Title: Luxury Vacations in Cayos Zapatilla 2026 | Expedia.ca ![](https://images.trvl-media.com/place/6286134/443bad9e-c57b-4b6d-aec8-29e5bf3e9898.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Cayos Zapatilla Luxury Vacations ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Flight and Luxury hotel deals in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Hotel Casa Panamá](https://images.trvl-media.com/lodging/13000000/12100000/12092000/12091977/6488c648_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Casa Panamá Casco Viejo CA $1,131 per person Apr 21 - Apr 28 found 1 day ago Roundtrip flight included Hamilton (YHM) to Panama City (PTY) 7.4/10 Good! (577 reviews) The staff was excellent. The rooms comfortable and very clean. Also the location was ideal. It was within walking distance to all the sites in Casco Viejo. Reviewed on Feb 2, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,788 per person Apr 21 - Apr 28 found 1 day ago Roundtrip flight included Hamilton (YHM) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) The room had no window to the outside it instead had a large window into an interior hall. Maid service was inconsistent. Breakfast was not a good value. Reviewed on Feb 5, 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,662 per person Apr 30 - May 7 found 3 hours ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) Nice hotel. Friendly staff Reviewed on Feb 9, 2026 ![Decapolis Hotel Panama City](https://images.trvl-media.com/lodging/2000000/1090000/1082800/1082793/067e7d25_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Decapolis Hotel Panama City San Francisco CA $2,106 per person Mar 26 - Apr 2 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 8.6/10 Excellent! (1,396 reviews) The staff was great, especially Martin, he was truly the best and most attentive. The buffet breakfast was also great, a lot of choices. The reason I didn’t give it a 5 was because the valet service was on and off, not always available which was frustrating. The location is also top notch. We had a great time at our suite. Reviewed on Feb 9, 2026 ![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Dreams Playa Bonita Panama - All Inclusive CA $2,315 per person Apr 21 - Apr 28 found 1 day ago Roundtrip flight included Hamilton (YHM) to Panama City (PTY) 7.4/10 Good! (1,002 reviews) It was a wonderful stay with wonderful people Reviewed on Feb 7, 2026 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-10/2026-03-17/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Luxury holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Renaissance Panama City Hotel ](https://images.trvl-media.com/lodging/1000000/530000/527200/527169/d8dfdd09_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Renaissance Panama City Hotel Bella Vista CA $1,278 per person Apr 21 - Apr 28 found 1 day ago Roundtrip flight included Hamilton (YHM) to Panama City (PTY) 9/10 Wonderful! (85 reviews) The room was super clean. The staff was really nice and helpful. If I had any questions they were able to answer them very quickly. Definitely recommend this hotel it’s really close to everything whether you’re walking or driving i will definitely stay here again Next time I visit Panama. Reviewed on Feb 3, 2026 ![JW Marriott Panama](https://images.trvl-media.com/lodging/5000000/4110000/4109200/4109123/fb42dbf6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### JW Marriott Panama San Francisco CA $1,896 per person Apr 21 - Apr 28 found 1 day ago Roundtrip flight included Hamilton (YHM) to Panama City (PTY) 9/10 Wonderful! (1,003 reviews) Beautiful hotel, great service. Breakfast buffet is amazing. Reviewed on Jan 29, 2026 ![W Panama](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/5dc0b3d1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### W Panama Bella Vista CA $1,644 per person Apr 21 - Apr 28 found 1 day ago Roundtrip flight included Hamilton (YHM) to Panama City (PTY) 9/10 Wonderful! (1,001 reviews) The room was very clean, the staff and amenities were excellent. My only complaint is the thin walls and windows. I heard everything going on in the next room, and all the cars blowing their horns outside. I was on the 17th floor and it was like I was outside. Reviewed on Feb 8, 2026 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-10/2026-03-17/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Luxury holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,219 per person Mar 25 - Mar 28 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) Nice hotel. Friendly staff Reviewed on Feb 9, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,334 per person Mar 25 - Mar 28 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) The room had no window to the outside it instead had a large window into an interior hall. Maid service was inconsistent. Breakfast was not a good value. Reviewed on Feb 5, 2026 ![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Dreams Playa Bonita Panama - All Inclusive CA $1,549 per person Mar 25 - Mar 28 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 7.4/10 Good! (1,002 reviews) It was a wonderful stay with wonderful people Reviewed on Feb 7, 2026 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-10/2026-03-17/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Luxury holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites CA $890 per person Apr 30 - May 4 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 10/10 Exceptional! (1 review) Excellent apartment on a golf resort. 5 Star. Reviewed on Jan 28, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,449 per person Apr 30 - May 4 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) The room had no window to the outside it instead had a large window into an interior hall. Maid service was inconsistent. Breakfast was not a good value. Reviewed on Feb 5, 2026 ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,076 per person Apr 30 - May 4 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) Everything was great, the food, room amenities and location Reviewed on Feb 8, 2026 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-10/2026-03-17/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Plan the perfect luxury Cayos Zapatilla vacation with Expedia #### What are some benefits when booking luxury Cayos Zapatilla vacations? When you book a luxury Cayos Zapatilla vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax. #### How can I find all-inclusive luxury vacations in Cayos Zapatilla? If you're looking for something luxurious in Cayos Zapatilla, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together. #### Can I book a cheap luxury vacation? While luxury vacations tend to be on the more costly end of the spectrum, ranging from CA $890, there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to 25\. After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first. #### Are there luxury spa vacations? Yes, luxury spa vacations are available and quite popular in Cayos Zapatilla. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search. #### What should I look for in a luxury family vacation in Cayos Zapatilla? When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout Cayos Zapatilla. #### Can I book last-minute luxury vacations? Yes, last-minute bookings are often available in Cayos Zapatilla. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces. #### What can help me find the best luxury vacation deals in Cayos Zapatilla? You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of Cayos Zapatilla or travelling to more obscure destinations altogether can often lead to lower prices. #### Can I book a luxury vacation that is fully refundable? Yes, fully refundable reservations are sometimes available on luxury vacation packages in Cayos Zapatilla. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking. #### Why should I book my luxury vacation with Expedia? When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ### Top Luxury Vacation Destinations > - [Luxury vacations in India ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/80/India) > - [Luxury vacations in France ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/59/France) > - [Luxury vacations in Switzerland ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/174/Switzerland) > - [Luxury vacations in Canada ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/31/Canada) > - [Luxury vacations in Jamaica ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/88/Jamaica) > - [Luxury vacations in Italy ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/86/Italy) > - [Luxury vacations in New Zealand ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/133/New-Zealand) > - [Luxury vacations in the Maldives ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/109/Maldives) > - [Luxury vacations in Costa Rica ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/42/Costa-Rica) > - [Luxury vacations in Florida Keys ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6023765/Florida-Keys) > - [Luxury vacations in Mexico ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/117/Mexico) > - [Luxury vacations in the Caribbean ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6022969/Caribbean) > - [Luxury vacations in Zanzibar ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/4186/Zanzibar) > - [Luxury vacations in Cancun ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/179995/Cancun) > - [Luxury vacations in Kerala ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/602187/Kerala) > - [Luxury vacations in Australia ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/10/Australia) > - [Luxury vacations in Puglia ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6048562/Puglia) > - [Luxury vacations in Cuba ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/44/Cuba) > - [Luxury vacations in Cyprus ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/45/Cyprus) ## More Vacations Ideas [Flights to Cayos Zapatilla ](https://expedia.ca/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[ Cayos Zapatilla Hotels ](https://expedia.ca/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[ Cayos Zapatilla Vacation Rentals ](https://expedia.ca/Cayos-Zapatilla-Vacation-Rentals.d6286134.Travel-Guide-VacationRentals)[ Cayos Zapatilla Car Rentals ](https://expedia.ca/Car-Rentals-In-Cayos-Zapatilla.d6286134.Car-Rental-Guide)[ Cayos Zapatilla Vacations ](https://expedia.ca/Cayos-Zapatilla.d6286134.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app