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Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

1. Depot Inn and Suites

La Plata

Kimberly

CA $122 total

includes taxes & fees

Dec 13 - Dec 14

A hotel bathroom with a hairdryer, towel rack, and a large mirror reflecting a bed and a red wall.

2. Travelier Motel

Macon

Jason

CA $74 total

includes taxes & fees

Dec 16 - Dec 17

A modern living room with a stone wall, a flat-screen TV, a built-in fish tank, a blue sofa, and a large window with a view of a parking lot.

3. Super 8 by Wyndham Kirksville-University Area

Kirksville

Cori

CA $109 total

includes taxes & fees

Nov 22 - Nov 23

A bar area with a long counter, multiple bottles, glasses, and a few chairs.

4. Oak Hill Inn & Suites

Canton

Peter

CA $153 total

includes taxes & fees

Dec 1 - Dec 2

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

5. Sleep Inn & Suites Hannibal West

Hannibal

Sarah

CA $182 total

includes taxes & fees

Dec 6 - Dec 7

A spacious hotel lobby with a central wooden table, seating, a treadmill, and a large potted plant.

6. Best Western On The River

Hannibal

Rob

CA $166 total

includes taxes & fees

Nov 16 - Nov 17

A buffet with labeled trays of turkey sausage and cookies.

7. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Jimmy

CA $180 total

includes taxes & fees

Dec 16 - Dec 17

An outdoor seating area with a fire pit, chairs, and two evergreen trees.

8. Pinemark Inn & Suites

St. Clair

Michael

CA $179 total

includes taxes & fees

Nov 22 - Nov 23

A Comfort Inn hotel with a modern design, featuring a covered entrance and a clear sky in the background.

9. Comfort Inn Sullivan

Sullivan

Wayne

CA $177 total

includes taxes & fees

Dec 6 - Dec 7

A hotel lobby with a seating area, a dining table, a kitchen, and an exit sign.

10. Super 8 by Wyndham Washington

Washington

Gary

CA $130 total

includes taxes & fees

Nov 23 - Nov 24

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

11. Hampton Inn By Hilton Warrenton I-70

Warrenton

Richard

CA $227 total

includes taxes & fees

Dec 15 - Dec 16

A hotel with a prominent tower, a fountain, and a landscaped garden.

12. The Wildwood Hotel

Wildwood

Lori

CA $130 total

includes taxes & fees

Dec 8 - Dec 9

A hot tub with a rocky backdrop and a mural.

13. Stoney Creek Inn Quincy

Quincy

Kent

CA $124 total

includes taxes & fees

Nov 22 - Nov 23

A covered outdoor swimming pool with lounge chairs and umbrellas, surrounded by a glass enclosure.

14. Baymont by Wyndham Sullivan

Sullivan

Peggy

CA $167 total

includes taxes & fees

Dec 6 - Dec 7

An outdoor patio with a beige sofa set, two armchairs, and a table.

15. Best Western Plus Washington Hotel

Washington

Carl

CA $218 total

includes taxes & fees

Nov 18 - Nov 19

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

16. Drury Inn & Suites St. Louis Arnold

Arnold

Kristine

CA $208 total

includes taxes & fees

Nov 19 - Nov 20

A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.

17. River City Casino & Hotel

St. Louis

jodi

CA $155 total

includes taxes & fees

Dec 14 - Dec 15

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

18. Best Western St. Louis Inn

St. Louis

Susan

CA $117 total

includes taxes & fees

Nov 22 - Nov 23

A modern interior with a high ceiling, large windows, and a brick wall. There are orange chairs and a green sofa with orange cushions.

19. Pear Tree Inn St. Louis Arnold

Arnold

Charlotte

CA $148 total

includes taxes & fees

Nov 19 - Nov 20

An indoor swimming pool with clear water, surrounded by wooden lounge chairs and a table.

20. Super 8 by Wyndham Union

Union

William

CA $125 total

includes taxes & fees

Nov 23 - Nov 24

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Vacation Rentals in Northeast Missouri

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Cottage

A covered porch with metal siding, a white door, and two folding chairs.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Aparthotel

A black building with large windows, a covered porch with a flag, and potted plants.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Treehouse

A wooden bridge leading to a two-story house with multiple windows and a covered porch.

The Cottage

Hermann

"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."

Apartment

A spacious living area with a blue sofa, wooden flooring, and a chandelier.

Spacious 3-Bedroom with King Bed

Central West End

"Had a great stay! I hosted a birthday dinner for my best friend! Everything was clean and looked great"

Vacation Home

A two-story building with a balcony, outdoor seating area, and string lights.

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Mount Pleasant

"The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc"

Apartment

A modern living room with a grey sofa, two side tables, a TV mounted on the wall, and a decorative wall panel.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Cottage

Peaceful Missouri Cabin Rental on Large Property

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A deck with outdoor furniture, a grill, and a view of a golf course and lake.

Charming Berger Apt on 42-acre Farm w/ Pool Access

Berger

Apartment

A red building with a porch and a sign that says "Catala."

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Cottage

A spacious room with a wooden interior, a staircase, a sofa, a table, and a cabinet.

Hillside Cabin on 43 Acres w/ Private Lake & View!

Defiance

"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"

Apartment

A covered outdoor patio with wooden flooring, metal chairs, tables, and ceiling fans.

Studio Stay w/ Deck in Missouri Wine Country

New Haven

"It is a clean efficiency with modern amenities but with a touch of country flair! Sara is the property manager and is absolutely wonderful! Based on their availability, I would absolutely stay there again!!!!! Even if I can't stay there, I am definitely going to get some of thar great ice cream and home cooking at the restaurant in the same building!"

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

A large eye sculpture in a park surrounded by trees.

Top Northeast Missouri Hotel Reviews

Forest Park Hotel by MDR

8/10 Good

"Pretty good for what I needed which was a clean, safe place to stay. Parking lot was well lit. Hotel room was great. Slight smell in hallway but not in room. Elevator is older than dirt though. Slow and a bit creaky and only one (of 2) seemed to be in operation."