Title: 4 Stars Hotels in Medical Center District, San Antonio from CA $132 - Find Cheap Medical Center District Hotels With 4 Stars | Expedia.ca

[Medical Center District Travel Guide](https://expedia.ca/San-Antonio-Medical-Center-District.dx553248635978913844)[Vacation Rentals in San Antonio](https://expedia.ca/San-Antonio-Vacation-Rentals.d178303.Travel-Guide-VacationRentals)[Flights to San Antonio](https://expedia.ca/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.ca/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center-District.d553248635978913844.Car-Rental-Guide)[Medical Center District Vacations](https://expedia.ca/Medical-Center-District.d553248635978913844.Destination-Travel-Guides)

![River walk in San Antonio](https://images.trvl-media.com/place/553248635978913844/ef5a7faf-f6d9-4f7e-b325-ac477c5ad14d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# 4 Stars Hotels in Medical Center District, San Antonio from CA $132

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## Check availability on Medical Center District 4 Star Hotels

Tonight

[Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-14&endDate=2025-12-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635978913844&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Medical Center District 4-star hotels

![Exterior](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/c044e985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/3870f4e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/fc81569e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Valencia Riverwalk

[](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information)

Downtown San Antonio

9.4/10

Exceptional

(2236)

"Beautful hotel would definitely recommend "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christina Ashley

CA $132

CA $195 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information)

![Game room](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite | Balcony](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/36103759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/655bb231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![King Balcony](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/05b729d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Riverwalk Plaza

[](https://www.expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

Downtown San Antonio

8.2/10

Very good

(6182)

"Nice hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gabriel

CA $123

CA $145 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/91d06689.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/1bef3f5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/5c95060a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/340000/330600/330528/w4224h4647x0y0-5192f475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Westin Riverwalk, San Antonio

[](https://www.expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information)

Downtown San Antonio

8.8/10

Excellent

(1428)

"Great service and nice rooms. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debby

CA $214

CA $255 total

includes taxes & fees

Dec 23 - Dec 24

[](https://www.expedia.ca/San-Antonio-Hotels-The-Westin-Riverwalk.h330528.Hotel-Information)

![Deluxe Room, 2 Queen Beds | View from room](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a20972d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Balcony view](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/aca78f83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/67b863e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Omni La Mansion del Rio

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information)

Downtown San Antonio

9.4/10

Exceptional

(2807)

"Overall a great place To stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

CA $274

CA $329 total

includes taxes & fees

Dec 23 - Dec 24

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information)

![Outdoor pool, open 9:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/f40a8bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/9b05a270.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/d2818479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/bb267c25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Plaza San Antonio Hotel & Spa, Autograph Collection

[](https://www.expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

Downtown San Antonio

9.4/10

Exceptional

(681)

"Friendly staff place was clean!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kayla

CA $219

CA $302 total

includes taxes & fees

Dec 19 - Dec 20

[](https://www.expedia.ca/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/b64c840a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/bb88f866.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/7faebc8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/60000/51000/50988/33e29968.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### InterContinental San Antonio Riverwalk by IHG

[](https://www.expedia.ca/San-Antonio-Hotels-InterContinental-San-Antonio-Riverwalk.h50988.Hotel-Information)

Downtown San Antonio

9.2/10

Wonderful

(632)

"Excellent place to stay at"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Adrian

CA $222

CA $318 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-InterContinental-San-Antonio-Riverwalk.h50988.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/b322b66a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 6:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/6ae451d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 6:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/580c2292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency San Antonio Riverwalk

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

Downtown San Antonio

9.2/10

Wonderful

(1921)

"Great stay overall "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melissa

CA $210

CA $296 total

includes taxes & fees

Dec 23 - Dec 24

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/a7c66471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/82048845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/w3288h3837x3y3-52c68d62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/2000000/1850000/1848300/1848212/d4b99fdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Grand Hyatt San Antonio River Walk

[](https://www.expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information)

Downtown San Antonio

9.2/10

Wonderful

(1312)

"Wonderful stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joseph

CA $198

CA $319 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-Grand-Hyatt-San-Antonio-River-Walk.h1848212.Hotel-Information)

![Outdoor pool, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/0cae8c15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/d6e73c4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/62d1e8b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/8800/8789/cdde05e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The St. Anthony, A Luxury Collection Hotel, San Antonio

[](https://www.expedia.ca/San-Antonio-Hotels-The-St-Anthony.h8789.Hotel-Information)

Downtown San Antonio

8.8/10

Excellent

(1004)

"Great hotel! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kace

CA $222

CA $262 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-The-St-Anthony.h8789.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/4db1357c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/3ded3c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/9bb2dd09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/7c5ba6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy by Hilton San Antonio Riverwalk

[](https://www.expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

Downtown San Antonio

9.2/10

Wonderful

(1584)

"The location was excellent - right on the Riverwalk!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ellen

CA $228

CA $307 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/e0a928b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/d243fede.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/76d8063a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges, cocktail bar, rooftop bar](https://images.trvl-media.com/lodging/105000000/104350000/104343200/104343109/f866e2f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Kimpton Santo San Antonio - Riverwalk by IHG

[](https://www.expedia.ca/San-Antonio-Hotels-Kimpton-Santo.h104343109.Hotel-Information)

Downtown San Antonio

9.4/10

Exceptional

(636)

"Great hotel, friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Darrin

CA $209

CA $289 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/San-Antonio-Hotels-Kimpton-Santo.h104343109.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/4b4814a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![City view](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/355c1583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/0173a5b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/fe9fa49b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AC Hotel by Marriott San Antonio Riverwalk

[](https://www.expedia.ca/San-Antonio-Hotels-AC-Hotel-By-Marriott-San-Antonio-Riverwalk.h64402184.Hotel-Information)

Downtown San Antonio

9.0/10

Wonderful

(1066)

"The space was clean , modern and cozy. The location was outstanding. The front desk was very helpful and having the wonderful rooftop bar was just chefs kiss."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kimberly

CA $157

CA $186 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-AC-Hotel-By-Marriott-San-Antonio-Riverwalk.h64402184.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/b99867e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/416e70de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/29446190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/3200/3187/54fbc661.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Westin San Antonio North

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information)

Vance Jackson

8.6/10

Excellent

(1211)

"Nice, clean, courteous staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Darren

CA $113

CA $135 total

includes taxes & fees

Dec 18 - Dec 19

[](https://www.expedia.ca/San-Antonio-Hotels-Omni-San-Antonio-Hotel-At-The-Colonnade.h3187.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/30000/25600/25575/bcb3494f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25600/25575/acd11953.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25600/25575/d9f6aac0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/25600/25575/8c034cbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Palacio Del Rio

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-Palacio-Del-Rio.h25575.Hotel-Information)

Downtown San Antonio

8.8/10

Excellent

(1086)

"Clean room, staff was helpful and food was good."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Velma

CA $221

CA $262 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-Palacio-Del-Rio.h25575.Hotel-Information)

![4 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/920f2185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/d28b35c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![6 restaurants, breakfast, lunch, dinner served; Tex-Mex cuisine](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/959c4c25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/3000000/2850000/2841800/2841775/f467a555.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### JW Marriott San Antonio Hill Country Resort & Spa

[](https://www.expedia.ca/San-Antonio-Hotels-JW-Marriott-San-Antonio-Hill-Country-Resort-Spa.h2841775.Hotel-Information)

San Antonio

9.0/10

Wonderful

(1001)

"Wonder stay can't wait to co.e back again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mike

CA $453

CA $629 total

includes taxes & fees

Dec 16 - Dec 17

[](https://www.expedia.ca/San-Antonio-Hotels-JW-Marriott-San-Antonio-Hill-Country-Resort-Spa.h2841775.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/w4500h3349x0y0-0f535e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/44e7c0ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/abb51634.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/990000/988500/988490/6f0d786f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mokara Hotel & Spa San Antonio

[](https://www.expedia.ca/San-Antonio-Hotels-Mokara-Hotel-Spa-San-Antonio.h988490.Hotel-Information)

Downtown San Antonio

9.6/10

Exceptional

(1002)

"great place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Perry

CA $453

CA $537 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/San-Antonio-Hotels-Mokara-Hotel-Spa-San-Antonio.h988490.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13400/13389/8f88f434.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13400/13389/ab72fc0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13400/13389/0c117045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/13400/13389/a86235e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### DoubleTree by Hilton San Antonio Downtown

[](https://www.expedia.ca/San-Antonio-Hotels-DoubleTree-By-Hilton-San-Antonio-Downtown.h13389.Hotel-Information)

Vista Verde South

8.2/10

Very good

(1002)

"Always a clean place to stay in the staff is always amazing"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

CA $112

CA $132 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-DoubleTree-By-Hilton-San-Antonio-Downtown.h13389.Hotel-Information)

![3 outdoor pools, cabanas (surcharge), sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/fc712ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges, cocktail bar](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/81c326f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/98af9826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/21700/21664/18d898f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency Hill Country Resort and Villas

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-Hill-Country-Resort-Spa.h21664.Hotel-Information)

Far West Side

8.8/10

Excellent

(1002)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lisa

CA $398

CA $544 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/San-Antonio-Hotels-Hyatt-Regency-Hill-Country-Resort-Spa.h21664.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/9bd4897b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/7003bd50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/cac980a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991849/1a9b583f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn San Antonio Downtown Riverwalk

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-Garden-Inn-San-Antonio-Downtown.h19991849.Hotel-Information)

Downtown San Antonio

8.4/10

Very good

(1002)

"Clean rooms, amazing staff, valet parking was great and location of hotel is amazing."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

CA $126

CA $150 total

includes taxes & fees

Dec 25 - Dec 26

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-Garden-Inn-San-Antonio-Downtown.h19991849.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/3d6f875a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/85b4b260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily to-go breakfast for a fee](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/bbead438.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/800000/792300/792228/95e2b02a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton San Antonio Hill Country

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-San-Antonio-Hill-Country.h792228.Hotel-Information)

Far West Side

8.4/10

Very good

(1044)

"Great location for Sea World. Always clean and friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

CA $134

CA $205 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/San-Antonio-Hotels-Hilton-San-Antonio-Hill-Country.h792228.Hotel-Information)

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## Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.

![Thompson San Antonio - Riverwalk, by Hyatt](https://images.trvl-media.com/lodging/60000000/59770000/59768200/59768128/w3837h2534x3y3-290fc02b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Thompson San Antonio - Riverwalk, by Hyatt

115 Lexington Avenue San Antonio TX

CA $233

CA $322 total

Dec 19 - Dec 20

includes taxes & fees

9/10 Wonderful! (912 reviews)

[](https://expedia.ca/San-Antonio-Hotels-Thompson-San-Antonio.h59768128.Hotel-Information)

![The Luxury Suites at Arrive Eilan](https://images.trvl-media.com/lodging/45000000/44920000/44917700/44917616/78044df4_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Luxury Suites at Arrive Eilan

17803 La Cantera Terrace San Antonio TX

[Get rates](https://expedia.ca/Hotel-Search?startDate=27%2F12%2F2025&endDate=28%2F12%2F2025&selected=44917616&PinnedHotelID=44917616&HadPinnedHotel=true&regionId=553248635978913844)

[](https://expedia.ca/San-Antonio-Hotels-The-Luxury-La-Cantera-Suites.h44917616.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Medical Center District.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&regionId=553248635978913844&star=40)

You can also use these popular filters to refine your search.

[Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&regionId=553248635978913844&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&regionId=553248635978913844&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&regionId=553248635978913844&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&regionId=553248635978913844&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=14%2F12%2F2025&endDate=15%2F12%2F2025&regionId=553248635978913844&star=40&star=40&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Top Medical Center District Hotel Reviews

![Omni La Mansion del Rio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955_y.jpg)

### Omni La Mansion del Rio

10/10 Excellent

"Excellent services !!! I recommend "

[](https://expedia.ca/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information)

![AC Hotel by Marriott San Antonio Riverwalk](https://images.trvl-media.com/lodging/65000000/64410000/64402200/64402184/eb0c229a_y.jpg)

### AC Hotel by Marriott San Antonio Riverwalk

10/10 Excellent

"The space was clean , modern and cozy. The location was outstanding. The front desk was very helpful and having the wonderful rooftop bar was just chefs kiss."

[](https://expedia.ca/San-Antonio-Hotels-AC-Hotel-By-Marriott-San-Antonio-Riverwalk.h64402184.Hotel-Information)

![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg)

### Riverwalk Plaza

10/10 Excellent

"Clean room, soft beds, friendly service "

[](https://expedia.ca/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![Hyatt Regency San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/93e4ec15_y.jpg)

### Hyatt Regency San Antonio Riverwalk

10/10 Excellent

"Great stay overall "

[](https://expedia.ca/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

![Hotel Contessa](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg)

### Hotel Contessa

10/10 Excellent

"The room was great, the only thing thay room was very cold. Other than that I enjoyed my stay. "

[](https://expedia.ca/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information)

## Frequently asked questions

### What are the best 4-star hotels in Medical Centre District?

### How much does it cost to stay in a 4-star hotel in Medical Centre District?

> - Search for the lowest price from CA $322

### What's the difference between 5-star and 4-star hotels in Medical Centre District?

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- [Romantic Hotels in Oakland Estates ](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Romantic-Hotel.0-n6230858-0-tRomanticHotel.Travel-Guide-Filter-Hotels)
- [Spa Hotels in Oakland Estates ](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Spa-Hotel.0-n6230858-0-tSpaHotel.Travel-Guide-Filter-Hotels)
- [Waterpark Hotels in Oakland Estates ](https://www.expedia.ca/Oakland-Estates-San-Antonio-Hotels-Waterpark-Hotels.0-n6230858-0-tWaterparkHotels.Travel-Guide-Filter-Hotels)
- [Olmos Park Terrace Hotels ](https://www.expedia.ca/Olmos-Park-Terrace-San-Antonio-Hotels.0-n553248635976469841-0.Travel-Guide-Filter-Hotels)
- [Hotels near Phil Hardberger Park ](https://www.expedia.ca/Phil-Hardberger-Park-Hotels.0-l553248621532643389-0.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Prospect Hill ](https://www.expedia.ca/Prospect-Hill-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976387013-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [San Antonio Hotels ](https://www.expedia.ca/San-Antonio-Hotels.d178303.Travel-Guide-Hotels)
- [Shavano Park Hotels ](https://www.expedia.ca/Shavano-Park-San-Antonio-Hotels.0-n6004947-0.Travel-Guide-Filter-Hotels)
- [Adults Only Resorts & in Shearer Hills - Ridgeview ](https://www.expedia.ca/Shearer-Hills-Ridgeview-San-Antonio-Hotels-Adults-Only-Resorts.0-n553248635976471907-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
- [Hotels near South Texas Medical Center ](https://www.expedia.ca/South-Texas-Medical-Center-Hotels.0-l6193120-0.Travel-Guide-Filter-Hotels)
- [Hotels near St. Mary's University ](https://www.expedia.ca/St-Marys-University-Hotels.0-l502632-0.Travel-Guide-Filter-Hotels)
- [Hotels near USAA Corporate Office Headquarters ](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Hotels.0-l553248621593511346-0.Travel-Guide-Filter-Hotels)
- [Hotels near University of Texas Health and Science Center at San Antonio ](https://www.expedia.ca/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Hotels.0-l6191585-0.Travel-Guide-Filter-Hotels)
- [All Inclusive Resorts and in Vance Jackson ](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels-All-Inclusive-Hotel.0-n553248635976480877-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
- [Vance Jackson Hotels ](https://www.expedia.ca/Vance-Jackson-San-Antonio-Hotels.0-n553248635976480877-0.Travel-Guide-Filter-Hotels)
- [Vista Del Norte Hotels ](https://www.expedia.ca/Vista-Del-Norte-San-Antonio-Hotels.0-n553248635976474068-0.Travel-Guide-Filter-Hotels)
- [Hotels near Wonderland of the Americas Mall ](https://www.expedia.ca/Wonderland-Of-The-Americas-Mall-Hotels.0-l6127197-0.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Woodlawn Lake ](https://www.expedia.ca/Woodlawn-Lake-San-Antonio-Hotels-Pet-Friendly-Hotel.0-n553248635976476298-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Hotels near Woodlawn Theater ](https://www.expedia.ca/Woodlawn-Theater-Hotels.0-l6083191-0.Travel-Guide-Filter-Hotels)
- [Best Western Hotels in Woodridge ](https://www.expedia.ca/Woodridge-San-Antonio-Hotels-Best-Western.0-n553248635976386203-0--bBestWestern.Travel-Guide-Filter-Hotels)

- [Flights from Vancouver (YVR) to San Antonio (SAT) ](https://www.expedia.ca/lp/flights/yvr/sat/vancouver-to-san-antonio)
- [Flights from Calgary (YYC) to San Antonio (SAT) ](https://www.expedia.ca/lp/flights/yyc/sat/calgary-to-san-antonio)
- [Flights from Toronto (YYZ) to San Antonio (SAT) ](https://www.expedia.ca/lp/flights/yyz/sat/toronto-to-san-antonio)

- [North Star Mall ](https://www.expedia.ca/North-Star-Mall-Uptown.d502628.Vacation-Attraction)
- [Visit Balcones Heights ](https://www.expedia.ca/San-Antonio-Balcones-Heights.dx553248634999172368)
- [Visit Castle Hills ](https://www.expedia.ca/San-Antonio-Castle-Hills.dx553248634999005679)
- [Visit Leon Valley ](https://www.expedia.ca/San-Antonio-Leon-Valley.dx125419)
- [Visit Oakland Estates ](https://www.expedia.ca/San-Antonio-Oakland-Estates.dx6230858)
- [Usaa Corporate Office Headquarters ](https://www.expedia.ca/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Vacation-Attraction)

- [Car rentals near Shavano Park ](https://www.expedia.ca/Car-Rentals-In-Shavano-Park.d6004947.Car-Rental-Guide)
- [Car rentals near USAA Corporate Office Headquarters ](https://www.expedia.ca/Car-Rentals-In-USAA-Corporate-Office-Headquarters.d553248621593511346.Car-Rental-Guide)

- [Book Hotels in Medical Center District on Expedia.com ](https://www.expedia.com/4Star-Medical-Center-District-San-Antonio-Hotels.s40-n553248635978913844-0.Travel-Guide-Filter-Hotels)