Book The Best Hotels in Northeast Missouri, MO for 2026 from CA $116 - Fully Refundable Options

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Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

A hotel lobby with a reception desk, seating area, and a sign for the general store.

A living room with a flat-screen TV, fireplace, and a couch with pillows.

A bedroom with a four-poster bed, a bedside table with a lamp, a desk with a telephone, and a bathroom with a bathtub and a hanging plant.

1. Depot Inn and Suites

La Plata

JERROD

CA $121

CA $131 total

includes taxes & fees

Oct 25 - Oct 26

A modern kitchen with a dining area, featuring a kitchen island with appliances and a coffee station.

A modern living room with a stone wall, a flat-screen TV, a built-in fish tank, a blue sofa, and a large window with a view of a parking lot.

A kitchenette with a coffee machine, a paper towel dispenser, and a trash bin labeled "THANK YOU".

A modern hotel lobby with a reception desk, seating area, and large windows.

2. Super 8 by Wyndham Kirksville-University Area

Kirksville

David

CA $111

CA $125 total

includes taxes & fees

Oct 14 - Oct 15

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A spacious hotel lobby with a central wooden table, seating, a treadmill, and a large potted plant.

A hotel kitchen with a buffet setup, including a coffee station and various food items.

A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

3. Best Western On The River

Hannibal

Raymond

CA $156

CA $180 total

includes taxes & fees

Oct 11 - Oct 12

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

A hotel entrance with a central fountain, large columns, and a clear sky.

A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

4. Quality Inn & Suites Hannibal West

Hannibal

Gayle

CA $108

CA $125 total

includes taxes & fees

Nov 1 - Nov 2

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

A modern lobby with a brown sofa, beige armchairs, a round table, and a floor lamp.

An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

A hotel room with a bed, a desk, a chair, a sofa, and a TV mounted on the wall.

5. Sleep Inn & Suites Hannibal West

Hannibal

Patricia

CA $168

CA $195 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

A hotel room with a sofa, armchair, small table, TV, dresser, and a bathtub.

A multi-story hotel with a covered entrance and a sign indicating it is part of the Oak Hill Inn & Suites.

A bar area with a long counter, multiple bottles, glasses, and a few chairs.

6. Oak Hill Inn & Suites

Canton

Marie

CA $144

CA $164 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel lobby with multiple seating areas, including a bar and dining tables.

An indoor swimming pool with clear water, surrounded by blue lounge chairs and a table with chairs.

A modern kitchen with a bar area, bar stools, a coffee station, and a large clock on the wall.

A hotel reception area with a modern design, featuring a reception desk, a large window, and a 'Treats' display.

7. Hampton Inn Kirksville

Kirksville

Phillip

CA $172

CA $195 total

includes taxes & fees

Oct 18 - Oct 19

A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.

A kitchen counter with fruits, a blender, and a refrigerator with a game display.

A reception area with a counter, a trash bin, and a seating area with chairs.

A hotel room with two beds, green walls, and artwork.

8. Travelier Motel

Macon

Jessica

CA $99

CA $119 total

includes taxes & fees

Oct 10 - Oct 11

A Comfort Inn hotel with a modern design, featuring a covered entrance and a clear sky in the background.

A hotel room with two beds, a desk, a TV, and a view of the outdoors.

A modern hotel lobby with a sofa, chairs, a coffee table, and a floor lamp.

A modern kitchen with a coffee station, bread display, and a sign that reads "RISE & SHINE".

9. Comfort Inn Sullivan

Sullivan

Sammy

CA $162

CA $177 total

includes taxes & fees

Nov 8 - Nov 9

A bathroom with a large bathtub, a chair, and a small shelf with plants.

A hotel room with two beds, wooden flooring, a desk with a chair, a microwave, and a potted plant.

An outdoor seating area with a fire pit, chairs, and two evergreen trees.

10. Pinemark Inn & Suites

St. Clair

John

CA $176

CA $192 total

includes taxes & fees

Nov 3 - Nov 4

A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.

A hotel room with a bed, a desk with a chair, a television, and a dining area with chairs.

A reception area with a reception desk, seating area with chairs, a patterned rug, and a large window with a view of the outside.

A hotel entrance with a sign reading "Quality Inn & Suites by Choice Hotels".

11. Quality Inn & Suites Quincy - Downtown

Quincy

Bryan

CA $158

CA $180 total

includes taxes & fees

Nov 8 - Nov 9

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

A hotel room with a large bed, two sofas, a desk, and a TV.

An outdoor patio with a beige sofa set, two armchairs, and a table.

12. Best Western Plus Washington Hotel

Washington

Shawn

CA $183

CA $209 total

includes taxes & fees

Oct 11 - Oct 12

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

13. Hampton Inn By Hilton Warrenton I-70

Warrenton

Kaiyla

CA $187

CA $214 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a sofa, a bed, a desk, a television, and two lamps.

A spacious lobby with a checkered floor, a large framed welcome sign, a ceiling fan, and a bar area.

A hotel room with two beds, a desk, a TV, and a cityscape view.

A Super 8 hotel with a covered parking area, a stone facade, and a prominent 'Super 8' sign on the building.

14. Super 8 by Wyndham Union

Union

Jacob

CA $114

CA $126 total

includes taxes & fees

Nov 8 - Nov 9

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A spacious living area with a staircase, a large painting, and a chandelier.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

15. The Wildwood Hotel

Wildwood

Ryan

CA $118

CA $137 total

includes taxes & fees

Nov 2 - Nov 3

A modern hotel lobby with a high ceiling, a central seating area with sofas and a coffee table, and a flat-screen TV mounted on the wall.

An indoor swimming pool with a hot tub, lounge chairs, and a tiled floor.

A spacious lobby with a high ceiling, a flat-screen TV mounted on the wall, and a seating area with sofas and ottomans.

A hotel room with a bed, a desk with a computer, a television, a sofa, and a window with a view.

16. Drury Inn & Suites Southwest St. Louis

Valley Park

Randy

CA $163

CA $191 total

includes taxes & fees

Oct 25 - Oct 26

A large indoor swimming pool with a glass ceiling, surrounded by lounge chairs and a stone wall.

A hotel room with a large bed, a TV on a wooden side table, a desk with a lamp, and a view of the outdoors through a window with curtains.

A restaurant with a marble dining table, wooden chairs, and a kitchen area with various appliances.

A gym with exercise equipment, a clock, and a television on the wall.

17. Baymont by Wyndham Sullivan

Sullivan

Peggy

CA $156

CA $170 total

includes taxes & fees

Nov 3 - Nov 4

A hot tub with a rocky backdrop and a mural.

An indoor swimming pool with a 'No Diving' sign, lounge chairs, and a mural on the wall.

A restaurant with wooden walls, a bar area, and multiple seating arrangements.

An outdoor patio area with wooden furniture, string lights, and umbrellas.

18. Stoney Creek Inn Quincy

Quincy

Kent

CA $171

CA $195 total

includes taxes & fees

Oct 11 - Oct 12

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

A modern lobby with a reception desk, seating area, and a fireplace.

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

A modern living room with a sectional sofa, a round coffee table, and large windows offering a view of the city.

19. Best Western St. Louis Inn

St. Louis

Harold

CA $101

CA $116 total

includes taxes & fees

Oct 25 - Oct 26

A modern interior with a high ceiling, large windows, and a brick wall. There are orange chairs and a green sofa with orange cushions.

A lobby with a reception desk, seating area, and large windows.

A hotel room with a bed, a desk, a television, a sofa, and a lamp.

A modern building with a prominent entrance, large windows, and a covered parking area.

20. Pear Tree Inn St. Louis Arnold

Arnold

Lynda

CA $128

CA $148 total

includes taxes & fees

Oct 19 - Oct 20

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Vacation Rentals in Northeast Missouri

Cabin

A park with a pond, picnic tables, and a gazebo.

A small, well-lit kitchen with a dining table, chairs, a refrigerator, a microwave, and a television mounted on the wall.

A row of rustic, single-story buildings with a grassy lawn and picnic tables.

A grassy area with a picnic table and a dog.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Aparthotel

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.

A swimming pool with lounge chairs and a covered seating area.

Lighthouse Inn & Suites

Hannibal

"Wonderful place to stay!"

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

A modern kitchen with white cabinets, a black refrigerator, and a dining area with a blue table runner.

A living room with a sofa, a table, a TV, and a dining area with chairs.

A modern living room with a grey sofa, a dining table with chairs, a small side table, and a floor lamp.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

A modern kitchen with a wooden island, bar stools, and a flat-screen TV.

A living room with a sofa, armchair, and coffee table. There is a staircase with a railing and a door in the background.

A compact kitchen with a marble backsplash, a refrigerator, a washing machine, and a dining area with chairs.

The Mercantile on the Katy Trail

Hermann

"It’s an absolute must do! Such a cool little town right on the Katy Trail!"

Apartment

A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.

A red deck with wicker furniture and a blue umbrella, overlooking a residential area with houses and a dome-shaped building.

A bedroom with a bed, a desk, a chair, a bench, and a ceiling fan.

A spacious living area with a blue sofa, wooden flooring, and a chandelier.

Spacious 3-Bedroom with King Bed

Central West End

"Clean room nice area "

Apartment

A spacious foyer with a grand staircase, a piano, and a large rug.

A hallway with wooden doors, a wall-mounted tree decoration, a small table with a plant, and a painting.

A spacious dining area with a round glass table, black metal chairs, and a wooden staircase leading to an upper level.

A backyard with a stone fire pit, two Adirondack chairs, and a hammock.

White House at Grand Central

Grand Center

"Nice find in the city"

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

A modern living room with a pool table, a seating area, and a large window offering a view of the outdoors.

A modern gym with treadmills, ellipticals, and weight machines. Large windows offer views of a swimming pool and greenery.

A modern living area with a grey sofa, a glass coffee table, and a black leather sofa. There are large windows and a visible interior space beyond.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Cottage

A modern kitchen with stainless steel appliances, wooden flooring, and dark cabinetry.

A house with a front porch, a door, and a small garden area.

A modern kitchen with a dishwasher, sink, and a coffee maker.

A modern kitchen with dark wooden cabinets, a white countertop, a stainless steel refrigerator, and a built-in microwave. There is a dining table with two chairs and a potted plant on it.

Walk to Tower Grove Park: St Louis Getaway

Tower Grove South

"great place and nice location"

Apartment

A red building with a sign for 'Catala House' and a 'Massage House' sign.

A kitchen with white cabinets, a wooden door, and a window.

A cozy loft-style living room with a brown leather sofa, a blue ottoman, and a patterned rug.

A bedroom with a bed, a flat-screen TV mounted on the wall, a brick pillar, and a window with curtains.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Apartment

A living room with a sofa, armchair, and coffee table. There is a ceiling fan, a TV mounted on the wall, and a window with blinds.

A modern kitchen with dark cabinets, a black refrigerator, a white stove, and a wooden floor.

A wooden deck with railings, a concrete foundation, and a view of a residential area with houses and trees.

A white door with a small mailbox and a mailbox with a bear figure on the front step.

Walk to Carondelet Park: Quiet Couple's Getaway

Carondelet

"We had a nice stay, close to things we wanted to do"

Apartment

A bedroom with a wooden headboard, a bed with a beige bedspread, a nightstand, and a dresser.

A covered outdoor patio with wooden flooring, metal chairs, tables, and ceiling fans.

A two-story building with a covered porch and a staircase leading to the upper level.

Near Wineries: Country Condo in Stony Hill

New Haven

"Clean and loved original architecture."

Cottage

A bedroom with a bed, bedside lamps, a wooden chest, and a ceiling fan.

A living room with a staircase, two patterned armchairs, a wooden cabinet, and a washing machine.

A wooden deck with a round table and chairs, a barbecue grill, and a large umbrella.

A room with a dining table, two armchairs, a wooden cabinet, and a blue rug.

Peaceful Country Home in Serene Setting With Yard

Washington

"We love the house and the amount of sleeping arrangements. The coffee maker broke and she told me that if I can get a new one she will pay me back and all I had to do was leave the receipt on top of the refrigerator. Everything worked out great. She was very responsive when we had questions. We will definitely try to rent again next year."

Cottage

A small attic bedroom with two beds, a window, and a view of a balcony.

A spacious dining area with wooden tables and chairs, a kitchen area with appliances, and a rustic ceiling.

A wooden deck with two chairs and a white railing, overlooking a green landscape with a fence and trees.

A kitchen with a red countertop, wooden cabinets, a stainless steel sink, and a microwave. There is a wooden door and a white wall with a light switch.

Updated Berger Cottage w/ Pool, on a Private Farm!

Berger

"Only positive things to say about our trip. Would 100% recommend to anyone wanting a quiet get away with family and friends. Far enough away from town to kick back and relax but close enough to the shops, restaurants, and wineries to enjoy all that Hermann has to offer!"

Cottage

A log cabin interior with a stone fireplace, leather furniture, and mounted animal heads on the walls.

A kitchen with wooden cabinets, a stone island, and a hanging deer head.

A log cabin with a deck, outdoor seating, and potted plants.

A spacious living room with a fireplace, a dining area with a stone wall, and a kitchen with wooden cabinets.

Spacious Ozarks Family Home - Private Pool & Grill

Bourbon

"It's perfect 100% recommended."

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

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A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.

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A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.

Busch Stadium

9.4/10 (4,850 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.

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A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)

Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.

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A stone fountain with water cascading down a tiered structure, surrounded by a pond and a grassy area with a building in the background.

Forest Park

9.2/10 (3,389 reviews)

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

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A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)

Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.

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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)

This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.

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America's Center Convention Complex

8.8/10 (306 reviews)

Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

Top Northeast Missouri Hotel Reviews

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

10/10 Excellent

"Loved the location. Very unique and “artsy”. Staff at check in and checkout, restaurant and bar were all friendly and helpful"

Pear Tree Inn St. Louis Near Union Station

8/10 Good

"sorry to see the bar is closed"

Courtyard by Marriott St. Louis Downtown/Convention Center

10/10 Excellent

"Staff was very helpful and nice!"

Home2 Suites by Hilton St. Louis Downtown

10/10 Excellent

"Great location Downtown. Staff were great. Parking on street is fine."

More cheap stays in Northeast Missouri

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr St. Louis MO

CA $101

CA $116 total

Oct 25 - Oct 26

includes taxes & fees

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO

CA $128

CA $152 total

Oct 13 - Oct 14

includes taxes & fees

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO

CA $132

CA $154 total

Nov 1 - Nov 2

includes taxes & fees

The West End

4215 Lindell Blvd St. Louis MO

CA $118

CA $166 total

Nov 3 - Nov 4

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

CA $169

CA $194 total

Oct 25 - Oct 26

includes taxes & fees

AC Hotel St. Louis Clayton

227 South Central Ave St. Louis MO

CA $182

CA $213 total

Oct 25 - Oct 26

includes taxes & fees

Hotels in Northeast Missouri with star rating

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Things to do in Northeast Missouri

Book Hotels in Northeast Missouri on Expedia.com

Find hotels in Northeast Missouri, MO from CA $116

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Northeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Northeast Missouri hotels

1. Depot Inn and Suites

2. Super 8 by Wyndham Kirksville-University Area

3. Best Western On The River

4. Quality Inn & Suites Hannibal West

5. Sleep Inn & Suites Hannibal West

6. Oak Hill Inn & Suites

7. Hampton Inn Kirksville

8. Travelier Motel

9. Comfort Inn Sullivan

10. Pinemark Inn & Suites

11. Quality Inn & Suites Quincy - Downtown

12. Best Western Plus Washington Hotel

13. Hampton Inn By Hilton Warrenton I-70

14. Super 8 by Wyndham Union

15. The Wildwood Hotel

16. Drury Inn & Suites Southwest St. Louis

17. Baymont by Wyndham Sullivan

18. Stoney Creek Inn Quincy

19. Best Western St. Louis Inn

20. Pear Tree Inn St. Louis Arnold

Vacation Rentals in Northeast Missouri

Cannon Dam Cabins

Lighthouse Inn & Suites

Peaceful Missouri Cabin Rental on 55 Acres!

The Mercantile on the Katy Trail

Spacious 3-Bedroom with King Bed

White House at Grand Central

Landing Furnished Apartments - Central West End

Walk to Tower Grove Park: St Louis Getaway

New Melle Apartment Near Missouri Wine Country

Walk to Carondelet Park: Quiet Couple's Getaway

Near Wineries: Country Condo in Stony Hill

Peaceful Country Home in Serene Setting With Yard

Updated Berger Cottage w/ Pool, on a Private Farm!

Spacious Ozarks Family Home - Private Pool & Grill

Stay near popular Northeast Missouri attractions

St. Louis Zoo

Enterprise Center

Busch Stadium

Dome at America’s Center

Forest Park

St. Louis University

City Museum

America's Center Convention Complex

Learn more about Northeast Missouri

Top Northeast Missouri Hotel Reviews

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Pear Tree Inn St. Louis Near Union Station

Courtyard by Marriott St. Louis Downtown/Convention Center

Home2 Suites by Hilton St. Louis Downtown

More cheap stays in Northeast Missouri

Best Western St. Louis Inn

Pear Tree Inn St. Louis Airport

Tru By Hilton St. Louis Downtown

The West End

Hampton Inn St. Charles St. Peters

AC Hotel St. Louis Clayton

Hotels in Northeast Missouri with star rating

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