clemson. ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90860000/90859000/90858915/9a82eed8.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Adorable & recently renovated condo within walking distance to downtown Clemson. Clemson **10/10**Exceptional (27 reviews) 10% off CA $219 CA $687 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=90858915&adults=2) ### Image gallery for 5★ Stunning Designer Cottage In Beautiful Neighborhood - Walk to Downtown ![Exterior](https://images.trvl-media.com/lodging/34000000/33710000/33704500/33704498/de914f83.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### 5★ Stunning Designer Cottage In Beautiful Neighborhood - Walk to Downtown Spartanburg **10/10**Exceptional (76 reviews) 10% off CA $299 CA $873 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=33704498&adults=2) ### Image gallery for Rustic cabin at Dupont Forest ![Exterior](https://images.trvl-media.com/lodging/74000000/73240000/73238300/73238216/33387117.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Rustic cabin at Dupont Forest Cedar Mountain **10/10**Exceptional (42 reviews) 10% off CA $119 CA $458 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=73238216&adults=2) ### Image gallery for Stunning 5BR Lodge - Hot Tub & Table Rock Views ![Outdoor dining](https://images.trvl-media.com/lodging/81000000/80600000/80597600/80597577/9cc4a7f1.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Stunning 5BR Lodge - Hot Tub & Table Rock Views Cleveland **9.6/10**Exceptional (17 reviews) 10% off CA $249 CA $970 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=80597577&adults=2) ### Image gallery for Quiet and relaxing 1 bedroom farm cabin with loft and deck. ![Exterior](https://images.trvl-media.com/lodging/97000000/96720000/96711400/96711370/6e742df8.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Quiet and relaxing 1 bedroom farm cabin with loft and deck. Woodruff **9.8/10**Exceptional (15 reviews) 10% off CA $112 CA $388 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-23&endDate=2026-01-25&selected=96711370&adults=2) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels) ## Learn more about Upstate South Carolina Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Frankie's Fun Park to The Shops at Greenridge. [See all hotels in Upstate South Carolina](https://www.expedia.ca/Hotel-Search?startDate=2026-01-28&endDate=2026-01-29&adults=2®ionId=6057939) ![The view from Caesars Head after a storm](https://images.trvl-media.com/place/553248621532656715/293b23c7-6024-49ab-80cb-4ee292c1b5a3.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) Photo by Michelle Hendrix ### Stay near popular Upstate South Carolina attractions [](https://expedia.ca/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) ![Clemson University](https://mediaim.expedia.com/destination/1/37a5b84dadafa74cfb0eac38a6f52509.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Clemson University 4/5(1 review) Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6127431) [](https://expedia.ca/Falls-Park-On-The-Reedy-Hotels.0-l6082697-0.Travel-Guide-Filter-Hotels) ![Falls Park on the Reedy](https://mediaim.expedia.com/destination/1/6bb0f4da89fedda644df8add227a3045.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Falls Park on the Reedy 5/5(5 reviews) Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the great live music or attend a sporting event in this family-friendly area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6082697) [](https://expedia.ca/Memorial-Stadium-Hotels.0-l6193935-0.Travel-Guide-Filter-Hotels) ![Memorial Stadium](https://mediaim.expedia.com/destination/2/ec5005d2dccfccf93e708f6a7dcbe420.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Memorial Stadium Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6193935) [](https://expedia.ca/Fred-W-Symmes-Chapel-Hotels.0-l553248621532656718-0.Travel-Guide-Filter-Hotels) ![Fred W. Symmes Chapel](https://mediaim.expedia.com/destination/2/d2417884cba305814948c6821df9be9a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fred W. Symmes Chapel You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532656718) [](https://expedia.ca/Bob-Jones-University-Hotels.0-l6169875-0.Travel-Guide-Filter-Hotels) ![Bob Jones University](https://mediaim.expedia.com/destination/2/d98740ba8ca1e63ee72d8d4cbaf89530.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Bob Jones University 5/5(1 review) Enjoy the collegiate vibe when you visit Bob Jones University, during your travels in Greenville. Attend a sporting event or visit the shops in this family-friendly area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6169875) [](https://expedia.ca/Devils-Fork-State-Park-Hotels.0-l6232058-0.Travel-Guide-Filter-Hotels) ![Devils Fork State Park](https://mediaim.expedia.com/destination/2/a118dda3e881509913d9a4f825c17cfe.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Devils Fork State Park You can take time to visit Devils Fork State Park during your travels to Salem. Wander the lakeside or discover the area's mountain views. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6232058) ## More cheap stays in Upstate South Carolina ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/ce467f24_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Anderson 1007 George Smith Mill Rd Anderson SC CA $87 CA $97 total Jan 29 - Jan 30 includes taxes & fees 7.8/10 Good! (1,002 reviews) [](https://expedia.ca/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd](https://images.trvl-media.com/lodging/1000000/210000/202200/202137/b07dd898_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd 1024 Woodruff Rd Greenville SC CA $96 CA $105 total Jan 29 - Jan 30 includes taxes & fees 8.2/10 Very Good! (1,002 reviews) [](https://expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h202137.Hotel-Information) ![ECHO Suites Extended Stay by Wyndham Spartanburg](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/ab517c5d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### ECHO Suites Extended Stay by Wyndham Spartanburg 490 W Blackstock Road Spartanburg SC CA $103 CA $116 total Jan 18 - Jan 19 includes taxes & fees 8/10 Very Good! (318 reviews) [](https://expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Greenville I-385 Inn & Suites 831 Congaree Rd Greenville SC CA $107 CA $118 total Jan 25 - Jan 26 includes taxes & fees 9/10 Wonderful! (1,429 reviews) [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Seneca Clemson Area US-123 226 Hi Tech Rd Seneca SC CA $105 CA $124 total Jan 25 - Jan 26 includes taxes & fees 7.8/10 Good! (668 reviews) [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Clemson Hotel & Conference Center 1310 Tiger Blvd Clemson SC CA $131 CA $145 total Jan 28 - Jan 29 includes taxes & fees 8.2/10 Very Good! (1,000 reviews) [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ## Hotels in Upstate South Carolina with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 11 properties [](https://expedia.ca/4Star-Upstate-South-Carolina-Hotels.s40-0-d6057939.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 194 properties [](https://expedia.ca/3Star-Upstate-South-Carolina-Hotels.s30-0-d6057939.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 316 properties [](https://expedia.ca/2Star-Upstate-South-Carolina-Hotels.s20-0-d6057939.Travel-Guide-Filter-Hotels) ## Recent reviews of Upstate South Carolina hotels ![The Westin Poinsett Greenville](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/3e47bf88_y.jpg) ### The Westin Poinsett Greenville 5/5 Excellent "The Westin is fabulous for a getaway! It’s so beautiful and the staff is wonderful! The beds are super comfortable- much more than other downtown Greenville hotels. Rooms are spacious and well stocked. " A verified traveller stayed at The Westin Poinsett Greenville Posted 3 hours ago [](https://expedia.ca/Greenville-Hotels-The-Westin-Poinsett-Greenville.h575983.Hotel-Information) ![Homewood Suites by Hilton Greenville Downtown](https://images.trvl-media.com/lodging/30000000/29060000/29050100/29050020/88b33cc2_y.jpg) ### Homewood Suites by Hilton Greenville Downtown 5/5 Excellent "Very nice" A verified traveller stayed at Homewood Suites by Hilton Greenville Downtown Posted 1 day ago [](https://expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville-Downtown.h29050020.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 5/5 Excellent "Loved our room, we had a king suite excellent modern decor.. The bed was super comfortable. The buffet breakfast had a great selection of food and the dining area was a nice decor and size. The staff was super friendly and helpful" A verified traveller stayed at Best Western Plus Greenville I-385 Inn & Suites Posted 3 days ago [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/401b294d_y.jpg) ### Hilton Greenville 5/5 Excellent "Convenient and clean" A verified traveller from Naples stayed at Hilton Greenville Posted 3 days ago [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/9a71f6a4_y.jpg) ### Hyatt Place Greenville/Haywood 5/5 Excellent "Friendly staff" A verified traveller from deerfield stayed at Hyatt Place Greenville/Haywood Posted 3 days ago [](https://expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg) ### Grand Bohemian Lodge Greenville, Autograph Collection 5/5 Excellent "Great room and view if falls" A verified traveller stayed at Grand Bohemian Lodge Greenville, Autograph Collection Posted 4 days ago [](https://expedia.ca/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ![ECHO Suites Extended Stay by Wyndham Spartanburg](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/ab517c5d_y.jpg) ### ECHO Suites Extended Stay by Wyndham Spartanburg 5/5 Excellent "It's perfect place to stay." A verified traveller stayed at ECHO Suites Extended Stay by Wyndham Spartanburg Posted 6 days ago [](https://expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 5/5 Excellent "Great" A verified traveller stayed at Hyatt Regency Greenville Posted 7 days ago [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![AC Hotel By Marriott Greenville](https://images.trvl-media.com/lodging/59000000/58290000/58282600/58282504/575c54cb_y.jpg) ### AC Hotel By Marriott Greenville 5/5 Excellent "Amazing" A verified traveller stayed at AC Hotel By Marriott Greenville Posted 8 days ago [](https://expedia.ca/Greenville-Spartanburg-Hotels-AC-Hotel-By-Marriott-Greenville.h58282504.Hotel-Information) ## Frequently asked questions ### Where can I find the best nightlife in Upstate South Carolina? > In Greenville, the West End is a hotspot for nightlife, featuring a variety of trendy bars, craft breweries, and live music venues. Here, you can enjoy everything from laid-back pubs to upscale cocktail lounges, all set against the backdrop of the picturesque Reedy River. > > > Spartanburg's downtown area is also bustling with nightlife options. Main Street is lined with a range of bars and restaurants that offer everything from craft cocktails to local brews. You'll find a vibrant atmosphere, especially on weekends, making it a great spot to enjoy a night out with friends. > > > If you're in the mood for a more great experience, check out the local breweries scattered across the region. Many of them host live music events and have food trucks, providing a fun and casual way to spend an evening. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Upstate South Carolina hotel booking with Expedia? ### How much is the nightly rate at a Upstate South Carolina hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Hotels near Bob Jones University ](https://www.expedia.ca/Bob-Jones-University-Hotels.0-l6169875-0.Travel-Guide-Filter-Hotels) - [Hotels near Bon Secours Wellness Arena ](https://www.expedia.ca/Bon-Secours-Wellness-Arena-Hotels.0-l6082715-0.Travel-Guide-Filter-Hotels) - [Hotels near Centre Stage ](https://www.expedia.ca/Centre-Stage-Hotels.0-l553248621532656774-0.Travel-Guide-Filter-Hotels) - [Colonel Elias Earle Historic District Hotels ](https://www.expedia.ca/Colonel-Elias-Earle-Historic-District-Greenville-Hotels.0-n6348165-0.Travel-Guide-Filter-Hotels) - [Greenville County Hotels ](https://www.expedia.ca/Destinations-In-Greenville-County.d553248635976432805.Hotel-Destinations) - 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