Luxury Vacations in Northeast Missouri 2026

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Flight and Luxury hotel deals in Northeast Missouri

Price found within the past 48 hours. Click for updated prices.

Marriott St. Louis Airport

Edmundson

CA $1,292

per person

Nov 16 - Nov 19

found 13 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

8/10 Very good! (1,001 reviews)

The Cheshire

CA $1,294

per person

Nov 16 - Nov 19

found 13 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

8.8/10 Excellent! (1,011 reviews)

The place had been heavy on the bad smoke of marijuana last time, but none of that this time. Staff are friendly. Asked for a 12 check-out as VIP, they said no problem, but were beating on the door at 10am next morning and hovering around till we left just after 11. Same thing last stay, poor communication between the night manager we spoke with night before and the maids. The place was pretty clean. No fridge, they found us one the second day, but had no shelves and was filthy! I would suggest you spend a little money and upgrade your rooms and add fridges. Too nice of a place to not have in all rooms. Restaurant was great! BREAKFAST was a highlight. The Bar is closed to early to enjoy after being out.

Reviewed on Oct 15, 2026

Ameristar Casino Resort and Spa

CA $1,336

per person

Nov 16 - Nov 19

found 13 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

8.6/10 Excellent! (1,062 reviews)

Very clean and professional

Reviewed on Oct 15, 2026

The Westin St. Louis

Downtown St. Louis

CA $1,340

per person

Nov 16 - Nov 19

found 13 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

8.6/10 Excellent! (1,012 reviews)

The bar experience left a little to be desired, but I was only there a couple times.

Reviewed on Oct 15, 2026

Moonrise Hotel

Delmar Loop

CA $1,371

per person

Nov 16 - Nov 19

found 13 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

9/10 Wonderful! (2,029 reviews)

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5* Luxury holidays in Northeast Missouri

Price found within the past 48 hours. Click for updated prices.

The Ritz-Carlton, St. Louis

Clayton

CA $2,543

per person

Nov 24 - Nov 27

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to St. Louis (STL)

9.2/10 Wonderful! (586 reviews)

Don't eat at the restaurant. The food was awful. The service was horrible, maybe worst I've ever had. Couldn't get orders. Couldn't get refills. Server not once asked how the food or drinks were (they were awful as well). And it was an anniversary dinner for us and stay. Hotel pillows were horrible. The TV sucked (can't even airplay??) So much for a 5 star experience. Cheap and mediocre. Will never go back.

Reviewed on Sep 8, 2026

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3 Night Luxury holidays in Northeast Missouri

Price found within the past 48 hours. Click for updated prices.

The Cheshire

CA $1,294

per person

Nov 16 - Nov 19

found 13 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

8.8/10 Excellent! (1,011 reviews)

Reviewed on Oct 15, 2026

Ameristar Casino Resort and Spa

CA $1,336

per person

Nov 16 - Nov 19

found 13 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

8.6/10 Excellent! (1,062 reviews)

Very clean and professional

Reviewed on Oct 15, 2026

The Westin St. Louis

Downtown St. Louis

CA $1,311

per person

Dec 26 - Dec 29

found 1 day ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

8.6/10 Excellent! (1,012 reviews)

The bar experience left a little to be desired, but I was only there a couple times.

Reviewed on Oct 15, 2026

Don't see what you're looking for?

See all available trips from Columbus to Northeast Missouri

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4 Night Luxury holidays in Northeast Missouri

Price found within the past 48 hours. Click for updated prices.

The Westin St. Louis

Downtown St. Louis

CA $926

per person

Nov 25 - Nov 29

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

8.6/10 Excellent! (1,012 reviews)

The bar experience left a little to be desired, but I was only there a couple times.

Reviewed on Oct 15, 2026

Moonrise Hotel

Delmar Loop

CA $1,166

per person

Nov 25 - Nov 29

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

9/10 Wonderful! (2,029 reviews)

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What are some benefits when booking luxury Northeast Missouri vacations?

When you book a luxury Northeast Missouri vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax.

How can I find all-inclusive luxury vacations in Northeast Missouri?

If you're looking for something luxurious in Northeast Missouri, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together.

Can I book a cheap luxury vacation?

While luxury vacations tend to be on the more costly end of the spectrum, ranging from CA $926, there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to 9. After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first.

Are there luxury spa vacations?

Yes, luxury spa vacations are available and quite popular in Northeast Missouri. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search.

What should I look for in a luxury family vacation in Northeast Missouri?

When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout Northeast Missouri.

Can I book last-minute luxury vacations?

Yes, last-minute bookings are often available in Northeast Missouri. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces.

What can help me find the best luxury vacation deals in Northeast Missouri?

You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of Northeast Missouri or travelling to more obscure destinations altogether can often lead to lower prices.

Can I book a luxury vacation that is fully refundable?

Yes, fully refundable reservations are sometimes available on luxury vacation packages in Northeast Missouri. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking.

Why should I book my luxury vacation with Expedia?

When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings.

Luxury Hotels in Northeast Missouri

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in ...

9.2/10 Wonderful! (1,000 reviews)

"Lovely room w excellent bed and sheets. Very fun bar onsite"

Reviewed on Oct 14, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular ...

8.6/10 Excellent! (1,073 reviews)

"Very clean and professional"

Reviewed on Oct 15, 2026

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Book a stay at this luxury hotel in St. Louis. Enjoy 2 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the room ...

9.2/10 Wonderful! (586 reviews)

"Don't eat at the restaurant. The food was awful. The service was horrible, maybe worst I've ever had. Couldn't get orders. Couldn't get refills. Server not once asked how the food or drinks were (they were awful as well). And it was an anniversary dinner for us and stay. Hotel pillows were horrible. ..."

Reviewed on Sep 8, 2026

See all 2,995 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.