Title: Hotels by Independent in Santee from CA $74 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Santee from CA $74 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 27 - Nov 28](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-27&endDate=2025-11-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 28 - Nov 29](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-28&endDate=2025-11-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santee Independent Hotels ![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/f65392f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/a8f3bd84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/ea2cde47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peach Tree Inn St. George 7.2/10 Good (133) "Air conditioning very good, check in easy, staff very pleasant" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda [](https://www.expedia.ca/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) ![Comfort Single Room](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/68f1bad2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/a28b899c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/acdf1d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/cd9fd1ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Orangeburg Inn & Suites Orangeburg 6.2/10 (55) "close to restaurants and shops " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jay [](https://www.expedia.ca/Orangeburg-Hotels-Orangeburg-Inn-Suites.h105693778.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/1438b095.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/edeeacb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/0d89d19d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room Double Bed](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/9501bd94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Inn of Manning Manning 7.4/10 Good (6) "I was not pleased that I called after making reservation to request a room on the main level and was told that they would make a note and that this would be arranged but when I got there, they had me in an upstairs room. When I discussed this with the young lady at the front desk, she was kind and accomodating but I was put in a room then switched to another room. The bath tub faucet came out of the wall when I tried to pull up the tub plug. There was no waste basket in the room and the floor... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) rhonda CA $103 CA $114 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Manning-Hotels-Best-Inn-Of-Manning.h120759451.Hotel-Information) ![Cabin, 1 Bedroom, Non Smoking, Lake View | Private kitchen](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/a4a585ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchenette](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/9d898fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/795ddf27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/cc5e5eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bells Marina & Resort Eutawville 8.6/10 Excellent (77) "Room was clean with a beautiful view of the Lake." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melanie CA $85 CA $94 total includes taxes & fees Dec 10 - Dec 11 [](https://www.expedia.ca/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information) ![Basic Double Room](https://images.trvl-media.com/lodging/38000000/37990000/37985500/37985493/9f33030a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom](https://images.trvl-media.com/lodging/38000000/37990000/37985500/37985493/939e2a74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37990000/37985500/37985493/ebd370dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom](https://images.trvl-media.com/lodging/38000000/37990000/37985500/37985493/dc0e6344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Starlight Stays Manning 6.4/10 (6) "It was nice for the area " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kendrell CA $66 CA $74 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Manning-Hotels-OYO-Hotel-Manning-SC.h37985493.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/3d5346d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/8fe42751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/1e69568c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/f4e6785a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6 Summerton 9.6/10 Exceptional (15) "Convenient location, enjoyed fishing from dock in front too. Just right for quick fishing trip." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris R. CA $120 CA $242 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/6d916484.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/c7cb77b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/89ff8c53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/2111d298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pet friendly country cottage with large fenced-in yard & horses on property Holly Hill 10/10 Exceptional (122) "Perfect, quiet spot for relaxing with your family and fur babies. This little house had everything we needed!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darlyn H. CA $158 CA $290 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Holly-Hill-Hotels-Come-Relax-In-The-Country.h95993146.Hotel-Information) ![Marina](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/431a876d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/32f986d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/2a06c7ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/0949138a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable Summerton 9.6/10 Exceptional (241) "Great place. Had a blast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim L. [](https://www.expedia.ca/Summerton-Hotels-SANITIZED-Lake-Marion-Lakefront-Sandy-Beach.h19993568.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/96000000/95950000/95947400/95947355/701a4df0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/96000000/95950000/95947400/95947355/50311486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/96000000/95950000/95947400/95947355/c8bee83b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/96000000/95950000/95947400/95947355/238cfd98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bunkhouse at St Julien - Vintage Waterfront Lake House Eutawville 9.8/10 Exceptional (28) "plenty of room, quiet, and perfect for a family getaway" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carin O. [](https://www.expedia.ca/Eutawville-Hotels-The-Bunkhouse-At-St-Julien-Vintage-Waterfront-Lake-House.h95947355.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/37000000/36700000/36699800/36699787/c375870c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/37000000/36700000/36699800/36699787/4a7a8e03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/37000000/36700000/36699800/36699787/90-fa84a108.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/37000000/36700000/36699800/36699787/90-b1151cf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful lake home to make your family vacation extra special! Summerton 9.0/10 Wonderful (58) "This was an awesome stay! Home was clean and comfortable. Great hosts!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lutricia J. [](https://www.expedia.ca/Sumter-Hotels-Beautiful-Lake-Home-To-Make-Your-Family-Vacation-Extra-Special.h36699787.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-13®ionId=9953&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels-Independent.0-0-d9953--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels-Independent.0-0-d9953--bIndependent.Travel-Guide-Filter-Hotels) ## Top Santee Hotel Reviews ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg) ### Fairfield Inn & Suites by Marriott Santee 10/10 Excellent "Everything was great!" [](https://expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg) ### Tru By Hilton Santee 10/10 Excellent "Clean room, friendly staff" [](https://expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "Check in was great. Latoya was wonderful she saw that I was pulling a trailer and made sure to tell me where I could park that was near my room. She was the sweetest lady. The room was clean. No bugs (big one for me). And although right off I95 it was very quiet. The rooms face outside so parking in front of your room. " [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg) ### Travelodge by Wyndham Santee 10/10 Excellent "Very comfortable beds and clean room!" [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "Room was clean and smelled clean... not musty or perfumey. Staff was friendly. " [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "Nice rooms and very good breakfast items." [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Charming 2 Bedroom Waterfront Lake Marion Condo](https://images.trvl-media.com/lodging/113000000/112150000/112150000/112149977/c68f4c0f_y.jpg) ### Charming 2 Bedroom Waterfront Lake Marion Condo 10/10 Excellent "The host was attentive and responsive, even inviting us to check in earlier. The home was lovely, well-cared for and thoughtfully appointed. The small touches, such as a basket of coffee and filters along with some snacks allowed us to have coffee the next morning despite getting into town when the stores were closed. We will absolutely return to this property and feel comfortable recommending it others. " [](https://expedia.ca/Santee-Hotels-Charming-2-Bedroom-Waterfront-Lake-Marion-Condo.h112149977.Hotel-Information) ![Red Roof Inn Santee](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f_y.jpg) ### Red Roof Inn Santee 10/10 Excellent "It's a good stop for the price " [](https://expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Everything was what we expected. " [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Manning](https://www.expedia.ca/5Star-Manning-Hotels.s50-0-d8454.Travel-Guide-Filter-Hotels) - [Independent Hotels in Blackville](https://www.expedia.ca/Blackville-Hotels-Independent.0-0-d3000455854--bIndependent.Travel-Guide-Filter-Hotels) - [B&B in Bowman](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Red Roof Inn Hotels in Bowman](https://www.expedia.ca/Bowman-Hotels-Red-Roof-Inn.0-0-d553248634998681915--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Bowman Hotels](https://www.expedia.ca/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [Apartments in Brookdale](https://www.expedia.ca/Brookdale-Apartments.d553248634999003908-aaApartments.Travel-Guide-Accommodation) - [Hotels with Free Breakfast in Brookdale](https://www.expedia.ca/Brookdale-Hotels-Hotels-With-Free-Breakfast.0-0-d553248634999003908-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - 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