Title: Book the Best BUSINESS Hotels in Santee in 2026 | Expedia.ca

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![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find Business Hotels in Santee, SC from CA $91

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## Check availability on Santee Business Hotels

Tonight

[Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

This weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Our top choices for Santee business-friendly hotels

![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c7187353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c5237c95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Santee

[](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

Santee

8.0/10

Very good

(1413)

"Very friendly staff. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ramil

CA $110

CA $122 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/442e4efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/e27bc6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Santee by IHG

[](https://www.expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information)

Santee

8.2/10

Very good

(972)

"Was able to walk to convenience store and other dinning alternatives. Safe secure building"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joan

CA $143

CA $159 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/dc9ab090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/725815f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/4aad61ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Santee Inn

[](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

Santee

8.8/10

Excellent

(1001)

"Nice rooms and very good breakfast items."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

CA $163

CA $180 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/a90b57ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/b105c391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/e9087580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Red Roof Inn Santee

[](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information)

Santee

6.6/10

(637)

"It's a good stop for the price "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Martin

CA $96

CA $107 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information)

![Business centre](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/3861a053.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/10951979.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/ccd798ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/1295e8cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn & Suites Santee I-95

[](https://www.expedia.ca/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information)

Santee

6.0/10

(455)

"exellent service"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mirjana

CA $75

CA $91 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/315e8dc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/aa634b56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/77599f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Santee

[](https://www.expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information)

Santee

6.8/10

(440)

"The staff was very friendly and helpful. Room was clean and beds were so comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathy

CA $90

CA $99 total

includes taxes & fees

Dec 18 - Dec 19

[](https://www.expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/23463ec8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/61b41f5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Santee I-95

[](https://www.expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information)

Santee

6.2/10

(541)

"The grounds and property were clean and you could tell they take pride in what they're offering."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric

CA $102

CA $113 total

includes taxes & fees

Jan 10 - Jan 11, 2026

[](https://www.expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/aa173c27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/6dc9f9a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/c7fdb599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/f8fbcf77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn by Marriott Orangeburg

[](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information)

Orangeburg

8.4/10

Very good

(695)

"The room was absolutely a pleasure to stay in. The bed was incredibly comfortable. The room was well stocked and thoroughly clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Robin

CA $116

CA $128 total

includes taxes & fees

Dec 28 - Dec 29

[](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/1bbd70f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/a4197341.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness studio](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/7b01c436.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru by Hilton Orangeburg

[](https://www.expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information)

Orangeburg

9.2/10

Wonderful

(1007)

"Wonderful stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Josephine

CA $146

CA $162 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/8acfa265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2557x0y3-a96a0495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/321b05a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2556x0y4-5cb4ef80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Spark by Hilton Orangeburg

[](https://www.expedia.ca/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information)

Orangeburg

7.8/10

Good

(1006)

"My first time staying at this Spark, and it was a good experience overall; no check in issues, clean room, good price point, and respectful staff. Would stay here again if in the area. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karesha

CA $120

CA $133 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01&regionId=9953&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

## Top Santee Hotel Reviews

![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg)

### Travelodge by Wyndham Santee

10/10 Excellent

"Clean , staff very courteous. Pet friendly!clean, friendly, on the beach, dog friendly beach area"

[](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information)

![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg)

### Baymont by Wyndham Santee

10/10 Excellent

"Had to be moved different room"

[](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information)

![Super 8 by Wyndham Santee](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881_y.jpg)

### Super 8 by Wyndham Santee

10/10 Excellent

"The staff was very friendly and helpful. Room was clean and beds were so comfortable. "

[](https://expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information)

![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg)

### Hampton Inn Santee-I-95

10/10 Excellent

"the breakfast was fresh. handicap parking close to entry"

[](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information)

![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1_y.jpg)

### Holiday Inn Santee by IHG

10/10 Excellent

"Was able to walk to convenience store and other dinning alternatives. Safe secure building"

[](https://expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information)

![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg)

### Comfort Inn & Suites Santee

10/10 Excellent

"We like this location and have stayed here several times. We travel with our service dogs and this location has a nice outdoor area that is well lit at night for potty breaks. \*\*\*PLEASE NOTE…this hotel is NOT pet friendly. We will often seek out pet friendly facilities as a first option when we travel and this location comes up in the search. However upon arrival there’s a sign on the door that reads service animals only. I only mention it as a heads up. Our first stay we had prepaid for our room and if our dogs were not service animals we would have been in a bad situation as it was late when we arrived and would have had no place to go. Otherwise this is a great location and place to stay for us on our travels up and down I-95!"

[](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information)

![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg)

### Best Western Plus Santee Inn

10/10 Excellent

"The room was spotless and the bed was very comfortable. We went out for the day, we were surprised that our bed was made and had clean towels. "

[](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information)

![Ramada by Wyndham Santee I-95](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6_y.jpg)

### Ramada by Wyndham Santee I-95

10/10 Excellent

"The grounds and property were clean and you could tell they take pride in what they're offering."

[](https://expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information)

![Econo Lodge](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/1f93ecf8_y.jpg)

### Econo Lodge

8/10 Good

"Clean room. No issues with late check"

[](https://expedia.ca/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information)

## Frequently asked questions

### How much do business-friendly hotels in Santee cost?

### What are the best business-friendly hotels in Santee?

### How many business-friendly hotels are there in Santee?

### What are the best cheap business-friendly hotels in Santee?

### What are the top business-friendly motels in Santee?

### Are there any family-friendly hotels in Santee that are also business friendly?

### Why book your business-friendly hotel in Santee with Expedia?

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