Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search over 665,000 properties worldwide and 550 airlines worldwide.

Expedia Add-On Advantage: Book a package & unlock up to 50% off select hotels. Terms apply.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Panama Vacation Packages

Discover charming colonial architecture, fascinating wildlife, breathtaking scenery and a world-renowned canal at the crossroads between Central and South America.

Home to an internationally famous canal, Panama is also a destination of incomparable natural beauty. Explore forest-clad mountains, relax on blissful tropical islands and spot wildlife on this narrow strip of land, fringed by Caribbean and Pacific coasts. Panama connects Central America with South America and was colonized by the Spanish in the 1500s. Today, Panama is home to diverse cultural groups.

Panama’s capital, Panama City, lies at the center of the country. This intriguing city blends sleepy colonial districts with street markets, a fast-paced financial center and an exciting nightlife. Panama City is a great base for visiting the country’s major attractions. Join a boat cruise along the Panama Canal, a fascinating feat of engineering that stretches for 48 miles (77 kilometers) from Panama City to Colón.

A varied landscape of rainforests, volcanos, mountains and wildlife reserves surround Panama City. Follow walking trails to spot tropical birds and monkeys in Soberanía National Park. Learn about native flora and fauna at Gamboa Rainforest Resort. Ride on horseback to the summit of Volcan Baru National Park, in the picturesque Chiriquí Province. Visit the Emberá and Wounaan communities in Darién National Park, a wilderness of beaches, jungles and mangrove swamps.

Go to the Caribbean coast to experience a culture influenced by Barbadians and Jamaicans. Unwind on white-sand beaches and snorkel at the idyllic islands of Bocas del Toro. Wander around the colonial ruins of Portobelo, the gateway to Isla Grande. Take a boat trip to the San Blas Islands, home to the Kuna people.

Panama’s beach life extends to the Pacific coast, too. Check out the resorts in Playa Coronado, join the carnival in Las Tablas or hit the surf breaks in Pedasi. Visit secluded islands such as Contadora and Taboga. Swim with multicolored marine life in the crystal-clear waters of Isla de Coiba.

Economic growth and a currency tied to the U.S. dollar make Panama one of Central America’s more expensive destinations. Enjoy consistently warm temperatures, history and gorgeous scenery in Panama.


Top Hotel Deals

See all 659 properties in Panama
RIU Plaza Panama C$126
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
     
    4.3
    of 5, from 1,620 reviews
    4.0 out of 5.0

    Located in the heart of Panama City, this spa hotel is 0.9 mi (1.5 km) from Avenida Central and within 3 mi (5 km) of Museum of Natural Science and Metropolitan Cathedral of Panama. Museum of History Panama and National Theater are also within 3 mi (5 km). Iglesia del Carmen Station is 11 minutes by foot and Santo Tomas Station is 23 minutes.

    Riande Aeropuerto Hotel & Casino C$111
    Riande Aeropuerto Hotel & Casino

    Riande Aeropuerto Hotel & Casino

    Vía Tocumen, Tocumen
       
      4.0
      of 5, from 1,990 reviews
      4.0 out of 5.0

      Just 1 mile (1.6 km) from the airport, this Panama City hotel is 5 minutes from the shopping center Shopping Metro Mall and 10 minutes from the ruins of Panamá Viejo.

      Hilton Garden Inn Panama C$63
      Hilton Garden Inn Panama

      Hilton Garden Inn Panama

      Eusebio A Morales y calle 49A oeste, Panama City
         
        4.3
        of 5, from 859 reviews
        3.5 out of 5.0

        Located in El Cangrejo, this hotel is 0.2 mi (0.4 km) from Via Espana and 2.8 mi (4.6 km) from Metropolitan Cathedral of Panama. Iglesia del Carmen and National Shrine of the Heart of Mary are also within 15 minutes. Iglesia del Carmen Station is 6 minutes by foot and Santo Tomas Station is 20 minutes.

        Sheraton Bijao Beach Resort - All Inclusive C$185
        Sheraton Bijao Beach Resort - All Inclusive

        Sheraton Bijao Beach Resort - All Inclusive

        Carretera Interamericana km 108, Rio Hato
           
          3.7
          of 5, from 764 reviews
          4.0 out of 5.0

          This family-friendly Rio Hato resort is located on the waterfront, 5.7 mi (9.1 km) from Santa Clara Beach, and within 12 mi (20 km) of Farallon Beach and Farallon Island. Parroquia Santiago Apóstol de Río Hato and Playa Blanca are also within 12 mi (20 km).

          Royal Decameron Golf, Beach Resort and Villas All Inclusive C$317
          Royal Decameron Golf, Beach Resort and Villas All Inclusive

          Royal Decameron Golf, Beach Resort and Villas All Inclusive

          KM 115 Carretera, Rio Hato
             
            3.6
            of 5, from 609 reviews
            3.5 out of 5.0

            This 852 room all-inclusive resort in Playa Blanca is located right on the beach, 90 minutes southwest of Panama City.

            Eurostars Panama City C$72
            Eurostars Panama City

            Eurostars Panama City

            Calle Ricardo Arias, Panama City
               
              4.1
              of 5, from 610 reviews
              4.0 out of 5.0

              Located in the heart of Panama City, this hotel is 0.1 mi (0.1 km) from Via Espana and 2.8 mi (4.5 km) from Metropolitan Cathedral of Panama. National Shrine of the Heart of Mary and Iglesia del Carmen are also within 10 minutes. Iglesia del Carmen Station is only a 3-minute walk and Santo Tomas Station is 20 minutes.

              The Bahia Grand Hotel C$156
              The Bahia Grand Hotel

              The Bahia Grand Hotel

              Punta Colon Street, Panama City
                 
                4.3
                of 5, from 37 reviews
                5.0 out of 5.0

                This family-friendly Panama City hotel is located by the ocean, within 3 mi (5 km) of Multiplaza Pacific Mall and Cinta Costera. Interoceanic Canal Museum and Metropolitan Cathedral of Panama are also within 6 mi (10 km).

                Hard Rock Hotel Panama Megapolis C$174
                Hard Rock Hotel Panama Megapolis

                Hard Rock Hotel Panama Megapolis

                Ave. Balboa al lado de Multicentro, Panama City
                   
                  4.3
                  of 5, from 1,980 reviews
                  4.5 out of 5.0

                  This family-friendly Panama City hotel is located by the ocean, just steps from Avenida Balboa and Multicentro Panama. Via Espana and Multiplaza Pacific Mall are also within 2 mi (3 km). Iglesia del Carmen Station is 24 minutes by foot and Santo Tomas Station is 30 minutes.

                  Top Flight + Hotel Deals

                  Top Deals On Flights

                  These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.