Title: Book the Best De Soto SPA Resorts from CA $285 - Spa Hotels in De Soto, MO | Expedia.ca [Hotels in De Soto](https://expedia.ca/De-Soto-Hotels.d6085105.Travel-Guide-Hotels)[Vacation Rentals in De Soto](https://expedia.ca/De-Soto-Vacation-Rentals.d6085105.Travel-Guide-VacationRentals)[De Soto Car Rentals](https://expedia.ca/Car-Rentals-In-De-Soto.d6085105.Car-Rental-Guide)[De Soto Vacation Packages](https://expedia.ca/De-Soto.d6085105.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/1f71f3ee006639c0d49d18546ddf62b5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jessica King # Find Spa Hotels in De Soto, MO from CA $285 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on De Soto Spa Hotels Tonight [Sep 26 - Sep 27](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-09-26&endDate=2025-09-27&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-09-27&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-09-26&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top De Soto Spa Hotels ![Exterior](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/94cc7abb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/2f3d8c4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/77123b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/e3a8a6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG De Soto 9.4/10 Exceptional (153) "Enjoyed our short stay, will definitely be back. " CA $250 CA $285 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Farmington-Hotels-Holiday-Inn-Club-Vacations-Timber-Creek-Resort.h1858536.Hotel-Information) ![TV, DVD player](https://images.trvl-media.com/lodging/72000000/71170000/71165200/71165148/c1eb51f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/72000000/71170000/71165200/71165148/aae87939.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/72000000/71170000/71165200/71165148/1ac6c733.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/72000000/71170000/71165200/71165148/3c2e5835.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Private Villa | 5-Hole Golf On-Site Desoto 9.0/10 Wonderful (13) "turned out to be a great spot to visit with family in the area and still have activities for evéryone" [](https://www.expedia.ca/De-Soto-Hotels-Lakeside-Private-Villa-5-Hole-Golf-On-Site.h71165148.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=6085105&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about De Soto ### Top De Soto attractions for a relaxing vacation In De Soto, Missouri, travellers seeking hotel spas can indulge in a well-rounded experience that caters to relaxation and adventure. Start with a visit to the picturesque Huzzah Conservation Area, where the scenic trails are perfect for hiking and discovering the beauty of nature. After an invigorating day outdoors, unwind at one of the local spas that offer rejuvenating treatments, such as massages and facials, ensuring you feel pampered and refreshed. For those interested in local culture, the De Soto Historical Society Museum presents fascinating exhibits that delve into the area's rich history, providing a unique insight that complements your stay. Families will enjoy a day at the nearby Washington State Park, which showcases beautiful picnic spots and swimming areas, allowing for a delightful day spent together. Finally, for a touch of local flair, explore the charming shops downtown that feature handcrafted goods and gourmet treats, perfect for leisurely browsing. Staying in the heart of De Soto not only places you close to these attractions but also ensures easy access to hotels that prioritise guest service and comfort, allowing you to unwind after a day of exploration. ## Top De Soto Hotel Reviews ![Crown Pointe Lodge, BW Signature Collection](//images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/83119f36_y.jpg) ### Crown Pointe Lodge, BW Signature Collection 10/10 Excellent "Very nice hotel, awesome breakfast." [](https://expedia.ca/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information) ![Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG](//images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/94cc7abb_y.jpg) ### Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG 10/10 Excellent "Very nice resort and accommodations were fantastic!! My young nephews loved the jetted tub. 2 bedrooms were spacious and the back balcony was wonderful to relax for the evening. Unique extra kitchenette in the Queen bedroom!! I would highly recommend and would return again. " [](https://expedia.ca/Farmington-Hotels-Holiday-Inn-Club-Vacations-Timber-Creek-Resort.h1858536.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in De Soto? > Soothe the senses with some time in one of our wonderful spa hotels. Hotels with spas are a great way to break out of your routine and add a layer of luxury to your vacation. ### What's there to see and do in De Soto? > Enjoy all that De Soto has to offer when you visit Sunrise Lake Beach, Washington State Park, and Big River. If you have a little extra time during your trip, you might want to make a stop at Victoria Glaces Conservation Area Trailhead and Big Lake. ### What is a De Soto spa hotel? > Spa hotels in De Soto provide lodging and have a full on-site spa offering services including couples massages as well as body treatments. Some also offer in-room treatments. 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