
Depew Vacation Packages
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Your Depew Vacation
A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.
Top Depew Vacation Deals

La Quinta Inn & Suites by Wyndham Buffalo Amherst
Reviewed on Sep. 1, 2025
Depew Hotel Deals

M Hotel Buffalo

Buffalo Airport Hotel

Hyatt Regency Buffalo / Hotel and Conference Center
Reviewed on Aug. 28, 2025
Discover the most popular places to visit in Depew

University At Buffalo - North Campus
Explore the campus of University At Buffalo - North Campus, a top college in Amherst. Experience the area's great live music and entertainment choices.

Highmark Stadium
Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's entertainment choices and great live music.

Buffalo Zoo
See more than 1,200 animals at this small zoo in Buffalo’s Delaware Park. Explore the rainforest building or see the big cats of the African plains.
What to do in Depew

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

Niagara Falls Self-Guided Driving Audio Tour from Toronto

Disco Murder Mystery Performance Double Decker Bus in Buffalo
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