
Hotels in Jefferson, San Antonio
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Our top choices for Jefferson hotels

1. San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical CenterMedical Center District, 4.9 km from Jefferson
8.6 out of 10, Excellent, (1,201 reviews)
The price is CA $121
CA $146 total
includes taxes & fees
Dec 11 - Dec 12

2. Courtyard by Marriott San Antonio Downtown/Market Square
Courtyard by Marriott San Antonio Downtown/Market Square5.9 km from Jefferson
9.2 out of 10, Wonderful, (817 reviews)
The price is CA $155
CA $185 total
includes taxes & fees
Nov 28 - Nov 29

3. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NWMedical Center District, 6.3 km from Jefferson
8.4 out of 10, Very good, (3,783 reviews)
The price is CA $125
CA $150 total
includes taxes & fees
Nov 15 - Nov 16

4. Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical CenterMedical Center District, 8.1 km from Jefferson
9.2 out of 10, Wonderful, (1,535 reviews)
The price is CA $127
CA $152 total
includes taxes & fees
Nov 15 - Nov 16

5. AC Hotel by Marriott San Antonio Riverwalk
AC Hotel by Marriott San Antonio Riverwalk5.9 km from Jefferson
9.2 out of 10, Wonderful, (1,383 reviews)
The price is CA $161
CA $192 total
includes taxes & fees
Nov 20 - Nov 21

6. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
Heritage Inn & Suites San Antonio Airport, Trademark WyndhamUptown Central, 8.4 km from Jefferson
9.0 out of 10, Wonderful, (2,398 reviews)
The price is CA $112
CA $133 total
includes taxes & fees
Nov 15 - Nov 16

7. Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio RiverwalkDowntown San Antonio, 6.1 km from Jefferson
9.4 out of 10, Exceptional, (5,504 reviews)
The price is CA $181
CA $216 total
includes taxes & fees
Nov 15 - Nov 16

8. Comfort Inn and Suites Near Medical Center
Comfort Inn and Suites Near Medical Center2.6 km from Jefferson
7.2 out of 10, Good, (2,413 reviews)
The price is CA $75
CA $93 total
includes taxes & fees
Dec 8 - Dec 9

9. Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB
Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB8.9 km from Jefferson
8.6 out of 10, Excellent, (1,010 reviews)
The price is CA $96
CA $112 total
includes taxes & fees
Dec 8 - Dec 9

10. Best Western Plus Downtown North
Best Western Plus Downtown North7.7 km from Jefferson
8.6 out of 10, Excellent, (1,003 reviews)
The price is CA $126
CA $147 total
includes taxes & fees
Nov 16 - Nov 17

11. Wyndham Garden San Antonio Airport
Wyndham Garden San Antonio AirportUptown Central, 8.4 km from Jefferson
8.6 out of 10, Excellent, (2,057 reviews)
The price is CA $115
CA $137 total
includes taxes & fees
Nov 22 - Nov 23

12. Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San AntonioMedical Center District, 7.1 km from Jefferson
8.8 out of 10, Excellent, (1,003 reviews)
The price is CA $126
CA $150 total
includes taxes & fees
Nov 27 - Nov 28

13. La Quinta Inn & Suites by Wyndham San Antonio Downtown
La Quinta Inn & Suites by Wyndham San Antonio DowntownArsenal, 6.1 km from Jefferson
9.0 out of 10, Wonderful, (3,677 reviews)
The price is CA $125
CA $150 total
includes taxes & fees
Nov 23 - Nov 24

14. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB9.8 km from Jefferson
9.2 out of 10, Wonderful, (1,172 reviews)
The price is CA $147
CA $172 total
includes taxes & fees
Nov 29 - Nov 30

15. Courtyard by Marriott San Antonio Lackland
Courtyard by Marriott San Antonio Lackland8.2 km from Jefferson
8.2 out of 10, Very good, (1,003 reviews)
The price is CA $117
CA $137 total
includes taxes & fees
Nov 15 - Nov 16

16. Element by Marriott San Antonio Riverwalk
Element by Marriott San Antonio Riverwalk5.9 km from Jefferson
9.2 out of 10, Wonderful, (1,481 reviews)
The price is CA $155
CA $185 total
includes taxes & fees
Nov 29 - Nov 30

17. Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Hyatt Vacation Club at Wild Oak Ranch, San AntonioFar West Side, 13.5 km from Jefferson
9.0 out of 10, Wonderful, (2,073 reviews)
The price is CA $104
CA $183 total
includes taxes & fees
Dec 1 - Dec 2

18. Crockett Hotel
Crockett HotelDowntown San Antonio, 6.5 km from Jefferson
8.8 out of 10, Excellent, (2,854 reviews)
The price is CA $108
CA $129 total
includes taxes & fees
Nov 15 - Nov 16

19. Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown RiverwalkDowntown San Antonio, 6.2 km from Jefferson
9.0 out of 10, Wonderful, (2,394 reviews)
The price is CA $109
CA $127 total
includes taxes & fees
Nov 23 - Nov 24

20. Candlewood Suites San Antonio Lackland AFB Area by IHG
Candlewood Suites San Antonio Lackland AFB Area by IHG9.9 km from Jefferson
9.2 out of 10, Wonderful, (976 reviews)
The price is CA $164
CA $192 total
includes taxes & fees
Nov 28 - Nov 29
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in Jefferson
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() La Quinta Inn & Suites by Wyndham San Antonio Downtown | 9.0 Wonderful 3,677 reviews | View | ||||||
![]() Drury Plaza Hotel San Antonio Riverwalk | 9.4 Exceptional 5,504 reviews | View | ||||||
![]() Drury Inn & Suites San Antonio Northwest Medical Center | 9.2 Wonderful 1,535 reviews | View | ||||||
![]() Hyatt Vacation Club at Wild Oak Ranch, San Antonio | 9.0 Wonderful 2,073 reviews | View | ||||||
![]() AC Hotel by Marriott San Antonio Riverwalk | 9.2 Wonderful 1,383 reviews | View |
Where to stay in Jefferson
Find the best Jefferson areas and neighborhoods for the activities you enjoy most.

Downtown San Antonio
Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Uptown Central
While visiting Uptown Central, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Far West Side
While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Medical Center District
While Medical Center District isn't home to many top sights, Wonderland of the Americas Mall and Huebner Oaks are some notable places to visit nearby.

Northwest Side
While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Crystal Ice Palace.
Top Jefferson Hotel Reviews

Home2 Suites by Hilton San Antonio Riverwalk, TX
10/10 Excellent
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