Title: 4 Stars Hotels in Medical Center District, San Antonio from CA $144 - Find Cheap Medical Center District Hotels With 4 Stars | Expedia.ca

  

[Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides)

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# 4 Stars Hotels in Medical Center District, San Antonio from CA $144

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## Check availability on Medical Center District 4 Star Hotels

Tonight

[Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-10&endDate=2025-10-11&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-11&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Medical Center District 4 Star Hotels

![Game room](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/2f723300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/e45c03dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/c353c92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Riverwalk Plaza

Downtown San Antonio

8.2/10

Very good

(5892)

"Great stay "

CA $125

CA $148 total

includes taxes & fees

Oct 13 - Oct 14

[](https://www.expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; American cuisine, alfresco dining ](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/cbd1f2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/6650d699.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/079cef30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Contessa

Downtown San Antonio

9.0/10

Wonderful

(3316)

"Loved our stay here, everything was perfect!"

CA $194

CA $251 total

includes taxes & fees

Oct 22 - Oct 23

[](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information)

![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/66cb446c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/7b808f74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/262d4090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/8ef6e9aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The St. Anthony, A Luxury Collection Hotel, San Antonio

Downtown San Antonio

8.8/10

Excellent

(1001)

"Beautiful property great staff "

CA $225

CA $266 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/San-Antonio-Hotels-The-St-Anthony.h8789.Hotel-Information)

![Balcony view](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/aca78f83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a1a78274.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/67b863e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Omni La Mansion del Rio

Downtown San Antonio

9.4/10

Exceptional

(2728)

"Loved everything about the hotel and location would stay again. "

CA $229

CA $274 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/3870f4e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/d9ae0b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/fc81569e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Valencia Riverwalk

Downtown San Antonio

9.4/10

Exceptional

(2037)

"Great stay"

CA $178

CA $248 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/b64c840a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/b46f887d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/c2295676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/eda20c18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### InterContinental San Antonio Riverwalk by IHG

Downtown San Antonio

9.4/10

Exceptional

(571)

"Beautiful hotel "

CA $178

CA $264 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-InterContinental-San-Antonio-Riverwalk.h50988.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/533974de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily buffet breakfast (USD 18.95 per person)](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/f65c9ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/4baf38da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Westin San Antonio North

Vance Jackson

8.4/10

Very good

(1115)

"Beautiful hotel! Loved the price "

CA $120

CA $144 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information)

![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/91d06689.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/bc64603a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/ecaa0261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Westin Riverwalk, San Antonio

Downtown San Antonio

8.8/10

Excellent

(1353)

"very nice property with easy access to the Riverwalk."

CA $234

CA $279 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information)

![4 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/963d6979.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![6 restaurants, breakfast, lunch, dinner served; Tex-Mex cuisine](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/82ceff23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/2e5653b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/4f6de9cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### JW Marriott San Antonio Hill Country Resort & Spa

San Antonio

9.0/10

Wonderful

(1004)

"Another amazing stay !!"

CA $421

CA $593 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/San-Antonio-Hotels-JW-Marriott-San-Antonio-Hill-Country-Resort-Spa.h2841775.Hotel-Information)

![Outdoor pool, open 9:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/4a007da3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/375fd9a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/2406f985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/7a721a70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Plaza San Antonio Hotel & Spa, Autograph Collection

Downtown San Antonio

9.4/10

Exceptional

(619)

"Great service, cute hotel and clean, comfortable bed! "

CA $212

CA $254 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/471a5828.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/5948aff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/d243fede.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/2cd84d09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Kimpton Santo San Antonio - Riverwalk by IHG

Downtown San Antonio

9.4/10

Exceptional

(540)

"The hotel was absolutely gorgeous."

CA $187

CA $263 total

includes taxes & fees

Nov 9 - Nov 10

[](https://www.expedia.ca/San-Antonio-Hotels-Kimpton-Santo.h104343109.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/b322b66a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 6:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/6ae451d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 6:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/580c2292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency San Antonio Riverwalk

Downtown San Antonio

9.2/10

Wonderful

(1848)

"Hotel is great all around for the family."

CA $213

CA $301 total

includes taxes & fees

Nov 5 - Nov 6

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/f90fa888.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden view](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/9d4d5eef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private pool](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/aecc2cdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, pay movies](https://images.trvl-media.com/lodging/1000000/290000/284400/284306/ce5d9113.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Signia by Hilton La Cantera Resort & Spa

La Cantera District

9.0/10

Wonderful

(1028)

"Very nice pools"

CA $573

CA $751 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/San-Antonio-Hotels-Signia-By-Hilton-La-Cantera-Resort-Spa.h284306.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/84000000/83450000/83445300/83445300/dcfe1f6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/84000000/83450000/83445300/83445300/7783086f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![City view](https://images.trvl-media.com/lodging/84000000/83450000/83445300/83445300/eeee237b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/84000000/83450000/83445300/83445300/a5abb3b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Element San Antonio Riverwalk

Downtown San Antonio

9.2/10

Wonderful

(1072)

"Great stay "

CA $176

CA $209 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/San-Antonio-Hotels-Element-San-Antonio-Riverwalk.h83445300.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/eb0c229a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/0173a5b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/fe9fa49b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![City view](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/2100fcb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AC Hotel by Marriott San Antonio Riverwalk

Downtown San Antonio

9.0/10

Wonderful

(953)

"Amazing stay"

CA $167

CA $197 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-AC-Hotel-By-Marriott-San-Antonio-Riverwalk.h64402184.Hotel-Information)

![3 outdoor pools, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/fc712ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/ca25f4a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/6a38dbd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Body treatments, aromatherapy, deep-tissue massages, sports massages](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/d40374ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency Hill Country Resort and Villas

Far West Side

8.8/10

Excellent

(1008)

"Great stay"

CA $346

CA $494 total

includes taxes & fees

Oct 29 - Oct 30

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-Hill-Country-Resort-Spa.h21664.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/04916744.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/0fe3a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/7c5ba6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/2bc2c917.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy by Hilton San Antonio Riverwalk

Downtown San Antonio

9.2/10

Wonderful

(1539)

"Amazing staff, rooms and restaurant. "

CA $175

CA $244 total

includes taxes & fees

Nov 10 - Nov 11

[](https://www.expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/3d6f875a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/9da9332b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/5c1b72b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/ea972596.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton San Antonio Hill Country

Far West Side

8.4/10

Very good

(1013)

"Excellent, clean accommodations!"

CA $142

CA $218 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-San-Antonio-Hill-Country.h792228.Hotel-Information)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/289c4b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/cc599cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/a7c66471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/w3840h2553x0y4-3b70afa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Grand Hyatt San Antonio River Walk

Downtown San Antonio

9.0/10

Wonderful

(1276)

"Great hotel for families "

CA $249

CA $339 total

includes taxes & fees

Oct 30 - Oct 31

[](https://www.expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/9bd4897b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/1a9b583f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/7003bd50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/155b4514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn San Antonio Downtown Riverwalk

Downtown San Antonio

8.4/10

Very good

(1011)

"Great place to stay!!! Definitely will stay again. "

CA $148

CA $177 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-Garden-Inn-San-Antonio-Downtown.h19991849.Hotel-Information)

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## Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.

![Thompson San Antonio - Riverwalk, by Hyatt](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/w3837h2534x3y3-290fc02b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Thompson San Antonio - Riverwalk, by Hyatt

115 Lexington Avenue, San Antonio, TX

CA $213

CA $300 total

Nov 2 - Nov 3

includes taxes & fees

9/10 Wonderful! (863 reviews)

[](https://expedia.ca/San-Antonio-Hotels-Thompson-San-Antonio.h59768128.Hotel-Information)

![The Luxury Suites at Arrive Eilan](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/78044df4_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Luxury Suites at Arrive Eilan

17803 La Cantera Terrace, San Antonio, TX

[Get rates](https://expedia.ca/Hotel-Search?startDate=25%2F10%2F2025&endDate=26%2F10%2F2025&selected=44917616&PinnedHotelID=44917616&HadPinnedHotel=true&regionId=553248635978913844)

[](https://expedia.ca/San-Antonio-Hotels-The-Luxury-La-Cantera-Suites.h44917616.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=12%2F10%2F2025&endDate=13%2F10%2F2025&regionId=553248635978913844&star=40)

You can also use these popular filters to refine your search.

[Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=12%2F10%2F2025&endDate=13%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=12%2F10%2F2025&endDate=13%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=12%2F10%2F2025&endDate=13%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=12%2F10%2F2025&endDate=13%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=12%2F10%2F2025&endDate=13%2F10%2F2025&regionId=553248635978913844&star=40&star=40&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Top Medical Center District Hotel Reviews

![Riverwalk Plaza](//images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg)

### Riverwalk Plaza

10/10 Excellent

"Great hotel. Affordable price. Amazing staff and great activities around the hotel. Rooms are nice and clean."

[](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![The Westin Riverwalk, San Antonio](//images.trvl-media.com/lodging/1000000/340000/330600/330528/cdee6e8f_y.jpg)

### The Westin Riverwalk, San Antonio

10/10 Excellent

"The staff were incredibly nice and accommodating."

[](https://expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information)

![The Westin San Antonio North](//images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6_y.jpg)

### The Westin San Antonio North

10/10 Excellent

"I did not have time for gym. Staff was excellent! I felt safe and comfortable. Love the Starbucks coffee every morning! I have stayed a total of 4 times. That should tell you something! "

[](https://expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information)

![Hyatt Regency San Antonio Riverwalk](//images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg)

### Hyatt Regency San Antonio Riverwalk

10/10 Excellent

"Relaxing stay. "

[](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

![Hotel Contessa](//images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg)

### Hotel Contessa

10/10 Excellent

"Gentleman at front desk was the most polite person, very professional "

[](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information)

![Plaza San Antonio Hotel & Spa, Autograph Collection](//images.trvl-media.com/lodging/1000000/30000/27900/27848/4a007da3_y.jpg)

### Plaza San Antonio Hotel & Spa, Autograph Collection

10/10 Excellent

"The staff goes above and beyond to make your stay enjoyable and comfortable. It smells clean and crisp when you walk in and throughout the building. Love it here!"

[](https://expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

![Grand Hyatt San Antonio River Walk](//images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/289c4b24_y.jpg)

### Grand Hyatt San Antonio River Walk

10/10 Excellent

"Great hotel for families "

[](https://expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information)

## Frequently asked questions

### What are the best 4-star hotels in Medical Centre District?

> [The Westin San Antonio North](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information) earns high praise from Expedia travellers. This 4-star hotel around Medical Centre District promises a memorable visit and plenty of handy amenities.

### How much does it cost to stay in a 4-star hotel in Medical Centre District?

> With Expedia's search and sort filters, locking in a fabulous deal on a 4-star hotel in Medical Centre District just got simpler. Start by entering your chosen arrival date and length of your break. Then list the results by price and choose a property that best suits your budget and style.
> 
>   
> 
> -   Search for the lowest price from CA $300

### What's the difference between 5-star and 4-star hotels in Medical Centre District?

> Offering a welcoming guest experience and upscale décor, 4-star hotels are an excellent option for your Medical Centre District trip. These types of stays generally come with loads of useful amenities that make it a breeze to unpack and recharge — think 24-hour room service, gyms and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. A personalized service, complimentary toiletries and fine dining are typically included at these swanky retreats.

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-   [Vista Del Norte Hotels](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Wonderland of the Americas Mall](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Woodlawn Lake](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Hotels near Woodlawn Theater](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels)
-   [Best Western Hotels in Woodridge](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels)

-   [Flights from Vancouver (YVR) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio)
-   [Flights from Calgary (YYC) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio)
-   [Flights from Toronto (YYZ) to San Antonio (SAT)](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio)

-   [North Star Mall](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction)
-   [Visit Balcones Heights](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368)
-   [Visit Castle Hills](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679)
-   [Visit Leon Valley](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419)
-   [Visit Oakland Estates](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858)
-   [Usaa Corporate Office Headquarters](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction)

-   [Car rentals near Shavano Park](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide)
-   [Car rentals near USAA Corporate Office Headquarters](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide)

-   [Book Hotels in Medical Center District on Expedia.com](https://www.expedia.com/4Star-Medical-Center-District-San-Antonio-Hotels.s40-n553248635978913844-0.Travel-Guide-Filter-Hotels)