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Upstate South Carolina Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Upstate South Carolina vacation rentals

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

1. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (942 reviews)
"Great location-we walked to soo many shops and restaurants!"
United States
Deborah
The price is CA $134
CA $147 total
includes taxes & fees
Dec 1 - Dec 2
Mint House Greenville Downtown by Kasa
Private kitchen

2. stayAPT Suites Greenville-Haywood Mall

stayAPT Suites Greenville-Haywood Mall
3.0 star property
Greenville
9.0 out of 10, Wonderful, (242 reviews)
"Great property and cozy. Safe area and close to mall and restaurants."
United States
Samantha Ann
The price is CA $189
CA $208 total
includes taxes & fees
Nov 19 - Nov 20
stayAPT Suites Greenville-Haywood Mall
A hotel room with a bed, desk, chair, and a bathroom with a mirror and sink.

3. King Bed Non-Smoking

King Bed Non-Smoking
Greenville SC
10.0 out of 10, Exceptional, (135 reviews)
"The location is fantastic if you're aiming to see local sights easily without stress,just a short drive or even a delightful walk if you have extra time!"
United States
Anonymous traveller
The price is CA $83
CA $102 total
includes taxes & fees
Nov 25 - Nov 26
King Bed Non-Smoking
A hotel room with a bed, a sofa, a small table, a lamp, and a refrigerator.

4. 1 Queen Bed | Non-Smoking, Micfridge

1 Queen Bed | Non-Smoking, Micfridge
Greenville SC
9.4 out of 10, Exceptional, (52 reviews)
"I absolutely love it here"
United States
Anonymous traveller
The price is CA $72
CA $79 total
includes taxes & fees
Nov 9 - Nov 10
1 Queen Bed | Non-Smoking, Micfridge
A compact kitchen with a central island, a dining area with a sofa, and a small side table.

5. Cute 1 BR with Fire Pit Near DT

Cute 1 BR with Fire Pit Near DT
Greenville
10.0 out of 10, Exceptional, (3 reviews)
"very nice close to lots of stuff"
United States
John
The price is CA $72
CA $210 total
includes taxes & fees
Nov 22 - Nov 23
Cute 1 BR with Fire Pit Near DT
A living room with a sofa, coffee table, and a ceiling fan.

6. Cozy 1BR Close to Downtown & Greenville Drive Baseball

Cozy 1BR Close to Downtown & Greenville Drive Baseball
Greenville
9.0 out of 10, Wonderful, (34 reviews)
"Good location, great communication"
United States
isaiah
The price is CA $72
CA $206 total
includes taxes & fees
Nov 15 - Nov 16
Cozy 1BR Close to Downtown & Greenville Drive Baseball
A house with a gravel driveway, a wooden fence, and a lawn.

7. Secluded Tiny Home in Exclusive Paris Mountain!

Secluded Tiny Home in Exclusive Paris Mountain!
Greenville
10.0 out of 10, Exceptional, (15 reviews)
"Great location, quiet and perfect for a couple stay. "
United States
craig d.
The price is CA $95
CA $181 total
includes taxes & fees
Nov 9 - Nov 10
Secluded Tiny Home in Exclusive Paris Mountain!
A bedroom with a bed, a window, a flat-screen TV, and a door.

8. Cozy Apt. Near Downtown (2BR, 1BA, 3 beds)

Cozy Apt. Near Downtown (2BR, 1BA, 3 beds)
Greenville
10.0 out of 10, Exceptional, (14 reviews)
"I was provided everything I needed."
United States
Pat
The price is CA $133
CA $228 total
includes taxes & fees
Nov 16 - Nov 17
Cozy Apt. Near Downtown (2BR, 1BA, 3 beds)
A log cabin with a wooden door, two windows, and a chimney. There are two white metal chairs and a small table in front of the cabin.

9. Historic 19th Century Cabin in Greenville

Historic 19th Century Cabin in Greenville
Greenville
9.6 out of 10, Exceptional, (24 reviews)
"The cabin was beautiful."
United States
John A.
The price is CA $116
CA $208 total
includes taxes & fees
Nov 9 - Nov 10
Historic 19th Century Cabin in Greenville
A modern building with outdoor seating and a garden.

10. The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (25 reviews)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is CA $310
CA $458 total
includes taxes & fees
Nov 29 - Nov 30
The Station by Compo Hotels
A modern kitchen with white cabinets, stainless steel appliances, a granite countertop, and a built-in oven.

11. The Blue Bungalow by Unity Park - Newly Renovated

The Blue Bungalow by Unity Park - Newly Renovated
Woodside Cotton Mill Village Historic District
9.8 out of 10, Exceptional, (115 reviews)
"Fully equipped, comfortable beds…everything to make for an enjoyable stay. "
United States
Ron E.
The price is CA $104
CA $303 total
includes taxes & fees
Nov 17 - Nov 18
The Blue Bungalow by Unity Park - Newly Renovated
A modern kitchen with a stainless steel refrigerator, a microwave, and a sink. There is a wooden dining table with chairs and a laundry basket labeled "laundry" in the foreground.

12. 2BR 2Bath - Swamp Rabbit Trail Resort

2BR 2Bath - Swamp Rabbit Trail Resort
Greenville
9.2 out of 10, Wonderful, (46 reviews)
"Great place!"
United States
Lisa W.
The price is CA $87
CA $255 total
includes taxes & fees
Nov 15 - Nov 16
2BR 2Bath - Swamp Rabbit Trail Resort
A living room with a grey sofa, a black coffee table, a lamp, and a painting on the wall.

13. Apt. near Downtown Greenville (2BR/1BA, 3 beds)

Apt. near Downtown Greenville (2BR/1BA, 3 beds)
Greenville
10.0 out of 10, Exceptional, (12 reviews)
"It was clean and quiet..I will stay here again. "
United States
Kimberly S.
The price is CA $133
CA $228 total
includes taxes & fees
Nov 17 - Nov 18
Apt. near Downtown Greenville (2BR/1BA, 3 beds)
A modern living room with a grey sofa, a round coffee table, and a dining area with a table and chairs.

14. Southern Charm Townhome

Southern Charm Townhome
Simpsonville
10.0 out of 10, Exceptional, (11 reviews)
"Very clean and safe location. Super cute interior decorations and comfortable. Also a great location for us to visit family who are local. Absolutely would stay again."
United States
Brianna F.
The price is CA $157
CA $531 total
includes taxes & fees
Nov 9 - Nov 10
Southern Charm Townhome
A modern living room with a sofa, a coffee table, and a TV. There is a kitchen area with a microwave, stove, and refrigerator.

15. Adorable Upscale cottage in Downtown Fountain Inn.

Adorable Upscale cottage in Downtown Fountain Inn.
Fountain Inn
10.0 out of 10, Exceptional, (49 reviews)
"It was a great location for us as we're building in Fountain Inn. Very cute, very comfortable, close to everything we needed. Host was great. Will stay again"
United States
Valerie
The price is CA $191
CA $354 total
includes taxes & fees
Nov 11 - Nov 12
Adorable Upscale cottage in Downtown Fountain Inn.
A modern kitchen with granite countertops, stainless steel appliances, and a dining area with a sofa and table.

16. 2BR Cedar Lane Road Retreat at Swamp Rabbit Trail!

2BR Cedar Lane Road Retreat at Swamp Rabbit Trail!
Greenville
9.4 out of 10, Exceptional, (41 reviews)
"The area is very quiet, a wonderful space, excellent service."
United States
Gabriel D.
The price is CA $89
CA $258 total
includes taxes & fees
Nov 24 - Nov 25
2BR Cedar Lane Road Retreat at Swamp Rabbit Trail!
Room

17. Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
10.0 out of 10, Exceptional, (4 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
United States
Katlynn
The price is CA $151
CA $285 total
includes taxes & fees
Dec 9 - Dec 10
Carolina Camp Cedar
A cabin with a cozy interior, a wooden exterior, and a view of the forest.

18. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (120 reviews)
"Perfect location for getting away in a quiet cabin!"
United States
Lori
The price is CA $119
CA $193 total
includes taxes & fees
Dec 8 - Dec 9
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A modern living room with a sectional sofa, a dining area with chairs, and a large bean bag.

19. Red Door Apartment 2.0 | Heart Of Downtown Greenville | Lovesac Bean Bag!

Red Door Apartment 2.0 | Heart Of Downtown Greenville | Lovesac Bean Bag!
Greenville Downtown
9.4 out of 10, Exceptional, (92 reviews)
"Best communication ever!!! Lovely apartment with close vicinity to great restaurants and enjoyable venues. Would stay again."
United States
Angela
The price is CA $240
CA $516 total
includes taxes & fees
Nov 9 - Nov 10
Red Door Apartment 2.0 | Heart Of Downtown Greenville | Lovesac Bean Bag!
A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.

20. Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
Clemson
9.6 out of 10, Exceptional, (10 reviews)
"We enjoyed our stay, it was the perfect size for our family of four. "
United States
Ashley
The price is CA $126
CA $336 total
includes taxes & fees
Nov 15 - Nov 16
Clemson Memorabilia House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Top Upstate South Carolina Hotel Reviews

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
Hotel Hartness

Hotel Hartness

Hotel Hartness
Greenville

10/10 Excellent

What a gem!! Definitely the place to stay when in Greenville, or even to visit specifically as a vacation. It’s not in the city (about 15min drive) and that’s the beauty of this place: it’s away from touristy stuff, and in the middle of nature, but close enough to the city that you can always go and visit. The service was 6 star! All the staff were super friendly, and while a part of it is “southern hospitality “, there for sure is an added factor of the culture of the hotel. Great dining...
Canada
anshu
Reviewed July 7, 2025
Hotel Hartness

Find out more about Upstate South Carolina

Everything you need to know about Upstate South Carolina vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Upstate South Carolina vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Upstate South Carolina vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Upstate South Carolina vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Upstate South Carolina. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Upstate South Carolina vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Upstate South Carolina vacation rentals we have selected for you start as low as CA $72 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Upstate South Carolina rentals

At Expedia, we put the best Upstate South Carolina vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Upstate South Carolina rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Upstate South Carolina vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Upstate South Carolina. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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