Title: Book the Best Ohio River Valley SPA Resorts from CA $133 - Spa Hotels in Ohio River Valley | Expedia.ca [United States of America Travel Guide](https://expedia.ca/United-States-Of-America.dx201)[Vacation Rentals in United States of America](https://expedia.ca/Destinations-In-United-States-Of-America.d201.Vacation-Rental-Destinations)[Flights to United States of America](https://expedia.ca/Destinations-In-United-States-Of-America.d201.Flight-Destinations)[Ohio River Valley Car Rentals](https://expedia.ca/Car-Rentals-In-Ohio-River-Valley.d6233674.Car-Rental-Guide)[Ohio River Valley Vacations](https://expedia.ca/Ohio-River-Valley.d6233674.Destination-Travel-Guides) ![Indianapolis featuring autumn leaves and a cemetery](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/25000/25344-Indianapolis.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Ohio River Valley from CA $133 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Ohio River Valley Spa Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-14&endDate=2025-10-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-15&endDate=2025-10-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6233674&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Ohio River Valley Spa Hotels ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/2abf4070.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/f8443363.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/e30e3380.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/c9ab692a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bradley Hotel Downtown 9.4/10 Exceptional (864) "Very nice hotel in the perfect location " CA $193 CA $222 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Fort-Wayne-Hotels-The-Bradley.h67630659.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20330000/20322600/20322580/96f264a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/21000000/20330000/20322600/20322580/42d360dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20330000/20322600/20322580/f348128c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking (Mobility Accessible)](https://images.trvl-media.com/lodging/21000000/20330000/20322600/20322580/540a2742.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Terre Haute Terre Haute 9.0/10 Wonderful (1014) "A great place to stay!" CA $140 CA $161 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Terre-Haute-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Terre-Haute.h20322580.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423555/78130bf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423555/dfa944db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423555/w4017h2675x0y0-6de349a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast (USD 16 per person)](https://images.trvl-media.com/lodging/20000000/19430000/19423600/19423555/ef96f783.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Louisville Mall of St. Matthews St. Matthews 9.4/10 Exceptional (821) "Great location " CA $149 CA $175 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Louisville-Hotels-Hilton-Garden-Inn-Louisville-Mall-Of-St-Matthews.h19423555.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/29000000/28910000/28909100/28909056/f1d204ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/29000000/28910000/28909100/28909056/0a005a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/29000000/28910000/28909100/28909056/35fa3877.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/29000000/28910000/28909100/28909056/ba42d241.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Graduate by Hilton Bloomington Bloomington 9.6/10 Exceptional (1003) "Enjoyable stay!" CA $214 CA $240 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Bloomington-Hotels-Graduate-Bloomington.h28909056.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474822/7c7ac3d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474822/df9adc0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474822/518735ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474822/4f6ae94b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn by Hilton Richwood Cincinnati South Walton 9.6/10 Exceptional (1003) "Very clean, friendly and helpful staff!" CA $167 CA $187 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Covington-Hotels-Hampton-Inn-Richwood-Cincinnati-South.h64474822.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16000/15914/96fcf8cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/16000/15914/4c6b9834.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/16000/15914/995e5029.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/16000/15914/e2396c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Cincinnati / Sharonville Convention Center Sharonville 8.8/10 Excellent (1332) "The breakfast was good for a hotel, friendly staff and clean facility." CA $142 CA $168 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Cincinnati-Hotels-Hyatt-Place-Cincinnati-Sharonville-Convention-Center.h15914.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2170000/2163100/2163055/e2e2323e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/3000000/2170000/2163100/2163055/7634107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2170000/2163100/2163055/17d8ace7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom](https://images.trvl-media.com/lodging/3000000/2170000/2163100/2163055/de8e7ad0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Terre Haute by IHG Downtown Terre Haute 9.2/10 Wonderful (845) "Friendly staff!" CA $133 CA $153 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Terre-Haute-Hotels-Candlewood-Suites-Terre-Haute.h2163055.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123900/123873/3cd8a731.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123900/123873/911ecf7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/130000/123900/123873/5eabcabc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/130000/123900/123873/85521f1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Lafayette, IN Lafayette East 9.6/10 Exceptional (1291) "Great staff in dining area, bar, and check in" CA $149 CA $167 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Lafayette-Hotels-Drury-Inn-Suites-Lafayette.h123873.Hotel-Information) ![Couples treatment rooms, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/6000/5940/3e161f6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room | Living room](https://images.trvl-media.com/lodging/1000000/10000/6000/5940/ad128bd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/1000000/10000/6000/5940/22680000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room](https://images.trvl-media.com/lodging/1000000/10000/6000/5940/128d7b81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Grand Resort Warren 9.4/10 Exceptional (752) "Was here for a wedding and everything was excellent " [](https://www.expedia.ca/Youngstown-Hotels-The-Grand-Resort.h5940.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11710000/11703400/11703343/d3f76254.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/12000000/11710000/11703400/11703343/cc85b249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/12000000/11710000/11703400/11703343/2fd2c2e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/12000000/11710000/11703400/11703343/3ee0c411.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Grove City - Outlet Center by IHG Mercer 8.8/10 Excellent (684) "Staff was super friendly and accommodations were beyond clean" CA $119 CA $133 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Hermitage-Hotels-Candlewood-Suites-Grove-City-Outlet-Center.h11703343.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-29&endDate=2025-10-30®ionId=6233674&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Ohio River Valley Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Room and service was amazing. Easy to get to and plenty to do in the area. Will definitely be our go to hotel when we travel to Louisville for here on out. " [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Drury Inn & Suites Louisville North](//images.trvl-media.com/lodging/13000000/12070000/12067900/12067887/cd166214_y.jpg) ### Drury Inn & Suites Louisville North 10/10 Excellent "Everything was great, parking around the entrances was tough and the spots seemed kinda tight, but overall was terrible!" [](https://expedia.ca/Louisville-Hotels-Drury-Inn-Suites-Louisville-North.h12067887.Hotel-Information) ![Courtyard by Marriott Louisville Airport](//images.trvl-media.com/lodging/1000000/880000/874400/874388/9148c40a_y.jpg) ### Courtyard by Marriott Louisville Airport 10/10 Excellent "Very nice staff and big clean rooms " [](https://expedia.ca/Louisville-Hotels-Courtyard-By-Marriott-Louisville-Airport.h874388.Hotel-Information) ![Radisson Hotel Cincinnati Riverfront](//images.trvl-media.com/lodging/1000000/10000/2800/2755/68cff2fd_y.jpg) ### Radisson Hotel Cincinnati Riverfront 10/10 Excellent "Yes" [](https://expedia.ca/Cincinnati-Hotels-Radisson-Hotel-Cincinnati-Riverfront.h2755.Hotel-Information) ![Drury Inn & Suites Louisville East](//images.trvl-media.com/lodging/1000000/800000/793000/792962/d2587f53_y.jpg) ### Drury Inn & Suites Louisville East 10/10 Excellent "Very good staff and property were great! " [](https://expedia.ca/Louisville-Hotels-Drury-Inn-Suites-Louisville-East.h792962.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [1 Star Hotels in Historic Route 66](https://www.expedia.ca/1Star-Historic-Route-66-Hotels.s10-0-d702654640613646336.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Historic Route 66](https://www.expedia.ca/2Star-Historic-Route-66-Hotels.s20-0-d702654640613646336.Travel-Guide-Filter-Hotels) - [B&B in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Bed-And-Breakfast.d702654640613646336-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Cabins.d702654640613646336-aaCabins.Travel-Guide-Accommodation) - [Chalets in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Chalets.d702654640613646336-aaChalets.Travel-Guide-Accommodation) - [Condo Rentals in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Condos.d702654640613646336-aaCondos.Travel-Guide-Accommodation) - [Cottages in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Cottages.d702654640613646336-aaCottages.Travel-Guide-Accommodation) - [Hostels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hostels.d702654640613646336-aaHostels.Travel-Guide-Accommodation) - [Cheap Hotels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hotels-Cheap-Hotels.0-0-d702654640613646336-tCheapHotels.Travel-Guide-Filter-Hotels) - [Club Quarters Hotels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hotels-Club-Quarters.0-0-d702654640613646336--bClubQuarters.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hotels-Luxury-Hotel.0-0-d702654640613646336-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hotels-Motel-6.0-0-d702654640613646336--bMotel6.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hotels-Red-Roof-Inn.0-0-d702654640613646336--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Sonesta Hotel in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hotels-Sonesta-Hotel.0-0-d702654640613646336--bSonestaHotel.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Hotels-Wyndham-Extra-Holidays.0-0-d702654640613646336--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Historic Route 66 Hotels](https://www.expedia.ca/Historic-Route-66-Hotels.d702654640613646336.Travel-Guide-Hotels) - [Inns in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Inns.d702654640613646336-aaInns.Travel-Guide-Accommodation) - [Lodges in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Lodges.d702654640613646336-aaLodges.Travel-Guide-Accommodation) - [Motels in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Motels.d702654640613646336-aaMotels.Travel-Guide-Accommodation) - [Resorts in Historic Route 66](https://www.expedia.ca/Historic-Route-66-Resort-Hotels.d702654640613646336-aaResortHotels.Travel-Guide-Accommodation) - [Hotels near Ohio River](https://www.expedia.ca/Ohio-River-Hotels.0-l681940626945888256-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Southeastern Indiana](https://www.expedia.ca/Southeastern-Indiana-Hotels-Boutique-Hotel.0-0-d6233889-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Southeastern Indiana](https://www.expedia.ca/Southeastern-Indiana-Hotels-Casino-Hotel.0-0-d6233889-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Southeastern Indiana](https://www.expedia.ca/Southeastern-Indiana-Hotels-Couples-Resorts-Hotels.0-0-d6233889-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in Southeastern Indiana](https://www.expedia.ca/Southeastern-Indiana-Hotels-Hotels-With-Smoking-Rooms.0-0-d6233889-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels in Southeastern Indiana](https://www.expedia.ca/Southeastern-Indiana-Hotels-Red-Roof-Inn.0-0-d6233889--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Southeastern Indiana](https://www.expedia.ca/Southeastern-Indiana-Hotels-Waterpark-Hotels.0-0-d6233889-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Southeastern Indiana Hotels](https://www.expedia.ca/Southeastern-Indiana-Hotels.d6233889.Travel-Guide-Hotels) - [Motels in Southeastern Indiana](https://www.expedia.ca/Southeastern-Indiana-Motels.d6233889-aaMotels.Travel-Guide-Accommodation) - [B&B in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Bed-And-Breakfast.d6059635-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Cabins.d6059635-aaCabins.Travel-Guide-Accommodation) - [Chalets in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Chalets.d6059635-aaChalets.Travel-Guide-Accommodation) - [Hostels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hostels.d6059635-aaHostels.Travel-Guide-Accommodation) - [Beach Hotel Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Beach-Hotel.0-0-d6059635-tBeachHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Casino-Hotel.0-0-d6059635-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Cheap-Hotels.0-0-d6059635-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Hilton-Hotels.0-0-d6059635--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Hotels-With-Free-Parking.0-0-d6059635-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Hotels-With-Hot-Tubs.0-0-d6059635-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotels with Tennis Courts in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Hotels-With-Tennis-Courts.0-0-d6059635-tHotelswithTennisCourts.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-La-Quinta-Inn-Suites.0-0-d6059635--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Luxury-Hotel.0-0-d6059635-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Marriott-Hotels-Resorts.0-0-d6059635--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Omni Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Omni.0-0-d6059635--bOmni.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Pet-Friendly-Hotel.0-0-d6059635-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Red-Roof-Inn.0-0-d6059635--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Romantic-Hotel.0-0-d6059635-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Hotels-Waterpark-Hotels.0-0-d6059635-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Southern Indiana Hotels](https://www.expedia.ca/Southern-Indiana-Hotels.d6059635.Travel-Guide-Hotels) - [Motels in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Motels.d6059635-aaMotels.Travel-Guide-Accommodation) - [Resorts in Southern Indiana](https://www.expedia.ca/Southern-Indiana-Resort-Hotels.d6059635-aaResortHotels.Travel-Guide-Accommodation) - [Cheap Hotels in Southwestern Indiana](https://www.expedia.ca/Southwestern-Indiana-Hotels-Cheap-Hotels.0-0-d6233876-tCheapHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Southwestern Indiana](https://www.expedia.ca/Southwestern-Indiana-Hotels-Historic-Hotel.0-0-d6233876-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Southwestern Indiana](https://www.expedia.ca/Southwestern-Indiana-Hotels-Hotels-With-Hot-Tubs.0-0-d6233876-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Southwestern Indiana](https://www.expedia.ca/Southwestern-Indiana-Hotels-Pet-Friendly-Hotel.0-0-d6233876-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels in Southwestern Indiana](https://www.expedia.ca/Southwestern-Indiana-Hotels-Red-Roof-Inn.0-0-d6233876--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Southwestern Indiana Hotels](https://www.expedia.ca/Southwestern-Indiana-Hotels.d6233876.Travel-Guide-Hotels) - [Resorts in Southwestern Indiana](https://www.expedia.ca/Southwestern-Indiana-Resort-Hotels.d6233876-aaResortHotels.Travel-Guide-Accommodation) - [Flights to Historic Route 66](https://www.expedia.ca/Cheap-Flights-To-Historic-Route-66.d702654640613646336.Travel-Guide-Flights) - [Flights to Southern Indiana](https://www.expedia.ca/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights) - [Flights to Southwestern Indiana](https://www.expedia.ca/Cheap-Flights-To-Southwestern-Indiana.d6233876.Travel-Guide-Flights) - [Flights from Atlanta to Southern Indiana](https://www.expedia.ca/lp/flights/178232/6059635/atlanta-to-southern-indiana) - [Flights from Philadelphia to Southern Indiana](https://www.expedia.ca/lp/flights/178297/6059635/philadelphia-to-southern-indiana) - [Flights from Phoenix to Historic Route 66](https://www.expedia.ca/lp/flights/178298/702654640613646336/phoenix-to-historic-route-66) - [Flights from Seattle to Southern Indiana](https://www.expedia.ca/lp/flights/178307/6059635/seattle-to-southern-indiana) - [Flights from Buffalo to Southern Indiana](https://www.expedia.ca/lp/flights/602674/6059635/buffalo-to-southern-indiana) - [Historic Route 66 Vacations](https://www.expedia.ca/Historic-Route-66.d702654640613646336.Destination-Travel-Guides) - [Southern Indiana Vacations](https://www.expedia.ca/Southern-Indiana.d6059635.Destination-Travel-Guides) - [Visit Southern Indiana](https://www.expedia.ca/Southern-Indiana.dx6059635) - [Visit Southwestern Indiana](https://www.expedia.ca/Southwestern-Indiana.dx6233876) - [Ada Rental Cars in Historic Route 66](https://www.expedia.ca/ADA-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1109.Car-Rental-Guide-Suppliers) - [Airport Van Rental Rental Cars in Historic Route 66](https://www.expedia.ca/Airport-Van-Rental-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1092.Car-Rental-Guide-Suppliers) - [Amigo Autos Rental Cars in Historic Route 66](https://www.expedia.ca/Amigo-Autos-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1128.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Historic Route 66](https://www.expedia.ca/Avis-Car-Rentals-In-Historic-Route-66.d702654640613646336-c41.Car-Rental-Guide-Suppliers) - [Car rentals near Historic Route 66](https://www.expedia.ca/Car-Rentals-In-Historic-Route-66.d702654640613646336.Car-Rental-Guide) - [Click & Rent Rental Cars in Historic Route 66](https://www.expedia.ca/Click-Rent-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1089.Car-Rental-Guide-Suppliers) - [Convertible Car Rentals in Historic Route 66](https://www.expedia.ca/Convertible-Car-Rentals-In-Historic-Route-66.d702654640613646336-tConvertible.Car-Rental-Guide-Class) - [Drive-A-Matic Rental Cars in Historic Route 66](https://www.expedia.ca/Drive-A-Matic-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1082.Car-Rental-Guide-Suppliers) - [Drive on Holidays Rental Cars in Historic Route 66](https://www.expedia.ca/Drive-On-Holidays-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1050.Car-Rental-Guide-Suppliers) - [Firefly Rental Cars in Historic Route 66](https://www.expedia.ca/Firefly-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1040.Car-Rental-Guide-Suppliers) - [Firefly Portugal Rental Cars in Historic Route 66](https://www.expedia.ca/Firefly-Portugal-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1071.Car-Rental-Guide-Suppliers) - [First Car Rental Rental Cars in Historic Route 66](https://www.expedia.ca/First-Car-Rental-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1107.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Historic Route 66](https://www.expedia.ca/Hertz-Car-Rentals-In-Historic-Route-66.d702654640613646336-c40.Car-Rental-Guide-Suppliers) - [Jumbo Car Rental Cars in Historic Route 66](https://www.expedia.ca/Jumbo-Car-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1067.Car-Rental-Guide-Suppliers) - [Luxury Car Rentals in Historic Route 66](https://www.expedia.ca/Luxury-Car-Rentals-In-Historic-Route-66.d702654640613646336-tLuxury.Car-Rental-Guide-Class) - [Midway Car Rental Rental Cars in Historic Route 66](https://www.expedia.ca/Midway-Car-Rental-Car-Rentals-In-Historic-Route-66.d702654640613646336-c27.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in Historic Route 66](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Historic-Route-66.d702654640613646336-c42.Car-Rental-Guide-Suppliers) - [Offer Car Hire Rental Cars in Historic Route 66](https://www.expedia.ca/Offer-Car-Hire-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1141.Car-Rental-Guide-Suppliers) - [Orlando Rental Cars in Historic Route 66](https://www.expedia.ca/Orlando-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1047.Car-Rental-Guide-Suppliers) - [Pickup Car Rentals in Historic Route 66](https://www.expedia.ca/Pickup-Car-Rentals-In-Historic-Route-66.d702654640613646336-tPickup.Car-Rental-Guide-Class) - [Priceless Car Rental Rental Cars in Historic Route 66](https://www.expedia.ca/Priceless-Car-Rental-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1060.Car-Rental-Guide-Suppliers) - [Rent A Wreck Rental Cars in Historic Route 66](https://www.expedia.ca/Rent-A-Wreck-Car-Rentals-In-Historic-Route-66.d702654640613646336-c33.Car-Rental-Guide-Suppliers) - [Rent A Wreck Rental Cars in Southern Indiana](https://www.expedia.ca/Rent-A-Wreck-Car-Rentals-In-Southern-Indiana.d6059635-c33.Car-Rental-Guide-Suppliers) - [Routes Rental Cars in Historic Route 66](https://www.expedia.ca/Routes-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1101.Car-Rental-Guide-Suppliers) - [Thai Cars Rental Cars in Historic Route 66](https://www.expedia.ca/Thai-Cars-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1027.Car-Rental-Guide-Suppliers) - [Thrifty Car Rental Rental Cars in Historic Route 66](https://www.expedia.ca/Thrifty-Car-Rental-Car-Rentals-In-Historic-Route-66.d702654640613646336-c45.Car-Rental-Guide-Suppliers) - [Van Car Rentals in Historic Route 66](https://www.expedia.ca/Van-Car-Rentals-In-Historic-Route-66.d702654640613646336-tVan.Car-Rental-Guide-Class) - [Wiber Rental Cars in Historic Route 66](https://www.expedia.ca/WIber-Car-Rentals-In-Historic-Route-66.d702654640613646336-c1127.Car-Rental-Guide-Suppliers) - [Historic Route 66 Vacation Rentals](https://www.expedia.ca/Historic-Route-66-Vacation-Rentals.d702654640613646336.Travel-Guide-VacationRentals) - [Things to do in Southern Indiana](https://www.expedia.ca/Things-To-Do-In-Southern-Indiana.d6059635.Travel-Guide-Activities) - [Book Hotels near Ohio River Valley on Expedia.com](https://www.expedia.com/Ohio-River-Valley-Hotels-Spa-Hotel.0-0-d6233674-tSpaHotel.Travel-Guide-Filter-Hotels)