Fishing Vacations in Upstate South Carolina 2026

Photo by RVLuckyorWhat

Plan, book, travel with confidence
Better together
Save up to CA $4,200 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Fishing Hotels in Upstate South Carolina

Carolina Landing RV Resort - Caravan Park

120 Carolina Landing Drive Fair Play SC

38 min drive from Clemson University

Enjoy free parking, a marina, and a fitness center. Popular attractions Lake Hartwell and Glenn Ferry Access Area are located nearby.

Budget Inn Greenville By Hotel O I-85

224 Bruce Rd Greenville SC

1 hour drive from Clemson University

Stay at this hotel in Greenville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Falls Park on the Reedy and Bon Secours Wellness ...

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

Seneca SC

21 min drive from Clemson University

Book a stay at this beach vacation home in Seneca. Enjoy free WiFi, a beach locale, and a garden. Popular attractions Friendship Recreation Area and Cross Creek ...

10/10 Exceptional! (245 reviews)

"Very well- equipped and appointed accommodations. The hosts went above and beyond to make sure our stay was lovely and added extra touches unique and special to our stay. The yard was lovely and in bloom. We spent most of our time on the wonderful screened in porch or out on the dock enjoying the ..."

Reviewed on Aug 7, 2026

See all 3,053 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.