San Francisco Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

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    Save up to CA $1,096 when you book a flight and hotel together*
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Your San Francisco Vacation

When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.

Top Holiday Package Deals in San Francisco

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Price was CA $1,831, price is now CA $1,169 per person
CA $1,169
per person
Oct 27 - Nov 3
found 12 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr. 18, 2025

Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Price was CA $4,631, price is now CA $2,520 per person
CA $2,520
per person
Nov 10 - Nov 16
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
No reviews
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $3,194, price is now CA $1,776 per person
CA $1,776
per person
Nov 8 - Nov 15
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
9/10 Wonderful! (974 reviews)
Everyone was very friendly and super helpful. Location was super convenient. Will definitely stay again.

Reviewed on Aug. 20, 2025

Casa Fofo Family House

Casa Fofo Family House

3 out of 5
Price was CA $3,087, price is now CA $1,743 per person
CA $1,743
per person
Nov 11 - Nov 18
found 1 day ago
Roundtrip flight included
Calgary (YYC) to Panama City (PTY)
No reviews
Isla Palenque Member of the Cayuga Collection

Isla Palenque Member of the Cayuga Collection

4 out of 5
Price was CA $7,420, price is now CA $4,672 per person
CA $4,672
per person
Nov 10 - Nov 16
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
10/10 Exceptional! (6 reviews)

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
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Casco Viejo

4/5(32 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

San Francisco Hotel Deals

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $186 per night from Aug 31 to Sep 1
CA $186
CA $205 total
Aug 31 - Sep 1
includes taxes & fees
8.4/10 Very Good! (930 reviews)
"Very nice experience"

Reviewed on Aug. 20, 2025

Sheraton Grand Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is CA $173 per night from Sep 13 to Sep 14
CA $173
CA $191 total
Sep 13 - Sep 14
includes taxes & fees
8.2/10 Very Good! (1,033 reviews)
"I like that they have shopping outlet which was convenient and their breakfast was great. I however did not like that I had to ask them to clean my room all they did was change towels and sometimes make the bed."

Reviewed on Aug. 19, 2025

Megapolis Hotel Panamá
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $341 per night from Aug 31 to Sep 1
CA $341
CA $375 total
Aug 31 - Sep 1
includes taxes & fees
8.8/10 Excellent! (1,007 reviews)
"Customer service great! Food was good"

Reviewed on Aug. 19, 2025

JW Marriott Panama
See all 1,528 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low CA $1,169, in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Discover the most popular places to visit in San Francisco

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall

Omar Torrijos Recreational Park

Omar Torrijos Recreational Park is just one of the places to see in Panama City, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's seaside and enjoy its lively bars.

Omar Torrijos Recreational Park

Things to do

Full-Day SAN BLAS ISLAND & Snorkeling Tour + Transport from Panama City

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

CA $197
per adult
Full-Day SAN BLAS ISLAND Tour + Transport from Panama City
3-Hour Private Custom Tour with a Local Guide in Panama City

Panama City : Custom Walking Tour with A Guide (Private Tour)

CA $84
per adult
Panama City : Custom Walking Tour with A Guide (Private Tour)
Live the Experience of a Full Day in San Blas

Live the Experience of a Full Day in San Blas

CA $213
per adult
100% of travellers recommend
Live the Experience of a Full Day in San Blas
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.