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Your San Francisco Vacation
When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.
Top Holiday Package Deals in San Francisco

Villa Botero By Casa Mojito B&B
Reviewed on Apr. 18, 2025


Central Hotel Panama Casco Viejo
Reviewed on Aug. 20, 2025

Where to stay in San Francisco

Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.
San Francisco Hotel Deals

Sheraton Grand Panama
Reviewed on Aug. 20, 2025

Megapolis Hotel Panamá
Reviewed on Aug. 19, 2025

JW Marriott Panama
Reviewed on Aug. 19, 2025
Frequently asked questions
Discover the most popular places to visit in San Francisco

Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Omar Torrijos Recreational Park
Omar Torrijos Recreational Park is just one of the places to see in Panama City, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's seaside and enjoy its lively bars.
Things to do

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

Panama City : Custom Walking Tour with A Guide (Private Tour)

Live the Experience of a Full Day in San Blas
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