San Francisco Vacation Packages

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Your San Francisco Vacation

When a fun city break is calling, answer it with a vacation package to San Francisco. The neighborhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco vacation is just a few clicks away. Explore flights, accommodations and more on Expedia for an adventure that's tailored to suit your travel style.

Top Holiday Package Deals in San Francisco

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

San Francisco
CA $1,258
per person
Nov 6 - Nov 13
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.6/10 Excellent! (1,716 reviews)
The property is excellent the fact that it’s connected to the mall and casino put it over the top. The staff are polite and always ready to assist you. Will definitely stay again.

Reviewed on Aug 28, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
CA $1,543
per person
Nov 6 - Nov 13
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,005 reviews)
Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
CA $1,312
per person
Nov 6 - Nov 13
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,671 reviews)
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

CA $1,434
per person
Nov 8 - Nov 15
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,815 reviews)
We arrived early and paid $45 for early check-in. We were told it would be accommodated and asked to wait 10 minutes. After waiting closer to 30, we went back to the front desk, only to find our room key was already there and ready. No one had let us know. The room had a weird musky smell and, strangely, parts of the walls were lined with galvanized zinc. The AC also started leaking. We reported it and were told someone would check it and, if it couldn’t be fixed, we’d be moved. No one ever came. Thankfully, it eventually stopped on its own. We also initially thought there was no hot water until we realized the taps were reversed (H ran cold and C ran hot). On the plus side, the gardens and pool are really nice and well maintained, although the hot tub doesn’t actually have hot water. The pool bar was also closed despite advertised hours of 11am–10pm. We ordered a margherita pizza and got what was essentially a cheese pizza with a small tub of pesto on the side. Despite the quirks, we both got some much-needed sleep, and the location is very convenient for the airport. Overall, though, at $210 for one night plus $45 for early check-in, I’m not sure we got value for money. Traveller tip: For the airport shuttle, wait 10–15 mins past the scheduled time when arriving. When leaving, get downstairs 10–15 mins early or you may have to wait for the next shuttle or Uber.

Reviewed on Aug 28, 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
CA $1,527
per person
Nov 6 - Nov 13
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.6/10 Exceptional! (415 reviews)
Very helpful staff and great amenities

Reviewed on Aug 28, 2026

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

2 out of top 10 points of interest in this area

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

A coastal city skyline with high-rise buildings, palm trees, and a clear sky.

Calidonia

2 out of top 10 points of interest in this area

You might enjoy the shopping while in Calidonia. Via Espana is a notable sight, and you can get around town at Lotería Station or Santo Tomás Station to see more of the city.

San Francisco Hotel Deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
CA $185
CA $185 total
Sep 3 - Sep 4
includes taxes & fees
Megapolis Hotel Panamá
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
CA $144
CA $159 total
Sep 7 - Sep 8
includes taxes & fees
9.6/10 Exceptional! (1,311 reviews)
"👌"

Reviewed on Aug 27, 2026

Ramada Plaza by Wyndham Panama Punta Pacifica
Aloft by Marriott Panama

Aloft by Marriott Panama

Via Israel & Calle 76 Panama City Panama
Fully refundableReserve now, pay when you stay
CA $165
CA $181 total
Sep 25 - Sep 26
includes taxes & fees
Aloft by Marriott Panama
See all 1,820 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low CA $1,258, in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Stay near popular San Francisco attractions

Multiplaza Pacific Mall

9.0/10 (4,497 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
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Via Espana

8.4/10 (2,902 reviews)
During your trip to Panama City, you can find the perfect gifts to bring home at Via Espana. Stroll along the seaside or visit the casinos in this vibrant area.
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ATLAPA Conventions Center

7.6/10 (31 reviews)
Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its top-notch restaurants.
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Multicentro Panama

8.2/10 (274 reviews)
During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.
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Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.
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Omar Torrijos Recreational Park

5.6/10 (4 reviews)
Omar Torrijos Recreational Park is just one of the places to see in Panama City, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's seaside and enjoy its lively bars.
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Things to do

Half day of Panama city and canal tour: shared and private

Half day of Panama city and canal tour: shared and private

CA $94
per adult
98% of travellers recommend
Half day of Panama city and canal tour: shared and private
Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

CA $66
per adult
96% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

CA $45
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.