A coastal fortress with a stone wall and a tiled-roof building.

5 Stars Hotels in Syracuse, Sicily from CA $216

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Check availability on Syracuse 5 Star Hotels

Tonight
Oct 6 - Oct 7
Tomorrow
Oct 7 - Oct 8
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Our top choices for Syracuse 5-star hotels

A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A balcony with a glass table and two red chairs, overlooking a coastal view with buildings and boats.
A balcony with a view of the sea and a cityscape, furnished with two chairs and a small table with a vase of flowers.
A grand atrium with a central column, ornate railings, and a large mural on the wall.

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
Mexico
ALFONSO
CA $499
CA $565 total
includes taxes & fees
Nov 1 - Nov 2
Ortea Palace Hotel, Sicily, Autograph Collection
A balcony with a view of the sea, a cactus, and potted plants.
A large, classical building with multiple windows and balconies, surrounded by a calm body of water with several yachts docked.
A dining area with a table set for two, overlooking a coastal view.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.

2. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
United States
SEAN
CA $400
CA $456 total
includes taxes & fees
Nov 4 - Nov 5
Grand Hotel Ortigia Siracusa
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A terrace with a view of the sea and a cruise ship, featuring outdoor seating and potted cacti.
A grand hallway with a marble floor, ornate columns, and a staircase leading to an upper level.
A grand hallway with ornate columns, a tiled floor, and large potted plants.

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
Canada
Steven
CA $901
CA $1,007 total
includes taxes & fees
Oct 29 - Oct 30
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A multi-story building with a rooftop terrace, balconies, and a street view.
A modern hotel room with a stone accent wall, a grey sofa, a large mirror, a chandelier, and a neatly made bed with rolled towels.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.

4. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
Canada
Dena
CA $202
CA $238 total
includes taxes & fees
Nov 5 - Nov 6
Caportigia Boutique Hotel
A spa room with a large window, a hot tub, and two candles.
A stone building with arched walkways and outdoor seating areas.
A spacious lobby with arched ceilings, a central round table with decorative items, and a modern chandelier.
A spacious living room with a high ceiling, white sofas, a coffee table, and a large mirror.

5. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
United Kingdom
Chris
CA $432
CA $491 total
includes taxes & fees
Oct 25 - Oct 26
Dimora Caiammari Luxury Hotel & Spa
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A table set with breakfast items overlooking a coastal view.
A modern bathroom with a freestanding bathtub, a small table with toiletries, and a view of the ocean.
A pathway lined with palm trees leading to a building with a red-tiled roof.

6. Minareto

Minareto
Syracuse
United Kingdom
Lekhbiro
CA $411
CA $468 total
includes taxes & fees
Nov 6 - Nov 7
Minareto
A large swimming pool with a modern building in the background.
An outdoor dining area with tables and chairs, a pool, and palm trees in the background.
A woman relaxing in a spa bath with a modern design, including a ceiling with blue lighting and a tiled floor.
A sauna with wooden benches and a central stone pillar.

7. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
United States
Jeffrey
CA $477
CA $541 total
includes taxes & fees
Nov 6 - Nov 7
Wellness & Spa Hotel Principe di Fitalia
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
CA $275
CA $318 total
Nov 6 - Nov 7
includes taxes & fees
Algila' Ortigia Charme Hotel
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

Via Diodoro Siculo 4 Syracuse SR
CA $189
CA $216 total
Oct 28 - Oct 29
includes taxes & fees
8.6/10 Excellent! (551 reviews)
UNA Hotels One Siracusa Wellness & SPA
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

Via Roma 66 Syracuse SR
CA $405
CA $461 total
Nov 3 - Nov 4
includes taxes & fees
9.4/10 Exceptional! (694 reviews)
Palazzo Artemide - VRetreats, SLH Collection
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Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Find out more about Syracuse

Five Star Hotels in Syracuse

There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places.

Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town.

Make Your Escape to Syracuse

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Syracuse! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Syracuse today and settle down in the lap of luxury tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Grand Hotel Ortigia Siracusa, Ortea Palace Hotel, Sicily, Autograph Collection and Grand Hotel Des Ètrangers are some of the most popular 5-star hotels in Syracuse, according to our traveller reviews. These upmarket hotels rate highly for things such as their location, amenities and service standards. Choose your favourite and enjoy the best of everything.
How much does it cost to stay in a 5-star hotel in Syracuse?
You'll find many different pricing options for 5-star hotels in Syracuse on Expedia. The amount you pay will depend on when you travel, length of your trip and other factors. Compare available properties for your chosen dates and use our pricing and other filters to discover the ideal luxury stay.
  • Search for the lowest price per night from CA $216
What makes a hotel 5 stars in Syracuse?
From gourmet dining venues and fitness centres to pools and luxury bedding, the 5-star experience in Syracuse is all about comfort and luxury. But it calls for more than just upscale perks to receive a 5-star rating. Stays must also deliver exceptional services like in-room beauty treatments, on-site laundry and dry cleaning and 24/7 room service.

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