Title: Luxury Vacations in Cayos Zapatilla 2026 | Expedia.ca ![](https://images.trvl-media.com/place/6246124/962b07b0-9b6f-43f9-a3da-ab98125d9cc6.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Cayos Zapatilla Luxury Vacations ## Book a Hotel + Flight or Car together to unlock savings Photo by Isa - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Flight and Luxury hotel deals in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Casa Contemporanea by Wynwood House](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/64939a66_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Contemporanea by Wynwood House Casco Viejo CA $2,092 per person Feb 14 - Feb 21 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 8.6/10 Excellent! (19 reviews) Great experience, beautiful apartment. Minor maintenance issues that were addressed in a timely fashion. Would definitely recommend and stay there again! Reviewed on Mar 28, 2025 ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo CA $2,722 per person Feb 14 - Feb 21 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) Beautiful apartment definitely recommend staying here if you are coming to Panama Reviewed on Nov 29, 2025 ![Yoo by Wynwood House](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/f526e4da_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Yoo by Wynwood House Calidonia CA $2,342 per person Feb 14 - Feb 21 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.2/10 Wonderful! (5 reviews) Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone. Reviewed on Jul 26, 2025 ![Hotel La Compañía Casco Antiguo](https://images.trvl-media.com/lodging/72000000/71140000/71136000/71135966/02cb9f51_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel La Compañía Casco Antiguo Casco Viejo CA $2,630 per person Jan 24 - Jan 31 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.8/10 Exceptional! (245 reviews) Recommend that all tours and events be booked a month in advance. It was a little hard to connect with someone to book the culinary and Neri Market tour with the chef. The rooms are exquisite and high end and the decor all the way through the hotel was well appointed. I recommend the king suite in the Spanish section facing the courtyard. The 1739 wine and dinner pairing was exceptional. Highly recommend. Make sure you spend time at the pool during midday and the drinks at night on the roof top with DJ. Thanks to Brian at the front desk for setting us up with right room and thanks to Isabely’s and Ericka for the wine and pairing suggestions. The front desk was awesome with accommodations. This was a very pleasant stay can’t wait to go back. Reviewed on Nov 29, 2025 ![Hotel La Compania Del Valle](https://images.trvl-media.com/lodging/112000000/111210000/111207500/111207482/bd071da6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel La Compania Del Valle CA $2,409 per person Feb 14 - Feb 21 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.8/10 Exceptional! (54 reviews) After the changes to the facilities and the new chain I have to say is a great luxury hotel Reviewed on Dec 7, 2025 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-13/2026-01-20/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Luxury holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,085 per person Jan 28 - Feb 2 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) Great staff and amenities. Very good breakfast. Reviewed on Dec 12, 2025 ![Hotel La Compania Del Valle](https://images.trvl-media.com/lodging/112000000/111210000/111207500/111207482/bd071da6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel La Compania Del Valle CA $2,409 per person Feb 14 - Feb 21 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.8/10 Exceptional! (54 reviews) After the changes to the facilities and the new chain I have to say is a great luxury hotel Reviewed on Dec 7, 2025 ![Hilton Panama](https://images.trvl-media.com/lodging/6000000/5940000/5938200/5938139/ae99e466_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hilton Panama Bella Vista CA $1,695 per person Feb 1 - Feb 8 found 1 day ago Roundtrip non-stop flight included Montreal (YUL) to Panama City (PTY) 8.8/10 Excellent! (1,001 reviews) The entire staff is professional and welcoming, especially Patricia at the front desk. The hotel is very clean. Everything was very good. Reviewed on Nov 27, 2025 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-13/2026-01-20/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Luxury holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Yoo by Wynwood House](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/f526e4da_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Yoo by Wynwood House Calidonia CA $1,314 per person Feb 16 - Feb 19 found 7 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 9.2/10 Wonderful! (5 reviews) Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone. Reviewed on Jul 26, 2025 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,747 per person Jan 15 - Jan 18 found 1 day ago Roundtrip flight included Toronto (YYZ) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Some people in the staff are not courteous Reviewed on Dec 12, 2025 ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo CA $1,473 per person Feb 16 - Feb 19 found 7 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) Beautiful apartment definitely recommend staying here if you are coming to Panama Reviewed on Nov 29, 2025 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-13/2026-01-20/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Luxury holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Playa Caracol Residences Vacation Rental](https://images.trvl-media.com/lodging/40000000/39140000/39130700/39130628/d7354164_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Playa Caracol Residences Vacation Rental CA $997 per person Feb 18 - Feb 22 found 23 hours ago Roundtrip non-stop flight included Montreal (YUL) to Panama City (PTY) 7.2/10 Good! (26 reviews) Property is great. The road is not good and its isolated no other activities nearby. But it so nice and reasonable I would stay there again. Reviewed on Jun 8, 2025 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,713 per person Feb 12 - Feb 16 found 1 day ago Roundtrip flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Some people in the staff are not courteous Reviewed on Dec 12, 2025 ![MARINN PLACE Financial District](https://images.trvl-media.com/lodging/91000000/90810000/90801900/90801879/c11e781a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### MARINN PLACE Financial District Bella Vista CA $1,299 per person Feb 12 - Feb 16 found 1 day ago Roundtrip flight included Toronto (YTO) to Panama City (PTY) 9.2/10 Wonderful! (298 reviews) Second stay, very nice Reviewed on Nov 7, 2025 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-13/2026-01-20/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Plan the perfect luxury Cayos Zapatilla vacation with Expedia #### What are some benefits when booking luxury Cayos Zapatilla vacations? When you book a luxury Cayos Zapatilla vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax. #### How can I find all-inclusive luxury vacations in Cayos Zapatilla? If you're looking for something luxurious in Cayos Zapatilla, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together. #### Can I book a cheap luxury vacation? While luxury vacations tend to be on the more costly end of the spectrum, ranging from CA $997, there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to 24\. After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first. #### Are there luxury spa vacations? Yes, luxury spa vacations are available and quite popular in Cayos Zapatilla. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search. #### What should I look for in a luxury family vacation in Cayos Zapatilla? When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout Cayos Zapatilla. #### Can I book last-minute luxury vacations? Yes, last-minute bookings are often available in Cayos Zapatilla. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces. #### What can help me find the best luxury vacation deals in Cayos Zapatilla? You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of Cayos Zapatilla or travelling to more obscure destinations altogether can often lead to lower prices. #### Can I book a luxury vacation that is fully refundable? Yes, fully refundable reservations are sometimes available on luxury vacation packages in Cayos Zapatilla. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking. #### Why should I book my luxury vacation with Expedia? When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ### Top Luxury Vacation Destinations > - [Luxury vacations in India ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/80/India) > - [Luxury vacations in France ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/59/France) > - [Luxury vacations in Switzerland ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/174/Switzerland) > - [Luxury vacations in Canada ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/31/Canada) > - [Luxury vacations in Jamaica ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/88/Jamaica) > - [Luxury vacations in Italy ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/86/Italy) > - [Luxury vacations in New Zealand ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/133/New-Zealand) > - [Luxury vacations in the Maldives ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/109/Maldives) > - [Luxury vacations in Costa Rica ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/42/Costa-Rica) > - [Luxury vacations in Florida Keys ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6023765/Florida-Keys) > - [Luxury vacations in Mexico ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/117/Mexico) > - [Luxury vacations in the Caribbean ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6022969/Caribbean) > - [Luxury vacations in Zanzibar ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/4186/Zanzibar) > - [Luxury vacations in Cancun ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/179995/Cancun) > - [Luxury vacations in Kerala ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/602187/Kerala) > - [Luxury vacations in Australia ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/10/Australia) > - [Luxury vacations in Puglia ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6048562/Puglia) > - [Luxury vacations in Cuba ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/44/Cuba) > - [Luxury vacations in Cyprus ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/45/Cyprus) ## More Vacations Ideas [Flights to Cayos Zapatilla ](https://expedia.ca/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[ Cayos Zapatilla Hotels ](https://expedia.ca/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[ Cayos Zapatilla Vacation Rentals ](https://expedia.ca/Cayos-Zapatilla-Vacation-Rentals.d6286134.Travel-Guide-VacationRentals)[ Cayos Zapatilla Car Rentals ](https://expedia.ca/Car-Rentals-In-Cayos-Zapatilla.d6286134.Car-Rental-Guide)[ Cayos Zapatilla Vacations ](https://expedia.ca/Cayos-Zapatilla.d6286134.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app