Title: 4 Stars Hotels in Medical Center District, San Antonio from CA $145 - Find Cheap Medical Center District Hotels With 4 Stars | Expedia.ca [Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/8f3b15d1d7d73e712570109708f4e829.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Linda Cronan # 4 Stars Hotels in Medical Center District, San Antonio from CA $145 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center District 4 Star Hotels Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-18&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-19&endDate=2025-10-20&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center District 4 Star Hotels ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/d9ae0b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/3870f4e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/fc81569e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Valencia Riverwalk Downtown San Antonio 9.4/10 Exceptional (2065) "The hotel staff were excellent. We really enjoyed our stay at Hotel Valencia. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jared CA $178 CA $248 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Game room](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/2f723300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/3e228819.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/c353c92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Riverwalk Plaza Downtown San Antonio 8.2/10 Very good (5917) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denira CA $125 CA $148 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/6744430c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 6:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/580c2292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/b322b66a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency San Antonio Riverwalk Downtown San Antonio 9.2/10 Wonderful (1850) "Hotel is great all around for the family." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ray CA $213 CA $302 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information) ![Outdoor pool, open 9:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/4a007da3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/375fd9a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/ce01fda6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/7a721a70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Plaza San Antonio Hotel & Spa, Autograph Collection Downtown San Antonio 9.4/10 Exceptional (626) "Clean and comfy rooms, reception staff very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adriana CA $212 CA $254 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free cabanas](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/777cd361.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, alfresco dining ](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/cbd1f2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/079cef30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Contessa Downtown San Antonio 9.0/10 Wonderful (3347) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $190 CA $240 total includes taxes & fees Nov 18 - Nov 19 [](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/289c4b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/a7c66471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/cc599cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/w3288h3837x3y3-47232cf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hyatt San Antonio River Walk Downtown San Antonio 9.0/10 Wonderful (1285) "Great hotel for families " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ammar CA $225 CA $311 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information) ![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/91d06689.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/bc64603a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/67d9454d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Riverwalk, San Antonio Downtown San Antonio 8.8/10 Excellent (1363) "very nice property with easy access to the Riverwalk." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janette CA $230 CA $274 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/533974de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (USD 18.95 per person)](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/f65c9ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/979b867c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin San Antonio North Vance Jackson 8.4/10 Very good (1136) "Great place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $121 CA $145 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) ![3 outdoor pools, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/fc712ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/903811ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/6a38dbd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/ca25f4a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Hill Country Resort and Villas Far West Side 8.8/10 Excellent (1012) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $347 CA $495 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-Hill-Country-Resort-Spa.h21664.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/04916744.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/7c5ba6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/0728da0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/2bc2c917.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Canopy by Hilton San Antonio Riverwalk Downtown San Antonio 9.2/10 Wonderful (1550) "Amazing staff, rooms and restaurant. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $209 CA $285 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/b64c840a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/b46f887d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/40890500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/c2295676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### InterContinental San Antonio Riverwalk by IHG Downtown San Antonio 9.4/10 Exceptional (576) "Beautiful hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandra CA $178 CA $252 total includes taxes & fees Nov 13 - Nov 14 [](https://www.expedia.ca/San-Antonio-Hotels-InterContinental-San-Antonio-Riverwalk.h50988.Hotel-Information) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/66cb446c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/7b808f74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/262d4090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/8ef6e9aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Anthony, A Luxury Collection Hotel, San Antonio Downtown San Antonio 8.8/10 Excellent (1007) "Beautiful hotel and comfy bed" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cecilia CA $225 CA $266 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/San-Antonio-Hotels-The-St-Anthony.h8789.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/471a5828.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/e9ca1e9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/2cd84d09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/5948aff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kimpton Santo San Antonio - Riverwalk by IHG Downtown San Antonio 9.4/10 Exceptional (553) "Really nice luxury hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan CA $194 CA $272 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Antonio-Hotels-Kimpton-Santo.h104343109.Hotel-Information) ![Balcony view](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/67b863e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds | View from room](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a20972d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a1a78274.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni La Mansion del Rio Downtown San Antonio 9.4/10 Exceptional (2742) "Loved everything about the hotel and location would stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joanne CA $229 CA $275 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3840h2557x0y3-7a64bf70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3837h2549x3y3-a19f857c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3840h2155x0y3-ce16cbd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/w3837h2555x3y3-71deb09d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Signia by Hilton La Cantera Resort & Spa La Cantera District 9.0/10 Wonderful (1032) "Great stay new hotel huge family friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diane CA $450 CA $611 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Antonio-Hotels-Signia-By-Hilton-La-Cantera-Resort-Spa.h284306.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/eb0c229a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/56196f19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/fe9fa49b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/2100fcb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel by Marriott San Antonio Riverwalk Downtown San Antonio 9.0/10 Wonderful (958) "We had a pleasant stay and was just a block away from riverwalk." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janis CA $167 CA $198 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-AC-Hotel-By-Marriott-San-Antonio-Riverwalk.h64402184.Hotel-Information) ![4 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/963d6979.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 restaurants, breakfast, lunch, dinner served; Tex-Mex cuisine](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/82ceff23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/b2388ce6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/2e5653b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### JW Marriott San Antonio Hill Country Resort & Spa San Antonio 9.0/10 Wonderful (1004) "Another amazing stay !!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richmond CA $510 CA $699 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Antonio-Hotels-JW-Marriott-San-Antonio-Hill-Country-Resort-Spa.h2841775.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/3d6f875a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/95e2b02a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/ea972596.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/5c1b72b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Antonio Hill Country Far West Side 8.4/10 Very good (1018) "Excellent, clean accommodations!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Crystal CA $143 CA $219 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Antonio-Hotels-Hilton-San-Antonio-Hill-Country.h792228.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/9bd4897b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/0c8a227e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/155b4514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/7003bd50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn San Antonio Downtown Riverwalk Downtown San Antonio 8.4/10 Very good (1015) "Great place to stay!!! Definitely will stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JANIE CA $143 CA $170 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/San-Antonio-Hotels-Hilton-Garden-Inn-San-Antonio-Downtown.h19991849.Hotel-Information) ![Water view](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/40020cde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Balcony (Luxury Spa Room)](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/9082aab5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/14047936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Balcony (Luxury Spa Room) | Balcony view](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/e749b075.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mokara Hotel & Spa San Antonio Downtown San Antonio 9.6/10 Exceptional (1005) "Exceptional service, clean and modern rooms, front desk was welcoming and helpful! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy CA $344 CA $407 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Antonio-Hotels-Mokara-Hotel-Spa-San-Antonio.h988490.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Medical-Center-District-San-Antonio-Hotels.s40-n553248635978913844-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Medical-Center-District-San-Antonio-Hotels.s40-n553248635978913844-0.Travel-Guide-Filter-Hotels) ## Explore similar 5-star hotels Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District. ![Thompson San Antonio - Riverwalk, by Hyatt](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/w3837h2534x3y3-290fc02b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Thompson San Antonio - Riverwalk, by Hyatt 115 Lexington Avenue, San Antonio, TX CA $237 CA $328 total Nov 2 - Nov 3 includes taxes & fees 9/10 Wonderful! (867 reviews) [](https://expedia.ca/San-Antonio-Hotels-Thompson-San-Antonio.h59768128.Hotel-Information) ![The Luxury Suites at Arrive Eilan](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/78044df4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Luxury Suites at Arrive Eilan 17803 La Cantera Terrace, San Antonio, TX [Get rates](https://expedia.ca/Hotel-Search?startDate=01%2F11%2F2025&endDate=02%2F11%2F2025&selected=44917616&PinnedHotelID=44917616&HadPinnedHotel=true®ionId=553248635978913844) [](https://expedia.ca/San-Antonio-Hotels-The-Luxury-La-Cantera-Suites.h44917616.Hotel-Information) Still don't see what you're looking for? [See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025®ionId=553248635978913844&star=40) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025®ionId=553248635978913844&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025®ionId=553248635978913844&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025®ionId=553248635978913844&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025®ionId=553248635978913844&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F10%2F2025&endDate=20%2F10%2F2025®ionId=553248635978913844&star=40&star=40&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Medical Center District Hotel Reviews ![Riverwalk Plaza](//images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg) ### Riverwalk Plaza 10/10 Excellent "Everything was great" [](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![Hotel Contessa](//images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg) ### Hotel Contessa 10/10 Excellent "Everything was wonderful with the exception of the shower and toilet. It had mold in it. " [](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information) ![Grand Hyatt San Antonio River Walk](//images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/289c4b24_y.jpg) ### Grand Hyatt San Antonio River Walk 10/10 Excellent "Front desk staff was over the top nice. Even switched rooms to accommodate our child wanting a different view. " [](https://expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information) ![The Westin San Antonio North](//images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6_y.jpg) ### The Westin San Antonio North 10/10 Excellent "There were multiple venues going on at the same time which made for hectic and entertaining times at the hotel A Pokémon branch of comicon was surreal until I found out what was going on. Previous stays were more sedate as one would expect in primarily business oriented hotel. It is convenient to just about any place you want to see but getting onto I 10 requires a learning curve if you drive. Parking fee with no valet service was a disappointment. " [](https://expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) ![Hyatt Regency Hill Country Resort & Spa](//images.trvl-media.com/lodging/1000000/30000/21700/21664/fc712ef3_y.jpg) ### Hyatt Regency Hill Country Resort & Spa 10/10 Excellent "Loved the staff so sweet and helpful " [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-Hill-Country-Resort-Spa.h21664.Hotel-Information) ![Hyatt Regency San Antonio Riverwalk](//images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg) ### Hyatt Regency San Antonio Riverwalk 10/10 Excellent "Love how it is centered on the river walk. " [](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information) ![The Westin Riverwalk, San Antonio](//images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg) ### The Westin Riverwalk, San Antonio 10/10 Excellent "Eugene was fantastic ! Checked us in and gave us some pointers on what to do in the area . Phyllis was top notch too. We thank you both for a pleasant stay …❤️" [](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information) ![Plaza San Antonio Hotel & Spa, Autograph Collection](//images.trvl-media.com/lodging/1000000/30000/27900/27848/4a007da3_y.jpg) ### Plaza San Antonio Hotel & Spa, Autograph Collection 10/10 Excellent "10/10 loved the property and customer service experience!" [](https://expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information) ## Frequently asked questions ### What are the best 4-star hotels in Medical Centre District? > [The Westin San Antonio North](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) earns high praise from Expedia travellers. This 4-star hotel around Medical Centre District promises a memorable visit and plenty of handy amenities. ### How much does it cost to stay in a 4-star hotel in Medical Centre District? > With Expedia's search and sort filters, locking in a fabulous deal on a 4-star hotel in Medical Centre District just got simpler. Start by entering your chosen arrival date and length of your break. Then list the results by price and choose a property that best suits your budget and style. > > > > - Search for the lowest price from CA $328 ### What's the difference between 5-star and 4-star hotels in Medical Centre District? > Offering a welcoming guest experience and upscale décor, 4-star hotels are an excellent option for your Medical Centre District trip. These types of stays generally come with loads of useful amenities that make it a breeze to unpack and recharge — think 24-hour room service, gyms and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. 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[Hotels near Monster Mini Golf](https://www.expedia.ca/Monster-Mini-Golf-Hotels.0-l553248621532643386-0.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in North Central](https://www.expedia.ca/North-Central-San-Antonio-Hotels-Hotels-With-Smoking-Rooms.0-n3000663370-0-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [North Central Hotels](https://www.expedia.ca/North-Central-San-Antonio-Hotels.0-n3000663370-0.Travel-Guide-Filter-Hotels) - [Hotels near North Star Mall](https://www.expedia.ca/North-Star-Mall-Hotels.0-l502628-0.Travel-Guide-Filter-Hotels) - [Golf Hotels in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Golf-Hotel.0-n553248635976480994-0-tGolfHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Hotels-With-Free-Parking.0-n553248635976480994-0-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Hotels-With-Indoor-Pool.0-n553248635976480994-0-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Northwest Los Angeles Heights](https://www.expedia.ca/Northwest-Los-Angeles-Heights-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976480994-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Cheap-Hotels.0-n887264728595001344-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Family-Hotel.0-n887264728595001344-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Hotels-With-Free-Airport-Shuttle.0-n887264728595001344-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Hotels-With-Kitchenettes.0-n887264728595001344-0-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n887264728595001344-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Northwest Side](https://www.expedia.ca/Northwest-Side-San-Antonio-Hotels-Spa-Hotel.0-n887264728595001344-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Hotels near Oak Hills Country Club](https://www.expedia.ca/Oak-Hills-Country-Club-Hotels.0-l553248621532643653-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Boutique-Hotel.0-n6230858-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Hotel-With-Early-Check-In.0-n6230858-0-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Romantic-Hotel.0-n6230858-0-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Spa-Hotel.0-n6230858-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Oakland Estates](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Waterpark-Hotels.0-n6230858-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Olmos Park Terrace Hotels](https://www.expedia.ca/Olmos-Park-Terrace-San-Antonio-Hotels.0-n553248635976469841-0.Travel-Guide-Filter-Hotels) - [Hotels near Phil Hardberger Park](https://www.expedia.ca/Phil-Hardberger-Park-Hotels.0-l553248621532643389-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Prospect Hill](https://www.expedia.ca/Prospect-Hill-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976387013-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [San Antonio Hotels](https://www.expedia.ca/San-Antonio-Hotels.d178303.Travel-Guide-Hotels) - [Shavano Park Hotels](https://www.expedia.ca/Shavano-Park-San-Antonio-Hotels.0-n6004947-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Shearer Hills - Ridgeview](https://www.expedia.ca/Shearer-Hills-Ridgeview-San-Antonio-Hotels-Adults-Only-Resorts.0-n553248635976471907-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Hotels near South Texas Medical Center](https://www.expedia.ca/South-Texas-Medical-Center-Hotels.0-l6193120-0.Travel-Guide-Filter-Hotels) - [Hotels near St. Mary's University](https://www.expedia.ca/St-Marys-University-Hotels.0-l502632-0.Travel-Guide-Filter-Hotels) - [Hotels near USAA Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Hotels.0-l553248621593511346-0.Travel-Guide-Filter-Hotels) - [Hotels near University of Texas Health and Science Center at San Antonio](https://www.expedia.ca/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Hotels.0-l6191585-0.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Vance Jackson](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Vance Jackson Hotels](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels) - [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels) - [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio) - [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio) - [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio) - [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction) - [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368) - [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679) - [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419) - [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858) - [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction) - [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide) - [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide) - 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