Wyndham Hotels Hotels in Santee
South Carolina
United States of America
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Find Hotels by Wyndham Hotels in Santee from CA $76

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your current months are November, 2026 and December, 2026.

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Top Santee Hotel Reviews

A hotel entrance with a sign reading "Best Western PLISS."

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

Best Western Plus Santee Inn

Santee

10/10 Excellent

Courteous reception,clean rooms and great breakfast! Have been there many times in the last 15 years and I will return.!

Roger

Reviewed February 18, 2026Reviewed February 18, 2026

Best Western Plus Santee Inn

A hotel room with a bed, bedside table, lamp, and a mirror.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

Baymont by Wyndham Santee

Santee

10/10 Excellent

Nice and cheap!

Martin

Reviewed August 1, 2026Reviewed August 1, 2026

Baymont by Wyndham Santee

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

Comfort Inn & Suites Santee

Santee

10/10 Excellent

Great location and staff

Nichole

Reviewed July 16, 2026Reviewed July 16, 2026

Comfort Inn & Suites Santee

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A motel with a brick facade, a covered entrance, and a satellite dish.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

Travelodge by Wyndham Santee

Santee

10/10 Excellent

Richard

Reviewed October 29, 2026Reviewed October 29, 2026

Travelodge by Wyndham Santee

A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.

A modern dining area with tables and chairs, large windows with sheer curtains, and pendant lighting.

A snack shop with a sign reading "Hampton Suite Shop" and a variety of snacks and drinks on display.

A hotel room with a large bed, a desk with a flat-screen TV, a chair, a desk lamp, and a window with curtains.

Hampton Inn & Suites Orangeburg

Orangeburg

10/10 Excellent

Our check in with Tanya was great! She was sooo friendly and efficient. And gave us great advice about getting dinner as we were late :-)

Monique

Reviewed October 1, 2023Reviewed October 1, 2023

Hampton Inn & Suites Orangeburg

A spacious dining area with multiple tables and chairs, a reception desk, and large windows providing natural light.

A modern lobby with a wooden ceiling, a central seating area with a round table, and a bar with a variety of bottles.

A hotel room with two beds, a seating area, and a large abstract painting on the wall.

An outdoor patio area with a fire pit, seating, and tables.

SpringHill Suites by Marriott Orangeburg

Orangeburg

10/10 Excellent

Mike

Reviewed April 4, 2026Reviewed April 4, 2026

SpringHill Suites by Marriott Orangeburg

A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.

A modern bar area with a stone fireplace, a flat-screen TV, and a coffee station.

A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.

A corner market with a refrigerator stocked with beverages and snacks.

Fairfield Inn by Marriott Orangeburg

Orangeburg

10/10 Excellent

Very good safety easy parking

gene

Reviewed May 8, 2026Reviewed May 8, 2026

Fairfield Inn by Marriott Orangeburg

A hotel room with two beds, a desk, a chair, and a mirror.

A wooden pergola with a bench, a well-maintained lawn, and a parking area with buildings in the background.

A modern cafe with a stone backsplash, wooden cabinets, and yellow chairs.

A living room with a sofa, armchair, coffee table, and a flat-screen TV mounted on the wall.

SureStay Hotel by Best Western Manning

Manning

10/10 Excellent

Le personnelle etait super bien , dejeuner bien , la chambre etait propre

Stéphanie

Reviewed August 16, 2026Reviewed August 16, 2026

SureStay Hotel by Best Western Manning

A Holiday Inn Express & Suites hotel with a prominent sign, a central entrance, and a symmetrical facade.

A buffet with various food items, including omelets and other dishes, served in metal trays.

A hotel room with a large bed, a desk, a chair, a nightstand, and a wall-mounted lamp.

Holiday Inn Express & Suites Orangeburg by IHG

Orangeburg

10/10 Excellent

We stopped here for the night as we were passing through SC, the hotel is going through renovations so expect some dust and tape on the walls but aside from that it is a lovely place, the rooms are very nice and the beds are extremely comfortable and we had no issue parking with a truck and trailer

Lianna

Reviewed March 8, 2026Reviewed March 8, 2026

Holiday Inn Express & Suites Orangeburg by IHG

A hotel lobby with multiple seating areas, a reception desk, and a television.

A hotel room with two beds, a TV, a desk, and a chair.

A hotel lobby with a reception desk, seating area, and a large potted plant.

A hotel lobby with seating areas, a television, and a patterned carpet.

Hampton Inn Manning

Manning

10/10 Excellent

Staff at check in very friendly. Made sure we had a quiet room.

Reviewed April 25, 2023Reviewed April 25, 2023

Hampton Inn Manning

A modern indoor pool area with a table and chairs, large windows, and a poolside lounge with sun loungers.

A modern indoor swimming pool with clear glass walls, sunlit lounge areas, and a view of greenery outside.

A modern kitchen with a wooden table and bench, blue cabinets, and a yellow pendant light fixture.

A hotel with a modern design, featuring a prominent 'Spark' sign, a well-maintained lawn, and a clear driveway.

Spark by Hilton Orangeburg

Orangeburg

10/10 Excellent

Excellent accueillant tranquille

Stephane

Reviewed August 6, 2026Reviewed August 6, 2026

Spark by Hilton Orangeburg

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Find Hotels by Wyndham Hotels in Santee from CA $76

Change your mind

Treat yourself

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Check prices for these dates

Top Santee Hotel Reviews

Best Western Plus Santee Inn

10/10 Excellent

Explore a world of travel with Expedia