Title: Hotels by Independent in Defiance from CA $74 | Expedia.ca [Defiance Travel Guide](https://expedia.ca/Defiance.dx6353634)[Hotels in Defiance](https://expedia.ca/Defiance-Hotels.d6353634.Travel-Guide-Hotels)[Vacation Rentals in Defiance](https://expedia.ca/Defiance-Vacation-Rentals.d6353634.Travel-Guide-VacationRentals)[Flights to Defiance](https://expedia.ca/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Defiance Car Rentals](https://expedia.ca/Car-Rentals-In-Defiance.d6353634.Car-Rental-Guide)[Defiance Vacation Packages](https://expedia.ca/Defiance.d6353634.Destination-Travel-Guides) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Defiance from CA $74 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 25 - Nov 26](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-11-25&endDate=2025-11-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 26 - Nov 27](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-11-26&endDate=2025-11-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Defiance Independent Hotels ![Lobby](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/3d3bc786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/7aa0940e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cleanliness standards](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/9192d05a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/f9889955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Relax Inn Saint Charles St. Charles 6.6/10 (1000) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Askar CA $86 CA $99 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information) ![Ballroom](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/1893bab9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/66ab3de8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Wildwood Hotel Wildwood 9.2/10 Wonderful (1606) "Great hotel in a great neighborhood " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda [](https://www.expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/ad47a940.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/b614d7da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/0a2f1564.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/b1e08b2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West Maryland Heights 7.4/10 Good (1005) "The 2 beautiful ladys at the front desk that checked me in was awesome. We went for a weekend getaway and we for sure had a great time. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ann M CA $63 CA $74 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/eb625205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/9ce09e24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/dc7a1896.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/6221ca39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Economy Inn Wentzville Wentzville 6.4/10 (497) "The Building has a nice exterior" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher CA $80 CA $91 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/St-Louis-Hotels-Economy-Inn-Wentzville.h8597.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/11000000/10020000/10013800/10013732/7266e88e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10020000/10013800/10013732/82725c2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/11000000/10020000/10013800/10013732/379dbf8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/11000000/10020000/10013800/10013732/2dc28531.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lodge Hotel and Banquets Bridgeton 5.2/10 (394) "The place was okay just need to be rebuilt and it’s very empty kinda creepy" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Delvic CA $85 CA $104 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/St-Louis-Hotels-The-Lodge-Hotel-And-Banquets.h10013732.Hotel-Information) ![Balcony view](https://images.trvl-media.com/lodging/74000000/73340000/73337200/73337142/c782f87e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/74000000/73340000/73337200/73337142/a0c10e84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/74000000/73340000/73337200/73337142/da468407.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Single Room](https://images.trvl-media.com/lodging/74000000/73340000/73337200/73337142/1e3360cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Elijah McLeans Washington 8.8/10 Excellent (133) "Modern" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $171 CA $195 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Washington-Hotels-The-Inn-At-Elijah-McLeans.h73337142.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/110000000/109320000/109317600/109317536/3c384067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109320000/109317600/109317536/ac83ba70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/110000000/109320000/109317600/109317536/273657bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room](https://images.trvl-media.com/lodging/110000000/109320000/109317600/109317536/aaf1f634.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Stay Warrenton Inn Warrenton 6.2/10 (14) "Staff was courteous and responsive. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $91 CA $105 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Warrenton-Hotels-Extended-Stay-Warrenton-Inn.h109317536.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/115000000/114880000/114876200/114876114/c9e98b49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Single Room, 1 King Bed, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/115000000/114880000/114876200/114876114/f0684f0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Single Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/115000000/114880000/114876200/114876114/c8df821f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114880000/114876200/114876114/5d64867f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### LAKEVIEWINN Lake St Louis 5.6/10 (30) "I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evelyn CA $107 CA $121 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/St-Louis-Hotels-LAKEVIEWINN.h114876114.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/7000000/6720000/6717700/6717650/ec725621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/7000000/6720000/6717700/6717650/78731ffb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/7000000/6720000/6717700/6717650/1743fa95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/7000000/6720000/6717700/6717650/653f0674.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cedar Creek New Haven 9.0/10 Wonderful (258) "The room was spotless and the bed was very comfortable. The screened in patio that our cabin room had was perfect for sitting outside and enjoying the fall weather. All the staff that we encountered were extremely friendly and helpful. They even got us out of a jam when we needed a corkscrew for our wine. The drive into Herman was not an issue at all and we have already talked about wanting to come back." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Phillip [](https://www.expedia.ca/Washington-Hotels-Cedar-Creek.h6717650.Hotel-Information) ![Family Studio Suite (No Elevator Access)](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/127d8869.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/be187969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Studio Suite](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/81de1e6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/ee872e80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### River Sirens Hotel Washington 9.8/10 Exceptional (180) "Nice, modern, ease of check in" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deborah [](https://www.expedia.ca/Washington-Hotels-Sirens-Hotel.h55078446.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-09&endDate=2025-12-10®ionId=6353634&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels-Independent.0-0-d6353634--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels-Independent.0-0-d6353634--bIndependent.Travel-Guide-Filter-Hotels) ## Top Defiance Hotel Reviews ![Hyatt Place St. Louis/Chesterfield](https://images.trvl-media.com/lodging/7000000/6590000/6583800/6583788/d7f7c2c1_y.jpg) ### Hyatt Place St. Louis/Chesterfield 10/10 Excellent "Very clean, friendly staff and great breakfast options " [](https://expedia.ca/St-Louis-Hotels-Hyatt-Place-St-LouisChesterfield.h6583788.Hotel-Information) ![Courtyard by Marriott St Louis Creve Coeur](https://images.trvl-media.com/lodging/1000000/20000/11100/11052/96f17f89_y.jpg) ### Courtyard by Marriott St Louis Creve Coeur 10/10 Excellent "It was comfortable and clean. Centrally located. " [](https://expedia.ca/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-Creve-Coeur.h11052.Hotel-Information) ![Drury Plaza Hotel St. Louis Creve Coeur](https://images.trvl-media.com/lodging/1000000/80000/74700/74657/3c4503ce_y.jpg) ### Drury Plaza Hotel St. Louis Creve Coeur 10/10 Excellent "My experience checking in was very swift and pleasant." [](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Creve-Coeur.h74657.Hotel-Information) ![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg) ### Country Inn & Suites by Radisson, St. Charles Historic District 10/10 Excellent "Great service - quaint location" [](https://expedia.ca/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) ![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/bfca870c_y.jpg) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham 10/10 Excellent "Room was clean and staff was friendly. Just all around great place to stay." [](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg) ### The Wildwood Hotel 10/10 Excellent "Very good hotel i can say one of the best hotels i have stayed at in the last 3 months " [](https://expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Wingate by Wyndham St. Louis/Fenton Route 66](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/5c35b8a4_y.jpg) ### Wingate by Wyndham St. Louis/Fenton Route 66 10/10 Excellent "Great price with good quality! " [](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Fenton.h40102.Hotel-Information) ![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg) ### Hollywood Casino & Hotel St. Louis 10/10 Excellent "Everything is great" [](https://expedia.ca/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/8c366380_y.jpg) ### Hampton Inn St. Charles St. Peters 10/10 Excellent "Great hotel. The ladies at the front desk were the sweetest too" [](https://expedia.ca/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Hotels near 9-11 Memorial](https://www.expedia.ca/9-11-Memorial-Hotels.0-l6268196-0.Travel-Guide-Filter-Hotels) - [B&B in Augusta](https://www.expedia.ca/Augusta-Bed-And-Breakfast.d6250878-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Boutique Hotels in Augusta](https://www.expedia.ca/Augusta-Hotels-Boutique-Hotel.0-0-d6250878-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Augusta](https://www.expedia.ca/Augusta-Hotels-Cheap-Hotels.0-0-d6250878-tCheapHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Augusta](https://www.expedia.ca/Augusta-Hotels-Historic-Hotel.0-0-d6250878-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Augusta](https://www.expedia.ca/Augusta-Hotels-Hotel-With-Pool.0-0-d6250878-tHotelwithPool.Travel-Guide-Filter-Hotels) - 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