10 Best Hotels in Mackenzie, St. Louis for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mackenzie hotels

A modern hotel lobby with a reception desk, seating area, and a refreshment bar.

1. SpringHill Suites St. Louis Brentwood

4.9 km from Mackenzie

Aaron

CA $208 total

includes taxes & fees

Nov 20 - Nov 21

A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

2. Drury Plaza Hotel St. Louis Brentwood

5.8 km from Mackenzie

Stacey Rochelle

CA $215 total

includes taxes & fees

Nov 22 - Nov 23

A swimming pool with a metal ladder, surrounded by chairs and large windows offering a view of the sunset.

3. La Quinta Inn & Suites by Wyndham St Louis Route 66

8.3 km from Mackenzie

Edward

CA $155 total

includes taxes & fees

Dec 10 - Dec 11

A spacious lobby with multiple seating areas, a central coffee table, and artwork on the walls.

4. Best Western St. Louis-Kirkwood Route 66

8.1 km from Mackenzie

Christopher

CA $152 total

includes taxes & fees

Nov 12 - Nov 13

An outdoor patio with a fire pit, seating, and a building in the background.

5. Courtyard by Marriott St. Louis Brentwood

5.5 km from Mackenzie

Anna

CA $203 total

includes taxes & fees

Nov 22 - Nov 23

A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.

6. River City Casino & Hotel

7.3 km from Mackenzie

jodi

CA $151 total

includes taxes & fees

Nov 18 - Nov 19

A hotel room with two beds, a desk, and a window with a view of trees.

7. Best Western Plus Fenton

12.2 km from Mackenzie

Brian

CA $151 total

includes taxes & fees

Nov 15 - Nov 16

A bar area with a long counter displaying numerous bottles of alcohol and several empty wine glasses lined up.

8. Holiday Inn St Louis SW - Route 66 by IHG

8.5 km from Mackenzie

Sara

CA $187 total

includes taxes & fees

Dec 10 - Dec 11

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

9. Holiday Inn Express & Suites St. Louis South - I-55 by IHG

11.2 km from Mackenzie

Thomas

CA $179 total

includes taxes & fees

Nov 29 - Nov 30

A hotel room with two beds, a chair, a desk, and a large window.

10. Forest Park Hotel by MDR

The Hill, 4.9 km from Mackenzie

Frantz

CA $131 total

includes taxes & fees

Nov 26 - Nov 27

A hotel room with two beds, a desk, a chair, and a television.

11. Clayton Plaza Hotel & Extended Stay

7.8 km from Mackenzie

Martha

CA $172 total

includes taxes & fees

Dec 6 - Dec 7

12. Drury Inn & Suites St. Louis Forest Park

4.7 km from Mackenzie

Tammy

CA $223 total

includes taxes & fees

Nov 15 - Nov 16

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

13. Hampton Inn & Suites St. Louis at Forest Park

Dogtown, 6.2 km from Mackenzie

Edmond

CA $217 total

includes taxes & fees

Nov 16 - Nov 17

A modern interior with hanging pendant lights, large windows, and a view of the outside.

14. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

13.8 km from Mackenzie

michael

CA $146 total

includes taxes & fees

Nov 12 - Nov 13

A spacious lobby with a stone fireplace, comfortable seating, and large windows.

15. Comfort Suites St. Louis - Sunset Hills

8.4 km from Mackenzie

Elvira

CA $208 total

includes taxes & fees

Nov 16 - Nov 17

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

16. Best Western St. Louis Inn

13.9 km from Mackenzie

Susan

CA $110 total

includes taxes & fees

Nov 16 - Nov 17

A cozy lounge area with leather sofas, a fireplace, and a bar counter.

17. The Cheshire

5.9 km from Mackenzie

Matthew

CA $251 total

includes taxes & fees

Nov 29 - Nov 30

A modern living room with a sofa set, a coffee table, and a TV mounted on the wall.

18. Fairfield Inn & Suites by Marriott St. Louis South

11.3 km from Mackenzie

Megan

CA $219 total

includes taxes & fees

Nov 15 - Nov 16

A hotel lobby with a staircase, dining area, and reception desk.

19. Holiday Inn Express & Suites St. Louis West - Fenton by IHG

14.2 km from Mackenzie

Ann

CA $152 total

includes taxes & fees

Nov 29 - Nov 30

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

20. The West End

Central West End, 8.9 km from Mackenzie

Adam

CA $144 total

includes taxes & fees

Nov 15 - Nov 16

View all properties

Compare popular hotels in Mackenzie

Property	Star rating	Guest rating
Drury Inn & Suites St. Louis Forest Park	3.0 star property	9.4 Exceptional 1,029 reviews	View
Courtyard by Marriott St. Louis Brentwood	3.0 star property	9.4 Exceptional 914 reviews	View
Holiday Inn St Louis SW - Route 66 by IHG	3.0 star property	9.2 Wonderful 603 reviews	View
Holiday Inn Express & Suites St. Louis South - I-55 by IHG	2.5 star property	9.4 Exceptional 1,002 reviews	View
SpringHill Suites St. Louis Brentwood	3.0 star property	9.0 Wonderful 1,003 reviews	View

Where to stay in Mackenzie

Find the best Mackenzie areas and neighborhoods for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Old Courthouse or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

See properties

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

See properties

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

See properties

A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

See properties

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

See properties

Top Mackenzie Hotel Reviews

SpringHill Suites St. Louis Brentwood

Brentwood

10/10 Excellent

EFREM

Hampton Inn & Suites St. Louis at Forest Park

Dogtown

10/10 Excellent

Raffaele

La Quinta Inn & Suites by Wyndham St Louis Route 66

St. Louis

10/10 Excellent

yu

Clayton Plaza Hotel & Extended Stay

Clayton

10/10 Excellent

Susan

Holiday Inn Express & Suites St. Louis West - Fenton by IHG

Fenton

10/10 Excellent

Jennifer

A rooftop terrace with modern outdoor seating, a fire pit, and a view of the cityscape.

AC Hotel St. Louis Clayton

Clayton

10/10 Excellent

Chris

A courtyard with outdoor seating, a central fountain, and a view of a tower.

The Knight Center at Washington University

St. Louis

10/10 Excellent

Carlos

Frequently Asked Questions

What's it like in Mackenzie?

Travelers will be sure to find plenty to entertain them in St. Louis's Mackenzie neighborhood.

If I need to cancel my hotel reservation in Mackenzie, will I receive a refund?

Yes! Most hotel bookings are fully refundable if cancelled before the hotel’s cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer in Mackenzie.

Where can I learn more about changing or cancelling my trip to Mackenzie?

To access more information about changing or cancelling your trip to Mackenzie, go to https://www.expedia.com/service/.

What is there to do in this St. Louis neighborhood?

Lindenwood Park, Repertory Theatre of St. Louis, and River des Peres Greenway Trailhead are just a few of the places to visit in and around Mackenzie. While you're out sightseeing, The Focal Point and Webster Groves Tennis Center are a couple of additional sights to visit in St. Louis.

Explore a world of travel with Expedia

St. Louis Vacation Rentals
Standard Link for St. Louis Vacation Rentals

Hotels in Mackenzie, St. Louis from CA $96

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Mackenzie hotels

1. SpringHill Suites St. Louis Brentwood

2. Drury Plaza Hotel St. Louis Brentwood

3. La Quinta Inn & Suites by Wyndham St Louis Route 66

4. Best Western St. Louis-Kirkwood Route 66

5. Courtyard by Marriott St. Louis Brentwood

6. River City Casino & Hotel

7. Best Western Plus Fenton

8. Holiday Inn St Louis SW - Route 66 by IHG

9. Holiday Inn Express & Suites St. Louis South - I-55 by IHG

10. Forest Park Hotel by MDR

11. Clayton Plaza Hotel & Extended Stay

12. Drury Inn & Suites St. Louis Forest Park

13. Hampton Inn & Suites St. Louis at Forest Park

14. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

15. Comfort Suites St. Louis - Sunset Hills

16. Best Western St. Louis Inn

17. The Cheshire

18. Fairfield Inn & Suites by Marriott St. Louis South

19. Holiday Inn Express & Suites St. Louis West - Fenton by IHG

20. The West End

Compare popular hotels in Mackenzie

Where to stay in Mackenzie

Downtown St. Louis

Clayton

St. Charles Historic District

Central West End

Creve Coeur

Top Mackenzie Hotel Reviews

SpringHill Suites St. Louis Brentwood

10/10 Excellent

Frequently Asked Questions

What's it like in Mackenzie?

If I need to cancel my hotel reservation in Mackenzie, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Mackenzie?

What is there to do in this St. Louis neighborhood?

Explore a world of travel with Expedia