Title: 4 Stars Hotels in Medical Center District, San Antonio from CA $145 - Find Cheap Medical Center District Hotels With 4 Stars | Expedia.ca

  

[Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides)

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Photo by Linda Cronan

# 4 Stars Hotels in Medical Center District, San Antonio from CA $145

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## Check availability on Medical Center District 4 Star Hotels

Tonight

[Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-17&endDate=2025-10-18&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-18&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Medical Center District 4 Star Hotels

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/d9ae0b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/3870f4e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/e750b64e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Valencia Riverwalk

Downtown San Antonio

9.4/10

Exceptional

(2065)

"The hotel staff were excellent. We really enjoyed our stay at Hotel Valencia. "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jared

CA $178

CA $248 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information)

![Game room](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/c353c92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/e45c03dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Suite](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/3e228819.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Riverwalk Plaza

Downtown San Antonio

8.2/10

Very good

(5916)

"Great stay "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Denira

CA $125

CA $148 total

includes taxes & fees

Oct 27 - Oct 28

[](https://www.expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 6:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/580c2292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/b322b66a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 6:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/6ae451d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency San Antonio Riverwalk

Downtown San Antonio

9.2/10

Wonderful

(1850)

"Hotel is great all around for the family."

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ray

CA $213

CA $302 total

includes taxes & fees

Nov 5 - Nov 6

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

![Outdoor pool, open 9:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/4a007da3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/ce01fda6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/375fd9a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/7a721a70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Plaza San Antonio Hotel & Spa, Autograph Collection

Downtown San Antonio

9.4/10

Exceptional

(625)

"Clean and comfy rooms, reception staff very friendly "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Adriana

CA $212

CA $254 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free cabanas](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/777cd361.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/079cef30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/6650d699.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Contessa

Downtown San Antonio

9.0/10

Wonderful

(3347)

"Great stay"

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

CA $190

CA $240 total

includes taxes & fees

Nov 18 - Nov 19

[](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/289c4b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/w3840h2553x0y4-3b70afa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/a7c66471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/cc599cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Grand Hyatt San Antonio River Walk

Downtown San Antonio

9.0/10

Wonderful

(1284)

"Great hotel for families "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ammar

CA $225

CA $311 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information)

![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/91d06689.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/ecaa0261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/bc64603a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Westin Riverwalk, San Antonio

Downtown San Antonio

8.8/10

Excellent

(1363)

"very nice property with easy access to the Riverwalk."

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janette

CA $230

CA $274 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily buffet breakfast (USD 18.95 per person)](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/f65c9ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/4baf38da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/979b867c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Westin San Antonio North

Vance Jackson

8.4/10

Very good

(1136)

"Great place to stay! "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Susan

CA $121

CA $145 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information)

![3 outdoor pools, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/fc712ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/6a38dbd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/903811ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/ca25f4a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency Hill Country Resort and Villas

Far West Side

8.8/10

Excellent

(1011)

"Great stay"

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lisa

CA $347

CA $495 total

includes taxes & fees

Oct 29 - Oct 30

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-Hill-Country-Resort-Spa.h21664.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/04916744.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/2bc2c917.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/0fe3a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/0728da0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy by Hilton San Antonio Riverwalk

Downtown San Antonio

9.2/10

Wonderful

(1548)

"Amazing staff, rooms and restaurant. "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Richard

CA $209

CA $285 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/b64c840a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/eda20c18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/40890500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/b46f887d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### InterContinental San Antonio Riverwalk by IHG

Downtown San Antonio

9.4/10

Exceptional

(575)

"Beautiful hotel "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sandra

CA $178

CA $252 total

includes taxes & fees

Nov 13 - Nov 14

[](https://www.expedia.ca/San-Antonio-Hotels-InterContinental-San-Antonio-Riverwalk.h50988.Hotel-Information)

![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/66cb446c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/8ef6e9aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/262d4090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/7b808f74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The St. Anthony, A Luxury Collection Hotel, San Antonio

Downtown San Antonio

8.8/10

Excellent

(1007)

"Beautiful hotel and comfy bed"

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cecilia

CA $225

CA $266 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/San-Antonio-Hotels-The-St-Anthony.h8789.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/471a5828.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/e9ca1e9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/d243fede.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/2cd84d09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Kimpton Santo San Antonio - Riverwalk by IHG

Downtown San Antonio

9.4/10

Exceptional

(553)

"Really nice luxury hotel"

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Juan

CA $194

CA $272 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/San-Antonio-Hotels-Kimpton-Santo.h104343109.Hotel-Information)

![Balcony view](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a1a78274.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/aca78f83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 2 Queen Beds | View from room](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a20972d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Omni La Mansion del Rio

Downtown San Antonio

9.4/10

Exceptional

(2742)

"Loved everything about the hotel and location would stay again. "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joanne

CA $229

CA $275 total

includes taxes & fees

Nov 6 - Nov 7

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3840h2557x0y3-7a64bf70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Couples treatment rooms, sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3837h2549x3y3-a19f857c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3840h2155x0y3-ce16cbd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3837h2555x3y3-71deb09d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Signia by Hilton La Cantera Resort & Spa

La Cantera District

9.0/10

Wonderful

(1032)

"Great stay new hotel huge family friendly "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Diane

CA $450

CA $611 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/San-Antonio-Hotels-Signia-By-Hilton-La-Cantera-Resort-Spa.h284306.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/eb0c229a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/fe9fa49b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/56196f19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![City view](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/2100fcb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AC Hotel by Marriott San Antonio Riverwalk

Downtown San Antonio

9.0/10

Wonderful

(958)

"We had a pleasant stay and was just a block away from riverwalk."

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janis

CA $167

CA $198 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-AC-Hotel-By-Marriott-San-Antonio-Riverwalk.h64402184.Hotel-Information)

![4 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/963d6979.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/2e5653b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/4f6de9cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![6 restaurants, breakfast, lunch, dinner served; Tex-Mex cuisine](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/82ceff23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### JW Marriott San Antonio Hill Country Resort & Spa

San Antonio

9.0/10

Wonderful

(1004)

"Another amazing stay !!"

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Richmond

CA $510

CA $699 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/San-Antonio-Hotels-JW-Marriott-San-Antonio-Hill-Country-Resort-Spa.h2841775.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/3d6f875a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/9da9332b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/95e2b02a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/ea972596.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton San Antonio Hill Country

Far West Side

8.4/10

Very good

(1018)

"Excellent, clean accommodations!"

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Crystal

CA $143

CA $219 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-San-Antonio-Hill-Country.h792228.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/9bd4897b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/1a9b583f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/155b4514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/0c8a227e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn San Antonio Downtown Riverwalk

Downtown San Antonio

8.4/10

Very good

(1015)

"Great place to stay!!! Definitely will stay again. "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

JANIE

CA $143

CA $170 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-Garden-Inn-San-Antonio-Downtown.h19991849.Hotel-Information)

![Water view](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/40020cde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed, Balcony (Luxury Spa Room)](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/9082aab5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/44e7c0ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/14047936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mokara Hotel & Spa San Antonio

Downtown San Antonio

9.6/10

Exceptional

(1005)

"Exceptional service, clean and modern rooms, front desk was welcoming and helpful! "

![](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammy

CA $344

CA $407 total

includes taxes & fees

Oct 31 - Nov 1

[](https://www.expedia.ca/San-Antonio-Hotels-Mokara-Hotel-Spa-San-Antonio.h988490.Hotel-Information)

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Save an average of 15% on thousands of hotels when you're signed in

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## Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.

![Thompson San Antonio - Riverwalk, by Hyatt](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/w3837h2534x3y3-290fc02b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Thompson San Antonio - Riverwalk, by Hyatt

115 Lexington Avenue, San Antonio, TX

CA $237

CA $328 total

Nov 2 - Nov 3

includes taxes & fees

9/10 Wonderful! (867 reviews)

[](https://expedia.ca/San-Antonio-Hotels-Thompson-San-Antonio.h59768128.Hotel-Information)

![The Luxury Suites at Arrive Eilan](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/78044df4_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Luxury Suites at Arrive Eilan

17803 La Cantera Terrace, San Antonio, TX

[Get rates](https://expedia.ca/Hotel-Search?startDate=01%2F11%2F2025&endDate=02%2F11%2F2025&selected=44917616&PinnedHotelID=44917616&HadPinnedHotel=true&regionId=553248635978913844)

[](https://expedia.ca/San-Antonio-Hotels-The-Luxury-La-Cantera-Suites.h44917616.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025&regionId=553248635978913844&star=40)

You can also use these popular filters to refine your search.

[Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Top Medical Center District Hotel Reviews

![Riverwalk Plaza](//images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg)

### Riverwalk Plaza

10/10 Excellent

"Everything was great"

[](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![Hotel Contessa](//images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg)

### Hotel Contessa

10/10 Excellent

"Everything was wonderful with the exception of the shower and toilet. It had mold in it. "

[](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information)

![The Westin San Antonio North](//images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6_y.jpg)

### The Westin San Antonio North

10/10 Excellent

"There were multiple venues going on at the same time which made for hectic and entertaining times at the hotel A Pokémon branch of comicon was surreal until I found out what was going on. Previous stays were more sedate as one would expect in primarily business oriented hotel. It is convenient to just about any place you want to see but getting onto I 10 requires a learning curve if you drive. Parking fee with no valet service was a disappointment. "

[](https://expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information)

![Hyatt Regency Hill Country Resort & Spa](//images.trvl-media.com/lodging/1000000/30000/21700/21664/fc712ef3_y.jpg)

### Hyatt Regency Hill Country Resort & Spa

10/10 Excellent

"Loved the staff so sweet and helpful "

[](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-Hill-Country-Resort-Spa.h21664.Hotel-Information)

![Hyatt Regency San Antonio Riverwalk](//images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg)

### Hyatt Regency San Antonio Riverwalk

10/10 Excellent

"Love how it is centered on the river walk. "

[](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

![The Westin Riverwalk, San Antonio](//images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg)

### The Westin Riverwalk, San Antonio

10/10 Excellent

"Eugene was fantastic ! Checked us in and gave us some pointers on what to do in the area . Phyllis was top notch too. We thank you both for a pleasant stay …❤️"

[](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information)

![Grand Hyatt San Antonio River Walk](//images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/289c4b24_y.jpg)

### Grand Hyatt San Antonio River Walk

10/10 Excellent

"Love the location! Hotel was very nice! Staff was just okay."

[](https://expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information)

![Plaza San Antonio Hotel & Spa, Autograph Collection](//images.trvl-media.com/lodging/1000000/30000/27900/27848/4a007da3_y.jpg)

### Plaza San Antonio Hotel & Spa, Autograph Collection

10/10 Excellent

"10/10 loved the property and customer service experience!"

[](https://expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

## Frequently asked questions

### What are the best 4-star hotels in Medical Centre District?

> [The Westin San Antonio North](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) earns high praise from Expedia travellers. This 4-star hotel around Medical Centre District promises a memorable visit and plenty of handy amenities.

### How much does it cost to stay in a 4-star hotel in Medical Centre District?

> With Expedia's search and sort filters, locking in a fabulous deal on a 4-star hotel in Medical Centre District just got simpler. Start by entering your chosen arrival date and length of your break. Then list the results by price and choose a property that best suits your budget and style.
> 
>   
> 
> -   Search for the lowest price from CA $328

### What's the difference between 5-star and 4-star hotels in Medical Centre District?

> Offering a welcoming guest experience and upscale décor, 4-star hotels are an excellent option for your Medical Centre District trip. These types of stays generally come with loads of useful amenities that make it a breeze to unpack and recharge — think 24-hour room service, gyms and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. A personalized service, complimentary toiletries and fine dining are typically included at these swanky retreats.

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-   [Hotels with Early Check-in in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Hotel-With-Early-Check-In.0-n6230858-0-thotelwithearlycheckin.Travel-Guide-Filter-Hotels)
-   [Romantic Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Romantic-Hotel.0-n6230858-0-tRomanticHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Spa-Hotel.0-n6230858-0-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Waterpark Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Waterpark-Hotels.0-n6230858-0-tWaterparkHotels.Travel-Guide-Filter-Hotels)
-   [Olmos Park Terrace Hotels](https://www.expedia.ca/Olmos-Park-Terrace-San-Antonio-Hotels.0-n553248635976469841-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Phil Hardberger Park](https://www.expedia.ca/Phil-Hardberger-Park-Hotels.0-l553248621532643389-0.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Prospect Hill](https://www.expedia.ca/Prospect-Hill-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976387013-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [San Antonio Hotels](https://www.expedia.ca/San-Antonio-Hotels.d178303.Travel-Guide-Hotels)
-   [Shavano Park Hotels](https://www.expedia.ca/Shavano-Park-San-Antonio-Hotels.0-n6004947-0.Travel-Guide-Filter-Hotels)
-   [Adults Only Resorts & in Shearer Hills - Ridgeview](https://www.expedia.ca/Shearer-Hills-Ridgeview-San-Antonio-Hotels-Adults-Only-Resorts.0-n553248635976471907-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
-   [Hotels near South Texas Medical Center](https://www.expedia.ca/South-Texas-Medical-Center-Hotels.0-l6193120-0.Travel-Guide-Filter-Hotels)
-   [Hotels near St. Mary's University](https://www.expedia.ca/St-Marys-University-Hotels.0-l502632-0.Travel-Guide-Filter-Hotels)
-   [Hotels near USAA Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Hotels.0-l553248621593511346-0.Travel-Guide-Filter-Hotels)
-   [Hotels near University of Texas Health and Science Center at San Antonio](https://www.expedia.ca/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Hotels.0-l6191585-0.Travel-Guide-Filter-Hotels)
-   [All Inclusive Resorts and in Vance Jackson](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
-   [Vance Jackson Hotels](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels)
-   [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels)
-   [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels)

-   [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio)
-   [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio)
-   [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio)

-   [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction)
-   [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368)
-   [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679)
-   [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419)
-   [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858)
-   [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction)

-   [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide)
-   [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide)

-   [Book Hotels in Medical Center District on Expedia.com](https://www.expedia.com/4Star-Medical-Center-District-San-Antonio-Hotels.s40-n553248635978913844-0.Travel-Guide-Filter-Hotels)