Plan, book, travel with confidence
Better together
Save up to CA $4,200 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your Port Isabel Vacation

When a break in the city is calling, answer it with a Port Isabel vacation package. The neighborhood of The Shores, which is great for families, watersports and nature, makes an excellent base for your adventures. Every trip to Port Isabel needs a well-thought-out itinerary. Fill yours with big-name attractions like Beach Park at Isla Blanca, South Padre Island Beach and Boca Chica State Park. Stop daydreaming and start adventuring. Explore the wide range of options on Expedia today and put your Port Isabel vacation plans into action!

Ready to book your vacation to Port Isabel?

Choose your dates

Port Isabel Hotel Deals

Port Isla Inn

200 2nd St Port Isabel TX

Fully refundableReserve now, pay when you stay

CA $82

CA $94 total

May 17 - May 18

includes taxes & fees

8/10 Very Good! (947 reviews)

Parking was easy, staff knowledgeable, room clean. No ice machine on site and no curtains on windows allowed too much light into the room at night.

Reviewed on May 5, 2026

Spacious Bay

35 Spacious way Port Isabel TX

Get rates

Casa Rosa Inn

761 W. Highway 100 Port Isabel TX

Fully refundable

CA $57

CA $80 total

May 17 - May 18

includes taxes & fees

See all 3,835 properties in Port Isabel

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.