Title: Hotels by Americinn in Historic Southwest from CA $116 | Expedia.ca [Historic Southwest Travel Guide](https://expedia.ca/Rochester-Historic-Southwest.dx553248635976469790)[Vacation Rentals in Rochester](https://expedia.ca/Rochester-Vacation-Rentals.d3041.Travel-Guide-VacationRentals)[Flights to Rochester](https://expedia.ca/Cheap-Flights-To-Rochester.d3041.Travel-Guide-Flights)[Things to do in Rochester](https://expedia.ca/Things-To-Do-In-Rochester.d3041.Travel-Guide-Activities)[Historic Southwest Car Rentals](https://expedia.ca/Car-Rentals-In-Historic-Southwest.d553248635976469790.Car-Rental-Guide)[Historic Southwest Vacations](https://expedia.ca/Historic-Southwest.d553248635976469790.Destination-Travel-Guides) ![Rochester which includes military items, a garden and a memorial](https://images.trvl-media.com/place/3041/f9568051-8ce0-4fbd-b192-a51f17d2edc0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Soldiers Field Veterans Memorial ![](https://images.trvl-media.com/place/3041/f9568051-8ce0-4fbd-b192-a51f17d2edc0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Feb 1 - Feb 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976469790&startDate=2026-02-01&endDate=2026-02-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 2 - Feb 3](https://www.expedia.ca/Hotel-Search?regionId=553248635976469790&startDate=2026-02-02&endDate=2026-02-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635976469790&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976469790&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Historic Southwest Americinn ![Serves lunch, dinner, and happy hour](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/96cfed25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/4090d22a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Patio Room, 1 King Bed, Pet-Friendly, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/079e9789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Rochester Near Mayo Clinic [](https://www.expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) Rochester 8.0/10 Very good (1,197 reviews) "Room was clean and very comfortable beds. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) susan CA $100 CA $116 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/317c9900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/7f31033f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/6c566811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 7:00 AM to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/80430d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Rochester South Mayo Clinic [](https://www.expedia.ca/Rochester-Hotels-AmericInn-By-Wyndham-Rochester-Airport.h853433.Hotel-Information) Rochester 8.8/10 Excellent (1,000 reviews) "Enjoyed our stay, rated breakfast as a erage as we did not try it." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jeanne CA $103 CA $119 total includes taxes & fees Mar 4 - Mar 5 [](https://www.expedia.ca/Rochester-Hotels-AmericInn-By-Wyndham-Rochester-Airport.h853433.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-15&endDate=2026-02-16®ionId=553248635976469790&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FHistoric-Southwest-Rochester-Hotels-Americinn.0-n553248635976469790-0--bAmericinn.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FHistoric-Southwest-Rochester-Hotels-Americinn.0-n553248635976469790-0--bAmericinn.Travel-Guide-Filter-Hotels) ## Top Historic Southwest Hotel Reviews ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Overall hospitality " [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Hotel Indigo Rochester – Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/48e45010_y.jpg) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG 10/10 Excellent "Nice staff. The room is shaped a bit weird and cramped but it was clean and cozy. " [](https://expedia.ca/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "The room was beautiful and spacious for my family and I. The staff I encountered was very friendly and helpful but a specific gentleman was especially helpful with every greeting, he had a smile and was extremely informational even with my kods Playstation! 5 stars and i would definitely stay here again as well as recommend others to stay here. 😃 ❤️ 💙 " [](https://expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "We stayed for one night and everything was great. I especially like that the hot tub is open 24 hours!" [](https://expedia.ca/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Happy with the stay, great breakfast included. Happy with our room. No concerns, so continently located to Mayo. " [](https://expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Brentwood Inn & Suites](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3_y.jpg) ### Brentwood Inn & Suites 10/10 Excellent "Clean" [](https://expedia.ca/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![Holiday Inn Express Rochester South - Mayo Area by IHG](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/62a372dd_y.jpg) ### Holiday Inn Express Rochester South - Mayo Area by IHG 10/10 Excellent "Great service!" [](https://expedia.ca/Rochester-Hotels-Comfort-Suites.h2184971.Hotel-Information) ![The Berkman](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/50c22b07_y.jpg) ### The Berkman 10/10 Excellent "Everything was excellent, second time staying there. " [](https://expedia.ca/Rochester-Hotels-Berkman-Hotel.h46291477.Hotel-Information) ![Med City Inn & Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/821fc05d_y.jpg) ### Med City Inn & Suites - Mayo Clinic Area 10/10 Excellent "Room was nice " [](https://expedia.ca/Rochester-Hotels-GuestHouse-Rochester.h4106.Hotel-Information) ## Find out more about Historic Southwest ## Historic Southwest Hotels Guide Expedia.ca offers a selection of 386 hotels in Historic Southwest. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Historic Southwest. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Historic Southwest neighborhood you prefer. Go ahead. 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