Plan, book, travel with confidence
Better together
Save up to CA $1,096 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your Port Isabel Vacation

When a break in the city is calling, answer it with a Port Isabel vacation package. The neighborhood of The Shores, which is great for families, watersports and nature, makes an excellent base for your adventures. Every trip to Port Isabel needs a well-thought-out itinerary. Fill yours with big-name attractions like Beach Park at Isla Blanca, South Padre Island Beach and Boca Chica State Park. Stop daydreaming and start adventuring. Explore the wide range of options on Expedia today and put your Port Isabel vacation plans into action!

Ready to book your vacation to Port Isabel?

Choose your dates

Port Isabel Hotel Deals

Port Isla Inn

200 2nd St Port Isabel TX

Fully refundableReserve now, pay when you stay

CA $68

CA $78 total

Apr 29 - Apr 30

includes taxes & fees

8/10 Very Good! (937 reviews)

House keeping kept the room very clean and stocked. I was very pleased.

Reviewed on Apr 21, 2026

Executive Inn and Suites

1411 TX-100 Port Isabel TX

Fully refundableReserve now, pay when you stay

CA $89

CA $102 total

Apr 22 - Apr 23

includes taxes & fees

5.6/10 (397 reviews)

Sucio y habían cucarachas

Reviewed on Apr 4, 2026

Spacious Bay

35 Spacious way Port Isabel TX

Get rates

See all 3,759 properties in Port Isabel

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.