Title: Book the Best Ohio River Valley LUXURY Hotels - Upscale Hotels in Ohio River Valley | Expedia.ca [Ohio River Valley Travel Guide](https://expedia.ca/Ohio-River-Valley.dx6233674)[Hotels in Ohio River Valley](https://expedia.ca/Ohio-River-Valley-Hotels.d6233674.Travel-Guide-Hotels)[Vacation Rentals in Ohio River Valley](https://expedia.ca/Ohio-River-Valley-Vacation-Rentals.d6233674.Travel-Guide-VacationRentals)[Flights to Ohio River Valley](https://expedia.ca/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights)[Ohio River Valley Car Rentals](https://expedia.ca/Car-Rentals-In-Ohio-River-Valley.d6233674.Car-Rental-Guide)[Ohio River Valley Vacation Packages](https://expedia.ca/Ohio-River-Valley.d6233674.Destination-Travel-Guides) ![Indianapolis featuring autumn leaves and a cemetery](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/25000/25344-Indianapolis.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Ohio River Valley ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Ohio River Valley Luxury Hotels Tonight [Oct 9 - Oct 10](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-09&endDate=2025-10-10&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-10&endDate=2025-10-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Ohio River Valley Luxury Hotels ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/w3822h2860x18y0-dc47fc22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/b16740d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/w2558h3836x3y4-7244cc45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/9b21e16f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Conrad Indianapolis Downtown Indianapolis 9.2/10 Wonderful (1007) "Stayed in the Modern Suite. Very nice room! Close to restaurants and walking distance to Lucas Oil Stadium. Would definitely stay here again. " CA $302 CA $357 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Indianapolis-Hotels-Conrad-Indianapolis.h1287480.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.4/10 Exceptional (1004) "Great stay overall. " CA $225 CA $271 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/220feee7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/14a6fe74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/bff88489.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![15 restaurants, breakfast served](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/95e75b78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### West Baden Springs Hotel West Baden Springs 9.6/10 Exceptional (310) [](https://www.expedia.ca/West-Baden-Springs-Hotels-West-Baden-Springs-Hotel.h1745075.Hotel-Information) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/e40ec4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/083528eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner and brunch served](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/17dd1cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/25619903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Cincinnati Downtown Cincinnati 8.8/10 Excellent (1004) "Great location and atmosphere" CA $225 CA $276 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/90dd12e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/bf4689cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/fdaa6912.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gift shop](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/f0cc451d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Cincinnatian Hotel Curio Collection by Hilton Downtown Cincinnati 7.6/10 Good (1004) "Nice Hotel to spend the nights in a very accessible location. Great staff." CA $206 CA $246 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Cincinnati-Hotels-The-Cincinnatian-Hotel-Curio-Collection-By-Hilton.h12411.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/2a2a7fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel Downtown Louisville 9.4/10 Exceptional (1085) "The hotel and the staff were great." CA $213 CA $251 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/ab0af7cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9c82234b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville 9.0/10 Wonderful (3671) "Th Galt House is a beautiful place to stay. " CA $194 CA $228 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/53b2e008.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 1 King Bed, Kitchenette](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/c26bf422.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/c391327c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Loft, 1 King Bed, Kitchenette | Living area](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/e8eba286.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Covington Cincinnati Riverfront Covington 9.6/10 Exceptional (1011) "Very nice and trendy hotel. Large clean rooms with great design" CA $276 CA $311 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Cincinnati-Hotels-Hotel-Covington-Cincinnati-Riverfront.h15108459.Hotel-Information) ![Dinner served](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/4e79a8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/c4d1fb67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/5bea9d61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Louisville Downtown Downtown Louisville 9.0/10 Wonderful (1022) "Nice room and great breakfast!! " CA $194 CA $229 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/574acdfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/2b30ef66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, individually furnished, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/97c1450b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/1802b8f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Olentangy Motor Inn Grandview Heights 9.0/10 Wonderful (1221) "Always a great experience, when I stay quarterly. Quiet, immaculate room, and always great front desk staff." CA $138 CA $163 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Columbus-Hotels-Olentangy-Motor-Inn.h687701.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-24&endDate=2025-10-25®ionId=6233674&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Ohio River Valley Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Wi-Fi connection was good. Room was a suite, which was awesome. I would only suggest more bright lighting in the living area, and some kind of lighting in closets. " [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Radisson Hotel Cincinnati Riverfront](//images.trvl-media.com/lodging/1000000/10000/2800/2755/68cff2fd_y.jpg) ### Radisson Hotel Cincinnati Riverfront 10/10 Excellent "Yes" [](https://expedia.ca/Cincinnati-Hotels-Radisson-Hotel-Cincinnati-Riverfront.h2755.Hotel-Information) ![Sheraton Indianapolis Hotel at Keystone Crossing](//images.trvl-media.com/lodging/1000000/20000/14900/14838/e72753e3_y.jpg) ### Sheraton Indianapolis Hotel at Keystone Crossing 10/10 Excellent "Deal and nice location " [](https://expedia.ca/Indianapolis-Hotels-Sheraton-Indianapolis-Hotel-At-Keystone-Crossing.h14838.Hotel-Information) ![Hyatt Regency Cincinnati](//images.trvl-media.com/lodging/1000000/20000/18700/18646/1ec5d305_y.jpg) ### Hyatt Regency Cincinnati 10/10 Excellent "Easy walk to the football stadium!!!" [](https://expedia.ca/Cincinnati-Hotels-Hyatt-Regency-Cincinnati.h18646.Hotel-Information) ![Hilton Columbus Downtown](//images.trvl-media.com/lodging/6000000/5280000/5270400/5270320/6a2e3c37_y.jpg) ### Hilton Columbus Downtown 10/10 Excellent "Clean, beautiful lobby, and room. Room was quiet, we could not hear neighbors or even people walking in the hallway. Perfect size for a couple on a weekend getaway." [](https://expedia.ca/Columbus-Hotels-Hilton-Columbus-Downtown.h5270320.Hotel-Information) ![Omni Severin Hotel](//images.trvl-media.com/lodging/1000000/20000/17700/17640/3e6b70fc_y.jpg) ### Omni Severin Hotel 10/10 Excellent "Great place! So close to stadium. We had a great time " [](https://expedia.ca/Indianapolis-Hotels-Omni-Severin-Hotel.h17640.Hotel-Information) ![Hilton Cincinnati Netherland Plaza](//images.trvl-media.com/lodging/1000000/10000/5900/5818/3a03c8ac_y.jpg) ### Hilton Cincinnati Netherland Plaza 10/10 Excellent "Very nice hotel in good location. Friendly staff and nice bar and restaurant " [](https://expedia.ca/Cincinnati-Hotels-Hilton-Cincinnati-Netherland-Plaza.h5818.Hotel-Information) ![Sonesta Columbus Downtown](//images.trvl-media.com/lodging/1000000/30000/26900/26870/d5b1e434_y.jpg) ### Sonesta Columbus Downtown 10/10 Excellent "Hotel was nice and very comfortable. The room was spacious and the staff are really friendly and helpful. " [](https://expedia.ca/Columbus-Hotels-Sonesta-Columbus.h26870.Hotel-Information) ![The Westin Cincinnati](//images.trvl-media.com/lodging/1000000/10000/3000/2972/62dde63a_y.jpg) ### The Westin Cincinnati 10/10 Excellent "Reception desk was awesome and friendly cleaning lady always a smile all around great staff I will be back" [](https://expedia.ca/Cincinnati-Hotels-The-Westin-Cincinnati.h2972.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [1 Star Hotels in Historic Route 66](https://www.expedia.ca/1Star-Historic-Route-66-Hotels.s10-0-d702654640613646336.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Historic Route 66](https://www.expedia.ca/2Star-Historic-Route-66-Hotels.s20-0-d702654640613646336.Travel-Guide-Filter-Hotels) - [B&B in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Bed-And-Breakfast.d702654640613646336-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Cabins.d702654640613646336-aaCabins.Travel-Guide-Accommodation) - 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