Photo by Andrew Hershfeld

Northeast Missouri Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Northeast Missouri vacation rentals

A wooden-paneled room with a bed, a nightstand, a wall-mounted mirror, and a small shelf with decorative items.

1. Tiny Cozy Cottage in Edina, MO

Tiny Cozy Cottage in Edina, MO
Edina
10.0 out of 10, Exceptional, (23 reviews)
"Very nice place , clean and easy ."
United States
John
The price is CA $109
CA $135 total
includes taxes & fees
Nov 17 - Nov 18
Tiny Cozy Cottage in Edina, MO
A park with a pond, picnic tables, and a gazebo.

2. Cannon Dam Cabins

Cannon Dam Cabins
3.0 star property
Perry
9.4 out of 10, Exceptional, (26 reviews)
"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"
United States
Erika
The price is CA $138
CA $146 total
includes taxes & fees
Dec 14 - Dec 15
Cannon Dam Cabins
A modern kitchen with white cabinets, a refrigerator, microwave, and a coffee maker.

3. Charming 1-bedroom cottage in Lewistown!

Charming 1-bedroom cottage in Lewistown!
lewistown
10.0 out of 10, Exceptional, (4 reviews)
"We loved the property, it was very clean and had everything we needed. It was very neat to be in the middle of the corn field. Bradley was super responsive and proactive in his communications."
United States
Joseph P.
The price is CA $178
CA $273 total
includes taxes & fees
Nov 17 - Nov 18
Charming 1-bedroom cottage in Lewistown!
A covered porch with wooden chairs and a small wooden table, a clock, and a view of a green landscape.

4. Lake Cabin near the Bourbeuse River

Lake Cabin near the Bourbeuse River
Leslie
10.0 out of 10, Exceptional, (60 reviews)
"Everything was absolutely perfect."
United States
Glenda
The price is CA $155
CA $221 total
includes taxes & fees
Nov 15 - Nov 16
Lake Cabin near the Bourbeuse River
A modern kitchen with white cabinets, stainless steel appliances, and a wooden floor.

5. Spacious & Modern 2BR Home with Attached Garage

Spacious & Modern 2BR Home with Attached Garage
Quincy
10.0 out of 10, Exceptional, (56 reviews)
"The place was immaculate and beautifully finished. Josh was great to work with, always responded quickly and very attentive. Highly recommend this property!!"
United States
Jeff C.
The price is CA $131
CA $274 total
includes taxes & fees
Nov 15 - Nov 16
Spacious & Modern 2BR Home with Attached Garage
A two-story house with a blue exterior, a front porch, and a small front yard.

6. Hickory Lake House

Hickory Lake House
3.0 star property
Wright City
The price is CA $399
CA $626 total
includes taxes & fees
Nov 24 - Nov 25
Hickory Lake House
A living room with a brown sofa, a wooden coffee table, a television on a stand, and a bookshelf.

7. Unwind on Vine

Unwind on Vine
Macon
9.6 out of 10, Exceptional, (38 reviews)
"We enjoy our stay in Macon and the location was perfect."
United States
Amy S.
The price is CA $242
CA $368 total
includes taxes & fees
Dec 5 - Dec 6
Unwind on Vine
A modern kitchen with stainless steel appliances, a stone accent wall, and a bar area.

8. Aunt Lele's Cozy Cottage

Aunt Lele's Cozy Cottage
Quincy
9.8 out of 10, Exceptional, (48 reviews)
"Perfect place for our family of 5 to enjoy a weekend visiting my wife’s family."
United States
Matt B.
The price is CA $128
CA $247 total
includes taxes & fees
Nov 17 - Nov 18
Aunt Lele's Cozy Cottage
A room with a brick wall, shelves with plants, a framed painting, and a patterned bench.

9. Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Hannibal
9.8 out of 10, Exceptional, (75 reviews)
"Very nice experience, and close to all the historical sites!"
United States
Steve G.
The price is CA $146
CA $229 total
includes taxes & fees
Dec 9 - Dec 10
Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

10. Lighthouse Inn & Suites

Lighthouse Inn & Suites
3.5 star property
Hannibal
8.8 out of 10, Excellent, (47 reviews)
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
United States
Connie
The price is CA $241
CA $278 total
includes taxes & fees
Nov 15 - Nov 16
Lighthouse Inn & Suites
Clubhouse

11. Serene Seebach Sights by Innsbrook Vacations!

Serene Seebach Sights by Innsbrook Vacations!
Innsbrook
9.6 out of 10, Exceptional, (15 reviews)
"Great clubhouse, plenty of wildlife roaming grounds, and friendly atmosphere."
United States
tony
The price is CA $134
CA $344 total
includes taxes & fees
Nov 14 - Nov 15
Serene Seebach Sights by Innsbrook Vacations!
A wooden bridge leading to a two-story house with multiple windows and a covered porch.

12. The Cottage

The Cottage
2.0 star property
Hermann
10.0 out of 10, Exceptional, (1 review)
"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."
United States
Linda
The price is CA $324
CA $443 total
includes taxes & fees
Nov 15 - Nov 16
The Cottage
A porch with two turquoise Adirondack chairs and a small table, surrounded by well-maintained greenery and a white house with black shutters.

13. WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
Augusta
10.0 out of 10, Exceptional, (44 reviews)
"This is a fantastic place to stay. We will return in the future."
United States
Mike S.
The price is CA $232
CA $402 total
includes taxes & fees
Nov 15 - Nov 16
WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
A building with a glass door marked "108" and a sign for "Web Print Radio Television Public Relations."

14. The Library, 1-queen bed, 1-bedroom apartment in Hannibal awaits your visit.

The Library, 1-queen bed, 1-bedroom apartment in Hannibal awaits your visit.
Hannibal
9.8 out of 10, Exceptional, (21 reviews)
"We had a great stay here. It was much larger than expected with a sitting room, bedroom, bath, kitchen and laundry area. In the heart of all in town and yet very safe."
United States
Dan R.
The price is CA $171
CA $204 total
includes taxes & fees
Nov 16 - Nov 17
The Library, 1-queen bed, 1-bedroom apartment in Hannibal awaits your visit.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a dining area with a wooden table and white chairs.

15. Peaceful, Country Cottage with Open Floor Plan

Peaceful, Country Cottage with Open Floor Plan
Quincy
9.8 out of 10, Exceptional, (227 reviews)
"The cottage was in a quiet location, clean, and with easy access to both Quincy, IL and Hannibal, MO. The property owner was available and easy to contact."
United States
Jodi
The price is CA $185
CA $355 total
includes taxes & fees
Nov 23 - Nov 24
Peaceful, Country Cottage with Open Floor Plan
A rustic kitchen with wooden walls, a dining table with placemats, and a hanging light fixture.

16. Historic Log Cabin in Augusta Wine Country

Historic Log Cabin in Augusta Wine Country
Augusta
8.8 out of 10, Excellent, (26 reviews)
"Cute little cabin. Very clean."
United States
Rebecca G.
The price is CA $146
CA $333 total
includes taxes & fees
Nov 17 - Nov 18
Historic Log Cabin in Augusta Wine Country
A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

17. The Mercantile on the Katy Trail

The Mercantile on the Katy Trail
4.5 star property
Hermann
9.8 out of 10, Exceptional, (45 reviews)
"We loved this place- very unique! Clean and great communication from hosts."
United States
Kristine
The price is CA $273
CA $293 total
includes taxes & fees
Dec 8 - Dec 9
The Mercantile on the Katy Trail
A modern house with a stone facade, a dark garage door, and a well-lit entrance.

18. Cool 2-bedroom three bed contemporary condo in a quiet area of Quincy.

Cool 2-bedroom three bed contemporary condo in a quiet area of Quincy.
Quincy
10.0 out of 10, Exceptional, (10 reviews)
"Very nice and clean place"
United States
G K.
The price is CA $160
CA $292 total
includes taxes & fees
Nov 16 - Nov 17
Cool 2-bedroom three bed contemporary condo in a quiet area of Quincy.
A rustic bar area with stone walls, wooden chairs, and hanging pendant lights.

19. Bright Lakefront Studio Condo at Innsbrook

Bright Lakefront Studio Condo at Innsbrook
Wright City
9.8 out of 10, Exceptional, (75 reviews)
"everything was clean and really beautiful, we enjoyed the stay "
United States
Vanessa O.
The price is CA $114
CA $272 total
includes taxes & fees
Nov 15 - Nov 16
Bright Lakefront Studio Condo at Innsbrook
A cozy living room with a brown leather couch, a wooden spiral staircase, and large windows offering a view of the outdoors.

20. The Nest, unplug& reconnect with that special someone in our charming birdhouse!

The Nest, unplug& reconnect with that special someone in our charming birdhouse!
Troy
9.4 out of 10, Exceptional, (57 reviews)
"The property was amazing perfect for a couple or a individual how wants to unplug."
United States
Jess H.
The price is CA $242
CA $279 total
includes taxes & fees
Nov 15 - Nov 16
The Nest, unplug& reconnect with that special someone in our charming birdhouse!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Find vacation rentals that suit your style

cabin image
Cabins
Cabins
Apartment image
Apartments
Apartments

Top Northeast Missouri Hotel Reviews

A well-lit lobby with a chandelier, potted plants, and a seating area.
Truitt Hotel

Truitt Hotel

Truitt Hotel
Lafayette Square

10/10 Excellent

It was all great, to Make it complete I think booze should be available at the bar in the living room, on honor system. Also a toaster and microwave would be handy
Canada
Harry
Reviewed October 13, 2026
Truitt Hotel

Find out more about Northeast Missouri

Everything you need to know about Northeast Missouri vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Northeast Missouri vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Northeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Northeast Missouri vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Northeast Missouri. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Northeast Missouri vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Northeast Missouri vacation rentals we have selected for you start as low as CA $105 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Northeast Missouri rentals

At Expedia, we put the best Northeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Northeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Northeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Northeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia