Title: Book the Best Santee FAMILY FRIENDLY Hotels from CA $94 - Kid-Friendly Hotels in Santee, SC | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Family Hotels Tonight [Feb 17 - Feb 18](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Tomorrow [Feb 18 - Feb 19](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-02-18&endDate=2026-02-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) This weekend [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Next weekend [Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) ## Our top choices for Santee family-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/67da47be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ec6d0d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn [](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) Santee 8.8/10 Excellent (1,000 reviews) "Nice rooms and very good breakfast items." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen CA $153 CA $170 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Santee 9.8/10 Exceptional (1,006 reviews) "Room had everything we wanted... very clean & fresh, microwave, fridge, comfy beds. Hotel was very nice and close to everything needed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcia CA $165 CA $183 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/aa87475c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/2824d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) Santee 8.0/10 Very good (1,003 reviews) "Clean rooms, nice staff, decent breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale CA $138 CA $153 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/ebe97e99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/eeb5fa18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Santee [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) Santee 7.2/10 Good (699 reviews) "Nice quiet room and a delicious breakfast at a reasonable rate." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph B CA $85 CA $94 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/46b8e295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/61772a9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/42ada466.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/c321e70e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) Santee 10/10 Exceptional (39 reviews) "Great house, very modern interior. Very clean. Close to town. We’ll definitely book the house on our fishing trip. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John H. CA $143 CA $454 total includes taxes & fees Mar 4 - Mar 5 [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/6c8567ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/1f93ecf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/0af71c77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/51caeaed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Santee [](https://www.expedia.ca/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) Santee 6.4/10 (310 reviews) "Last minute arrangements stay was quiet and peaceful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Iasia CA $94 CA $104 total includes taxes & fees Mar 3 - Mar 4 [](https://www.expedia.ca/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/c1880a3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, towels](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/bc8b5a93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/efa2345e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peach Tree Inn [](https://www.expedia.ca/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) St. George 7.4/10 Good (166 reviews) "Clean rooms and pleasant staff. Could use newer towels. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia [](https://www.expedia.ca/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) ![Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/e088653f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/59cd1b4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/2eadf4bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/e85d0e8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham St George [](https://www.expedia.ca/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) St. George 7.6/10 Good (1,000 reviews) "Clean, relaxing, friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Smith CA $121 CA $135 total includes taxes & fees Feb 19 - Feb 20 [](https://www.expedia.ca/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/59c2a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/ed7f19cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/0c397544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/876cda77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country living lake style near Santee [](https://www.expedia.ca/Sumter-Hotels-Country-Living-Lake-Style.h68032053.Hotel-Information) Summerton 10/10 Exceptional (42 reviews) "Great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim E. CA $130 CA $292 total includes taxes & fees Feb 21 - Feb 22 [](https://www.expedia.ca/Sumter-Hotels-Country-Living-Lake-Style.h68032053.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-04&endDate=2026-03-05®ionId=9953&adults=2&travelerType=family_friendly&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at family-friendly hotels in Santee Breakfast included Pool All-inclusive 4 stars 5 stars ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AFFINITY_SPRING_PROMO_9953) ## Top Santee Hotel Reviews ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "Room was nice and clean. Great staff and very personable front Desk. I must say usually the breakfast buffet is just so so but the woman running the breakfast Beverly was just outstanding and she really made everything from the biscuits to the scrambled eggs standout. " [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "Clean room, quiet, good continental breakfast. Friendly staff." [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg) ### Travelodge by Wyndham Santee 10/10 Excellent "Front desk staff friendly and professional. Clean rooms " [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "Clean, spacious room. Comfortable bed. Quiet " [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Place was nice and will stay there again." [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1_y.jpg) ### Holiday Inn Santee by IHG 10/10 Excellent "Bed was so comfy….clean. Great staff." [](https://expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Ramada by Wyndham Santee I-95](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6_y.jpg) ### Ramada by Wyndham Santee I-95 10/10 Excellent "The room was the cleanest of many hotels on a long road trip; cleaner than fancier hotels. Don't freak out when you drive up....it looks like an abandoned building...but the rooms are nice" [](https://expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Super 8 by Wyndham Santee](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881_y.jpg) ### Super 8 by Wyndham Santee 10/10 Excellent "The staff was very friendly and helpful. Room was clean and beds were so comfortable. " [](https://expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ## Frequently asked questions ### What's Santee like for family-friendly vacations? ### What's the best place to stay for families in Santee? ### When's the best time to book a family-friendly vacation in Santee? ### What's there to see and do with your family in Santee? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Bowman ](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Red Roof Inn Hotels in Bowman ](https://www.expedia.ca/Bowman-Hotels-Red-Roof-Inn.0-0-d553248634998681915--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Bowman Hotels ](https://www.expedia.ca/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [Apartments in Brookdale ](https://www.expedia.ca/Brookdale-Apartments.d553248634999003908-aaApartments.Travel-Guide-Accommodation) - 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