Title: Book the Best BUSINESS Hotels in Santee in 2025 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/271db9a9db85f6f3488271b71d2f238f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Santee, SC from CA $106 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Business Hotels Tonight [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-11&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-12&endDate=2025-10-13&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-17&endDate=2025-10-19&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-24&endDate=2025-10-26&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santee Business Hotels ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c5237c95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee Santee 8.0/10 Very good (1356) "Good overall stay." CA $112 CA $124 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/442e4efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/8a3aa504.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Santee by IHG Santee 8.2/10 Very good (953) "Friendly and helpful staff. Overall a very good stay." CA $156 CA $173 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/dc9ab090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/4aad61ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn Santee 8.8/10 Excellent (1003) "The staff was very friendly and welcoming. The enviroment was very calm and peaceful." CA $190 CA $211 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/315e8dc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/77599f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/aa634b56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Santee Santee 6.8/10 (435) "The nicest bathroom on our 12 day trip" CA $105 CA $117 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/a90b57ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/b105c391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/e9087580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee Santee 6.6/10 (629) "Despite offering breakfast, it was lackluster " CA $98 CA $109 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/61b41f5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/740d6803.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Santee I-95 Santee 6.2/10 (537) "The grounds and property were clean and you could tell they take pride in what they're offering." CA $100 CA $111 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/3861a053.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/c97df40a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/1295e8cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/10951979.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Santee 6.0/10 (443) "Entire place was filthy I did not even check in " CA $88 CA $106 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/1bbd70f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/57735ca3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/a4197341.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg Orangeburg 9.2/10 Wonderful (1007) "Great little hotel. Perfect for a short stay. " CA $148 CA $164 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/aa173c27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/6dc9f9a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/ae964a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/f8fbcf77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn by Marriott Orangeburg Orangeburg 8.4/10 Very good (653) "Enjoyed my stay for homecoming go Bulldogs ! " CA $118 CA $131 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/8acfa265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/321b05a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2557x3y3-7acc8337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2556x0y4-5cb4ef80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Orangeburg Orangeburg 7.8/10 Good (1005) "Very close to highway, I come to the area 3 times a year, and this is the nicest place yet" CA $122 CA $136 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=9953&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Santee Hotel Reviews ![Holiday Inn Santee by IHG](//images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1_y.jpg) ### Holiday Inn Santee by IHG 10/10 Excellent "Acting GM was very friendly Happy hour was nice" [](https://expedia.ca/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Baymont by Wyndham Santee](//images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "Great place to stop on our way to Florida. Places to shop and dine. Hotel is nice and good breakfast. " [](https://expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Travelodge by Wyndham Santee](//images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg) ### Travelodge by Wyndham Santee 10/10 Excellent "The counter tops and appliances needed cleaning, they were greasy. Otherwise the room was okay." [](https://expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Hampton Inn Santee-I-95](//images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "We had a nice and courteous and friendly. Bed was comfortable " [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Ramada by Wyndham Santee I-95](//images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6_y.jpg) ### Ramada by Wyndham Santee I-95 10/10 Excellent "The grounds and property were clean and you could tell they take pride in what they're offering." [](https://expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Best Western Plus Santee Inn](//images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "This was our second stay at Best Western+ Santee, and the service was as great as the first time. The hotel is aesthetically beautiful and very clean. Our favorite is the morning down home breakfast that’s served fresh every morning. Mrs. Barbara is amazing, as she puts love and care into her cooking, as everything is delicious, and displayed nicely and the dining area is always immaculate and clean, resort style. There’s nowhere else we’d rather stay when we travel to South Carolina." [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Comfort Inn & Suites Santee](//images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Pleasant people to work with, friendly and gracious. Hotel is well maintained and CLEAN. Fridge was cold, shower was hot, bed was comfortable, breakfast was nice! This was an overnight stay on a two day driving trip. Definitely gave us a good start to our second day " [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Super 8 by Wyndham Santee](//images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881_y.jpg) ### Super 8 by Wyndham Santee 10/10 Excellent "The nicest bathroom on our 12 day trip" [](https://expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ![Econo Lodge](//images.trvl-media.com/lodging/1000000/910000/905400/905358/1f93ecf8_y.jpg) ### Econo Lodge 8/10 Good "Clean room. No issues with late check" [](https://expedia.ca/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Santee cost? > Expect to pay between CA $106 and CA $211 per night for business-friendly hotels in Santee. Epic deals on properties that cater to work-related guests are only a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best business-friendly hotels in Santee? > Lots of corporate travellers recommend [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information). This 2.5-stars stay offers amenities such as a swimming pool and a firepit. [Hampton Inn Santee-I-95](https://www.expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) is another top-rated option. It has a 2.5-stars rating and conveniences including a terrace and a swimming pool. There are multiple business-friendly hotels in Santee that have a total average guest review rating of 7.4. ### How many business-friendly hotels are there in Santee? > Santee has 11 hotels that cater to corporate travellers. Whether you're seeking a location closer to the city or amenities like conference rooms and dependable WiFi, you'll find the perfect place on Expedia. ### What are the best cheap business-friendly hotels in Santee? > [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) is a good choice for corporate travellers in search of a money-saving option. It has amenities like a barbecue grill and a swimming pool. Another affordable stay for a work-related trip is [Hampton Inn Santee-I-95](https://www.expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information). A swimming pool and a terrace are among the conveniences available here. Rates for business-friendly hotels in Santee start at just CA $106 per night, so you'll have more dollars left over to spend on post-conference entertainment. Your official business trip doesn't need to be all networking and no fun. [Santee Outlets](https://www.expedia.ca/Santee-Outlets-Santee.d6140634.Vacation-Attraction) is a terrific free attraction to visit during your time off in Santee. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the top business-friendly motels in Santee? > Mix work and play at [Super 8 by Wyndham Santee](https://www.expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information), located around 2 kilometres southeast of downtown Santee. This business-friendly option offers a host of amenities, such as pool sun loungers and laundry services.With so many shopping, cultural and dining opportunities to enjoy, you might consider extending your work trip to Santee. [Santee State Park](https://www.expedia.ca/Santee-State-Park-Santee.d6140632.Vacation-Attraction) and [Santee Cooper Country Club](https://www.expedia.ca/Santee-Cooper-Country-Club-Santee.d553248621532654899.Vacation-Attraction) are popular places to kick off your sightseeing adventures. ### Are there any family-friendly hotels in Santee that are also business friendly? > If you're taking the family to Santee but still have to work, look up [Fairfield Inn & Suites by Marriott Santee](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information). This 2.5-stars escape offers amenities like complimentary breakfast and a firepit. [Comfort Inn & Suites Santee](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) is another pick that's suited to both corporate and leisure guests. It has a 2.5-stars rating and conveniences including complimentary breakfast and laundry facilities. Once you've gotten work out of the way, there are tons of family-friendly attractions to explore around Santee. [Santee State Park](https://www.expedia.ca/Santee-State-Park-Santee.d6140632.Vacation-Attraction) and [Santee Cooper Country Club](https://www.expedia.ca/Santee-Cooper-Country-Club-Santee.d553248621532654899.Vacation-Attraction) guarantee fun for all ages. ### Why book your business-friendly hotel in Santee with Expedia? > Here at Expedia, our job is to help you find the ideal stay at the right price. From luxurious, corporate-friendly retreats to affordable motels filled with handy amenities, you'll have your next work trip booked in just a few clicks. ### How can I find cheap business-friendly hotels in Santee? > When work takes you on the road in Santee, our "business friendly" filter will help you find the right hotel. From free WiFi to concierge services and conference spaces, they come with the amenities you need for a productive and comfortable stay. Another handy tip? Narrow your search by your preferred star rating and budget to view the most affordable stays. ### What is there to do in Santee near my business-friendly hotel? > If you want to make the most of your downtime in Santee, be sure to visit [Santee State Park](https://www.expedia.ca/Santee-State-Park-Santee.d6140632.Vacation-Attraction). It's popular with locals and tourists alike. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Bowman](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Red Roof Inn Hotels in Bowman](https://www.expedia.ca/Bowman-Hotels-Red-Roof-Inn.0-0-d553248634998681915--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Bowman Hotels](https://www.expedia.ca/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [Apartments in Brookdale](https://www.expedia.ca/Brookdale-Apartments.d553248634999003908-aaApartments.Travel-Guide-Accommodation) - [Hotels with Free Breakfast in Brookdale](https://www.expedia.ca/Brookdale-Hotels-Hotels-With-Free-Breakfast.0-0-d553248634999003908-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Farmstay in Cameron](https://www.expedia.ca/Cameron-Agritourism.d553248634998916920-aaAgritourism.Travel-Guide-Accommodation) - [Aparthotels in Cameron](https://www.expedia.ca/Cameron-Apart-Hotels.d553248634998916920-aaApartHotels.Travel-Guide-Accommodation) - 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