Title: Book the Best Santee FAMILY FRIENDLY Hotels from CA $94 - Kid-Friendly Hotels in Santee, SC | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Family Hotels in Santee, SC from CA $94 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Family Hotels Tonight [Nov 18 - Nov 19](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-18&endDate=2025-11-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Tomorrow [Nov 19 - Nov 20](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-19&endDate=2025-11-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) This weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-21&endDate=2025-11-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) ## Top Santee Family Hotels ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/e78e5670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee Santee 9.8/10 Exceptional (1003) "Very welcoming, hotel has a clean and friendly presentation." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) VALERIE AND JOHN CA $163 CA $181 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/aa87475c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/ddfa8a2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/6e319d52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee Santee 8.0/10 Very good (1003) "Service was great breakfast was good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary CA $150 CA $167 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/4aad61ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/725815f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn Santee 8.8/10 Excellent (1000) "We really enjoyed our stay and will be back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $166 CA $184 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/eeb5fa18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/756c72ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Santee Santee 7.0/10 Good (668) "Good location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $85 CA $94 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/46b8e295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/dc99579a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/339c1207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/431d124d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! Santee 10/10 Exceptional (36) "Amazing host, comfy furniture, the fenced in yard was perfect for our fur babies! Hope to stay here again. 1.2 miles away from I-95! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren B. CA $141 CA $462 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/1f93ecf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/6c8567ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/51caeaed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/60673add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Santee 6.4/10 (309) "Check in was easy." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy CA $88 CA $98 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/377ba79f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/cc6b1fba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/5fe5c871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Non Smoking (Efficiency)](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990272/1c1fc707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Orangeburg Orangeburg 8.0/10 Very good (537) "The room was clean, and the bed was comfortable. The staff was friendly and welcoming. The breakfast was pretty good, too." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LINA CA $134 CA $149 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites.h1990272.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/c19ebd52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/a07c5e78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/1732be44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/600000/597800/597750/acfce64d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Orangeburg by IHG Orangeburg 8.6/10 Excellent (790) "Easley to find, clean, great breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) albert CA $171 CA $190 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Orangeburg-Hotels-Holiday-Inn-Express-Hotel-Suites-Orangeburg.h597750.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/2eadf4bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/816f12dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/e088653f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/a66aad1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham St George St. George 7.6/10 Good (1003) "Helpful folks at check in and super clean room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peter CA $105 CA $117 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/59c2a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/26332b61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/ed7f19cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/a3fff5e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country living lake style near Santee Summerton 10/10 Exceptional (39) "Great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim E. CA $120 CA $283 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Sumter-Hotels-Country-Living-Lake-Style.h68032053.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-02&endDate=2025-12-03®ionId=9953&adults=2&travelerType=family_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Santee Hotel Reviews ### Travelodge by Wyndham Santee 10/10 Excellent "They are renovating this hotel. It was nice now, but will be great when the renovation is completed." [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ### Comfort Inn & Suites Santee 10/10 Excellent "Friendly staff room was clean" [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ### Hampton Inn Santee-I-95 10/10 Excellent "Clean room and friendly staff. " [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ### Baymont by Wyndham Santee 10/10 Excellent "Room is very clean. Good for the prize. I recommend this place " [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ### Super 8 by Wyndham Santee 10/10 Excellent "Clean, easy to get on and off 95 north or south" [](https://expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ### Holiday Inn Santee by IHG 10/10 Excellent "Very friendly staff. Easy location right off 95...Perfect. " [](https://expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ### Best Western Plus Santee Inn 10/10 Excellent "Room was nice and friendly staff!" [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ### Ramada by Wyndham Santee I-95 10/10 Excellent "The grounds and property were clean and you could tell they take pride in what they're offering." [](https://expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ### Econo Lodge 8/10 Good "Clean room. No issues with late check" [](https://expedia.ca/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) ## Frequently asked questions ### What's Santee like for family-friendly vacations? > The welcoming destination of Santee is a great choice if you've been thinking about a vacation with the kids. The excursions, lake views, and golfing are just a few things that make this an attractive vacation spot for families. Arrange a flight into Columbia Metropolitan Airport (CAE), which is located 49 mi (78.8 km) from the city center. ### What's the best place to stay for families in Santee? > [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. [Comfort Inn & Suites Santee](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) is another choice for your stay with the kids. ### When's the best time to book a family-friendly vacation in Santee? > The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches. ### What's there to see and do with your family in Santee? > While you and your family are visiting Santee, you might want to check out some kid-friendly attractions such as Santee Indian Mound and Fort Watson Site and Orangeburg County Library Mentor Branch. 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