Title: Hotels by Independent in Santee from CA $76 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/271db9a9db85f6f3488271b71d2f238f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Santee from CA $76 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-11&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santee Independent Hotels ![Comfort Single Room](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/68f1bad2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/acdf1d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/cd9fd1ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/106000000/105700000/105693800/105693778/a28b899c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Orangeburg Inn & Suites Orangeburg 6.2/10 (50) "close to restaurants and shops " CA $67 CA $76 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Orangeburg-Hotels-Orangeburg-Inn-Suites.h105693778.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/495c8e2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/795ddf27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, coffee/tea maker, blender](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/9d898fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/cc5e5eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bells Marina & Resort Eutawville 8.6/10 Excellent (75) "Had a great stay" CA $129 CA $143 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/6d916484.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/cc0e968f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/89ff8c53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/96000000/96000000/95993200/95993146/c7cb77b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pet friendly country cottage with large fenced-in yard & horses on property Holly Hill 10/10 Exceptional (112) "My daughter, dog and I were traveling from NC to Tampa, FL. on local roads and Kay's cottage was the best place to stop at! Her cottage has everything you need for a comfortable stay and a perfect fenced in front yard for our dog. We truly enjoyed our stay. Wish we could have stayed longer! " CA $158 CA $284 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Holly-Hill-Hotels-Come-Relax-In-The-Country.h95993146.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/f65392f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/ea2cde47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/a844f756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peach Tree Inn St. George 7.2/10 Good (122) "Enjoyed my stay" CA $95 CA $102 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/3d5346d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/1e69568c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/8fe42751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/f4e6785a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6 Summerton 10/10 Exceptional (11) "Absolutely loved the property, and the property manager was very friendly and answered all inquiries." CA $105 CA $225 total includes taxes & fees Oct 22 - Oct 23 [](https://www.expedia.ca/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/91000000/90710000/90707500/90707426/bfad6db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90710000/90707500/90707426/94e37995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/91000000/90710000/90707500/90707426/e312bca7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90710000/90707500/90707426/ad268e4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Marion Lakehouse with 180° lake view Elloree 10/10 Exceptional (73) "I would stay here again. Great location." [](https://www.expedia.ca/Elloree-Hotels-Lake-Marion-Lakehouse.h90707426.Hotel-Information) ![Marina](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/431a876d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/2a06c7ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/0949138a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/20000000/20000000/19993600/19993568/1c153d9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable Summerton 9.6/10 Exceptional (241) "The property was nice and had enough room for all 12 of us, 3 boats and all of the fishing equipment. Loved the long dock and the location that’s not far from the big water. We would stay here again when we come back to fish Lake Marion." [](https://www.expedia.ca/Summerton-Hotels-SANITIZED-Lake-Marion-Lakefront-Sandy-Beach.h19993568.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/85000000/84060000/84051800/84051774/9ca79187.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/85000000/84060000/84051800/84051774/8e3d35e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, foosball](https://images.trvl-media.com/lodging/85000000/84060000/84051800/84051774/83c6ff16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/85000000/84060000/84051800/84051774/99351946.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!! Summerton 9.6/10 Exceptional (44) "Clean house. Had a nice dock and view of lake. Owner live next door and was very friendly. Great place, would stay again." [](https://www.expedia.ca/Summerton-Hotels-Beautiful-Lakefront-Views-On-Lake-Marion-Pet-Friendly.h84051774.Hotel-Information) ![Fireplace](https://images.trvl-media.com/lodging/91000000/90990000/90985000/90984996/3ab6f603.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90990000/90985000/90984996/a32d6966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90990000/90985000/90984996/c7db76fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/91000000/90990000/90985000/90984996/66830060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Big Mama's Lakeside Cottage Lake Marion Manning 10/10 Exceptional (13) "We enjoyed our stay at Big Mama’s Cottage. The house has lots of space and a nice dock for fishing. One side of the yard is fenced in for your dog. We would stay again! " [](https://www.expedia.ca/Manning-Hotels-Big-Mamas-Lakeside-Cottage-Lake-Marion.h90984996.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/3f704424.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/fa6eea82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/7ade87f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/108000000/107440000/107431600/107431587/d3a39e7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Resting Spot just off I95. 12 miles west on hwy 6. Elloree 9.2/10 Wonderful (19) "It was very clean and had everything i needed. The host checked in with me while i was there though messages which was nice too. " CA $145 CA $211 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Elloree-Hotels-Country-Resting-Spot.h107431587.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=9953&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels-Independent.0-0-d9953--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels-Independent.0-0-d9953--bIndependent.Travel-Guide-Filter-Hotels) ## Top Santee Hotel Reviews ![Fairfield Inn & Suites by Marriott Santee](//images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg) ### Fairfield Inn & Suites by Marriott Santee 10/10 Excellent "place was beautiful, workers were nice and courteous and helpful" [](https://expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Holiday Inn Santee by IHG](//images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1_y.jpg) ### Holiday Inn Santee by IHG 10/10 Excellent "Acting GM was very friendly Happy hour was nice" [](https://expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Tru By Hilton Santee](//images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg) ### Tru By Hilton Santee 10/10 Excellent "Very nice facility " [](https://expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Baymont by Wyndham Santee](//images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "Great place to stop on our way to Florida. Places to shop and dine. Hotel is nice and good breakfast. " [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Travelodge by Wyndham Santee](//images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg) ### Travelodge by Wyndham Santee 10/10 Excellent "The counter tops and appliances needed cleaning, they were greasy. Otherwise the room was okay." [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!](//images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/dc99579a_y.jpg) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! 10/10 Excellent "Great house, very modern interior. Very clean. Close to town. We’ll definitely book the house on our fishing trip. " [](https://expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![Hampton Inn Santee-I-95](//images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "We had a nice and courteous and friendly. Bed was comfortable " [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Quality Inn & Suites](//images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/3861a053_y.jpg) ### Quality Inn & Suites 10/10 Excellent "Great place. Excellent people. Great service" [](https://expedia.ca/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) ![Ramada by Wyndham Santee I-95](//images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6_y.jpg) ### Ramada by Wyndham Santee I-95 10/10 Excellent "The grounds and property were clean and you could tell they take pride in what they're offering." 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