Title: Book the Best BOUTIQUE Hotels in Ohio River Valley in 2025 | Expedia.ca [Ohio River Valley Travel Guide](https://expedia.ca/Ohio-River-Valley.dx6233674)[Hotels in Ohio River Valley](https://expedia.ca/Ohio-River-Valley-Hotels.d6233674.Travel-Guide-Hotels)[Vacation Rentals in Ohio River Valley](https://expedia.ca/Ohio-River-Valley-Vacation-Rentals.d6233674.Travel-Guide-VacationRentals)[Flights to Ohio River Valley](https://expedia.ca/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights)[Ohio River Valley Car Rentals](https://expedia.ca/Car-Rentals-In-Ohio-River-Valley.d6233674.Car-Rental-Guide)[Ohio River Valley Vacation Packages](https://expedia.ca/Ohio-River-Valley.d6233674.Destination-Travel-Guides) ![Indianapolis featuring autumn leaves and a cemetery](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/25000/25344-Indianapolis.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Boutique Hotels in Ohio River Valley ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Ohio River Valley Boutique Hotels Tonight [Sep 25 - Sep 26](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-09-25&endDate=2025-09-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 26 - Sep 27](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-09-26&endDate=2025-09-27&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-09-26&endDate=2025-09-28&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Ohio River Valley Boutique Hotels ![Front of property](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/ab0c13a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed (Hardesty) | Private kitchenette](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/573e9242.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (Macbeth) | Exterior](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/e9d667ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed (Miller)](https://images.trvl-media.com/lodging/11000000/10660000/10656500/10656466/6a2d7a53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Landoll's Mohican Castle Loudonville 8.8/10 Excellent (310) "Neat place" CA $320 CA $364 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Mansfield-Hotels-Landolls-Mohican-Castle.h10656466.Hotel-Information) ![Grand Suite with Deck | Balcony view](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/dfab44c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room | Living area](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/83868763.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/69a9fa93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/6000000/5200000/5190700/5190689/9bccc7a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### St Paul Hotel Wooster Wooster 9.6/10 Exceptional (250) "A modern boutique Hotel in an historic old town. Very close to good restaurants, too." CA $297 CA $335 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Mansfield-Hotels-St-Paul-Hotel-Wooster.h5190689.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/46279487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/a276c9db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed, Fireplace](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/86d15582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/ce1b7eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Market Street Inn Jeffersonville 9.8/10 Exceptional (116) "We’ve stayed at this beautiful B&B twice. The location, charm, cleanliness, and staff make it an absolute treasure." CA $245 CA $276 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/2a2a7fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel Downtown Louisville 9.4/10 Exceptional (1082) "The hotel and the staff were great." CA $225 CA $265 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/cef338e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.4/10 Exceptional (1010) "Fun place to stay! Eclectic, unique and eccentric decor. Really enjoyed the location and convenient, walkable access. " CA $236 CA $285 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/e40ec4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/5b64e900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner and brunch served](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/17dd1cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/25619903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Cincinnati Downtown Cincinnati 8.8/10 Excellent (1011) "Quick check in and gracious welcomes!" CA $250 CA $305 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) ![3 bars/lounges, rooftop bar, cocktail bar](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/f9ecae0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/d59d898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, rooftop bar, cocktail bar](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/48809bd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/9000000/8330000/8329200/8329138/00cd462d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Metropolitan at The 9, Autograph Collection Downtown Cleveland 9.0/10 Wonderful (908) "Great downtown location close to everything you need! The facility is nice and service was wonderful. " CA $277 CA $325 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Cleveland-Hotels-Metropolitan-At-The-9.h8329138.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-09&endDate=2025-10-10®ionId=6233674&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Ohio River Valley Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Hated that the pool was closed for the season and there wasnt a microwave in the room, but room service was fast and amazing, the room was HUGE and super clean, everyone was so nice!! Already talking about booking again!! " [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Ironworks Hotel Indy](//images.trvl-media.com/lodging/20000000/19300000/19294100/19294032/02753ebe_y.jpg) ### Ironworks Hotel Indy 10/10 Excellent "Beautiful design and interestingly appointed rooms. The restaurants in and near the hotel are excellent. Cozy atmosphere." [](https://expedia.ca/Indianapolis-Hotels-Ironworks-Hotel-Indy.h19294032.Hotel-Information) ![I Hotel And Illinois Conference Center](//images.trvl-media.com/lodging/2000000/1900000/1897400/1897350/b24d7833_y.jpg) ### I Hotel And Illinois Conference Center 10/10 Excellent "Very nice and flexible staff when needing room changes!" 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