A train crossing a stone bridge over a river, surrounded by lush greenery.

Find Spa Hotels in Perryville, MO from CA $102

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Perryville Spa Hotels

Tonight
Aug 23 - Aug 24
Tomorrow
Aug 24 - Aug 25
Next weekend
Aug 28 - Aug 30
In two weeks
Sep 4 - Sep 6
No exact matches found, but these alternatives could be just right

Recommended hotels in Perryville

A modern hotel lobby with a reception desk, a bar area, a seating area, and a patterned carpet.
A hotel lobby with a patterned carpet, seating area, and a reception desk.
A swimming pool with clear blue water, surrounded by lounge chairs and tables, with pool rules signs on the wall.
A Holiday Inn Express & Suites building with a covered entrance and stone pillars.

1. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
Perryville
CA $133
CA $153 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express & Suites Perryville by IHG
A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.
A playground with a wooden playhouse, a slide, and two animal-shaped swings.
A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.
A log cabin with a green metal roof, a wooden porch with a bench, and a small window.

2. Perryville RV Resort

Perryville RV Resort
Perryville
CA $91
CA $105 total
includes taxes & fees
Aug 25 - Aug 26
Perryville RV Resort
A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.
A hotel room with a large mirror, a bathtub, a sofa, a small table with a lamp, and a desk with a lamp.
A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.
A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

3. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
Perryville
CA $89
CA $102 total
includes taxes & fees
Sep 15 - Sep 16
Super 8 by Wyndham Perryville
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.
A building with a sign that reads "The Atrium Boutique Hotel".
A modern bathroom with a hexagonal tile wall, a shower with a curved head, and a bathtub.
A fireplace with a decorative mantel, a framed sign, and a small table with plants.

4. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
CA $104
CA $220 total
includes taxes & fees
Aug 24 - Aug 25
The Atrium - A Boutique Hotel
A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.
A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.
A hotel hallway with a patterned carpet, blue walls, and a sign indicating an office.
A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

5. Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville
Perryville
CA $93
CA $106 total
includes taxes & fees
Aug 24 - Aug 25
Days Inn by Wyndham Perryville
A lobby with a TV, framed pictures, a plant, and patterned chairs.
A hotel room with a desk, a television, a coffee maker, a chair, and a window with curtains.
A breakfast bar with a toaster, coffee maker, and fruit juice dispenser.
A hotel reception desk with a sign that reads "Quality by Choice Hotels."

6. Quality Inn Perryville I-55

Quality Inn Perryville I-55
Perryville
CA $93
CA $106 total
includes taxes & fees
Sep 1 - Sep 2
Quality Inn Perryville I-55
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A shower with a hexagonal tile wall, a white bathtub, and a grey shower curtain.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.
A hallway with exposed brick walls, wooden flooring, and a white door.

7. Urban Lofts

Urban Lofts
Perryville
CA $277
CA $428 total
includes taxes & fees
Aug 24 - Aug 25
Urban Lofts
A hot tub in a backyard with a clear blue sky and clouds.
A compact kitchen with a microwave, coffee maker, and storage cabinets.
A modern living room with a grey sofa, a coffee machine, and a dining area with a table and chairs.
A bedroom with a bed, a clock, a small table with items, and a green wall.

8. Retreat Air - King Bed, Swim Spa & No cleaning fee

Retreat Air - King Bed, Swim Spa & No cleaning fee
Perryville
CA $213
CA $259 total
includes taxes & fees
Sep 11 - Sep 12
Retreat Air - King Bed, Swim Spa & No cleaning fee
A modern kitchen with stainless steel appliances, a large window, and a green cabinet.
A bathroom with a black tiled backsplash, a white sink with gold fixtures, and a wooden vanity.
A room with a white door, a radiator, a blue carpet, and a mural on the wall.
A kitchen with a large black sink, a window with a view of trees, and a microwave on the counter.

9. The Mediterranean House 1858

The Mediterranean House 1858
Perryville
CA $661
CA $1,086 total
includes taxes & fees
Aug 24 - Aug 25
The Mediterranean House 1858
A modern kitchen with dark wood cabinets, a central island, and a brick wall.
A dining area with a brick wall, wooden furniture, and a pineapple centerpiece.
A spacious kitchen with a central island, brick walls, and a dining area with chairs and a table.
A bedroom with a brick wall, a bed, a dresser, a chair, a television, and a ceiling fan.

10. Downtown Loft w/ Amazing Bath Tub & Shower

Downtown Loft w/ Amazing Bath Tub & Shower
Perryville
CA $268
CA $437 total
includes taxes & fees
Aug 24 - Aug 25
Downtown Loft w/ Amazing Bath Tub & Shower
View all properties

Choose what matters most at spa hotels in Perryville

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Perryville Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"I love the drury and all the extras they give. Our family all enjoyed it."
Rachel 1-night trip
Posted 13 hours ago
Drury Inn & Suites Jackson MO

Frequently asked questions

Looking to vacation at a spa hotel in Perryville?
Treat yourself to some pampering and book a hotel with a spa. Check out the natural parks in Perryville - worth a picture or two! Take part in recreational activities such as golfing during your vacation. Spa hotels are the perfect way to break out of your daily routine and add a layer of luxury to your weekend away.
What's there to see and do in Perryville?
Enjoy all that Perryville has to offer and visit National Shrine of Our Lady of the Miraculous Medal, Mark Twain National Forest, and Mississippi River. If you have a little extra time during your trip, you might want to check out Saint Marys Lake and Feltz Street Park.
What is a Perryville spa hotel?
Spa hotels in Perryville feature on-site spas which offer services such as massages and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.

Explore a world of travel with Expedia