Title: Santa Isabel Vacation Rentals from CA $437: Short-Term Rentals for 2026 | Expedia.ca

[Hotels in Santa Isabel](https://expedia.ca/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Santa Isabel Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Isabel.d6203540.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.ca/Santa-Isabel.d6203540.Destination-Travel-Guides)

![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=6203540&startDate=2026-02-27&endDate=2026-03-01&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=6203540&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 8 - May 10](https://www.expedia.ca/Hotel-Search?regionId=6203540&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 5 - Jun 7](https://www.expedia.ca/Hotel-Search?regionId=6203540&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santa Isabel vacation rentals

![Beach nearby, beach towels](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/a2a99590.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/bed98230.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/6f230b81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/da467749.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Exclusive sailboat for 2 people all inclusive in San Blas islands

[](https://www.expedia.ca/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information)

Guna Yala

10/10

Exceptional

(1 review)

"Anita e Federico sono state il valore aggiunto in queste isole meravigliose. La loro disponibilita, le loro attenzioni, i sorridenti contatti di Anita con la popolazione dei Guna e la cucina superlativa di Federico hanno reso speciale la nostra vacanza che ha soddisfatto appieno le nostre aspettative. Discreta e deliziosa la presenza della gattina (la principessa di bordo) Shanu. Grazie di tutto!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Grazia B.

CA $720

CA $823 total

includes taxes & fees

Feb 15 - Feb 16

[](https://www.expedia.ca/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/803cd264.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/9304c3cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/c41bafb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Beach](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/1b7d8cbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Catamaran experience in paradise

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Catamaran-Experience-In-Paradise.h71141036.Hotel-Information)

Guna Yala Comarca

CA $806

CA $1,654 total

includes taxes & fees

Feb 14 - Feb 15

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Catamaran-Experience-In-Paradise.h71141036.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/ddaf5491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/a9525fbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/5da2e9cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/9dbdc819.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Caribbean getaway: beach cottage just on the sand

[](https://www.expedia.ca/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information)

Palenque

10/10

Exceptional

(1 review)

"The beach view was perfect! I loved hearing the waves all day and throughout the night. My dog and I enjoyed everything and felt very comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth N.

CA $353

CA $437 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-27&endDate=2026-02-28&regionId=6203540&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale 

Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 

[Book now](https://expedia.ca/deals?rfrr=VR_SPRING_PROMO_6203540)

## Find vacation rentals that suit your style

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama&regionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-05-14&d1=2026-05-14&endDate=2026-05-17&d2=2026-05-17&lodging=COTTAGE)

Villas

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama&regionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-05-14&d1=2026-05-14&endDate=2026-05-17&d2=2026-05-17&lodging=VILLA)

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama&regionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-05-14&d1=2026-05-14&endDate=2026-05-17&d2=2026-05-17&lodging=VACATION_HOME)

Houseboats

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama&regionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-05-14&d1=2026-05-14&endDate=2026-05-17&d2=2026-05-17&lodging=HOUSE_BOAT)

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## Top Santa Isabel Hotel Reviews

![BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES](https://images.trvl-media.com/lodging/31000000/30800000/30792300/30792236/afc188ba_y.jpg)

### BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

10/10 Excellent

"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. "

[](https://expedia.ca/Palenque-Hotels-Palenque-Spectacular-Caribbean-Ocean-Front-Property-In-Panama.h30792236.Hotel-Information)

![Exclusive sailboat for 2 people all inclusive in San Blas islands](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/3296d6de_y.jpg)

### Exclusive sailboat for 2 people all inclusive in San Blas islands

10/10 Excellent

"Anita e Federico sono state il valore aggiunto in queste isole meravigliose. La loro disponibilita, le loro attenzioni, i sorridenti contatti di Anita con la popolazione dei Guna e la cucina superlativa di Federico hanno reso speciale la nostra vacanza che ha soddisfatto appieno le nostre aspettative. Discreta e deliziosa la presenza della gattina (la principessa di bordo) Shanu. Grazie di tutto!"

[](https://expedia.ca/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information)

![Caribbean getaway: beach cottage just on the sand](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/24e34d16_y.jpg)

### Caribbean getaway: beach cottage just on the sand

10/10 Excellent

"The beach view was perfect! I loved hearing the waves all day and throughout the night. My dog and I enjoyed everything and felt very comfortable. "

[](https://expedia.ca/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information)

## Find out more about Santa Isabel

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.  
  
As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santa Isabel. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.   
  
It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.   

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## Frequently asked questions

### Are there vacation rentals in Santa Isabel?

### What are some of the best vacation rentals that Santa Isabel has to offer?

### What’s there to see and do in Santa Isabel?

### What’s a vacation rental in Santa Isabel like?

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