
Northeast Missouri Vacation Packages
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Your Northeast Missouri Vacation
When you're ready for your next big adventure, our Northeast Missouri vacation packages are the answer. Dining and culture are among the many things that make this destination truly unforgettable. Kick off your trip to Northeast Missouri with some time exploring St. Louis visiting popular sights like Enterprise Centre and Busch Stadium. St. Charles is another top city that draws travellers from far and wide. Ameristar Casino St. Charles and Westport Plaza are two of the leading places to see in this destination. From the moment you book your Northeast Missouri vacation to when you get back home, Expedia will take care of you each step of the way.
Top Northeast Missouri Vacation Deals

Capital O Amerihost Inn and Suites Mexico Hwy 54 MO
Reviewed on Aug. 5, 2025




Capital O Amerihost Inn and Suites Fulton Hwy 54 MO
Reviewed on Aug. 26, 2025
Where to stay in Northeast Missouri

Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Northeast Missouri Hotel Deals

Renaissance St. Louis Airport Hotel

Clayton Plaza Hotel & Extended Stay

Pear Tree Inn St. Louis Airport
Discover the most popular places to visit in Northeast Missouri

Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

City Museum
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
What to do in Northeast Missouri

Tom's Town Distillery Tour and Tasting

Kansas City: Country Club Plaza Escape Game
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