Title: Book the Best Southeastern Indiana SPA Resorts from CA $123 - Spa Hotels in Southeastern Indiana | Expedia.ca [Southeastern Indiana Travel Guide](https://expedia.ca/Southeastern-Indiana.dx6233889)[Hotels in Southeastern Indiana](https://expedia.ca/Southeastern-Indiana-Hotels.d6233889.Travel-Guide-Hotels)[Vacation Rentals in Southeastern Indiana](https://expedia.ca/Southeastern-Indiana-Vacation-Rentals.d6233889.Travel-Guide-VacationRentals)[Flights to Southeastern Indiana](https://expedia.ca/Cheap-Flights-To-Southeastern-Indiana.d6233889.Travel-Guide-Flights)[Southeastern Indiana Car Rentals](https://expedia.ca/Car-Rentals-In-Southeastern-Indiana.d6233889.Car-Rental-Guide)[Southeastern Indiana Vacation Packages](https://expedia.ca/Southeastern-Indiana.d6233889.Destination-Travel-Guides) ![Belle of Louisville which includes a bay or harbour and a ferry as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeastern Indiana Spa Hotels Tonight [Feb 5 - Feb 6](https://www.expedia.ca/Hotel-Search?regionId=6233889&startDate=2026-02-05&endDate=2026-02-06&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 6 - Feb 7](https://www.expedia.ca/Hotel-Search?regionId=6233889&startDate=2026-02-06&endDate=2026-02-07&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6233889&startDate=2026-02-06&endDate=2026-02-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6233889&startDate=2026-02-13&endDate=2026-02-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeastern Indiana hotels with a spa ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/aa5bcd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9d86b349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/0261f02d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/63654a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) Downtown Louisville 9.0/10 Wonderful (4,041 reviews) "Great hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lazaro CA $210 CA $247 total includes taxes & fees Feb 17 - Feb 18 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/04047b8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, in-room safe, individually decorated](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/2ac61b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/7f00b921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/30bbd7c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Belterra Casino Resort [](https://www.expedia.ca/Madison-Hotels-Belterra-Casino-Resort.h1152807.Hotel-Information) Florence 8.6/10 Excellent (1,000 reviews) "Nice room, staff curteous" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie L CA $207 CA $249 total includes taxes & fees Mar 2 - Mar 3 [](https://www.expedia.ca/Madison-Hotels-Belterra-Casino-Resort.h1152807.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/54f0e03a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/a36c57b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/80fbdedc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/bea44cd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caesars Southern Indiana - A Caesars Rewards Destination [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) Elizabeth 8.2/10 Very good (1,002 reviews) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ismael CA $119 CA $160 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/aaadeb96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/06213b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,001 reviews) "Location and the staff was fabulous." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Madeline CA $245 CA $295 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Sauna, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/547de83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/9798709f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/78105fdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) Downtown Louisville 9.2/10 Wonderful (1,776 reviews) "Amazing stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erin CA $283 CA $333 total includes taxes & fees Feb 10 - Feb 11 [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/00e4c915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/a0c5fbcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/eec2d0c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/071da00d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Reserve on Main [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) Downtown Louisville 10/10 Exceptional (1 review) "Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) georgios CA $225 CA $329 total includes taxes & fees Mar 3 - Mar 4 [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/49600/49545/a62748ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/49600/49545/1ea5b0fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/49600/49545/d25d1009.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/50000/49600/49545/914ff829.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seymour I-65 [](https://www.expedia.ca/Columbus-Hotels-Quality-Inn-Seymour-I-65.h49545.Hotel-Information) Seymour 7.0/10 Good (567 reviews) "Was quiet and enjoyed our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) BARBARA CA $110 CA $123 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Columbus-Hotels-Quality-Inn-Seymour-I-65.h49545.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/95d9177a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/1e2d6baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/787112cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/94b6bd82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Central Park Bed & Breakfast [](https://www.expedia.ca/Louisville-Hotels-Central-Park-Bed-Breakfast.h106915308.Hotel-Information) Old Louisville 9.2/10 Wonderful (63 reviews) "My partner and I do regular romantic staycations at Central Park Inn and we love it. The rooms are comfortable and unique and the staff we've met are lovely. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda CA $172 CA $200 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Louisville-Hotels-Central-Park-Bed-Breakfast.h106915308.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/40c412dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Apartment, Multiple Beds, Pets Allowed, Garden View | Living area](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/3fd39b2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/82066f84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/e77d0e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pillow and Paddock B&B [](https://www.expedia.ca/Louisville-Hotels-Pillow-And-Paddock-BB.h11688222.Hotel-Information) La Grange 10/10 Exceptional (52 reviews) "Courteous staff and the room was outstanding. It was our second stay at the inn. Everything is first class. We highly recommend it." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fran CA $478 CA $527 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Louisville-Hotels-Pillow-And-Paddock-BB.h11688222.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20®ionId=6233889&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at spa hotels in Southeastern Indiana Pool Breakfast included Hot tub 4 stars 5 stars ## Top Southeastern Indiana Hotel Reviews ![Big Splash Adventure Indoor Water Park & Resort](https://images.trvl-media.com/lodging/5000000/4860000/4857100/4857069/63744e7b_y.jpg) ### Big Splash Adventure Indoor Water Park & Resort 10/10 Excellent "Great service" [](https://expedia.ca/French-Lick-Hotels-Big-Splash-Adventure-Indoor-Water-Park-Resort.h4857069.Hotel-Information) ![Hampton Inn New Albany Louisville West](https://images.trvl-media.com/lodging/1000000/30000/25400/25301/eb53eba8_y.jpg) ### Hampton Inn New Albany Louisville West 10/10 Excellent "nice staff and warm, comfy lobby. " [](https://expedia.ca/Louisville-Hotels-Hampton-Inn-New-Albany-Louisville-West.h25301.Hotel-Information) ![Ramada by Wyndham Sellersburg/Louisville North](https://images.trvl-media.com/lodging/1000000/660000/659000/658960/dbc92ac1_y.jpg) ### Ramada by Wyndham Sellersburg/Louisville North 10/10 Excellent "The hotel was very nice and the staff was pleasant and helpful" [](https://expedia.ca/Sellersburg-Hotels-Ramada-By-Wyndham-SellersburgLouisville-North.h658960.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [Hotels near Cumberland River ](https://www.expedia.ca/Cumberland-River-Hotels.0-l681609143447191552-0.Travel-Guide-Filter-Hotels) - [Hotels near Kentucky Lake ](https://www.expedia.ca/Kentucky-Lake-Hotels.0-l6059618-0.Travel-Guide-Filter-Hotels) - [Hotels near Lake Barkley ](https://www.expedia.ca/Lake-Barkley-Hotels.0-l553248635976193790-0.Travel-Guide-Filter-Hotels) - [Hotels near Ohio River ](https://www.expedia.ca/Ohio-River-Hotels.0-l681940626945888256-0.Travel-Guide-Filter-Hotels) - 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