10 Best Hotels in Mackenzie, St. Louis for 2026

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Our top choices for Mackenzie hotels

1. Drury Inn & Suites St. Louis Forest Park

4.7 km from Mackenzie

Tammy

CA $223 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with multiple seating areas, a central coffee table, and artwork on the walls.

2. Best Western St. Louis-Kirkwood Route 66

8.1 km from Mackenzie

Christopher

CA $152 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor patio with a fire pit, seating, and a building in the background.

3. Courtyard by Marriott St. Louis Brentwood

5.5 km from Mackenzie

Anna

CA $203 total

includes taxes & fees

Nov 23 - Nov 24

A swimming pool with a metal ladder, surrounded by chairs and large windows offering a view of the sunset.

4. La Quinta Inn & Suites by Wyndham St Louis Route 66

8.3 km from Mackenzie

Edward

CA $155 total

includes taxes & fees

Dec 10 - Dec 11

A spacious lobby with a high ceiling, a central chandelier, and a patterned floor.

5. River City Casino & Hotel

7.3 km from Mackenzie

jodi

CA $146 total

includes taxes & fees

Dec 10 - Dec 11

A hotel room with two beds, a desk, and a window with a view of trees.

6. Best Western Plus Fenton

12.2 km from Mackenzie

Brian

CA $151 total

includes taxes & fees

Nov 15 - Nov 16

A modern lobby with a grey sofa, two armchairs, a round table, and a chandelier. There are two posters on the wall and a reception desk in the background.

7. Holiday Inn St Louis SW - Route 66 by IHG

8.5 km from Mackenzie

Sara

CA $193 total

includes taxes & fees

Dec 10 - Dec 11

A hotel room with two beds, a chair, a desk, and a large window.

8. Forest Park Hotel by MDR

The Hill, 4.9 km from Mackenzie

Frantz

CA $127 total

includes taxes & fees

Dec 10 - Dec 11

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

9. Holiday Inn Express & Suites St. Louis South - I-55 by IHG

11.2 km from Mackenzie

Thomas

CA $179 total

includes taxes & fees

Nov 29 - Nov 30

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

10. Hampton Inn & Suites St. Louis at Forest Park

Dogtown, 6.2 km from Mackenzie

Edmond

CA $217 total

includes taxes & fees

Nov 23 - Nov 24

An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.

11. Drury Plaza Hotel St. Louis Brentwood

5.8 km from Mackenzie

Stacey Rochelle

CA $215 total

includes taxes & fees

Nov 29 - Nov 30

A hotel room with two beds, a desk, a chair, and a television.

12. Clayton Plaza Hotel & Extended Stay

7.8 km from Mackenzie

Martha

CA $172 total

includes taxes & fees

Dec 6 - Dec 7

A spacious lobby with a stone fireplace, comfortable seating, and large windows.

13. Comfort Suites St. Louis - Sunset Hills

8.4 km from Mackenzie

Elvira

CA $194 total

includes taxes & fees

Nov 16 - Nov 17

A modern interior with hanging pendant lights, large windows, and a view of the outside.

14. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

13.8 km from Mackenzie

michael

CA $146 total

includes taxes & fees

Nov 23 - Nov 24

A grand building with a fountain in front.

15. The Cheshire

5.9 km from Mackenzie

Matthew

CA $250 total

includes taxes & fees

Nov 29 - Nov 30

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

16. The West End

Central West End, 8.9 km from Mackenzie

Trevor

CA $144 total

includes taxes & fees

Nov 11 - Nov 12

A Courtyard by Marriott hotel with a modern design, multiple floors, and a well-lit entrance.

17. Courtyard by Marriott St. Louis West County

12.4 km from Mackenzie

Kevin

CA $213 total

includes taxes & fees

Nov 20 - Nov 21

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

18. Best Western St. Louis Inn

13.9 km from Mackenzie

Susan

CA $110 total

includes taxes & fees

Nov 15 - Nov 16

A hotel lobby with a staircase, dining area, and reception desk.

19. Holiday Inn Express & Suites St. Louis West - Fenton by IHG

14.2 km from Mackenzie

Hollis

CA $152 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a high ceiling, modern lighting fixtures, a seating area with sofas and chairs, and a bar area with stools.

20. Hampton Inn & Suites St. Louis/South I-55

11.2 km from Mackenzie

Areege

CA $178 total

includes taxes & fees

Nov 22 - Nov 23

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Compare popular hotels in Mackenzie

Property	Star rating	Guest rating
Drury Inn & Suites St. Louis Forest Park	3.0 star property	9.4 Exceptional 1,032 reviews	View
Courtyard by Marriott St. Louis Brentwood	3.0 star property	9.4 Exceptional 914 reviews	View
Holiday Inn St Louis SW - Route 66 by IHG	3.0 star property	9.2 Wonderful 603 reviews	View
Holiday Inn Express & Suites St. Louis South - I-55 by IHG	2.5 star property	9.4 Exceptional 1,002 reviews	View
SpringHill Suites St. Louis Brentwood	3.0 star property	9.0 Wonderful 1,002 reviews	View

Where to stay in Mackenzie

Find the best Mackenzie areas and neighborhoods for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Old Courthouse or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

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A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

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A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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Top Mackenzie Hotel Reviews

Hampton Inn & Suites St. Louis at Forest Park

Dogtown

10/10 Excellent

Raffaele

Clayton Plaza Hotel & Extended Stay

Clayton

10/10 Excellent

Susan

La Quinta Inn & Suites by Wyndham St Louis Route 66

St. Louis

10/10 Excellent

yu

A rooftop terrace with modern outdoor seating, a fire pit, and a view of the cityscape.

AC Hotel St. Louis Clayton

Clayton

10/10 Excellent

Chris

Holiday Inn Express & Suites St. Louis West - Fenton by IHG

Fenton

10/10 Excellent

Jennifer

The exterior of the Charles F. Knight Center with a stone facade, large arched entrance, and a sign above the doors.

The Knight Center at Washington University

St. Louis

10/10 Excellent

Carlos

Frequently Asked Questions

What's it like in Mackenzie?

Travelers will be sure to find plenty to entertain them in St. Louis's Mackenzie neighborhood.

If I need to cancel my hotel reservation in Mackenzie, will I receive a refund?

Yes! Most hotel bookings are fully refundable if cancelled before the hotel’s cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer in Mackenzie.

Where can I learn more about changing or cancelling my trip to Mackenzie?

To access more information about changing or cancelling your trip to Mackenzie, go to https://www.expedia.com/service/.

What is there to do in this St. Louis neighborhood?

Lindenwood Park, Repertory Theatre of St. Louis, and River des Peres Greenway Trailhead are just a few of the places to visit in and around Mackenzie. While you're out sightseeing, The Focal Point and Webster Groves Tennis Center are a couple of additional sights to visit in St. Louis.

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Hotels in Mackenzie, St. Louis from CA $96

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Our top choices for Mackenzie hotels

1. Drury Inn & Suites St. Louis Forest Park

2. Best Western St. Louis-Kirkwood Route 66

3. Courtyard by Marriott St. Louis Brentwood

4. La Quinta Inn & Suites by Wyndham St Louis Route 66

5. River City Casino & Hotel

6. Best Western Plus Fenton

7. Holiday Inn St Louis SW - Route 66 by IHG

8. Forest Park Hotel by MDR

9. Holiday Inn Express & Suites St. Louis South - I-55 by IHG

10. Hampton Inn & Suites St. Louis at Forest Park

11. Drury Plaza Hotel St. Louis Brentwood

12. Clayton Plaza Hotel & Extended Stay

13. Comfort Suites St. Louis - Sunset Hills

14. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

15. The Cheshire

16. The West End

17. Courtyard by Marriott St. Louis West County

18. Best Western St. Louis Inn

19. Holiday Inn Express & Suites St. Louis West - Fenton by IHG

20. Hampton Inn & Suites St. Louis/South I-55

Compare popular hotels in Mackenzie

Where to stay in Mackenzie

Downtown St. Louis

Clayton

St. Charles Historic District

Central West End

Creve Coeur

Top Mackenzie Hotel Reviews

Hampton Inn & Suites St. Louis at Forest Park

10/10 Excellent

Frequently Asked Questions

What's it like in Mackenzie?

If I need to cancel my hotel reservation in Mackenzie, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Mackenzie?

What is there to do in this St. Louis neighborhood?

Explore a world of travel with Expedia